Search Hotels in Otay Mesa, San Diego
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Our top choices for Otay Mesa hotels
1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHGOtay Mesa
8.4 out of 10, Very good, (1,940 reviews)
"Staff was amazing and beds were sooo comfy"
Helen
The price is ฿4,524
฿5,146 total
includes taxes & fees
23 Nov - 24 Nov
2. Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay MesaOtay Mesa
7.2 out of 10, Good, (1,001 reviews)
"clean room nice place to stay"
Anonymous traveller
The price is ฿3,473
฿3,950 total
includes taxes & fees
8 Nov - 9 Nov
3. Ayres Hotel San Diego South - Chula Vista
Ayres Hotel San Diego South - Chula Vista6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,037 reviews)
"I was very impressed with this hotel. The rooms were comfortable and modern and the staff was warm and welcoming."
Rosemary
The price is ฿6,503
฿7,166 total
includes taxes & fees
11 Nov - 12 Nov
4. Best Western Chula Vista/Otay Valley Hotel
Best Western Chula Vista/Otay Valley Hotel7.1 km from Otay Mesa
8.0 out of 10, Very good, (2,026 reviews)
"Good hotel"
Mario
The price is ฿3,702
฿4,080 total
includes taxes & fees
1 Nov - 2 Nov
5. Holiday Inn Express San Diego South - Chula Vista by IHG
Holiday Inn Express San Diego South - Chula Vista by IHG14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,635 reviews)
"Great stay"
Daniel
The price is ฿5,605
฿6,165 total
includes taxes & fees
5 Nov - 6 Nov
6. Comfort Inn Chula Vista San Diego South
Comfort Inn Chula Vista San Diego South13 km from Otay Mesa
8.4 out of 10, Very good, (1,707 reviews)
"The breakfast and the staff were great!"
Xochitl
The price is ฿3,322
฿3,661 total
includes taxes & fees
22 Nov - 23 Nov
7. La Quinta Inn by Wyndham San Diego Chula Vista
La Quinta Inn by Wyndham San Diego Chula Vista12.9 km from Otay Mesa
8.8 out of 10, Excellent, (1,783 reviews)
"Enjoyed our stay"
Nuwan
The price is ฿3,587
฿3,946 total
includes taxes & fees
8 Nov - 9 Nov
8. SpringHill Suites by Marriott Chula Vista Eastlake
SpringHill Suites by Marriott Chula Vista Eastlake10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (806 reviews)
"Great hotel and service"
Joey
The price is ฿6,069
฿6,687 total
includes taxes & fees
8 Nov - 9 Nov
9. Valli Hi Motel
Valli Hi Motel7.9 km from Otay Mesa
8.2 out of 10, Very good, (1,160 reviews)
"Great stay and good room."
Christian
The price is ฿2,796
฿3,186 total
includes taxes & fees
2 Nov - 3 Nov
10. The Rambler Hotel
The Rambler Hotel14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,212 reviews)
"Solid place to stay"
Neal
The price is ฿3,538
฿4,377 total
includes taxes & fees
8 Nov - 9 Nov
11. Hercor Hotel - Urban Boutique
Hercor Hotel - Urban Boutique13.6 km from Otay Mesa
8.8 out of 10, Excellent, (1,565 reviews)
"Great stay"
fannie
The price is ฿3,759
฿4,142 total
includes taxes & fees
18 Nov - 19 Nov
12. Best Western Plus Marina Gateway Hotel
Best Western Plus Marina Gateway Hotel16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (4,221 reviews)
"Clean room staff was very helpful restaurant across the way was very good"
Michael
The price is ฿4,832
฿5,325 total
includes taxes & fees
8 Nov - 9 Nov
13. Howard Johnson by Wyndham National City/San Diego South
Howard Johnson by Wyndham National City/San Diego South18.3 km from Otay Mesa
7.6 out of 10, Good, (1,179 reviews)
"Clean and nice hotel."
Claudia
The price is ฿2,583
฿2,846 total
includes taxes & fees
27 Oct - 28 Oct
14. Best Western Americana Inn
Best Western Americana Inn8 km from Otay Mesa
8.8 out of 10, Excellent, (1,419 reviews)
"The staff was wonderful and the room was clean! Breakfast had great options and all good. Recommend for a great affordable stay!"
Rene
The price is ฿3,536
฿4,022 total
includes taxes & fees
1 Nov - 2 Nov
15. Hotel Palmeras Chula Vista
Hotel Palmeras Chula Vista14.4 km from Otay Mesa
7.4 out of 10, Good, (2,426 reviews)
"A modest and clean hotel, recommended, with reasonable prices."
AHMAD
The price is ฿2,311
฿2,542 total
includes taxes & fees
29 Oct - 30 Oct
16. Sycuan Casino Resort
Sycuan Casino Resort28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (2,206 reviews)
"Beautiful resort, and the staff is super helpful and friendly."
Sarah
The price is ฿3,329
฿4,067 total
includes taxes & fees
16 Nov - 17 Nov
17. Holiday Inn Express & Suites San Diego - Mission Valley by IHG
Holiday Inn Express & Suites San Diego - Mission Valley by IHG28.8 km from Otay Mesa
8.8 out of 10, Excellent, (1,008 reviews)
"Room was clean. Staff was friendly and helpful. Breakfast was basic but still really good."
Lilli
The price is ฿4,356
฿5,115 total
includes taxes & fees
8 Nov - 9 Nov
18. Hilton San Diego Bayfront
Hilton San Diego BayfrontMarina District, 23.6 km from Otay Mesa
8.8 out of 10, Excellent, (2,525 reviews)
"Great location!"
Jason
The price is ฿5,711
฿8,274 total
includes taxes & fees
22 Nov - 23 Nov
19. Bay Club Hotel & Marina
Bay Club Hotel & Marina29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (4,048 reviews)
"Excellent stay!"
Victoria
The price is ฿5,136
฿5,903 total
includes taxes & fees
28 Oct - 29 Oct
20. Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area30.1 km from Otay Mesa
8.0 out of 10, Very good, (3,093 reviews)
"Clean and spacious room, good breakfast, nice staff."
Antonia
The price is ฿4,318
฿4,963 total
includes taxes & fees
15 Nov - 16 Nov
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in Otay Mesa
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG | 8.4 Very good 1,940 reviews | View | ||||||
 Quality Suites San Diego Otay Mesa | 7.2 Good 1,001 reviews | View | ||||||
 Ayres Hotel San Diego South - Chula Vista | 9.8 Exceptional 1,037 reviews | View | ||||||
 Best Western Americana Inn | 8.8 Excellent 1,419 reviews | View | ||||||
 SpringHill Suites by Marriott Chula Vista Eastlake | 9.6 Exceptional 806 reviews | View |
Where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.
Gaslamp Quarter
San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.
