A calm body of water, a sandy beach, and a forested area in the distance.

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Check availability on Cape Girardeau Spa Hotels

Tonight
8 Sep - 9 Sep
Tomorrow
9 Sep - 10 Sep
This weekend
11 Sep - 13 Sep
Next weekend
18 Sep - 20 Sep

Our top choices for Cape Girardeau hotels with a spa

Exterior
Suite, 1 King Bed | Premium bedding, down duvets, pillow-top beds, in-room safe
Free breakfast
Indoor pool, open 8 AM to 11 PM, pool loungers

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
  • Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
฿3,322
฿3,781 total
includes taxes & fees
13 Sept - 14 Sept
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
View all properties

Choose what matters most at spa hotels in Cape Girardeau

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Cape Girardeau Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Nice place! Breakfast was amazing!"
Rebecca 2-night trip
Posted 3 days ago
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent
"Great experience! Great property! Great stay! Great food! Water slide was excellent surprise!!! Lol"
roger 2-night trip
Posted 3 days ago
Drury Inn & Suites Jackson MO
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"This was a great place to stay. Everything about it was fantastic. We especially enjoyed the free breakfast and dinner!"
Gregory 2-night trip
Posted 4 days ago
Drury Plaza Hotel Cape Girardeau Conference Center

Frequently asked questions

Looking for a spa hotel in Cape Girardeau?
Treat yourself to some pampering and book a hotel with a spa. Travellers recommend the gourmet restaurants in Cape Girardeau. Enjoy the historical sites and riverfront during your holiday. Hotels with spas are a great way to break away from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Cape Girardeau?
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top spa hotel featuring a pool and a fitness centre.
How many spa hotels will I find in Cape Girardeau?
Among Expedia's 69 accommodation options in Cape Girardeau, there is 1 spa hotel.
What's there to see and do in Cape Girardeau?
Experience all that Cape Girardeau has to offer when you visit Century Casino & Hotel Cape Girardeau, Hunter Valley Winery and Trail of Tears State Park. If you have a bit of extra time while you're in the area, you might want to check out Shawnee National Forest and Mississippi River.
What is a Cape Girardeau spa hotel?
Spa hotels in Cape Girardeau have full on-site spas offering services including massages and a selection of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation and relaxation.

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