Mission Bay Packages (Flight + Hotel)
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Where to stay in Mission Bay
Find the best Mission Bay areas and neighborhoods for the activities you enjoy most. Learn more about Mission Bay
Fisherman's Wharf
1 out of top 10 points of interest in this area
This waterfront neighborhood dates back to the gold rush era and is a hub for tourist activities, sea lions and seafood restaurants.
Union Square
Fashion puts on its finest face in one of the country’s largest shopping plazas.
Downtown San Francisco
3 out of top 10 points of interest in this area
Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and San Francisco Bay are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.
South of Market
From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.
Nob Hill
Examine architecturally significant buildings, visit the Cable Car Museum and enjoy magnificent views of greater San Francisco in this affluent district.
Top hotels in Mission Bay
LUMA Hotel San Francisco
100 Channel Street San Francisco CA
Fully refundableReserve now, pay when you stay
฿7,122
฿8,383 total
20 Sept - 21 Sept
includes taxes & fees
9.6/10 Exceptional! (2,595 reviews)
"Parking too expensive"
Reviewed on 10 Sept 2026
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
฿5,035
฿5,926 total
20 Sept - 21 Sept
includes taxes & fees
Hilton San Francisco Union Square
333 O'Farrell St. San Francisco CA
Fully refundableReserve now, pay when you stay
฿5,677
฿6,682 total
3 Oct - 4 Oct
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Mission Bay holiday package cost?
Custom make your Mission Bay holiday package from as low as . Pick from any combination of hotels, flights and rental cars to build the getaway you've been dreaming of. Be sure to add on a few activities!
How do I get a cheap travel package to Mission Bay?
Bundle your flights and hotels, throw in extras such as activities or a rental car, and save with a Mission Bay holiday package. You won't just pick up big discounts on your adventure — you'll have a world of choice too. When you book with Expedia, you'll have your pick of over 550 airlines and 1,000,000 hotels all over the world. Your next epic adventure begins right here, right now!
Where should I stay in Mission Bay?
A trip to Mission Bay isn't complete without seeing Pier 39 and Alcatraz Island. Reserve a room close by and easily access these popular tourist attractions.
How far in advance should I book my Mission Bay holiday?
Smart travellers often book as early as possible. You can usually compare international fares on Expedia up to 12 months before your flight. If you've left booking to the last minute, fear not. Budget prices sometimes appear just weeks before departure dates.
What does an Expedia Mission Bay travel package include?
Choose from a combination of hotels, rental cars and flights. Once you've made your booking, you can also add on activities and tours. Want to pick your airfare class? That's possible too. The choice is all yours when it comes to putting together your perfect Mission Bay trip.
What should I know before booking a Mission Bay travel package?
You'll pick up great savings when you bundle your flights, hotels and rental cars into a package. Not only that, booking everything in one place makes trip planning much easier. So why waste your time or money? Whether you're organising an upscale romantic escape or a budget solo adventure, explore our package deals today.
Can I choose my airline with a Mission Bay Expedia holiday package?
You can, and with more than 550 airlines to choose from worldwide, you're not short on choice. Scroll through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Mission Bay holiday package?
Plans can change unexpectedly, so yes, you can. You may be able to cancel and rebook your Mission Bay holiday package for free within 24 hours of booking. For bookings made more than 24 hours ago, you can still make the necessary changes, but your airline, hotel or car rental company may impose a fee. Want more information? Take a look at our Customer Service Portal. We'll help make sure your getaway goes off without a hitch.
Stay near popular Mission Bay attractions
Chase Center
8.8/10 (1,176 reviews)
Catch an event at Chase Center during your trip to San Francisco. Amble around this vibrant area's Chinatown or experience its fascinating museums.
Mission Bay Conference Center at UCSF
Learn about the events happening in Mission Bay Conference Center at UCSF during your trip to San Francisco. Amble around this vibrant area's Chinatown or experience its acclaimed art galleries.
PIER 48 - Lot #39
After visiting PIER 48 - Lot #39, make a plan to see the other sights and activities in San Francisco. Amble around this vibrant area's Chinatown or seek out the local tours.
Lefty O'Doul Bridge
You can find out about the history of San Francisco with a stop at Lefty O'Doul Bridge. Take in the acclaimed theatre scene and beautiful sunsets in this vibrant area.
Lucky Strike San Francisco
You can take time to visit Lucky Strike San Francisco during your travels to San Francisco. Amble around this vibrant area's Chinatown or experience its fascinating museums.
Things to do
Golden Gate Bay Cruise - Sail Around Alcatraz! (1-hour)
฿1,279
per adult
96% of travellers recommend
California Academy of Sciences Daytime Admission
฿1,607
per adult
86% of travellers recommend
Go City: San Francisco All-Inclusive Pass with 30+ Attractions
฿4,989
per adult
88% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.