Santa Cruz Packages (Flight + Hotel)

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ฿27,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Top hotels in Santa Cruz

Hotel de Turistas Iquitos

Hotel de Turistas Iquitos

3 out of 5
Napo Iquitos Loreto
Fully refundableReserve now, pay when you stay
The price is ฿1,970 per night from 2 Nov to 3 Nov
฿1,970
฿1,970 total
2 Nov - 3 Nov
9/10 Wonderful! (73 reviews)
"Such a nice hotel and so needed after a stay in the Amazon. The staff was so helpful booking us transport and the rooftop bar was lovely. Good air conditioning too and vegan option at the restaurant! We had a great time. Super confortable beds too"

Reviewed on 31 Oct 2026

Hotel de Turistas Iquitos
El Dorado Classic Hotel

El Dorado Classic Hotel

3 out of 5
Napo 362 Iquitos Loreto
Fully refundableReserve now, pay when you stay
The price is ฿1,312 per night from 13 Nov to 14 Nov
฿1,312
฿1,631 total
13 Nov - 14 Nov
8.2/10 Very good! (162 reviews)
"X"

Reviewed on 20 Oct 2026

El Dorado Classic Hotel
DoubleTree by Hilton Iquitos

DoubleTree by Hilton Iquitos

5 out of 5
Napo 258 Iquitos
Fully refundableReserve now, pay when you stay
The price is ฿4,222 per night from 10 Nov to 11 Nov
฿4,222
฿4,729 total
10 Nov - 11 Nov
DoubleTree by Hilton Iquitos
See all 228 properties in Loreto Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Cruz holiday package cost?
You'll find cheap prices on Expedia for your Santa Cruz getaway. However, factors like the length of stay, hotel choice and season will influence how much your holiday to Santa Cruz costs.
What are the cheapest months to go to Santa Cruz?
January, February and April are great times to search for cheap Santa Cruz holiday packages. Opting to travel in quieter periods means you can typically find lower prices on flights and accommodation.
How many days is enough for Santa Cruz?
With a well-organised itinerary, you can easily hit the top Santa Cruz attractions in a handful of days. But if you'd like to discover hidden gems or take day trips, consider booking your Santa Cruz holiday for longer.
How to find the best Santa Cruz package deals?
Bagging a cheap Santa Cruz package deal is easy with Expedia. After you've entered your trip dates and destination under our "Packages" tab, set your budget, add some filters and browse what's available. You can personalise your search by "Property class," "Number of bedrooms," "Traveller experience" and more. Order the results by "Price: low to high" to discover the most wallet-friendly Santa Cruz package deals. Want a simple trick to get the biggest savings? Be flexible with your departure dates and consider travelling on a weekday, when prices are typically lower.
Is it cheaper to book a Santa Cruz holiday as a package?
Expedia holiday packages are designed to give you more bang for your buck. Bundle your hotel, flight and car rental into one great-value price and you could save hundreds of dollars. You'll usually land a better deal than booking each component individually. And you'll still get the flexibility to create a customised Santa Cruz holiday by choosing your favourite airline, accommodation type and car class.
When to book a holiday package to Santa Cruz?
If you've got your Santa Cruz holiday dates confirmed, book as early as you can to bag some unbeatable deals. With Expedia, you can typically reserve some flights up to one year ahead of time. Prefer spur-of-the-moment adventures? Our last-minute deals are ideal for impromptu escapes.
How to plan a trip to Santa Cruz?

  1. Choose the perfect time to travel: Your schedule, preferred season and the type of weather you enjoy can all impact your decision on when to go to Santa Cruz.
  2. Set a budget: Factor in costs such as food, flights and transportation when working out how much to set aside for your trip to Santa Cruz. Then, pick a hotel that matches your budget, whether that's an economical stay or a swankier getaway.
  3. Determine how many days away: Start by compiling a list of the attractions and activities you'd like to get to in Santa Cruz. Then, estimate how long you'll need at each, including any travel time.
  4. Combine your accommodation and airfare: After you've settled on your travel dates and duration, lock in the right Santa Cruz holiday package for you.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.