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Our top choices for Portsmouth Regional Hospital hotels

Holiday Inn Express Hotel & Suites Seabrook by IHG

Holiday Inn Express Hotel & Suites Seabrook by IHG
2.5 star property
0.7 km from Portsmouth Regional Hospital
8.8 out of 10, Excellent, (1003)
"Second time staying here and it was convenient and the price was great! "
United States
Kimberly
The price is ฿2,324
฿2,522 total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express Hotel & Suites Seabrook by IHG

Best Western Hampshire Inn

Best Western Hampshire Inn
2.5 star property
0.3 km from Portsmouth Regional Hospital
8.4 out of 10, Very good, (1000)
"Easy checking -- Good Staff - Nice room "
United States
Raymond
The price is ฿2,803
฿3,041 total
includes taxes & fees
25 Dec - 26 Dec
Best Western Hampshire Inn

Hampton Falls Inn

Hampton Falls Inn
2.5 star property
1.4 km from Portsmouth Regional Hospital
7.6 out of 10, Good, (1000)
"I always enjoy staying here."
United States
Gary
The price is ฿2,261
฿2,516 total
includes taxes & fees
24 Dec - 25 Dec
Hampton Falls Inn

Seabrook Inn

Seabrook Inn
2.5 star property
1.2 km from Portsmouth Regional Hospital
6.6 out of 10, (1000)
"Perfect location "
United States
Mike
The price is ฿2,167
฿2,352 total
includes taxes & fees
23 Dec - 24 Dec
Seabrook Inn

Hampton House Hotel

Hampton House Hotel
2.0 star property
5.8 km from Portsmouth Regional Hospital
9.4 out of 10, Exceptional, (1003)
"Place was clean staff was helpful and the view was amazing would definitely go again"
United States
john
The price is ฿3,816
฿4,140 total
includes taxes & fees
28 Dec - 29 Dec
Hampton House Hotel

Lamie's Inn and The Old Salt Restaurant

Lamie's Inn and The Old Salt Restaurant
3.0 star property
6.3 km from Portsmouth Regional Hospital
9.4 out of 10, Exceptional, (1000)
"Great property with a really great restaurant!"
United States
Steven
Lamie's Inn and The Old Salt Restaurant

Hampton Inn by Hilton Amesbury

Hampton Inn by Hilton Amesbury
2.5 star property
5.7 km from Portsmouth Regional Hospital
9.0 out of 10, Wonderful, (1001)
"Perfect location and facilities "
United States
kathleen
The price is ฿3,065
฿3,423 total
includes taxes & fees
29 Dec - 30 Dec
Hampton Inn by Hilton Amesbury

Atlantic Breeze Suites

Atlantic Breeze Suites
3.0 star property
6.3 km from Portsmouth Regional Hospital
9.4 out of 10, Exceptional, (405)
"Super clean as always. Amazing view. Easy check in and check out"
United States
Michael
The price is ฿5,239
฿5,855 total
includes taxes & fees
23 Dec - 24 Dec
Atlantic Breeze Suites

Blue Jay Motel

Blue Jay Motel
2.0 star property
4.9 km from Portsmouth Regional Hospital
8.6 out of 10, Excellent, (191)
"Great place to stay while visiting Hampton Beach!"
United States
James
The price is ฿4,494
฿4,876 total
includes taxes & fees
26 Dec - 27 Dec
Blue Jay Motel

SpringHill Suites by Marriott Hampton Portsmouth

SpringHill Suites by Marriott Hampton Portsmouth
2.5 star property
7.4 km from Portsmouth Regional Hospital
9.4 out of 10, Exceptional, (846)
"Yes everything was excellent. Loved having a handicapped accessable room due to having my mom who's 77 year's old. It was clean and no problems heat worked great "
United States
Sharon
The price is ฿3,204
฿3,476 total
includes taxes & fees
3 Jan - 4 Jan 2026
SpringHill Suites by Marriott Hampton Portsmouth

Mari-Anne Motel

Mari-Anne Motel
2.0 star property
4.8 km from Portsmouth Regional Hospital
8.2 out of 10, Very good, (226)
"Check in/out was easy. Room was spotless. Frankly better than I expected for a last minute motel booking."
United States
Erin
The price is ฿4,212
฿4,570 total
includes taxes & fees
23 Dec - 24 Dec
Mari-Anne Motel

Fairfield Inn By Marriott Amesbury

Fairfield Inn By Marriott Amesbury
2.5 star property
6.1 km from Portsmouth Regional Hospital
8.6 out of 10, Excellent, (1002)
"Very comfortable and enjoyed breakfast "
United States
Kristen
The price is ฿3,043
฿3,400 total
includes taxes & fees
30 Dec - 31 Dec
Fairfield Inn By Marriott Amesbury

Nautical Motel

Nautical Motel
2.0 star property
5 km from Portsmouth Regional Hospital
8.2 out of 10, Very good, (257)
"Great location!"
United States
Susan
The price is ฿4,680
฿5,078 total
includes taxes & fees
23 Dec - 24 Dec
Nautical Motel

Ashworth by the Sea

Ashworth by the Sea
3.0 star property
5.7 km from Portsmouth Regional Hospital
8.2 out of 10, Very good, (1321)
"Clean room, beach view was great, staff was very nice."
United States
Gregory
The price is ฿3,252
฿4,381 total
includes taxes & fees
1 Jan - 2 Jan 2026
Ashworth by the Sea

The Victoria Inn

The Victoria Inn
3.5 star property
7.6 km from Portsmouth Regional Hospital
9.2 out of 10, Wonderful, (120)
"Property was beautiful, rooms were excellent and breakfast was delicious. "
United States
anna
The price is ฿5,653
฿6,134 total
includes taxes & fees
18 Jan - 19 Jan 2026
The Victoria Inn

Compass Rose Inn

Compass Rose Inn
4.0 star property
9 km from Portsmouth Regional Hospital
9.8 out of 10, Exceptional, (202)
"Amazing staff and the room was adorable! "
United States
Valerie
The price is ฿7,188
฿8,029 total
includes taxes & fees
2 Jan - 3 Jan 2026
Compass Rose Inn

Clark Currier Inn

Clark Currier Inn
4.0 star property
9.3 km from Portsmouth Regional Hospital
9.6 out of 10, Exceptional, (541)
"Excellent place to stay. A charming inn with character. The owners were very friendly and helpful. Great location. Walking distance to downtown shops and restaurants."
United States
Joshua
The price is ฿6,321
฿7,061 total
includes taxes & fees
23 Dec - 24 Dec
Clark Currier Inn

Essex Street Inn & Suites, an Ascend Collection Hotel

Essex Street Inn & Suites, an Ascend Collection Hotel
3.5 star property
9.2 km from Portsmouth Regional Hospital
9.4 out of 10, Exceptional, (677)
"Lovely welcome, clean, beautifully appointed room. Great location too!"
United States
Ellen
The price is ฿3,177
฿4,020 total
includes taxes & fees
12 Jan - 13 Jan 2026
Essex Street Inn & Suites, an Ascend Collection Hotel

Garrison Inn Boutique Hotel

Garrison Inn Boutique Hotel
3.0 star property
9.1 km from Portsmouth Regional Hospital
9.4 out of 10, Exceptional, (406)
"Love it here, perfect location and beautiful hotel!"
United States
Amanda
The price is ฿10,365
฿11,577 total
includes taxes & fees
23 Dec - 24 Dec
Garrison Inn Boutique Hotel

Hampton Village Inn

Hampton Village Inn
2.5 star property
6.8 km from Portsmouth Regional Hospital
8.0 out of 10, Very good, (1000)
"Was great small place but room was clean and it was quiet "
United States
Heather
The price is ฿2,239
฿2,430 total
includes taxes & fees
1 Jan - 2 Jan 2026
Hampton Village Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Portsmouth Regional Hospital Hotel Reviews

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Frequently asked questions

What's the area like around Portsmouth Regional Hospital?
Portsmouth Regional Hospital is located in Seabrook. This family-friendly area is known for its beautiful beaches. You'll find 611 hotels and other accommodations within a few miles for a convenient home base.
What's the best hotel to stay close to Portsmouth Regional Hospital?
Adjacent to Portsmouth Regional Hospital, Best Western Hampshire Inn is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. Other good choices close by include Holiday Inn Express Hotel & Suites Seabrook by IHG and Seabrook Inn.
How many hotels can I expect to find near Portsmouth Regional Hospital?
Expedia has 611 hotels and other accommodation options a few miles from Portsmouth Regional Hospital.
If I need to cancel the hotel reservation for my stay near Portsmouth Regional Hospital, will I receive a refund?
Yes! Most hotel reservations are fully refundable if you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of booking. Add dates, click "Search", then you can filter by "fully refundable" to review the top deals on offer near Portsmouth Regional Hospital.
What can I see and do near Portsmouth Regional Hospital?
James House, Tuck Museum and Seacoast Fire Museum feature captivating exhibits. Explore notable local landmarks like Lowell's Boat Shop, Port City Tours and Mary Baker Eddy Historic House. You might spend a leisurely day outdoors at Salisbury Beach State Reservation and Atkinson Common.