Search Hotels Near Mississippi River,

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
21 Aug - 22 Aug
Tomorrow
22 Aug - 23 Aug
This weekend
22 Aug - 24 Aug
Next weekend
29 Aug - 31 Aug

Filter by

Guest rating
Guest rating
Property class

Top Trending Hotels Near Mississippi River

Our top choices for Mississippi River hotels

River's Edge Motel
Balcony

River's Edge Motel

2.0 star property
9.0 out of 10, Wonderful, (335)
"Great clean place to stay with friendly staff"
The price is ฿2,605
฿2,958 total
includes taxes & fees
23 Aug - 24 Aug
River's Edge Motel
The Eagles Nest Inn
Interior

The Eagles Nest Inn

3.0 star property
9.2 out of 10, Wonderful, (10)
"It was very clean and very nice place to stay, has a very home and cozy feeling walking into the room."
The price is ฿3,224
฿3,661 total
includes taxes & fees
26 Aug - 27 Aug
The Eagles Nest Inn
Baymont by Wyndham Hannibal
Desk, laptop workspace, iron/ironing board, free WiFi

Baymont by Wyndham Hannibal

2.5 star property
6.2 out of 10, (695)
"A true 70s time capsil. Enjoyed our stay."
The price is ฿1,993
฿2,305 total
includes taxes & fees
24 Aug - 25 Aug
Baymont by Wyndham Hannibal
Riverside Inn Hannibal
55-inch TV with cable channels, Netflix, Hulu

Riverside Inn Hannibal

2.5 star property
9.4 out of 10, Exceptional, (134)
"Very nice rooms right on the river!"
The price is ฿4,110
฿5,842 total
includes taxes & fees
19 Sept - 20 Sept
Riverside Inn Hannibal
Best Western On The River
Indoor pool, seasonal outdoor pool, pool umbrellas, pool loungers

Best Western On The River

2.5 star property
8.6 out of 10, Excellent, (1002)
"Nice location for seeing the area"
The price is ฿3,910
฿4,491 total
includes taxes & fees
2 Sept - 3 Sept
Best Western On The River
Lighthouse Inn & Suites
Deluxe Room | 1 bedroom, down duvets, blackout curtains, iron/ironing board

Lighthouse Inn & Suites

4.0 star property
9.0 out of 10, Wonderful, (16)
"Location is excellent! Close to historic downtown but far enough away to be quiet and peaceful! Very clean and decor is wonderful!"
The price is ฿4,660
฿5,352 total
includes taxes & fees
22 Aug - 23 Aug
Lighthouse Inn & Suites
Garden House Bed and Breakfast
Front of property

Garden House Bed and Breakfast

2.0 star property
8.6 out of 10, Excellent, (25)
"A beautiful 19th century mansion, decorated in period. Quiet and comfortable."
The price is ฿3,195
฿3,669 total
includes taxes & fees
22 Aug - 23 Aug
Garden House Bed and Breakfast
Super 8 by Wyndham O'Fallon MO/St. Louis Area
Standard Room, 2 Queen Beds | Desk, iron/ironing board, free WiFi, bed sheets

Super 8 by Wyndham O'Fallon MO/St. Louis Area

2.0 star property
6.8 out of 10, (962)
"Great staff clean room"
The price is ฿2,215
฿2,612 total
includes taxes & fees
7 Sept - 8 Sept
Super 8 by Wyndham O'Fallon MO/St. Louis Area
Economy Inn Wentzville
Lobby

Economy Inn Wentzville

2.0 star property
6.4 out of 10, (450)
"Best value around this location. Not going to be as nice as holiday Inn , but way better than most budget friendly places."
The price is ฿2,280
฿2,586 total
includes taxes & fees
22 Aug - 23 Aug
Economy Inn Wentzville
Sleep Inn & Suites
Exterior

Sleep Inn & Suites

2.5 star property
9.6 out of 10, Exceptional, (1001)
"Great stay!"
The price is ฿3,294
฿3,816 total
includes taxes & fees
21 Sept - 22 Sept
Sleep Inn & Suites
Motel 6 Hannibal, MO
Lobby sitting area

Motel 6 Hannibal, MO

2.0 star property
7.4 out of 10, Good, (1000)
"Economical and comfortable, staff is anxious to serve. "
The price is ฿1,791
฿2,057 total
includes taxes & fees
25 Aug - 26 Aug
Motel 6 Hannibal, MO
Baymont by Wyndham Keokuk
Lobby

Baymont by Wyndham Keokuk

2.5 star property
6.2 out of 10, (461)
"Great location for geode hunting. Irish Pub behind the hotel is the best."
The price is ฿1,760
฿1,971 total
includes taxes & fees
23 Aug - 24 Aug
Baymont by Wyndham Keokuk
Super 8 by Wyndham Hannibal
Exterior

Super 8 by Wyndham Hannibal

2.0 star property
7.2 out of 10, Good, (1000)
"Service was good and staff was friendly. The breakfast left some to be desired."
The price is ฿1,938
฿2,226 total
includes taxes & fees
3 Sept - 4 Sept
Super 8 by Wyndham Hannibal
LAKEVIEWINN
Exterior

LAKEVIEWINN

2.5 star property
5.8 out of 10, (22)
"I felt like the place had permanent residents. Right outside my door was the community grill which had 5 or so people hanging out."
The price is ฿2,768
฿3,127 total
includes taxes & fees
22 Aug - 23 Aug
LAKEVIEWINN
Comfort Inn & Suites - Hannibal
Indoor pool, pool loungers

Comfort Inn & Suites - Hannibal

2.5 star property
7.6 out of 10, Good, (625)
"The beds were super comfy"
The price is ฿3,251
฿3,831 total
includes taxes & fees
24 Aug - 25 Aug
Comfort Inn & Suites - Hannibal
Relax Inn Saint Charles
Lobby

Relax Inn Saint Charles

2.0 star property
6.4 out of 10, (994)
"Great place for traveling."
The price is ฿2,052
฿2,358 total
includes taxes & fees
24 Aug - 25 Aug
Relax Inn Saint Charles
Days Inn by Wyndham St Peters/St Charles
Lobby

Days Inn by Wyndham St Peters/St Charles

2.0 star property
6.2 out of 10, (971)
"Nice hotel in a safe area. Normally do not stay at days inn, but this one was actually decent pricing and good area. Did not feel unsafe. "
The price is ฿2,132
฿2,450 total
includes taxes & fees
1 Sept - 2 Sept
Days Inn by Wyndham St Peters/St Charles
Days Inn by Wyndham Hannibal
Room, 2 Queen Beds, Non Smoking | 1 bedroom, desk, laptop workspace, free WiFi

Days Inn by Wyndham Hannibal

2.0 star property
7.2 out of 10, Good, (192)
"I always stay here and have a very good experience"
The price is ฿2,198
฿2,525 total
includes taxes & fees
2 Sept - 3 Sept
Days Inn by Wyndham Hannibal
Extended Stay America Select Suites St Louis Earth City
Property amenity

Extended Stay America Select Suites St Louis Earth City

2.5 star property
6.6 out of 10, (857)
"I love staying at this ESA location. The staff is wonderful "
The price is ฿2,227
฿2,686 total
includes taxes & fees
24 Aug - 25 Aug
Extended Stay America Select Suites St Louis Earth City
La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North
Deluxe Room, 1 King Bed, Non Smoking (Deluxe Executive Room) | Premium bedding, desk, laptop workspace, iron/ironing board

La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North

3.0 star property
6.4 out of 10, (1001)
"Always a great stay ! "
The price is ฿2,076
฿2,538 total
includes taxes & fees
24 Aug - 25 Aug
La Quinta Inn by Wyndham St. Louis Hazelwood - Airport North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Mississippi River Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent
"Perfect location "
Jose 1-night trip
Posted 2 days ago
Drury Plaza Hotel St. Louis at the Arch

Frequently asked questions

What's the area like around Mississippi River?

Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.

What's the best hotel to stay close to Mississippi River?

Hollywood Casino & Hotel St. Louis is one of the top choices for your stay based on our traveller data, and this hotel offers a casino and 7 restaurants. You'll find it 65.7 mi (105.7 km) from Mississippi River. Other good options around the area include Hyatt Regency St. Louis at The Arch and Clayton Plaza Hotel & Extended Stay.

If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?

Yes! Most room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.