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Check prices for these dates

Next weekend
13 Nov - 15 Nov
In two weeks
20 Nov - 22 Nov
In one month
4 Dec - 6 Dec
In two months
1 Jan - 3 Jan
No exact matches found, but these alternatives could be just right

Recommended hotels in Santa Cruz

A modern hotel lobby with a reception desk, seating area, and a large glass wall with a sign.

1. Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra
3.0 star property
Equipetrol
9.4 out of 10, Exceptional, (159 reviews)
"Good location and value for money."
United States
Hui Hua
The price is ฿1,148
฿1,148 total
20 Nov - 21 Nov
Ibis Santa Cruz DE LA Sierra
A spacious living area with a high ceiling, wooden beams, a staircase, and a view of a balcony.

2. Lido Hotel

Lido Hotel
3.0 star property
Centro Histórico
9.2 out of 10, Wonderful, (57 reviews)
"Lovely stay for a night. Great location within easy walking distance to the center."
United States
Gabrielle
The price is ฿830
฿830 total
6 Nov - 7 Nov
Lido Hotel
A multi-level indoor space with a pool, wooden flooring, and potted plants.

3. Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique
3.5 star property
Centro Histórico
9.2 out of 10, Wonderful, (140 reviews)
"Small but beautiful and very much in the center"
United States
Rajendra
The price is ฿1,798
฿1,798 total
8 Nov - 9 Nov
Cosmopolitano Hotel Boutique
A balcony with a table set for breakfast, including a plate of fruit, a glass of orange juice, and a cup. The view includes a cityscape with buildings and a clear sky.

4. Hotel Las Américas

Hotel Las Américas
3.0 star property
Centro Histórico
8.0 out of 10, Very good, (35 reviews)
"Very clean room and great staff"
Canada
Stanley
The price is ฿881
฿881 total
5 Nov - 6 Nov
Hotel Las Américas
A hotel room with a large bed, bedside tables, a desk with a chair, a small refrigerator, and a TV mounted on the wall.

5. HOTEL OSHO

HOTEL OSHO
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (60 reviews)
"Room was great and staff were very accommodating!"
Canada
David
The price is ฿1,481
฿1,481 total
5 Nov - 6 Nov
HOTEL OSHO
A poolside area with lounge chairs and a palm tree.

6. Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
3.5 star property
Equipetrol
9.0 out of 10, Wonderful, (424 reviews)
"I love how nice and helpful staff was."
United States
Lizzie
The price is ฿5,136
฿5,136 total
9 Nov - 10 Nov
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
A hotel with a large swimming pool, multiple balconies, and a central arched entrance.

7. Sun Hotel

Sun Hotel
3.5 star property
Santa Cruz
8.2 out of 10, Very good, (415 reviews)
"The staff was wonderful,airport shuttle was on time, the room was very clean!!"
United States
Ivan
The price is ฿3,555
฿3,555 total
5 Nov - 6 Nov
Sun Hotel
A modern restaurant with a city view, featuring glass tables, white chairs, and a large window with curtains.

8. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (290 reviews)
"The room was very clean and the breakfast was fantastic. Overall it was a great experience."
United States
Scott
The price is ฿2,485
฿2,485 total
7 Nov - 8 Nov
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
A modern hotel with a rooftop pool featuring illuminated blue and purple lights, lounge chairs, and a palm tree.

9. Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (261 reviews)
"Amazing hotel"
United States
Deivis
The price is ฿4,161
฿4,161 total
15 Nov - 16 Nov
Marriott Santa Cruz de la Sierra Hotel
A swimming pool with a decorative center, surrounded by a building with a blue roof and a mural.

10. Gran Hotel Santa Cruz

Gran Hotel Santa Cruz
4.5 star property
Centro Histórico
The price is ฿1,674
฿1,674 total
3 Dec - 4 Dec
Gran Hotel Santa Cruz
The exterior of the ECO HOTEL with illuminated signage and a wooden canopy.

11. Chairú Eco Hotel

Chairú Eco Hotel
3.5 star property
Santa Cruz
9.4 out of 10, Exceptional, (81 reviews)
"clean close to restaurants friendly staff shop nearby overall excellent place to stay"
United States
Luis
The price is ฿1,595
฿1,595 total
14 Nov - 15 Nov
Chairú Eco Hotel
A rooftop pool with clear skies and a city view.

12. Hotel Pascana centro

Hotel Pascana centro
3.5 star property
Centro Histórico
9.4 out of 10, Exceptional, (3 reviews)
"El hotel se encuentra en el Centro histórico de la ciudad, es una estructura dentro del marco historico de la ciudad, pero se encuentra en buenas condiciones. Con facil acceso al transporte. Camina el centro de la ciudad histórica con tranquilidad."
United States
Miguel
The price is ฿2,583
฿2,583 total
5 Nov - 6 Nov
Hotel Pascana centro
A rooftop pool with a water feature, surrounded by modern buildings and a clear sky.

13. Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
8.8 out of 10, Excellent, (121 reviews)
"great place to stay!"
United States
Luisa
The price is ฿1,553
฿1,553 total
7 Nov - 8 Nov
Premium Suites Deluxe Aparthotel Equipetrol
Breakfast area

14. Gran Hotel Mediterráneo

Gran Hotel Mediterráneo
3.5 star property
Centro Histórico
10.0 out of 10, Exceptional, (1 review)
"Desde a recepção, a equipe da limpeza e o pessoal do café da manhã, foram sempre muito prestativos e disponíveis para ajudar no que foi necessário, voltaremos. A localização é bem próxima a praça central."
Brazil
Emerson
The price is ฿1,846
฿1,846 total
18 Nov - 19 Nov
Gran Hotel Mediterráneo
A hotel sign with the text "Apart Hotel Premium Suites Santa Cruz".

15. Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
3.5 star property
Santa Cruz
8.6 out of 10, Excellent, (107 reviews)
"Great location."
United States
Ruben
The price is ฿911
฿911 total
5 Nov - 6 Nov
Apart Hotel Premium Suites Santa Cruz
A modern bedroom with a bed, bedside table, and a desk with a laptop.

16. Hotel G

Hotel G
3.5 star property
Santa Cruz
7.8 out of 10, Good, (111 reviews)
"Excelente Hotel "
Mexico
JACOB
The price is ฿927
฿927 total
4 Dec - 5 Dec
Hotel G
A narrow hallway with wooden walls and a central counter with a sink.

17. Onkel Inn Airport Sleepbox

Onkel Inn Airport Sleepbox
1.5 star property
Santa Cruz
6.0 out of 10, (4 reviews)
"The check in times are incorrect. I arrived tired at 11pm for a long overnight layover. When I attempted to check in around midnight( as per The check in instructions) I was told check in was at 3pm. They were also overbooked and had a lady before me With a similar problem. I waited for a couple Hours to be able to speak to the front desk attendant to check in. The front desk attendant was kind enough to let me stay for literally only two hours and then I had to leave. The beds were comfy and...
United States
Carla
The price is ฿2,967
฿2,967 total
14 Nov - 15 Nov
Onkel Inn Airport Sleepbox
A hotel room with a bed, a desk, a chair, a large window, and a plant.

18. 518 RENT

518 RENT
3.0 star property
Centro Histórico
The price is ฿378
฿547 total
18 Nov - 19 Nov
518 RENT
A resort with a large swimming pool, lounge chairs, and a building labeled 'MARA GRANDE Country Club'.

19. Mora Grande

Mora Grande
3.0 star property
Santa Cruz
The price is ฿2,127
฿2,127 total
18 Nov - 19 Nov
Mora Grande
A modern living room with a white sofa, a wooden coffee table, and a large window with sheer curtains.

20. Posada Express Fast Check

Posada Express Fast Check
3.0 star property
Santa Cruz
8.2 out of 10, Very good, (12 reviews)
"The posada expres was closed and "
United States
Marcelo
The price is ฿1,519
฿1,671 total
5 Nov - 6 Nov
Posada Express Fast Check
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

See all hotels in Santa Cruz
A historic cathedral with two prominent towers, surrounded by urban buildings and palm trees.

Top reviews in Santa Cruz

A multi-level indoor space with a pool, wooden flooring, and potted plants.
Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique
Centro Histórico

10/10 Excellent

Top class and 5 Stars. Attentive , caring staff and wonderful food ! A great location, only 10 minutes from 24 Septiembre plaza. Thoroughly recommend.
United Kingdom
Malcolm
Reviewed March 16, 2025
Cosmopolitano Hotel Boutique

Frequently Asked Questions

What can I expect from a motel trip to Santa Cruz?

If you're having trouble locating a motel in Santa Cruz, expand your search to find motels in the surrounding area or let us help you find a similar property from over 312 hotels and other lodging options. Just use our search tools to filter by nightly room rate or cost-saving amenities such as free parking and free breakfast.

What are motels like?

Motels often include free parking, and many also include an outdoor pool. Often one or two storeys high, motel properties usually have outdoor access to guestrooms from the car park. Starting in the early 1950s, eye-catching neon signs enticed road-weary travellers, and you can see these today along the historic US Route 66.

What are the best motels in Santa Cruz?

These are some more economical accommodations where you can stay in Santa Cruz. Ibis Santa Cruz DE LA Sierra - Hotel Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel - Hotel Marriott Santa Cruz de la Sierra Hotel - Guest house Novotel Santa Cruz De La Sierra - Hotel Sun Hotel - Hotel

What things can I to do in Santa Cruz?

Visitors like Santa Cruz for its shops. As you're sightseeing around the area, make sure that you enjoy all there is to see and do. These are some of the parks and outdoorsy places: Arenal Park, Guembe Biocenter and Lomas de Arena Regional Park. Attractions the whole family can enjoy include Santa Cruz Zoo and Play Land Amusement Park. During your trip, here are some other places to visit: Plaza 24 de Septiembre, Blacutt Square and Ramon Tahuichi Aguilera Stadium.

What's the weather like in Santa Cruz?

Weather can make or break a road trip, so here's some data about year-round temperatures in Santa Cruz to help you plan yours: The hottest months are usually October and November, with an average temperature of 26°C, while the coldest months are June and July, with an average of 21°C. Average annual precipitation for Santa Cruz is 1208 mm.

What are my options for getting around Santa Cruz while staying in a motel?

We’ve gathered some information about local transportation options in Santa Cruz to help you navigate your stay: Fly into Santa Cruz (SRZ-El Trompillo), which is located 1.2 mi (1.9 km) away from the city centre. Otherwise, you can search for flights to Santa Cruz (VVI-Viru Viru Intl.), which is 9.8 mi (15.8 km) away. If you want to venture outside the area, hop aboard a train at Santa Cruz de la Sierra Station.