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Check prices for these dates

This weekend
13 Nov - 15 Nov
Next weekend
20 Nov - 22 Nov

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Our top choices for Mississippi River hotels

A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.

1. Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1,000 reviews)
"Clean rooms, comfy beds, nice pool and good variety at breakfast. Couldn’t ask for much more!"
United States
Sarah
The price is ฿3,703
฿4,308 total
includes taxes & fees
6 Dec - 7 Dec
Sleep Inn & Suites Hannibal West
A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

2. Best Western On The River

Best Western On The River
2.5 star property
25.3 km from Mississippi River
8.8 out of 10, Excellent, (1,001 reviews)
"Location was great!"
United States
Rob
The price is ฿3,395
฿3,916 total
includes taxes & fees
16 Nov - 17 Nov
Best Western On The River
A gazebo with a table and benches, surrounded by trees and a body of water.

3. River's Edge Motel

River's Edge Motel
2.0 star property
13.6 km from Mississippi River
8.8 out of 10, Excellent, (395 reviews)
"Nice location."
United States
Jeff
The price is ฿2,803
฿3,183 total
includes taxes & fees
8 Dec - 9 Dec
River's Edge Motel
An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

4. Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
30 km from Mississippi River
8.0 out of 10, Very good, (1,007 reviews)
"Our go to hotel for years when we visit Hannibal."
United States
Gayle
The price is ฿2,256
฿2,625 total
includes taxes & fees
6 Dec - 7 Dec
Quality Inn & Suites Hannibal West
A hotel room with a large bed, a desk with a computer, a television, and a bathtub.

5. Oak Hill Inn & Suites

Oak Hill Inn & Suites
2.5 star property
71.8 km from Mississippi River
9.2 out of 10, Wonderful, (1,008 reviews)
"As always the stay was great"
United States
Peter
The price is ฿3,159
฿3,600 total
includes taxes & fees
1 Dec - 2 Dec
Oak Hill Inn & Suites
A hotel room with a bed, two bedside lamps, a headboard, and a patterned carpet.

6. Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
25.1 km from Mississippi River
9.6 out of 10, Exceptional, (205 reviews)
"Very nice room and great view of the river. Very comfortable bed and very nice shower. Walking distance to so many restaurants and shops. We enjoyed our stay very much!"
United States
Christina
The price is ฿5,121
฿7,076 total
includes taxes & fees
16 Nov - 17 Nov
Riverside Inn Hannibal
A modern kitchen with wooden cabinets, a granite countertop, a coffee machine, a microwave, a toaster, and a refrigerator.

7. Heritage Hotel Quincy

Heritage Hotel Quincy
2.0 star property
47.8 km from Mississippi River
8.6 out of 10, Excellent, (486 reviews)
"Very nice clean friendly"
United States
paul
The price is ฿2,601
฿2,964 total
includes taxes & fees
16 Nov - 17 Nov
Heritage Hotel Quincy
A hot tub with a rocky backdrop and a mural.

8. Stoney Creek Inn Quincy

Stoney Creek Inn Quincy
2.0 star property
46.5 km from Mississippi River
8.6 out of 10, Excellent, (1,000 reviews)
"The hotel was rustic, clean, and a great place to stay."
United States
Kent
The price is ฿2,554
฿2,911 total
includes taxes & fees
22 Nov - 23 Nov
Stoney Creek Inn Quincy
A hotel room with a bed, a sofa, a desk, and a lamp.

9. Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (776 reviews)
"Front desk helpful Clean rooms Great breakfast and lady fixing our breakfast was helpful and kept plenty of food ready for all"
United States
Jerry
The price is ฿2,467
฿2,946 total
includes taxes & fees
19 Nov - 20 Nov
Comfort Inn & Suites - Hannibal
A spacious lobby with a black leather sofa, a matching armchair, a coffee table, and a chandelier.

10. Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1,000 reviews)
"Excellent place to stay"
United States
Jared
The price is ฿1,958
฿2,259 total
includes taxes & fees
15 Nov - 16 Nov
Motel 6 Hannibal, MO
A hotel room with two beds, a wooden headboard, a nightstand with a phone, and a wall-mounted lamp.

11. Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal
2.0 star property
26.4 km from Mississippi River
7.4 out of 10, Good, (299 reviews)
"Pretty good place to stay at with a great price !!"
United States
Christian
The price is ฿1,976
฿2,279 total
includes taxes & fees
19 Nov - 20 Nov
Days Inn by Wyndham Hannibal
A modern hotel with a flat roof, multiple windows, and a sign indicating it is a Super 8 hotel.

12. Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
2.0 star property
26.3 km from Mississippi River
7.2 out of 10, Good, (1,002 reviews)
"Clean, safe hotel and friendly staff"
United States
Julie
The price is ฿1,866
฿2,152 total
includes taxes & fees
22 Nov - 23 Nov
Super 8 by Wyndham Hannibal
A modern reception area with a marble counter, a wooden panel with a light fixture, a fireplace, and a seating area with a sofa and chairs.

13. Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
3.0 star property
46.1 km from Mississippi River
8.8 out of 10, Excellent, (699 reviews)
"The hotel was in a great location with clean rooms."
United States
Colleen
The price is ฿3,816
฿4,350 total
includes taxes & fees
13 Dec - 14 Dec
Holiday Inn Quincy East by IHG
A hotel room with a bed, a desk with a computer, a TV, and a bathroom with a shower.

14. Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown
2.5 star property
47.8 km from Mississippi River
8.8 out of 10, Excellent, (499 reviews)
"Great stay for a wedding in the area."
United States
Bryan
The price is ฿3,884
฿4,427 total
includes taxes & fees
13 Dec - 14 Dec
Quality Inn & Suites Quincy - Downtown
A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

15. Lighthouse Inn & Suites

Lighthouse Inn & Suites
3.5 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (47 reviews)
"The room was very clean. It had a hot tub in it and it was also very clean and worked properly. We enjoyed our stay there."
United States
Connie
The price is ฿5,677
฿6,548 total
includes taxes & fees
15 Nov - 16 Nov
Lighthouse Inn & Suites
A hotel lobby with a dining area, a bar, and a fireplace.

16. Fairfield Inn & Suites Quincy

Fairfield Inn & Suites Quincy
3.0 star property
46 km from Mississippi River
8.6 out of 10, Excellent, (366 reviews)
"Room was clean and staff was nice."
United States
Jeremy
The price is ฿3,972
฿4,527 total
includes taxes & fees
22 Nov - 23 Nov
Fairfield Inn & Suites Quincy
A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.

17. Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
95.3 km from Mississippi River
9.6 out of 10, Exceptional, (1,000 reviews)
"All the people were very nice and talkative. The happy hour food was good and so were the cocktails. The hotel was clean and comfortable."
United States
Michael
The price is ฿3,714
฿4,270 total
includes taxes & fees
22 Nov - 23 Nov
Drury Inn & Suites St. Louis St. Peters
A hotel room with a bed, a desk, a chair, a television, and a window with curtains.

18. Microtel Inn & Suites by Wyndham Quincy Downtown/River Area

Microtel Inn & Suites by Wyndham Quincy Downtown/River Area
2.5 star property
47.9 km from Mississippi River
7.6 out of 10, Good, (1,000 reviews)
"Nice place. Convenient location."
United States
Robert
The price is ฿2,572
฿2,931 total
includes taxes & fees
18 Nov - 19 Nov
Microtel Inn & Suites by Wyndham Quincy Downtown/River Area
A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

19. DoubleTree by Hilton Quincy

DoubleTree by Hilton Quincy
3.5 star property
47.9 km from Mississippi River
8.4 out of 10, Very good, (788 reviews)
"Rooms were very clean and the staff was amazing and very accommodating for all of our family. There were 10 different families and they made sure we were all in the same floor."
United States
Ronda
The price is ฿3,711
฿4,230 total
includes taxes & fees
1 Dec - 2 Dec
DoubleTree by Hilton Quincy
A wooden staircase with a handrail, a small table with a lamp, and a chair in a room with a door and windows.

20. Garden House Bed and Breakfast

Garden House Bed and Breakfast
3.0 star property
25.2 km from Mississippi River
8.4 out of 10, Very good, (57 reviews)
"Beautiful Queen Ann B&B, was reasonably priced and within walking distance to the river and down town Hannibal attractions."
United States
Debbie
The price is ฿3,601
฿4,154 total
includes taxes & fees
13 Nov - 14 Nov
Garden House Bed and Breakfast
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels close to Mississippi River

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.
Sleep Inn & Suites Hannibal West
2.5 star property
9.6
Exceptional
1,000 reviews
View
A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.
Best Western On The River
2.5 star property
8.8
Excellent
1,001 reviews
View
A gazebo with a table and benches, surrounded by trees and a body of water.
River's Edge Motel
2.0 star property
8.8
Excellent
395 reviews
View
An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.
Quality Inn & Suites Hannibal West
2.5 star property
8.0
Very good
1,007 reviews
View
A hotel room with a large bed, a desk with a computer, a television, and a bathtub.
Oak Hill Inn & Suites
2.5 star property
9.2
Wonderful
1,008 reviews
View

Top Mississippi River Hotel Reviews

21C Museum Hotel St Louis

21C Museum Hotel St Louis

10/10 Excellent
"This is by far my favorite hotel. It is always clean, the staff is very kind and helpful, the gym and hot tub is SO COOL and huge. One of the most unique hotels I’ve ever stayed in. Rooms are very comfortable, they leave water, chocolates, and a robe for you. Sometimes they even give you a complimentary whiskey. The dinner menu isn’t as good as it used to be and breakfast is overpriced but the atmosphere truly makes up for it. Theres a museum on the second floor, a pool table, a really cool stairwell of colors and art. I would recommend this hotel 100x."
Brandi 1-night trip
Posted 11 hours ago
21C Museum Hotel St Louis

Other attractions near Mississippi River

Mark Twain Cave

8.8/10 (89 reviews)
You can find out about the history of Hannibal with a visit to Mark Twain Cave. While in this trendy area, you can savour the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best hotel to stay close to Mississippi River?
Hollywood Casino & Hotel St. Louis is one of the top choices for your stay based on our traveller data, and this hotel offers a casino and 7 restaurants. You'll find it 65.7 mi (105.7 km) from Mississippi River. Other good options around the area include Hyatt Regency St. Louis at The Arch and Clayton Plaza Hotel & Extended Stay.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.