Santa Clara Packages (Flight + Hotel)

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    Save up to ฿27,000 when you book a flight and hotel together*

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Top hotels in Santa Clara

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is ฿4,449 per night from 1 Dec to 2 Dec
฿4,449
฿4,894 total
1 Dec - 2 Dec
includes taxes & fees
9/10 Wonderful! (6,176 reviews)
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Reviewed on 3 Nov 2026

Hotel Riu Plaza Panama
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
Fully refundableReserve now, pay when you stay
The price is ฿3,914 per night from 3 Dec to 4 Dec
฿3,914
฿4,306 total
3 Dec - 4 Dec
includes taxes & fees
7.8/10 Good! (1,008 reviews)
"Clean and welcoming"

Reviewed on 3 Nov 2026

Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
The price is ฿5,645 per night from 11 Nov to 12 Nov
฿5,645
฿6,209 total
11 Nov - 12 Nov
includes taxes & fees
8.6/10 Excellent! (1,835 reviews)
"Asked for a pharmacy and they didn’t know or just didn’t want to give info. There were three just on the other side of the building and 24 hours"

Reviewed on 3 Nov 2026

Megapolis Hotel Panamá
See all 1,677 properties in Santa Clara
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santa Clara attractions

Culebra Cut

8.0/10 (14 reviews)
You can learn about the history of Santa Clara when you stop by Culebra Cut. Visit the casinos and top-notch restaurants in this walkable area.
See properties

What to do in Santa Clara

Monkey and Sloth Jungle Habitat Panama Tour

Monkey and Sloth Jungle Habitat Panama Tour

฿1,012
per adult
96% of travellers recommend
Monkey and Sloth Jungle Habitat Panama Tour
MiraLift

Transfer to Panama Canal (Miraflores Locks)

฿472
per adult
100% of travellers recommend
Transfer to Panama Canal (Miraflores Locks)
Magnificent Gatun lake

Monkey Watch and Gatun Lake Wildlife Safari Private Tour

฿2,531
per adult
Monkey Watch and Gatun Lake Wildlife Safari Private Tour
See all activities in Santa Clara

Frequently asked questions

How much does a Santa Clara holiday package cost?
You can snap up a holiday package to this destination on Expedia. However, how much your holiday to Santa Clara costs will depend on your hotel choice, season and length of stay.
What are the cheapest months to go to Santa Clara?
If you're hoping to snag a cheap Santa Clara holiday package, consider travelling in September, October and November. You're likely to find lower rates on accommodation and flights during these quieter months — ideal for a budget-friendly break.
How many days is enough for Santa Clara?
With a well-organised travel plan, you can easily tick off the top Santa Clara attractions in a few days. But if you prefer to discover hidden spots or go on day trips, think about booking your Santa Clara holiday for longer.
How to find the best Santa Clara package deals?
Landing a cheap Santa Clara package deal is easy with Expedia. After you've entered your preferred dates and destination under our "Packages" tab, set your maximum budget, add a few filters and browse what's available. You can tweak your search by "Property class," "Number of bedrooms," "Traveller experience" and more. Sort the results by "Price: low to high" to view the most affordable Santa Clara package deals. Want a simple trick to score even more savings? Have some flexibility with your departure dates and consider travelling on a weekday, when prices are generally lower.
Is it cheaper to book a Santa Clara holiday as a package?
An Expedia holiday package could land you significant savings when compared to arranging flights and stays separately. Better still, you can customise your Santa Clara trip to fit your exact style. Choose your preferred flight time, select the hotel type and add a rental car. Check out our great deals to see how much you can save.
When to book a holiday package to Santa Clara?
If you have your Santa Clara holiday dates finalized, book as early as you can to bag some incredible deals. With Expedia, you can generally reserve some flights up to one year in advance. Prefer spontaneous getaways? Our last-minute deals are perfect for quick escapes.
How to plan a trip to Santa Clara?

  1. Choose when to go: Check your schedule and get your bags packed. Your favourite time of year and the available activities will also help you decide when to escape to Santa Clara.
  2. Set a budget: Factor in costs like flights, meals and transportation when calculating how much to set aside for your trip to Santa Clara. Then, pick a hotel that matches your budget, whether that's an economical option or a lavish retreat.
  3. Decide how many days away: Start by listing all the activities and attractions you want to experience in Santa Clara. Then, estimate how long you'll need at each, as well as any travel time.
  4. Combine your airfare and accommodation: Once you've nailed down your travel dates and duration, book the perfect Santa Clara holiday package for you.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.