Search Hotels in Otay Mesa, San Diego

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
30 Jul - 31 Jul
Tomorrow
31 Jul - 1 Aug
This weekend
1 Aug - 3 Aug
Next weekend
8 Aug - 10 Aug

Filter by

Guest rating
Guest rating
Property class

Top Trending Hotels Near Otay Mesa, San Diego

Sycuan Casino Resort
3 outdoor pools, pool cabanas (surcharge), pool umbrellas

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1444)
"We had a wonderful stay, will definitely visit again!"
Sycuan Casino Resort
Best Western San Diego Pacific Beach/Mission Bay
Outdoor pool

Best Western San Diego Pacific Beach/Mission Bay

2.5 star property
7.2 out of 10, Good, (1250)
"Excellent hotel !! "
The price is ฿2,438
฿2,802 total
includes taxes & fees
7 Aug - 8 Aug
Best Western San Diego Pacific Beach/Mission Bay
Quality Suites San Diego Otay Mesa
Desk, laptop workspace, blackout curtains, iron/ironing board

Quality Suites San Diego Otay Mesa

2.5 star property
7.2 out of 10, Good, (1007)
"Great location and spacious room "
The price is ฿3,534
฿4,020 total
includes taxes & fees
1 Aug - 2 Aug
Quality Suites San Diego Otay Mesa
Sea Harbor Hotel
Marina

Sea Harbor Hotel

2.0 star property
8.6 out of 10, Excellent, (906)
"Great location, very customer friendly staff."
The price is ฿6,899
฿7,778 total
includes taxes & fees
8 Aug - 9 Aug
Sea Harbor Hotel
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Exterior

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
7.8 out of 10, Good, (1403)
"Great stay, close to the Cross Border Xpress "
The price is ฿4,117
฿4,683 total
includes taxes & fees
6 Aug - 7 Aug
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
La Quinta Inn by Wyndham San Diego Chula Vista
Exterior

La Quinta Inn by Wyndham San Diego Chula Vista

3.0 star property
8.6 out of 10, Excellent, (1326)
"Love the breakfast and convenient location. "
The price is ฿3,939
฿4,333 total
includes taxes & fees
3 Aug - 4 Aug
La Quinta Inn by Wyndham San Diego Chula Vista
Best Western Plus Marina Gateway Hotel
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace

Best Western Plus Marina Gateway Hotel

3.5 star property
9.2 out of 10, Wonderful, (3163)
"This location was great for our family get away"
The price is ฿4,931
฿5,434 total
includes taxes & fees
10 Aug - 11 Aug
Best Western Plus Marina Gateway Hotel
SpringHill Suites by Marriott Chula Vista Eastlake
Outdoor pool

SpringHill Suites by Marriott Chula Vista Eastlake

3.5 star property
9.6 out of 10, Exceptional, (385)
"Clean property and great breakfast!"
The price is ฿4,483
฿4,941 total
includes taxes & fees
31 Aug - 1 Sept
SpringHill Suites by Marriott Chula Vista Eastlake
Legacy Resort Hotel & Spa
Garden

Legacy Resort Hotel & Spa

4.0 star property
9.2 out of 10, Wonderful, (2859)
"Great stay"
The price is ฿4,299
฿4,941 total
includes taxes & fees
25 Aug - 26 Aug
Legacy Resort Hotel & Spa
Berkshire Motor Hotel
Suite | Private kitchenette

Berkshire Motor Hotel

2.5 star property
8.4 out of 10, Very good, (951)
"Great location within walking distance from the places we wanted to visit."
The price is ฿3,061
฿3,451 total
includes taxes & fees
3 Aug - 4 Aug
Berkshire Motor Hotel
Hampton Inn & Suites by Hilton San Diego Seaworld
Reception

Hampton Inn & Suites by Hilton San Diego Seaworld

2.5 star property
The price is ฿4,361
฿5,012 total
includes taxes & fees
28 Aug - 29 Aug
Hampton Inn & Suites by Hilton San Diego Seaworld
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Desk, blackout curtains, iron/ironing board, free WiFi

Studio 6 Suites San Ysidro, CA -San Diego South Bay

2.5 star property
7.8 out of 10, Good, (1162)
"Nice hotel to stay in "
The price is ฿2,690
฿3,066 total
includes taxes & fees
4 Aug - 5 Aug
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Ayres Hotel San Diego South - Chula Vista
Lobby lounge

Ayres Hotel San Diego South - Chula Vista

3.0 star property
9.8 out of 10, Exceptional, (1082)
"Very nice hotel"
The price is ฿6,607
฿7,281 total
includes taxes & fees
3 Aug - 4 Aug
Ayres Hotel San Diego South - Chula Vista
Valli Hi Motel
Desk, blackout curtains, soundproofing, free WiFi

Valli Hi Motel

2.5 star property
8.2 out of 10, Very good, (1003)
"Staff was friendly hotel was clean and easy day trips back and forth throughout San Diego area."
Valli Hi Motel
Quality Inn San Diego South - Chula Vista
Coffee service

Quality Inn San Diego South - Chula Vista

2.5 star property
7.8 out of 10, Good, (1000)
"Good hotel "
The price is ฿3,004
฿3,304 total
includes taxes & fees
10 Aug - 11 Aug
Quality Inn San Diego South - Chula Vista
Best Western Americana Inn
1 bedroom, pillow-top beds, in-room safe, desk

Best Western Americana Inn

2.5 star property
9.0 out of 10, Wonderful, (1134)
"The breakfast was very good and the front desk and housekeeping hospitality were great. I would definitely stay here again!"
The price is ฿3,965
฿4,511 total
includes taxes & fees
24 Aug - 25 Aug
Best Western Americana Inn
Best Western Chula Vista/Otay Valley Hotel
Lobby

Best Western Chula Vista/Otay Valley Hotel

2.5 star property
7.8 out of 10, Good, (1456)
"Clean, great staff. "
The price is ฿3,830
฿4,213 total
includes taxes & fees
24 Aug - 25 Aug
Best Western Chula Vista/Otay Valley Hotel
Sentral Gaslamp Quarter
Premium bedding, pillow-top beds, desk, laptop workspace

Sentral Gaslamp Quarter

3.0 star property
9.2 out of 10, Wonderful, (224)
"great place to stay"
The price is ฿4,830
฿6,530 total
includes taxes & fees
17 Aug - 18 Aug
Sentral Gaslamp Quarter
Palihotel San Diego Gaslamp Quarter
Rooftop terrace

Palihotel San Diego Gaslamp Quarter

4.0 star property
8.8 out of 10, Excellent, (1569)
"Great hotel highly recommended"
The price is ฿3,093
฿4,502 total
includes taxes & fees
27 Aug - 28 Aug
Palihotel San Diego Gaslamp Quarter
Best Western Plus La Mesa San Diego
Lobby

Best Western Plus La Mesa San Diego

2.5 star property
8.2 out of 10, Very good, (1001)
"Staff was friendly, hotel was clean and breakfast was great"
The price is ฿3,735
฿4,108 total
includes taxes & fees
17 Aug - 18 Aug
Best Western Plus La Mesa San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.
Downtown San Diego map

Downtown San Diego

2 out of top 10 points of interest in this area

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Belmont Park featuring a park and rides
Mission Beach map

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Pacific Beach Park showing a beach
Pacific Beach map

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Gaslamp Quarter featuring a bar, night scenes and street scenes
Gaslamp Quarter map

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Ocean Beach map

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Otay Mesa Hotel Reviews

Handlery Hotel

Handlery Hotel

10/10 Excellent
"Excellant place to stay, staff are friendly, drinks by the pool. Great place to stay"
ANTHONY 2-night trip
Posted 18 hours ago
Handlery Hotel

Frequently asked questions

What's it like in Otay Mesa?

Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.

How many hotels will I find in the Otay Mesa area?

Expedia has 5 Otay Mesa hotels and other accommodation options, and one might make a good home base for venturing out into the greater San Diego area.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.

What is there to do in this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.