Search Hotels Near Mississippi River,

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Mississippi River hotels

River's Edge Motel

River's Edge Motel
2.0 star property
13.6 km from Mississippi River
9.0 out of 10, Wonderful, (359 reviews)
"Excellent stay !!! Quite "
United States
Bradley
The price is ฿2,489
฿2,826 total
includes taxes & fees
21 Feb - 22 Feb
River's Edge Motel

The Eagles Nest Inn

The Eagles Nest Inn
3.0 star property
14.2 km from Mississippi River
9.4 out of 10, Exceptional, (21 reviews)
"Room was spacious and clean. Had a great stay. The restaurant was delicious. "
United States
James
The price is ฿2,975
฿3,378 total
includes taxes & fees
19 Feb - 20 Feb
The Eagles Nest Inn

Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal
2.5 star property
26.3 km from Mississippi River
6.4 out of 10, (741 reviews)
"Thanks to the staff very help and kind. Very good stay. "
United States
Terry
The price is ฿1,820
฿2,105 total
includes taxes & fees
22 Feb - 23 Feb
Baymont by Wyndham Hannibal

Best Western On The River

Best Western On The River
2.5 star property
25.3 km from Mississippi River
8.6 out of 10, Excellent, (1,000 reviews)
"Everything was great. Will definitely stay again."
United States
Ethan
The price is ฿2,016
฿2,316 total
includes taxes & fees
19 Feb - 20 Feb
Best Western On The River

Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
25.1 km from Mississippi River
9.4 out of 10, Exceptional, (167 reviews)
"Great place to stay!"
United States
Sandy
The price is ฿4,427
฿6,157 total
includes taxes & fees
2 Mar - 3 Mar
Riverside Inn Hannibal

Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area
2.0 star property
90.7 km from Mississippi River
6.8 out of 10, (1,000 reviews)
"Staff was awesome and accomodating. Room and price was great. "
United States
Anthony
The price is ฿2,076
฿2,448 total
includes taxes & fees
26 Feb - 27 Feb
Super 8 by Wyndham O'Fallon MO/St. Louis Area

Economy Inn Wentzville

Economy Inn Wentzville
2.0 star property
86.8 km from Mississippi River
6.4 out of 10, (518 reviews)
"Really cozy place to stay at!"
United States
Yufei
The price is ฿1,867
฿2,118 total
includes taxes & fees
19 Feb - 20 Feb
Economy Inn Wentzville

Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1,000 reviews)
"It was a good midway stop for us on our way to Memphis."
United States
Joel
The price is ฿3,167
฿3,669 total
includes taxes & fees
15 Mar - 16 Mar
Sleep Inn & Suites Hannibal West

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
98 km from Mississippi River
6.8 out of 10, (1,000 reviews)
"Clean room very nice staff it’s nice"
United States
Mercedez
The price is ฿1,960
฿2,253 total
includes taxes & fees
19 Feb - 20 Feb
Relax Inn Saint Charles

Lighthouse Inn & Suites

Lighthouse Inn & Suites
4.0 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (25 reviews)
"Nice room. Matched the pictures. Exactly what we were looking for."
United States
John
The price is ฿5,255
฿7,107 total
includes taxes & fees
19 Feb - 20 Feb
Lighthouse Inn & Suites

Garden House Bed and Breakfast

Garden House Bed and Breakfast
2.0 star property
25.2 km from Mississippi River
8.6 out of 10, Excellent, (38 reviews)
"Great location. Clean rooms, Staff very friendly."
United States
Charles
The price is ฿3,018
฿3,466 total
includes taxes & fees
19 Feb - 20 Feb
Garden House Bed and Breakfast

Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles
2.0 star property
93.8 km from Mississippi River
6.2 out of 10, (1,000 reviews)
"Room was excellent and clean"
United States
catherine
The price is ฿1,931
฿2,220 total
includes taxes & fees
22 Feb - 23 Feb
Days Inn by Wyndham St Peters/St Charles

Baymont by Wyndham Keokuk

Baymont by Wyndham Keokuk
2.5 star property
96.1 km from Mississippi River
6.2 out of 10, (497 reviews)
"Great location for geode hunting. Irish Pub behind the hotel is the best."
United States
Marty
The price is ฿1,860
฿2,083 total
includes taxes & fees
22 Feb - 23 Feb
Baymont by Wyndham Keokuk

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (673 reviews)
"Everything was clean and staff was friendly. Just needed some updates. "
United States
Georgia
The price is ฿2,241
฿2,667 total
includes taxes & fees
27 Feb - 28 Feb
Comfort Inn & Suites - Hannibal

La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North

La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North
3.0 star property
109.6 km from Mississippi River
6.6 out of 10, (1,003 reviews)
"Great staff and the place is nice and clean and the breakfast is awesome."
United States
Kerry
The price is ฿1,836
฿2,244 total
includes taxes & fees
1 Mar - 2 Mar
La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North

Holiday Inn Express & Suites Hannibal - Medical Center by IHG

Holiday Inn Express & Suites Hannibal - Medical Center by IHG
2.5 star property
30.7 km from Mississippi River
9.8 out of 10, Exceptional, (387 reviews)
"Excellent property, great staff, delicious breakfast, clean rooms!"
United States
Cassandra
The price is ฿3,857
฿4,430 total
includes taxes & fees
22 Feb - 23 Feb
Holiday Inn Express & Suites Hannibal - Medical Center by IHG

LAKEVIEWINN

LAKEVIEWINN
2.5 star property
89.4 km from Mississippi River
5.6 out of 10, (34 reviews)
"I enjoyed it! And the owners were so sweet and understanding. I would absolutely stay there again!"
United States
Evelyn
The price is ฿2,100
฿2,372 total
includes taxes & fees
22 Feb - 23 Feb
LAKEVIEWINN

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
30 km from Mississippi River
8.0 out of 10, Very good, (1,011 reviews)
"Good breakfast selections. Close to a good restaurant. "
United States
Steve
The price is ฿2,165
฿2,508 total
includes taxes & fees
26 Feb - 27 Feb
Quality Inn & Suites Hannibal West

Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1,000 reviews)
"Overall, very nice stay"
United States
Cary
The price is ฿1,711
฿1,965 total
includes taxes & fees
3 Mar - 4 Mar
Motel 6 Hannibal, MO

Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
2.0 star property
26.3 km from Mississippi River
7.2 out of 10, Good, (1,001 reviews)
"clean room - soft beds - friendly staff - very welcoming - lobby nice"
United States
Maxine
The price is ฿1,784
฿2,049 total
includes taxes & fees
22 Feb - 23 Feb
Super 8 by Wyndham Hannibal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels close to Mississippi River

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Property grounds
River's Edge Motel
2.0 star property
9.0
Wonderful
359 reviews
View
Interior
The Eagles Nest Inn
3.0 star property
9.4
Exceptional
21 reviews
View
Indoor pool
Baymont by Wyndham Hannibal
2.5 star property
6.4
741 reviews
View
Desk, iron/ironing board, WiFi, bed sheets
Best Western On The River
2.5 star property
8.6
Excellent
1,000 reviews
View
Honeymoon Room, River View | Egyptian cotton sheets, premium bedding, pillow-top beds
Riverside Inn Hannibal
2.5 star property
9.4
Exceptional
167 reviews
View

Top Mississippi River Hotel Reviews

Hotels near other Mississippi River attractions

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best hotel to stay close to Mississippi River?
Pear Tree Inn St. Louis Airport is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and free parking. You'll find it 69.9 mi (112.5 km) from Mississippi River. Other good options around the area include Clayton Plaza Hotel & Extended Stay and Hollywood Casino & Hotel St. Louis.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.