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Find hotels in Sikeston, MO from ฿1,999

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24 Dec - 25 Dec
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25 Dec - 26 Dec
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26 Dec - 28 Dec
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2 Jan - 4 Jan

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Our top choices for Sikeston hotels

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
"Great place and staff, very accommodating!"
United States
Megan
The price is ฿2,799
฿3,158 total
includes taxes & fees
29 Dec - 30 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"This our favorite place to stop for a good night sleep. "
United States
Eileen
The price is ฿2,799
฿3,218 total
includes taxes & fees
28 Dec - 29 Dec
Drury Inn & Suites Sikeston, MO
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1000)
"Great stay"
United States
Heather
The price is ฿2,177
฿2,456 total
includes taxes & fees
29 Dec - 30 Dec
Pear Tree Inn Cape Girardeau West
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1009)
"Great stay, everything was clean and comfortable. "
United States
Charles
The price is ฿2,353
฿2,682 total
includes taxes & fees
29 Dec - 30 Dec
Best Western Plus Sikeston
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (722)
"Room was good as usual. This is 4th stay over past 5 years. Only issue I had on this stay was the orange juice from breakfast options. "
United States
Todd
The price is ฿1,726
฿1,967 total
includes taxes & fees
20 Jan - 21 Jan 2026
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (674)
"Great place "
United States
GUY
The price is ฿2,619
฿2,835 total
includes taxes & fees
7 Jan - 8 Jan 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is ฿2,832
฿3,195 total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Business centre
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"Very friendly staff and great breakfast"
United States
Ray
The price is ฿2,799
฿3,158 total
includes taxes & fees
29 Dec - 30 Dec
Drury Inn & Suites Cape Girardeau
Breakfast, lunch, dinner served; American cuisine
Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (388)
"Very nice"
United States
Dennis
The price is ฿2,358
฿2,647 total
includes taxes & fees
25 Dec - 26 Dec
Travelodge by Wyndham Dexter
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is ฿3,888
฿4,406 total
includes taxes & fees
18 Jan - 19 Jan 2026
Courtyard by Marriott Cape Girardeau Downtown
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (450)
"clean room, comfy bedding, nice staff, convenient location "
United States
Alexa
The price is ฿3,035
฿3,437 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn Sikeston
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1011)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is ฿2,581
฿2,729 total
includes taxes & fees
28 Dec - 29 Dec
Drury Inn & Suites Jackson MO
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1004)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is ฿2,177
฿2,456 total
includes taxes & fees
29 Dec - 30 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (142)
"Nice hotel, clean and comfortable "
United States
Laura
The price is ฿2,737
฿3,088 total
includes taxes & fees
1 Jan - 2 Jan 2026
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1002)
"Everything was clean, staff was friendly "
United States
Matthew
The price is ฿2,333
฿2,682 total
includes taxes & fees
29 Dec - 30 Dec
Pear Tree Inn Sikeston
Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (476)
"The room was clean and the mattress was extremely comfortable "
United States
Stacy
The price is ฿2,996
฿3,379 total
includes taxes & fees
29 Dec - 30 Dec
The Riverview
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is ฿3,266
฿3,698 total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
Lobby
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.2 out of 10, Good, (686)
"Overall was wonderful customer service and breakfast"
United States
Stephanie
The price is ฿1,792
฿2,021 total
includes taxes & fees
30 Dec - 31 Dec
Quality Inn Cape Girardeau North
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.2 out of 10, Very good, (885)
"Room was clean and spacious."
United States
George
The price is ฿2,395
฿2,873 total
includes taxes & fees
21 Jan - 22 Jan 2026
Candlewood Suites Cape Girardeau by IHG
Exterior
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (282)
"Room was clean, breakfast was very good. "
United States
Connie
The price is ฿2,750
฿3,134 total
includes taxes & fees
19 Jan - 20 Jan 2026
Comfort Inn & Suites Sikeston I-55
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Sikeston attractions

City of Miner Convention Center

This versatile 16,000-square-foot venue in Miner, Missouri hosts conferences, weddings, and community gatherings. Modern meeting rooms and a commercial kitchen make it ideal for various events.
See properties

Sikeston Depot Museum

3.8/5 (33 reviews)
Housed in a restored 1916 train depot, this museum showcases Sikeston's cotton-growing heritage and local art. Explore regional history through rotating exhibits while admiring the building's National Register status.
See properties

Sikeston and related destinations

Home to Lambert's Café, the 'Home of Throwed Rolls,' where servers toss fresh bread across the room to hungry diners. Visit the historic Sikeston Depot or catch the annual rodeo where professional cowboys compete in thrilling events each August.

See all hotels in Sikeston
The best restaurant I have EVER been to! Hands down!!!
Photo by Ryan Coleman
Open Photo by Ryan Coleman

Top Sikeston Hotel Reviews

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10/10 Excellent
"Very clean environment. Staff is very nice and friendly. Will not mind staying here again in future. "
Rahveen 2-night trip
Posted 10 days ago
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

More cheap stays in Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
The price is ฿1,957 per night from 20 Jan to 21 Jan
฿1,957
฿2,230 total
20 Jan - 21 Jan 2026
includes taxes & fees
7.2/10 Good! (1,000 reviews)

Frequently asked questions

Where is the best place to stay in Sikeston?
Pear Tree Inn Sikeston is ranked highly by Expedia customers. This hotel offers free breakfast and an outdoor pool. Other top choices based on reviews include Fairfield Inn & Suites by Marriott Sikeston and Drury Inn & Suites Sikeston, MO. See all available top hotels, or vacation rentals in Sikeston.
If I need to cancel my hotel reservation in Sikeston, will I receive a refund?
Yes, you'll find most room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If your reservation is non-refundable, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Sikeston.
What's the best budget-friendly hotel in Sikeston?
Based on reviews, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) is a popular hotel for our travellers who want a more economical choice, and features free breakfast and free Wi-Fi. View all budget hotels in Sikeston.
What's the best family accommodation in Sikeston?
Drury Inn & Suites Sikeston, MO is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Pear Tree Inn Sikeston is another good choice for your family trip. Find more child-friendly accommodations in Sikeston.
What's the best LGBTQ-friendly hotel in Sikeston?
Drury Inn & Suites Sikeston, MO is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Pear Tree Inn Sikeston and Hampton Inn Sikeston are two other good choices for your holiday. See all available hotels listed as LGBTQ-friendly in Sikeston.
What's the best dog-friendly hotel in Sikeston?
Drury Inn & Suites Sikeston, MO is a top hotel for people travelling with their pets, and offers an indoor pool and free WiFi for its human guests. Other good choices for you and your pet's trip include Days Inn and Suites by Wyndham Sikeston and Hampton Inn Sikeston. See more pet-friendly hotel accommodations in Sikeston.
What are some hotels with pools in Sikeston?
Best Western Plus Sikeston is a top hotel with a pool, free full breakfast and free self-parking. TownePlace Suites by Marriott Sikeston is another choice with an on-site pool. View all hotels with pools in Sikeston.
What is staying in Sikeston like?
Families will find child-friendly activities in Sikeston, and visitors give high marks for the top-notch restaurants and shopping. This welcoming city also attracts tourists with its riverfront and university setting. In Sikeston, there are 15 hotels and other accommodation options to choose from. Find out more about Sikeston.
What is there to see in Sikeston?
A couple of favourite places to visit are Sikeston Depot Museum and Central Park. You'll also find River Ridge Winery and Front Street Studio & Art Gallery in the area. Take a look at what more there is to see and do in Expedia's Sikeston guide.
What's the seasonal weather in Sikeston?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Sikeston is 1536 mm.

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