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Our top choices for Siesta Isle hotels

A row of turquoise Adirondack chairs with umbrellas, a wooden deck, and a marina in the background.

1. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
Siesta Isle
9.0 out of 10, Wonderful, (1,000 reviews)
"I like this hotel we have been twice"
United States
Giovanna
The price is ฿3,186
฿3,553 total
includes taxes & fees
5 Nov - 6 Nov
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
A large, clear swimming pool with multiple lounge areas and palm trees.

2. Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers
4.0 star property
2.6 km from Siesta Isle
9.0 out of 10, Wonderful, (2,733 reviews)
"Everything about the resort was excellent"
United States
Lance
The price is ฿6,039
฿8,425 total
includes taxes & fees
29 Nov - 30 Nov
Margaritaville Beach Resort Fort Myers
A swimming pool with a rock arch structure, a multi-story building with balconies, and palm trees in the background.

3. Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
1.8 km from Siesta Isle
9.4 out of 10, Exceptional, (1,488 reviews)
"It's nice place to stay"
United States
Mario
The price is ฿7,261
฿10,317 total
includes taxes & fees
15 Nov - 16 Nov
Pink Shell Beach Resort and Marina
An outdoor patio with tables and chairs, umbrellas, and a pool in the background.

4. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
2.7 km from Siesta Isle
9.2 out of 10, Wonderful, (1,004 reviews)
"Clean Hotel! Convenient for one night stay, close to airport and beaches."
United States
Kimberly
The price is ฿3,405
฿3,797 total
includes taxes & fees
22 Nov - 23 Nov
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
A spacious lobby with a high ceiling, a seating area with a sofa and chairs, a small round table, and a decorative wall with artwork.

5. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
2.6 km from Siesta Isle
8.8 out of 10, Excellent, (1,006 reviews)
"One of the best properties I’ve stayed in and the staff were excellent."
United States
Christina
The price is ฿3,092
฿3,448 total
includes taxes & fees
15 Nov - 16 Nov
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
A modern dining area with wooden flooring, white chairs, and large windows offering a view of the beach.

6. Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
2.2 km from Siesta Isle
9.4 out of 10, Exceptional, (1,002 reviews)
"Convenient location, friendly staff and clean rooms."
United States
Stacy
The price is ฿7,304
฿8,144 total
includes taxes & fees
29 Nov - 30 Nov
Best Western Plus Beach Resort
A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

7. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
2.7 km from Siesta Isle
8.8 out of 10, Excellent, (1,001 reviews)
"Loved the balcony view, breakfast spread, hot tub and heated pool."
United States
Lora
The price is ฿3,304
฿3,684 total
includes taxes & fees
22 Nov - 23 Nov
Residence Inn by Marriott Fort Myers Sanibel
A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

8. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
2.3 km from Siesta Isle
8.2 out of 10, Very good, (1,399 reviews)
"The staff was very helpful during my stay."
United States
Samantha
The price is ฿2,697
฿3,007 total
includes taxes & fees
23 Nov - 24 Nov
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a stone archway.

9. The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites
3.0 star property
2.4 km from Siesta Isle
8.6 out of 10, Excellent, (1,847 reviews)
"excellent place to stay"
United States
Shayne
The price is ฿2,716
฿3,702 total
includes taxes & fees
29 Nov - 30 Nov
The Lighthouse Resort Inn & Suites
A bedroom with a single bed, a window with curtains, a wall-mounted air conditioner, a painting, and a bedside table with a lamp.

10. Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
1.1 km from Siesta Isle
8.6 out of 10, Excellent, (1,002 reviews)
"Great place to stay, especially on a fishing trip!"
United States
Mitchel
The price is ฿3,004
฿3,349 total
includes taxes & fees
5 Nov - 6 Nov
Latitude 26 Waterfront Resort & Marina
A balcony with wicker furniture, a view of a beach, and a clear sky.

11. Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
2.7 km from Siesta Isle
8.8 out of 10, Excellent, (2,174 reviews)
"It was great to be right on the beach! The restaurants were also good."
United States
Tanya
The price is ฿4,359
฿5,612 total
includes taxes & fees
3 Dec - 4 Dec
Lani Kai Beachfront Resort
A beach view from a balcony with a pool, palm trees, and a building with a balcony.

12. Edison Beach House

Edison Beach House
3.5 star property
2.3 km from Siesta Isle
9.4 out of 10, Exceptional, (1,958 reviews)
"One of the best locations on Ft Myers Beach"
United States
mark
The price is ฿5,583
฿7,541 total
includes taxes & fees
9 Nov - 10 Nov
Edison Beach House
A beachfront hotel with a pool, beach, and ocean view.

13. DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
2.9 km from Siesta Isle
9.2 out of 10, Wonderful, (1,329 reviews)
"excellent place will stay again!"
United States
James Edward
The price is ฿6,751
฿8,843 total
includes taxes & fees
3 Dec - 4 Dec
DiamondHead Beach Resort
A marina with boats docked, surrounded by palm trees and a building with a red-tiled roof.

14. Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina
3.0 star property
2.1 km from Siesta Isle
9.4 out of 10, Exceptional, (1,000 reviews)
"I love Matanza. It's in a great location, walking distance to everything. I enjoyed sitting on the canal/bay and seeing all the wildlife, especially Manatee! We stayed in the 2 bedroom and it was perfect!"
United States
Tammy
The price is ฿9,407
฿11,331 total
includes taxes & fees
16 Nov - 17 Nov
Matanzas Inn Bayside Resort and Marina
A balcony with tables set for dining, overlooking a beach with palm trees and the ocean.

15. The Bay Inn at Lani Kai

The Bay Inn at Lani Kai
3.0 star property
2.7 km from Siesta Isle
7.8 out of 10, Good, (539 reviews)
"Clean room, helpful staff, very close to the beach."
United States
Andrea
The price is ฿3,611
฿4,778 total
includes taxes & fees
5 Nov - 6 Nov
The Bay Inn at Lani Kai
A hotel entrance with a sign reading 'Candlewood Suites' and a parking lot with a handicapped parking space.

16. Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG
3.0 star property
4.9 km from Siesta Isle
7.6 out of 10, Good, (1,000 reviews)
"I was satisfied with the price for a short stay."
United States
James
The price is ฿2,495
฿2,782 total
includes taxes & fees
29 Nov - 30 Nov
Candlewood Suites Fort Myers Sanibel Gateway by IHG
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

17. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
9.7 km from Siesta Isle
9.4 out of 10, Exceptional, (1,744 reviews)
"Very clean - nice breakfast - great parking"
United States
Sherri
The price is ฿3,372
฿3,759 total
includes taxes & fees
10 Nov - 11 Nov
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
An outdoor patio with a barbecue area, seating, and string lights.

18. Homewood Suites by Hilton Fort Myers Airport/FGCU

Homewood Suites by Hilton Fort Myers Airport/FGCU
3.0 star property
17 km from Siesta Isle
9.4 out of 10, Exceptional, (1,001 reviews)
"Great property good location friendly staff very clean room good breakfast"
United States
Leo
The price is ฿4,156
฿4,633 total
includes taxes & fees
29 Nov - 30 Nov
Homewood Suites by Hilton Fort Myers Airport/FGCU
A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.

19. Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
5.7 km from Siesta Isle
8.6 out of 10, Excellent, (1,001 reviews)
"I love everything about this hotel"
United States
Yunior
The price is ฿6,994
฿8,980 total
includes taxes & fees
18 Nov - 19 Nov
Marriott Sanibel Harbour Resort & Spa
A Drury Inn & Suites hotel with a parking lot full of cars.

20. Drury Inn & Suites Fort Myers Airport FGCU

Drury Inn & Suites Fort Myers Airport FGCU
4.0 star property
16.5 km from Siesta Isle
9.6 out of 10, Exceptional, (1,001 reviews)
"clean nice location breakfast nice"
United States
Giselia Dos Santos
The price is ฿4,012
฿4,473 total
includes taxes & fees
1 Dec - 2 Dec
Drury Inn & Suites Fort Myers Airport FGCU
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Siesta Isle

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A row of turquoise Adirondack chairs with umbrellas, a wooden deck, and a marina in the background.
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
9.0
Wonderful
1,000 reviews
View
A swimming pool with a rock arch structure, a multi-story building with balconies, and palm trees in the background.
Pink Shell Beach Resort and Marina
4.0 star property
9.4
Exceptional
1,488 reviews
View
An outdoor patio with tables and chairs, umbrellas, and a pool in the background.
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
9.2
Wonderful
1,004 reviews
View
A modern dining area with wooden flooring, white chairs, and large windows offering a view of the beach.
Best Western Plus Beach Resort
2.5 star property
9.4
Exceptional
1,002 reviews
View
A large, clear swimming pool with multiple lounge areas and palm trees.
Margaritaville Beach Resort Fort Myers
4.0 star property
9.0
Wonderful
2,733 reviews
View

Where to stay in Siesta Isle

Find the best Siesta Isle areas for the activities you enjoy most.
A sunset over a calm sea with trees framing the view.

Mid Island

While visiting Mid Island, you might make a stop by sights like Estero Boulevard Beach and Sterling Ave Beach.

A pier extending into the water with two gazebos at the end, under a sunset sky.

South Island

While visiting South Island, you might make a stop by sights like Santini Marina Shopping Plaza and Castle Beach.

A coastal town with a marina, residential buildings, and a clear view of the ocean.

TP Hill's

When in TP Hill's, you can plan a visit to Key West Express and Estero Boulevard Beach, some noteworthy sights in the nearby area.

A beach at sunset with a pink and purple sky, people walking, and a lifeguard tower in the distance.
Photo by Abby Chase
Open Photo by Abby Chase

Downtown Fort Myers Beach

If you're spending some time in Downtown Fort Myers Beach, Lynn Hall Memorial Park and Estero Boulevard Beach are top sights worth seeing.

A coastal town with a beach, buildings, and a road.

Winklers

Winklers might not have many top sights, but Key West Express and Estero Boulevard Beach are two attractions nearby that you can check out.

Top Siesta Isle Hotel Reviews

A row of turquoise Adirondack chairs with umbrellas, a wooden deck, and a marina in the background.
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
Siesta Isle

10/10 Excellent

Amazing find. Place was spotless and had everything we needed. Love relaxing in the hammock out by the dock and spotting dolphins and manatees there. Pool area really nice and plenty of choice of things to do around .
United Kingdom
Martin
Reviewed May 16, 2026
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Frequently Asked Questions

What is Siesta Isle like?

Travellers will be sure to find plenty to entertain them in Fort Myers Beach's Siesta Isle neighbourhood. Consider a visit to San Carlos Bay - Bunche Beach Preserve as part of your Siesta Isle travel plans.

Where is the best place to stay in Siesta Isle?

Based on our traveller data, Latitude 26 Waterfront Boutique Resort - Fort Myers Beach is one of the top choices for your stay in Siesta Isle. This hotel offers a marina and free breakfast.

How many hotels will I find in the Siesta Isle area?

If you're searching for places to stay in Fort Myers Beach, Expedia has something to meet your needs with 27 Siesta Isle hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in Siesta Isle, will I receive a refund?

Yes! You'll find that most hotel reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the best deals in Siesta Isle.

What are the top things to see and do in Siesta Isle?

San Carlos Bay - Bunche Beach Preserve is an attraction you might want to check out while you're in Siesta Isle. Key West Express and Bunche Beach are also worth a visit when you're out sightseeing in Fort Myers Beach.