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Check prices for these dates

Tonight
12 Nov - 13 Nov
Tomorrow
13 Nov - 14 Nov
This weekend
13 Nov - 15 Nov
Next weekend
20 Nov - 22 Nov

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Our top choices for Mark Twain Cave hotels

A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.

1. Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
9.2 km from Mark Twain Cave
9.6 out of 10, Exceptional, (1,000 reviews)
"Clean rooms, comfy beds, nice pool and good variety at breakfast. Couldn’t ask for much more!"
United States
Sarah
The price is ฿3,703
฿4,308 total
includes taxes & fees
6 Dec - 7 Dec
Sleep Inn & Suites Hannibal West
A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

2. Best Western On The River

Best Western On The River
2.5 star property
3.5 km from Mark Twain Cave
8.8 out of 10, Excellent, (1,001 reviews)
"Location was great!"
United States
Rob
The price is ฿3,395
฿3,916 total
includes taxes & fees
16 Nov - 17 Nov
Best Western On The River
An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

3. Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
9 km from Mark Twain Cave
8.0 out of 10, Very good, (1,007 reviews)
"Our go to hotel for years when we visit Hannibal."
United States
Gayle
The price is ฿2,256
฿2,625 total
includes taxes & fees
6 Dec - 7 Dec
Quality Inn & Suites Hannibal West
A hotel room with a bed, two bedside lamps, a headboard, and a patterned carpet.

4. Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
3.3 km from Mark Twain Cave
9.6 out of 10, Exceptional, (205 reviews)
"Very nice room and great view of the river. Very comfortable bed and very nice shower. Walking distance to so many restaurants and shops. We enjoyed our stay very much!"
United States
Christina
The price is ฿5,121
฿7,076 total
includes taxes & fees
16 Nov - 17 Nov
Riverside Inn Hannibal
A hotel room with a bed, a sofa, a desk, and a lamp.

5. Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
6 km from Mark Twain Cave
7.6 out of 10, Good, (776 reviews)
"Front desk helpful Clean rooms Great breakfast and lady fixing our breakfast was helpful and kept plenty of food ready for all"
United States
Jerry
The price is ฿2,467
฿2,946 total
includes taxes & fees
19 Nov - 20 Nov
Comfort Inn & Suites - Hannibal
A spacious lobby with a black leather sofa, a matching armchair, a coffee table, and a chandelier.

6. Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
4.9 km from Mark Twain Cave
7.4 out of 10, Good, (1,000 reviews)
"Excellent place to stay"
United States
Jared
The price is ฿1,958
฿2,259 total
includes taxes & fees
15 Nov - 16 Nov
Motel 6 Hannibal, MO
A hotel room with two beds, a wooden headboard, a nightstand with a phone, and a wall-mounted lamp.

7. Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal
2.0 star property
6.2 km from Mark Twain Cave
7.4 out of 10, Good, (299 reviews)
"Pretty good place to stay at with a great price !!"
United States
Christian
The price is ฿1,976
฿2,279 total
includes taxes & fees
19 Nov - 20 Nov
Days Inn by Wyndham Hannibal
A modern hotel with a flat roof, multiple windows, and a sign indicating it is a Super 8 hotel.

8. Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
2.0 star property
5.1 km from Mark Twain Cave
7.2 out of 10, Good, (1,002 reviews)
"Clean, safe hotel and friendly staff"
United States
Julie
The price is ฿1,866
฿2,152 total
includes taxes & fees
22 Nov - 23 Nov
Super 8 by Wyndham Hannibal
A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

9. Lighthouse Inn & Suites

Lighthouse Inn & Suites
3.5 star property
3.9 km from Mark Twain Cave
8.8 out of 10, Excellent, (47 reviews)
"The room was very clean. It had a hot tub in it and it was also very clean and worked properly. We enjoyed our stay there."
United States
Connie
The price is ฿5,677
฿6,548 total
includes taxes & fees
15 Nov - 16 Nov
Lighthouse Inn & Suites
A large indoor swimming pool with multiple levels of balconies, surrounded by seating areas and potted plants.

10. Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal
2.0 star property
6.2 km from Mark Twain Cave
7.4 out of 10, Good, (188 reviews)
"Great price! Nice comfortable clean room"
United States
Debbie
The price is ฿1,945
฿2,259 total
includes taxes & fees
1 Dec - 2 Dec
Howard Johnson BY Wyndham Hannibal
A wooden staircase with a handrail, a small table with a lamp, and a chair in a room with a door and windows.

11. Garden House Bed and Breakfast

Garden House Bed and Breakfast
3.0 star property
3.4 km from Mark Twain Cave
8.4 out of 10, Very good, (57 reviews)
"Beautiful Queen Ann B&B, was reasonably priced and within walking distance to the river and down town Hannibal attractions."
United States
Debbie
The price is ฿3,601
฿4,154 total
includes taxes & fees
13 Nov - 14 Nov
Garden House Bed and Breakfast
An indoor swimming pool with a tiled ceiling, multiple levels with windows, and seating areas around the pool.

12. Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal
2.5 star property
6.2 km from Mark Twain Cave
6.4 out of 10, (832 reviews)
"Thanks for the hospitality. We enjoyed this stay very clean."
United States
Natasha
The price is ฿1,722
฿2,000 total
includes taxes & fees
1 Dec - 2 Dec
Baymont by Wyndham Hannibal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Compare popular hotels close to Mark Twain Cave

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.
Sleep Inn & Suites Hannibal West
2.5 star property
9.6
Exceptional
1,000 reviews
View
A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.
Best Western On The River
2.5 star property
8.8
Excellent
1,001 reviews
View
An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.
Quality Inn & Suites Hannibal West
2.5 star property
8.0
Very good
1,007 reviews
View
A hotel room with a bed, two bedside lamps, a headboard, and a patterned carpet.
Riverside Inn Hannibal
2.5 star property
9.6
Exceptional
205 reviews
View
A hotel room with a bed, a sofa, a desk, and a lamp.
Comfort Inn & Suites - Hannibal
2.5 star property
7.6
Good
776 reviews
View

Hotels recommended for families near Mark Twain Cave

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

Best Western On The River

Best Western On The River
2.5 star property
Hannibal
8.8 out of 10, Excellent, (1,001)
The price is ฿3,395
฿3,916 total
includes taxes & fees
16 Nov - 17 Nov
Best Western On The River

Other attractions near Mark Twain Cave

Mark Twain Memorial Lighthouse

8.8/10 (143 reviews)
You can find out about the history of Hannibal with a trip to Mark Twain Memorial Lighthouse. While in this family-friendly area, you can savour the top-notch restaurants.
See properties

Top Mark Twain Cave Hotel Reviews

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.
Best Western On The River

Best Western On The River

Best Western On The River
Hannibal

10/10 Excellent

Very nice one night stay here
United Kingdom
Wendy
Reviewed June 30, 2026
Best Western On The River

Frequently Asked Questions

What's the area like around Mark Twain Cave?

Mark Twain Cave is located in a welcoming area of Hannibal known for its array of dining options. You'll find 51 hotels and other accommodations within a few miles for a convenient home base.

What's the best place to stay close to Mark Twain Cave?

Best Western On The River is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. It's located 2.2 mi (3.5 km) from Mark Twain Cave. Other good choices within a few miles include Comfort Inn & Suites - Hannibal and Motel 6 Hannibal, MO.

How many hotels should I expect to find close to Mark Twain Cave?

Expedia has 51 hotels and other accommodation options a few miles from Mark Twain Cave.

If I need to cancel the hotel reservation for my stay near Mark Twain Cave, will I receive a refund?

Yes, the majority of hotel room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to review the best deals near Mark Twain Cave.

What can I see and do near Mark Twain Cave?

Study the collections at Mark Twain Boyhood Home and Museum, Jim's Journey: The Huck Finn Freedom Center or Molly Brown Museum and Home. Rockcliffe Mansion, Mark Twain Memorial Lighthouse and Bluff City Theater are monuments to see when you're exploring the area around Mark Twain Cave. You might spend a leisurely day outdoors at Sawyer's Creek Fun Park and Sodalis Nature Preserve.