Sikeston Packages (Flight + Hotel)

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ฿4,531 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Top hotels in Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is ฿3,584 per night from 9 Apr to 10 Apr
฿3,584
฿4,120 total
9 Apr - 10 Apr
includes taxes & fees
9.4/10 Exceptional! (1,009 reviews)
Clean, friendly staff, comfortable!

Reviewed on 6 Apr 2026

Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
The price is ฿3,358 per night from 26 Apr to 27 Apr
฿3,358
฿3,802 total
26 Apr - 27 Apr
includes taxes & fees
9/10 Wonderful! (527 reviews)
Was very clean & pet-friendly. Great place to stop on toad

Reviewed on 4 Apr 2026

Hampton Inn Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Fully refundableReserve now, pay when you stay
The price is ฿2,500 per night from 26 Apr to 27 Apr
฿2,500
฿2,850 total
26 Apr - 27 Apr
includes taxes & fees
8.4/10 Very Good! (1,000 reviews)
The bed and chair was hard. Will not go back

Reviewed on 30 Mar 2026

Best Western Plus Sikeston I-55
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.