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Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very good, (1,757 reviews)
"Clean, friendly staff, great breakfast!!"
United States
Flor
The price is ฿4,609
฿5,243 total
includes taxes & fees
14 Jun - 15 Jun
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,007 reviews)
"Very clean, bed was comfortable!"
United States
Michael A
The price is ฿3,714
฿4,224 total
includes taxes & fees
22 Jun - 23 Jun
Quality Suites San Diego Otay Mesa

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,884 reviews)
"Great stay"
United States
Cameron
The price is ฿5,601
฿6,172 total
includes taxes & fees
16 Jun - 17 Jun
Best Western Plus Marina Gateway Hotel

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
8.8 out of 10, Excellent, (1,299 reviews)
"Room is nice, clean, & breakfast is good. We always stay here when in the area."
United States
Travis
The price is ฿4,027
฿4,581 total
includes taxes & fees
28 Jun - 29 Jun
Best Western Americana Inn

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,731 reviews)
"Good location, clean room and nice staff. A great place to stay."
United States
Patricia
The price is ฿5,643
฿6,486 total
includes taxes & fees
29 Jun - 30 Jun
Hampton Inn & Suites San Diego Airport Liberty Station

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,973 reviews)
"Always a great stay"
United States
Jeanette
The price is ฿4,366
฿5,197 total
includes taxes & fees
16 Jun - 17 Jun
Sycuan Casino Resort

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,530 reviews)
"Great location and shuttle service to and from the airport."
Canada
Malinda
The price is ฿5,242
฿7,690 total
includes taxes & fees
5 Jul - 6 Jul
Sheraton San Diego Resort

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,233 reviews)
"Room fit our family of 6 and the breakfast was good."
United States
Jamie
The price is ฿5,401
฿5,941 total
includes taxes & fees
29 Jun - 30 Jun
Holiday Inn Express San Diego South - Chula Vista by IHG

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
26.8 km from Otay Mesa
9.4 out of 10, Exceptional, (1,705 reviews)
"Lovely hotel, very aesthetic place"
United States
Roxana
The price is ฿8,198
฿9,424 total
includes taxes & fees
15 Jun - 16 Jun
Lafayette Hotel & Club

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (662 reviews)
"It was great, one of the best stays we have had while traveling this year!"
United States
Ken
The price is ฿7,900
฿8,705 total
includes taxes & fees
28 Jun - 29 Jun
SpringHill Suites by Marriott Chula Vista Eastlake

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very good, (1,549 reviews)
"Everything was excellent. Room, breakfast location and staff. This was our second time staying here and we'll be back."
United States
Chris
The price is ฿4,170
฿4,595 total
includes taxes & fees
5 Jul - 6 Jul
Comfort Inn Chula Vista San Diego South

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,639 reviews)
"Great place to stay at, would definitely stay there again."
United States
Jose
The price is ฿3,778
฿4,156 total
includes taxes & fees
5 Jul - 6 Jul
La Quinta Inn by Wyndham San Diego Chula Vista

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
2.5 star property
24.6 km from Otay Mesa
8.4 out of 10, Very good, (1,011 reviews)
"We enjoyed our stay."
United States
Lauren
The price is ฿4,530
฿4,983 total
includes taxes & fees
14 Jun - 15 Jun
Best Western Plus La Mesa San Diego

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
7.8 out of 10, Good, (1,783 reviews)
"Price reflects the quality but would definitely stay here again on a budget trip. Good location for many of the things we planned to do."
United States
Lynn
The price is ฿3,890
฿4,287 total
includes taxes & fees
5 Jul - 6 Jul
Best Western Chula Vista/Otay Valley Hotel

Hampton Inn Chula Vista Eastlake

Hampton Inn Chula Vista Eastlake
2.5 star property
10.4 km from Otay Mesa
9.2 out of 10, Wonderful, (1,011 reviews)
"I have stayed several times Over the years the staff and property have always been excellent. Great breakfast. Rooms are always well maintained."
United States
Donald
The price is ฿7,512
฿8,278 total
includes taxes & fees
23 Jun - 24 Jun
Hampton Inn Chula Vista Eastlake

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,103 reviews)
"Nice place good food for breakfast 👍"
United States
Paul
The price is ฿7,023
฿7,739 total
includes taxes & fees
6 Jul - 7 Jul
Ayres Hotel San Diego South - Chula Vista

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 33.1 km from Otay Mesa
8.6 out of 10, Excellent, (1,477 reviews)
"Great resort!"
United States
Jean-Michelle
The price is ฿8,857
฿11,921 total
includes taxes & fees
14 Jun - 15 Jun
San Diego Mission Bay Resort

Courtyard by Marriott San Diego Airport/Liberty Station

Courtyard by Marriott San Diego Airport/Liberty Station
3.0 star property
29.7 km from Otay Mesa
9.2 out of 10, Wonderful, (1,302 reviews)
"Great location, good parking, great staff."
United States
Rosemary
The price is ฿6,124
฿7,039 total
includes taxes & fees
15 Jun - 16 Jun
Courtyard by Marriott San Diego Airport/Liberty Station

Old Town Inn

Old Town Inn
2.5 star property
30.1 km from Otay Mesa
9.2 out of 10, Wonderful, (1,898 reviews)
"Breakfast was good, rooms were decent."
United States
Andrea
The price is ฿5,117
฿5,872 total
includes taxes & fees
29 Jun - 30 Jun
Old Town Inn

The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,163 reviews)
"Cool vibe in an easy spot to get on and off the highway."
United States
Jami
The price is ฿3,909
฿4,523 total
includes taxes & fees
11 Jun - 12 Jun
The Rambler Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and USS Midway Museum are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on our traveller data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

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