Search Hotels in Otay Mesa, San Diego
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Our top choices for Otay Mesa hotels
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHGOtay Mesa
8.0 out of 10, Very good, (1,667 reviews)
"Clean, great breakfast, good service."
Sara
The price is ฿4,112
฿4,677 total
includes taxes & fees
15 Mar - 16 Mar
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay MesaOtay Mesa
7.0 out of 10, Good, (1,006 reviews)
"Great staff.. location close to the airport!"
Vivian
The price is ฿3,430
฿3,901 total
includes taxes & fees
5 Apr - 6 Apr
Crowne Plaza San Diego - Mission Valley by IHG
Crowne Plaza San Diego - Mission Valley by IHG29.8 km from Otay Mesa
8.0 out of 10, Very good, (1,016 reviews)
"Great stay"
Viviann
The price is ฿3,347
฿3,859 total
includes taxes & fees
5 Apr - 6 Apr
Sheraton San Diego Resort
Sheraton San Diego Resort28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,370 reviews)
"Love this hotel will always stay here when I come to San Diego "
Darlene
The price is ฿3,984
฿5,982 total
includes taxes & fees
1 Apr - 2 Apr
Lafayette Hotel & Club
Lafayette Hotel & Club26.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,512 reviews)
"Stunning hotel, I could have stayed there all day looking at every little design detail. "
Holly
The price is ฿7,299
฿8,376 total
includes taxes & fees
10 Mar - 11 Mar
Sycuan Casino Resort
Sycuan Casino Resort28.5 km from Otay Mesa
9.2 out of 10, Wonderful, (1,784 reviews)
"Very clean resort. "
Petrina
Valli Hi Motel
Valli Hi Motel7.9 km from Otay Mesa
8.4 out of 10, Very good, (1,007 reviews)
"Excelente "
Julio
Best Western Chula Vista/Otay Valley Hotel
Best Western Chula Vista/Otay Valley Hotel7.1 km from Otay Mesa
7.8 out of 10, Good, (1,646 reviews)
"Clean rooms and the breakfast was amazing "
Vanessa
The price is ฿3,289
฿3,618 total
includes taxes & fees
15 Mar - 16 Mar
SpringHill Suites by Marriott Chula Vista Eastlake
SpringHill Suites by Marriott Chula Vista Eastlake10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (587 reviews)
"Clean room and friendly staff "
Michael
The price is ฿5,450
฿6,006 total
includes taxes & fees
22 Mar - 23 Mar
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld31.3 km from Otay Mesa
7.4 out of 10, Good, (4,192 reviews)
"Good location friendly staff"
Anya
The price is ฿3,155
฿3,627 total
includes taxes & fees
10 Mar - 11 Mar
Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town
Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town30.8 km from Otay Mesa
9.2 out of 10, Wonderful, (707 reviews)
"Great place to stay, nice room Highly recommended !!"
Wilfredo
The price is ฿5,063
฿5,820 total
includes taxes & fees
11 Mar - 12 Mar
Ocean Villa Inn
Ocean Villa InnOcean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very good, (1,196 reviews)
"Beds are super comfy clean and renovated"
Esmeralda
Holiday Inn Express San Diego Airport - Old Town by IHG
Holiday Inn Express San Diego Airport - Old Town by IHG28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,068 reviews)
"great stay"
Jose
The price is ฿4,335
฿4,983 total
includes taxes & fees
10 Mar - 11 Mar
Comfort Inn Sea World Area
Comfort Inn Sea World Area30.8 km from Otay Mesa
8.6 out of 10, Excellent, (3,452 reviews)
"Nice beds and breakfast, really convenient "
Margarita
The price is ฿3,299
฿3,792 total
includes taxes & fees
11 Mar - 12 Mar
Best Western Plus La Mesa San Diego
Best Western Plus La Mesa San Diego24.6 km from Otay Mesa
8.4 out of 10, Very good, (1,013 reviews)
"Room was clean, pleasant staff and great breakfast "
Wendy
The price is ฿3,799
฿4,179 total
includes taxes & fees
15 Mar - 16 Mar
Wyndham San Diego Bayside
Wyndham San Diego Bayside25.7 km from Otay Mesa
8.4 out of 10, Very good, (6,089 reviews)
"Great place to stay"
David
The price is ฿4,849
฿6,732 total
includes taxes & fees
11 Mar - 12 Mar
Hilton Garden Inn San Diego Old Town/SeaWorld Area
Hilton Garden Inn San Diego Old Town/SeaWorld AreaOld Town San Diego, 30.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,356 reviews)
"Great location, great price, nice hotel "
Estela
The price is ฿4,179
฿4,804 total
includes taxes & fees
15 Mar - 16 Mar
Best Western Americana Inn
Best Western Americana Inn8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,225 reviews)
"Great stay"
Elisa
The price is ฿3,766
฿4,284 total
includes taxes & fees
16 Mar - 17 Mar
Old Town Western Inn & Suites
Old Town Western Inn & SuitesOld Town San Diego, 29.6 km from Otay Mesa
7.6 out of 10, Good, (1,013 reviews)
"Clean, good staff, quiet, good location "
Raul
The price is ฿3,041
฿3,428 total
includes taxes & fees
11 Mar - 12 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Gaslamp Quarter
San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.
Ocean Beach
Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach and Dog Beach.
Top Otay Mesa Hotel Reviews
Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town
10/10 Excellent
