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Our top choices for Mississippi River hotels

Interior
The Eagles Nest Inn

The Eagles Nest Inn

The Eagles Nest Inn
3.0 star property
14.2 km from Mississippi River
9.4 out of 10, Exceptional, (19)
"It was very clean and very nice place to stay, has a very home and cozy feeling walking into the room."
United States
Bryan
The price is ฿3,282
฿3,726 total
includes taxes & fees
18 Jan - 19 Jan 2026
The Eagles Nest Inn
Exterior
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1001)
"Great area"
United States
kelvin
The price is ฿2,883
฿3,340 total
includes taxes & fees
11 Jan - 12 Jan 2026
Sleep Inn & Suites Hannibal West
Property grounds
River's Edge Motel

River's Edge Motel

River's Edge Motel
2.0 star property
13.6 km from Mississippi River
9.0 out of 10, Wonderful, (356)
"Excellent stay !!! Quite "
United States
Bradley
The price is ฿2,513
฿2,853 total
includes taxes & fees
22 Dec - 23 Dec
River's Edge Motel
55-inch TV with cable channels, Netflix, Hulu
Riverside Inn Hannibal

Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
25.1 km from Mississippi River
9.4 out of 10, Exceptional, (165)
"Great place to stay!"
United States
Sandy
The price is ฿4,763
฿6,553 total
includes taxes & fees
26 Dec - 27 Dec
Riverside Inn Hannibal
Down duvets, blackout curtains, iron/ironing board, free WiFi
Lighthouse Inn & Suites

Lighthouse Inn & Suites

Lighthouse Inn & Suites
4.0 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (24)
"Very nice room, close enough to walk to riverfront attractions. "
United States
Robert
The price is ฿5,303
฿6,091 total
includes taxes & fees
21 Dec - 22 Dec
Lighthouse Inn & Suites
Desk, iron/ironing board, WiFi, bed sheets
Best Western On The River

Best Western On The River

Best Western On The River
2.5 star property
25.3 km from Mississippi River
8.6 out of 10, Excellent, (1002)
"Great stay! Clean and cozy!!"
United States
Courtney
The price is ฿3,046
฿3,499 total
includes taxes & fees
21 Dec - 22 Dec
Best Western On The River
Desk, blackout curtains, iron/ironing board, free WiFi
Town & Country Inn and Suites

Town & Country Inn and Suites

Town & Country Inn and Suites
2.5 star property
45.2 km from Mississippi River
9.2 out of 10, Wonderful, (895)
"Staff extremely helpful and kind"
United States
Sandra
Town & Country Inn and Suites
TV
Garden House Bed and Breakfast

Garden House Bed and Breakfast

Garden House Bed and Breakfast
2.0 star property
25.2 km from Mississippi River
8.6 out of 10, Excellent, (38)
"Overall stay was great and the host chris is great aswell nothing bad to say about any aspect of our stay!"
United States
Josh
The price is ฿3,364
฿3,863 total
includes taxes & fees
9 Jan - 10 Jan 2026
Garden House Bed and Breakfast
Indoor spa tub
Stoney Creek Inn Quincy

Stoney Creek Inn Quincy

Stoney Creek Inn Quincy
2.0 star property
46.5 km from Mississippi River
8.8 out of 10, Excellent, (1000)
"Always love staying here"
United States
Ashlynn
Stoney Creek Inn Quincy
Exterior
Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
3.0 star property
46.1 km from Mississippi River
8.8 out of 10, Excellent, (603)
"Overall very nice property. "
United States
Jeffrey
The price is ฿3,486
฿3,974 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Quincy East by IHG
Free daily continental breakfast
Heritage Hotel Quincy

Heritage Hotel Quincy

Heritage Hotel Quincy
2.0 star property
47.8 km from Mississippi River
8.8 out of 10, Excellent, (270)
"Room was very clean Breakfast was satisfying "
United States
Mark
The price is ฿2,671
฿3,045 total
includes taxes & fees
4 Jan - 5 Jan 2026
Heritage Hotel Quincy
Iron/ironing board, free cots/infant beds, rollaway beds, free WiFi
Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown
2.5 star property
47.8 km from Mississippi River
8.8 out of 10, Excellent, (448)
"It was in a very quite area and easy to find places to est. able to explore the Mississippi river. "
United States
James
The price is ฿3,337
฿3,804 total
includes taxes & fees
18 Jan - 19 Jan 2026
Quality Inn & Suites Quincy - Downtown
Lobby
Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
30 km from Mississippi River
8.0 out of 10, Very good, (1000)
"Very nice place to stay during a snow storm. "
United States
Teresa
The price is ฿2,373
฿2,749 total
includes taxes & fees
4 Jan - 5 Jan 2026
Quality Inn & Suites Hannibal West
Lobby
Fairfield Inn & Suites Quincy

Fairfield Inn & Suites Quincy

Fairfield Inn & Suites Quincy
2.5 star property
46 km from Mississippi River
8.6 out of 10, Excellent, (335)
"We were very pleased with our stay. The room was clean and the staff was VERY friendly. We were also VERY impressed the breakfast. We would definitely stay there again."
United States
Julie
The price is ฿3,444
฿3,925 total
includes taxes & fees
28 Dec - 29 Dec
Fairfield Inn & Suites Quincy
Jetted bathtub
Oak Hill Inn & Suites

Oak Hill Inn & Suites

Oak Hill Inn & Suites
2.5 star property
71.8 km from Mississippi River
9.2 out of 10, Wonderful, (870)
"Great service & room .... highly recommend "
United States
Chad
The price is ฿3,307
฿3,769 total
includes taxes & fees
21 Dec - 22 Dec
Oak Hill Inn & Suites
In-room safe, desk, blackout curtains, iron/ironing board
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (659)
"Below average facility. Needs some upgrades and could use a good cleaning. Staff was helpful."
United States
JACQUI
The price is ฿2,387
฿2,836 total
includes taxes & fees
28 Dec - 29 Dec
Comfort Inn & Suites - Hannibal
Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
86.2 km from Mississippi River
9.4 out of 10, Exceptional, (841)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is ฿3,455
฿4,146 total
includes taxes & fees
3 Jan - 4 Jan 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Exterior
WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
93.4 km from Mississippi River
9.6 out of 10, Exceptional, (22)
"Very nice place. Clean room. Staff was excellent. "
United States
Richard
The price is ฿2,324
฿2,752 total
includes taxes & fees
22 Dec - 23 Dec
WoodSpring Suites St Peters-OFallon
Lobby lounge
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1000)
"Very clean rooms and staff is very friendly "
United States
Sherrie
The price is ฿1,821
฿2,092 total
includes taxes & fees
4 Jan - 5 Jan 2026
Motel 6 Hannibal, MO
Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, free WiFi, bed sheets
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal
2.0 star property
26.4 km from Mississippi River
7.4 out of 10, Good, (216)
"Left before breakfast great cup of coffee"
United States
David
The price is ฿2,035
฿2,337 total
includes taxes & fees
21 Dec - 22 Dec
Days Inn by Wyndham Hannibal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi River Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent
"All is perfect except room cleanse "
BINIAM 3-night trip
Posted 3 days ago
Drury Plaza Hotel St. Louis at the Arch

Hotels near other Mississippi River attractions

Mark Twain Cave

4.4/5 (128 reviews)
Explore the great outdoors at Mark Twain Cave, a lovely green space in Hannibal. While in this trendy area, you can savour the top-notch restaurants.
See properties

Mark Twain Cave and Cameron Cave

4.5/5 (51 reviews)
You can find out about the history of Hannibal with a visit to Mark Twain Cave and Cameron Cave. While in this trendy area, you can savour the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best hotel to stay close to Mississippi River?
Hilton St. Louis Airport is one of the top choices for your stay based on our traveller data, and this hotel offers 2 restaurants and a 24-hour fitness centre. You'll find it 70.4 mi (113.3 km) from Mississippi River. Other good options around the area include Hyatt Regency St. Louis at The Arch and Magnolia Hotel St. Louis, a Tribute Portfolio Hotel.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.