Default HTG hotel image

Find hotels in Santa Cruz from ฿514

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
13 Sep - 14 Sep
Tomorrow
14 Sep - 15 Sep
Next weekend
18 Sep - 20 Sep
In two weeks
25 Sep - 27 Sep

Filter by

Star rating

Guest rating

Save an average of 15% on thousands of hotels when you're signed in

Top Santa Cruz Hotel Reviews

More cheap stays in Santa Cruz

HOTEL SELVA

HOTEL SELVA

1024 Av. Grau Iquitos Loreto
฿514
฿514 total
15 Sept - 16 Sept
HOTEL SELVA
Casa del Jaguar

Casa del Jaguar

Calle Jaen Iquitos Loreto
฿669
฿669 total
15 Sept - 16 Sept
10/10 Exceptional! (1 review)
Casa del Jaguar
Studio 69

Studio 69

Jr. Pevas 669 Iquitos Loreto
฿1,071
฿1,071 total
15 Sept - 16 Sept
9.2/10 Wonderful! (86 reviews)
Studio 69
Hotel La Casona

Hotel La Casona

Avenida Fitzcarrald 147 Iquitos Loreto
฿1,239
฿1,239 total
15 Sept - 16 Sept
Hotel La Casona
Amazon Lodge Varillal

Amazon Lodge Varillal

Carretera Iquitos Nauta 137 km San Juan Bautista Iquitos
฿1,243
฿1,243 total
15 Sept - 16 Sept
Amazon Lodge Varillal
La Posada Del Cauchero Hotel & Suites

La Posada Del Cauchero Hotel & Suites

449 Antonio Raimondi Iquitos Loreto
฿1,874
฿1,874 total
15 Sept - 16 Sept
8.8/10 Excellent! (12 reviews)
La Posada Del Cauchero Hotel & Suites

Frequently asked questions

If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you may still be able to cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
What should I see while I'm in Santa Cruz?
The picturesque setting of Pacaya-Samiria National Reserve and Huallaga River exemplify the area's natural beauty. Take a look at what more there is to see and do in Expedia's Santa Cruz guide.
What's the seasonal weather like in Santa Cruz?
The hottest months are usually September and October, with an average temperature of 26°C, while the coldest months are July and June, with an average of 25°C. The rainiest months in Santa Cruz are March, April, February and May, with each month seeing an average of 337 mm of rainfall.