Downtown Clayton Travel Guide

St. Louis

A bronze bell with an eagle atop, surrounded by greenery and a street scene in the background.

Things to do

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

฿794
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
St. Louis: Museum of Illusions Entry Ticket

St. Louis: Museum of Illusions Entry Ticket

฿1,158
per adult
88% of travellers recommend
St. Louis: Museum of Illusions Entry Ticket
Saint Louis Self Guided Driving and Walking Audio Tour

St. Louis & Gateway Arch NP Self Guided Drive & Walk Audio Tour

฿562
per traveller
St. Louis & Gateway Arch NP Self Guided Drive & Walk Audio Tour
The Gateway Arch National Park & Museum

StL's Signature "Sights and Bites" - Private Tour in St. Louis

฿5,791
per adult
StL's Signature "Sights and Bites" - Private Tour in St. Louis
Downtown St. Louis Smartphone Guided Audio Walking Tour App

Downtown St. Louis Smartphone Guided Audio Walking Tour App

฿256
per adult
100% of travellers recommend
Downtown St. Louis Smartphone Guided Audio Walking Tour App
Landmarks Downtown-West Walking Tour

Landmarks Downtown-West Walking Tour

฿662
per adult
Landmarks Downtown-West Walking Tour
See all activities in St. Louis

Top hotels in Downtown Clayton

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
The price is ฿3,023 per night from 30 Aug to 31 Aug
฿3,023
฿3,529 total
30 Aug - 31 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free Wi-Fi and a 24-hour fitness centre. Our guests praise the breakfast and the pool ...
8.8/10 Excellent! (3,368 reviews)
"The staff was excellent! The room was clean and spacious. Unfortunately, the elevators were not working and our shower gel dispenser was empty. Breakfast was ok."

Reviewed on 11 Aug 2026

Clayton Plaza Hotel & Extended Stay
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

4 out of 5
7730 Bonhomme Ave St. Louis MO
The price is ฿5,020 per night from 16 Aug to 17 Aug
฿5,020
฿5,911 total
16 Aug - 17 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge) and a 24-hour fitness centre. Our guests praise the helpful staff ...
8.8/10 Excellent! (756 reviews)
"Would have liked juice or flavored waters in the to go items in lobby. Something without caffeine or artificial sugars."

Reviewed on 10 Aug 2026

Le Méridien St. Louis Clayton
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3 out of 5
227 South Central Ave St. Louis MO
The price is ฿3,899 per night from 16 Aug to 17 Aug
฿3,899
฿4,551 total
16 Aug - 17 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Popular attractions St. Louis Zoo and Forest Park are ...
9.2/10 Wonderful! (359 reviews)
"I felt safe and relaxed; absolutely loved that I could have breakfast and dinner there."

Reviewed on 11 Aug 2026

AC Hotel St. Louis Clayton
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundable
The price is ฿4,425 per night from 28 Aug to 29 Aug
฿4,425
฿5,218 total
28 Aug - 29 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy free Wi-Fi, 3 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
Hyatt Regency St. Louis at The Arch
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
The price is ฿3,296 per night from 8 Sept to 9 Sept
฿3,296
฿4,826 total
8 Sept - 9 Sept
includes taxes & fees
Stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants and a casino. Our guests praise the helpful staff and the clean rooms ...
Hollywood Casino & Hotel St. Louis
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road St. Louis MO
The price is ฿3,663 per night from 27 Aug to 28 Aug
฿3,663
฿4,285 total
27 Aug - 28 Aug
includes taxes & fees
Stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge) and a free airport shuttle. Our guests praise the helpful staff ...
Renaissance St. Louis Airport Hotel
See all 1,954 properties in Downtown Clayton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown Clayton

Find the best Downtown Clayton areas for the activities you enjoy most.
The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.

A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

An ornate hall with arched ceilings and intricate patterns.
Photo by Terry Eaves
Open Photo by Terry Eaves

Downtown West

While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.

A modern building with a brick facade, parked cars, and a flower bed with tulips.

Central West End

The abundant dining options and forests are just a few top-rate features of the neighbourhood. Make a stop by World Chess Hall of Fame or Blue Strawberry while you're visiting, and jump aboard the metro at Central West End Station to get around town.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Downtown Clayton Travel Guide