The Best Hotels in Otay Mesa West, San Diego - 2026 Updated Prices

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Our top choices for Otay Mesa West hotels

A spacious lobby with a fireplace, wooden furniture, and a chandelier.

1. Best Western Americana Inn

2.1 km from Otay Mesa West

Erika

฿4,005 total

includes taxes & fees

13 Dec - 14 Dec

A buffet with various food items, including omelets and other dishes, served in metal trays.

2. Holiday Inn Express San Diego South - Chula Vista by IHG

8 km from Otay Mesa West

Daniel

฿5,880 total

includes taxes & fees

10 Dec - 11 Dec

A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

3. Comfort Inn Chula Vista San Diego South

7.9 km from Otay Mesa West

Lori

฿4,006 total

includes taxes & fees

22 Nov - 23 Nov

A spacious lobby with a modern design, featuring a large seating area, a reception desk, and large windows offering views of the city.

4. Ayres Hotel San Diego South - Chula Vista

9.2 km from Otay Mesa West

Rosemary

฿6,769 total

includes taxes & fees

29 Nov - 30 Nov

A breakfast bar with La Quinta branding, a coffee machine, and a waffle display.

5. La Quinta Inn by Wyndham San Diego Chula Vista

7.8 km from Otay Mesa West

Luis

฿3,803 total

includes taxes & fees

29 Nov - 30 Nov

A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

6. Hercor Hotel - Urban Boutique

6.8 km from Otay Mesa West

justin

฿4,124 total

includes taxes & fees

18 Nov - 19 Nov

A spacious restaurant with high ceilings, exposed beams, and hanging plants. There are multiple seating areas with tables and chairs.

7. Best Western Plus Marina Gateway Hotel

10.4 km from Otay Mesa West

Brandon

฿4,968 total

includes taxes & fees

29 Nov - 30 Nov

A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

8. The Rambler Hotel

8 km from Otay Mesa West

Mark S.

฿3,851 total

includes taxes & fees

16 Nov - 17 Nov

9. SpringHill Suites by Marriott Chula Vista Eastlake

12.4 km from Otay Mesa West

leslie

฿6,049 total

includes taxes & fees

6 Dec - 7 Dec

A high-rise building complex with multiple floors, large windows, and a waterfront view.

10. Manchester Grand Hyatt San Diego

Marina District, 18.2 km from Otay Mesa West

Petra

฿8,378 total

includes taxes & fees

13 Dec - 14 Dec

A modern kitchen area with a self-serve station, including a waffle maker, coffee machine, and various food items.

11. Best Western Chula Vista/Otay Valley Hotel

2.4 km from Otay Mesa West

Edna

฿4,062 total

includes taxes & fees

22 Nov - 23 Nov

An outdoor seating area with fire pits, lounge chairs, and string lights against a sunset backdrop.

12. Loews Coronado Bay Resort

9.6 km from Otay Mesa West

Josh

฿8,084 total

includes taxes & fees

13 Dec - 14 Dec

A hotel room with a bed, a desk with a chair, a nightstand, and a wall-mounted TV displaying a sunset scene.

13. Hotel Palmeras Chula Vista

7.8 km from Otay Mesa West

Wendy

฿2,381 total

includes taxes & fees

16 Nov - 17 Nov

A hotel with a Holiday Inn Express sign, a modern building with balconies, and a view of the city skyline at night.

14. Holiday Inn Express San Diego Downtown by IHG

18.6 km from Otay Mesa West

Angel

฿5,262 total

includes taxes & fees

16 Nov - 17 Nov

A swimming pool with palm trees and a mountain in the background.

15. Sycuan Casino Resort

31.2 km from Otay Mesa West

Kimberly

฿3,784 total

includes taxes & fees

16 Nov - 17 Nov

A hotel room with a large window offering a city view, a bed, a chair, and a small table.

16. The DEXTRO Little Italy, BW Premier Collection

19.1 km from Otay Mesa West

Kelly

฿4,937 total

includes taxes & fees

18 Nov - 19 Nov

A breakfast buffet area with a stone wall, a coffee station, and a fruit display.

17. Hampton Inn San Diego-Kearny Mesa

29.7 km from Otay Mesa West

Jeffrey

฿4,216 total

includes taxes & fees

11 Dec - 12 Dec

A modern hotel with a courtyard featuring outdoor seating, a chess table, and a well-maintained lawn.

18. Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

24.3 km from Otay Mesa West

David

฿5,880 total

includes taxes & fees

22 Nov - 23 Nov

A modern bar area with wooden ceiling beams, bar stools, and a long counter.

19. Courtyard by Marriott San Diego Central

28.8 km from Otay Mesa West

Ahmad

฿5,207 total

includes taxes & fees

22 Nov - 23 Nov

An outdoor seating area with fire pits, lounge chairs, and a modern building in the background.

20. Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

23.5 km from Otay Mesa West

Edith

฿5,288 total

includes taxes & fees

1 Dec - 2 Dec

View all properties

Compare popular hotels in Otay Mesa West

Property	Property class	Guest rating
Best Western Americana Inn	2.5 star property	8.8 Excellent 1,431 reviews	View
Holiday Inn Express San Diego South - Chula Vista by IHG	2.5 star property	9.4 Exceptional 1,655 reviews	View
Ayres Hotel San Diego South - Chula Vista	3.0 star property	9.8 Exceptional 1,027 reviews	View
La Quinta Inn by Wyndham San Diego Chula Vista	3.0 star property	8.6 Excellent 1,791 reviews	View
The Rambler Hotel	3.0 star property	9.0 Wonderful 2,208 reviews	View

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas for the activities you enjoy most.

A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

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A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

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Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

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A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

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An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

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Top Otay Mesa West Hotel Reviews

Best Western Americana Inn

San Ysidro

10/10 Excellent

Amir

Holiday Inn Express San Diego South - Chula Vista by IHG

Chula Vista

10/10 Excellent

Niki Andrew

Ayres Hotel San Diego South - Chula Vista

Otay Ranch

10/10 Excellent

Very large spacious modern room . Comfy beds good blackout blinds. Large bathtub and nice shower over it . All staff friendly. Good hotel gym modern equipment and nice view from it. Good location lots of shops and restaurants nearby. Nice breakfast enough choice, the made fresh omelettes are tasty like that it is proper crockery and cutlery rather than disposable. Pool area very clean and towels provided saw the chlorine levels being checked and added . Large bubbling hot tub. Very good stay

Stephen

SpringHill Suites by Marriott Chula Vista Eastlake

Chula Vista

10/10 Excellent

Thomas

Hercor Hotel - Urban Boutique

Chula Vista

10/10 Excellent

Brian

The Rambler Hotel

Chula Vista

10/10 Excellent

Roberta

Hampton Inn San Diego-Kearny Mesa

Kearny Mesa

10/10 Excellent

We selected this hotel for location, however the services provided by the hotel and staff were excellent. Staff could not have been more helpful, from the manager (very visible during our stay), to reception and housekeeping staff. The complimentary breakfast was very good, and again staff couldn't have been more attentive during this service. Rooms were well equipped (even had a microwave). I would highly recommend this hotel.

Claire

A hotel entrance with a stone archway, a reception desk, and potted plants.

Holiday Inn Express San Diego Airport - Old Town by IHG

Mission Hills

10/10 Excellent

Mark

A conference room with multiple round tables, blue chairs, and white tablecloths.

Bay Club Hotel & Marina

Point Loma

10/10 Excellent

Laura

Frequently Asked Questions

What is Otay Mesa West like?

Otay Mesa West is a neighbourhood that travellers like for its cathedral.

If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?

Yes! The majority of room reservations are refundable if you cancel before the hotel’s cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to review top deals in Otay Mesa West.

What is there to do around this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets and Sesame Place San Diego. While you're out sightseeing in San Diego, make sure that you visit other sights such as Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.

How can I get around Otay Mesa West and the greater San Diego area?

Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.

Search Hotels in Otay Mesa West, San Diego

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Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Otay Mesa West hotels

1. Best Western Americana Inn

2. Holiday Inn Express San Diego South - Chula Vista by IHG

3. Comfort Inn Chula Vista San Diego South

4. Ayres Hotel San Diego South - Chula Vista

5. La Quinta Inn by Wyndham San Diego Chula Vista

6. Hercor Hotel - Urban Boutique

7. Best Western Plus Marina Gateway Hotel

8. The Rambler Hotel

9. SpringHill Suites by Marriott Chula Vista Eastlake

10. Manchester Grand Hyatt San Diego

11. Best Western Chula Vista/Otay Valley Hotel

12. Loews Coronado Bay Resort

13. Hotel Palmeras Chula Vista

14. Holiday Inn Express San Diego Downtown by IHG

15. Sycuan Casino Resort

16. The DEXTRO Little Italy, BW Premier Collection

17. Hampton Inn San Diego-Kearny Mesa

18. Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

19. Courtyard by Marriott San Diego Central

20. Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

Compare popular hotels in Otay Mesa West

Where to stay in Otay Mesa West

Downtown San Diego

Pacific Beach

Gaslamp Quarter

Mission Beach

Mission Bay

Top Otay Mesa West Hotel Reviews

Best Western Americana Inn

10/10 Excellent

Frequently Asked Questions

What is Otay Mesa West like?

If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?

What is there to do around this San Diego neighbourhood?

How can I get around Otay Mesa West and the greater San Diego area?