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Check prices for these dates

This weekend
24 Jul - 26 Jul
Next weekend
31 Jul - 2 Aug

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Our top choices for South Central Houston hotels

Outdoor pool, free pool cabanas, pool umbrellas

1. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,165 reviews)
"The customer service is amazing from the valet to the front desk"
United States
Tanasia
The price is ฿5,433
฿6,763 total
includes taxes & fees
24 Jul - 25 Jul
The Westin Houston Medical Center/Museum District
Terrace/patio

2. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very good, (2,034 reviews)
"Great place to stay at super clean and nice area and everything was nearby"
United States
Marvin
The price is ฿3,569
฿4,215 total
includes taxes & fees
21 Aug - 22 Aug
Hilton Houston Plaza/Medical Center
Reception

3. Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1,011 reviews)
"Great AC, Clean room, would stay again"
United States
Haylie
The price is ฿2,494
฿2,918 total
includes taxes & fees
23 Jul - 24 Jul
Americas Best Value Inn Medical Center Downtown
Outdoor pool, open 6:00 AM to 10:00 PM, pool loungers

4. InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.4 out of 10, Exceptional, (1,000 reviews)
"Was a over great place to stay"
United States
Danny
The price is ฿4,784
฿6,272 total
includes taxes & fees
21 Aug - 22 Aug
InterContinental Houston by IHG
Dinner served

5. Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,000 reviews)
"Good convenient hotel. Wanted to have more choice of restaurant."
Japan
Yasuhito
The price is ฿4,814
฿6,704 total
includes taxes & fees
25 Jul - 26 Jul
Houston Marriott Medical Center/Museum District
Premium bedding, pillow-top beds, minibar, in-room safe

6. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,012 reviews)
"The hotel was very clean, the staff was awesome, and the hotel has a very unique vibe that made a cool place to stay."
United States
Stephanie
The price is ฿7,400
฿9,869 total
includes taxes & fees
23 Jul - 24 Jul
Hotel Zaza Houston Museum District
Laptop workspace, blackout curtains, soundproofing

7. Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
9.2 out of 10, Wonderful, (208 reviews)
"Parking was great to have on property and very friendly staff! Cleaned rooms and provided anything that was needed!"
United States
Aaliyah
The price is ฿3,230
฿3,779 total
includes taxes & fees
29 Jul - 30 Jul
Downtowner Inns - Houston Downtown
Exterior detail

8. Sentral Forme Houston

Sentral Forme Houston
4.5 star property
South Central Houston
8.8 out of 10, Excellent, (66 reviews)
"Amazing stay!!"
Canada
Elizabeth
The price is ฿6,022
฿8,030 total
includes taxes & fees
9 Aug - 10 Aug
Sentral Forme Houston
Breakfast, lunch and dinner served

9. DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (635 reviews)
"Good location for the medical center, and decent rates. The breakfast was very good."
United States
John
The price is ฿4,121
฿4,821 total
includes taxes & fees
7 Aug - 8 Aug
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Exterior

10. La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (588 reviews)
"Lovely property that’s convenient to the Museum District, downtown, and other central Houston attractions. We thoroughly enjoyed our stay. The delicious breakfasts by Chef Joseph deserve special mention, and we appreciated the free parking. Highly recommended."
United States
Melanie
The price is ฿6,022
฿7,046 total
includes taxes & fees
24 Jul - 25 Jul
La Maison in Midtown an urban B&B
Outdoor pool

11. Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (215 reviews)
"Beautiful place and wonderful management. Would definitely stay again! "
United States
Shelly
The price is ฿6,964
฿8,652 total
includes taxes & fees
23 Jul - 24 Jul
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
Lobby

12. Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (962 reviews)
"Very clean room. Staff were amazing. Had a small problem with door lock and for the inconvenience they immediately compensated me by adding miles to my account. This is like my 3rd time staying here and will be coming back."
United States
Jessica
The price is ฿5,214
฿6,100 total
includes taxes & fees
30 Jul - 31 Jul
Hilton University of Houston
Lobby

13. Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
5.8 out of 10, (1,006 reviews)
"Love the pet friendly property"
United States
Nelda
The price is ฿2,458
฿2,886 total
includes taxes & fees
26 Jul - 27 Jul
Extended Stay America Suites Houston Med Ctr Braeswood Bl
Standard Room, 1 King Bed | 1 bedroom, premium bedding, blackout curtains, free WiFi

14. Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (242 reviews)
"I was pleasantly surprised by how well kept the room was and the staff was very friendly"
United States
Brian
The price is ฿2,018
฿2,361 total
includes taxes & fees
26 Jul - 27 Jul
Southmore Boulevard Motel
House | 3 bedrooms, Internet

15. Newly Built Modern 3 Bedroom Houston Home

Newly Built Modern 3 Bedroom Houston Home
2.0 star property
South Central Houston
10.0 out of 10, Exceptional, (4 reviews)
"great place to stay will be staying again if available next time i come!"
United States
DEVEN
The price is ฿7,975
฿17,877 total
includes taxes & fees
25 Jul - 26 Jul
Newly Built Modern 3 Bedroom Houston Home
Iron/ironing board (on request), bed sheets

16. Scott Inn Suites - Downtown Houston

Scott Inn Suites - Downtown Houston
2.0 star property
South Central Houston
8.4 out of 10, Very good, (47 reviews)
"Nice staff, good clean room and close to public transportation"
United States
Sergio
The price is ฿2,523
฿3,120 total
includes taxes & fees
20 Aug - 21 Aug
Scott Inn Suites - Downtown Houston
Coffee/tea maker, full-sized fridge, microwave, oven

17. Luxury Med Center Fully Equipped King Sized Bed Condos

Luxury Med Center Fully Equipped King Sized Bed Condos
4.0 star property
South Central Houston
8.4 out of 10, Very good, (92 reviews)
"Facility was nice. DRIFTRS, the management company, is really bad. We were there for 4 days. Upon arrival we noticed no toilet paper and half the light bulbs burned out. The place was so dark I needed a flashlight to use the kitchen. We reported these issues immediately. They told us to use kitchen paper towels as toilet paper and did not respond to all the burned out light bulbs. We woke up every morning with the apartment hot and stuffy. The NEST thermostat is programmed to continually...
United States
Gordon
The price is ฿5,375
฿9,484 total
includes taxes & fees
26 Jul - 27 Jul
Luxury Med Center Fully Equipped King Sized Bed Condos
Free WiFi, bed sheets

18. MorningSide Inn

MorningSide Inn
2.0 star property
South Central Houston
6.0 out of 10, (522 reviews)
"The staff is very friendly and responsive. We needed some help after check in and they fulfilled all quickly and in a friendly manner. The room was clean. There is no fan. A/C was good but a fan in the sitting area would be good. The bathroom was clean but old looking. The hotel is in a nice neighborhood and it was peaceful and safe. I stayed there with my family for the world cup match. The stadium was very near. We had a peaceful stay and its very value for the money"
United States
Anand
The price is ฿2,394
฿2,802 total
includes taxes & fees
23 Jul - 24 Jul
MorningSide Inn
Interior

19. Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.2 out of 10, Very good, (209 reviews)
"Excellent stay experience"
United States
Binkeung
The price is ฿2,089
฿2,444 total
includes taxes & fees
24 Jul - 25 Jul
Wanderstay Houston Hostel
House | 2 bedrooms

20. 2-bedroom - Equipped Kitchen - Gated Parking

2-bedroom - Equipped Kitchen - Gated Parking
2.0 star property
South Central Houston
The price is ฿2,885
฿21,298 total
includes taxes & fees
23 Jul - 24 Jul
2-bedroom - Equipped Kitchen - Gated Parking
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in South Central Houston

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Exterior
La Maison in Midtown an urban B&B
3.5 star property
9.8
Exceptional
588 reviews
View
Outdoor pool
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
9.6
Exceptional
215 reviews
View
Laptop workspace, blackout curtains, soundproofing
Downtowner Inns - Houston Downtown
2.0 star property
9.2
Wonderful
208 reviews
View
Outdoor pool, open 6:00 AM to 10:00 PM, pool loungers
InterContinental Houston by IHG
4.0 star property
9.4
Exceptional
1,000 reviews
View
Premium bedding, pillow-top beds, minibar, in-room safe
Hotel Zaza Houston Museum District
4.5 star property
9.2
Wonderful
1,012 reviews
View

Where to stay in South Central Houston

Find the best South Central Houston areas for the activities you enjoy most.
A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

A large, modern shopping mall with a glass ceiling and multiple levels.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A modern cityscape with a tram and tall buildings.
Photo by George Zimzores
Open Photo by George Zimzores

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Central Houston Hotel Reviews

Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District

10/10 Excellent
"Appreciated. Clean Room,Great Staff,Excellent Restaurant,Shuttle drivers punctual and polite."
Craig 2-night trip
Posted 15 hours ago
Houston Marriott Medical Center/Museum District

Frequently asked questions

What's it like in South Central Houston?
Travellers are sure to enjoy a stay in Houston's South Central Houston neighbourhood. Looking for sights you might find in a travel guide about South Central Houston? Consider a visit to Houston Zoo while you're in the neighbourhood.
What's the best accommodation in South Central Houston?
Based on our traveller data, Hilton Houston Plaza/Medical Center is one of the top choices for your stay in South Central Houston. This hotel is a short 2-minute walk from Rice University, and it offers 2 restaurants and 2 bars. Other good options for your stay in the area include Hotel Zaza Houston Museum District and InterContinental Houston by IHG.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1237 hotels and other accommodation options in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals available in South Central Houston.
What is there to do around this Houston neighbourhood?
Spend some time exploring the great outdoors at Hermann Park, James Turrell's Twilight Epiphany Skyscape and Cullen Sculpture Garden. Houston Zoo and TDECU Stadium are some other stops worth a visit in the neighbourhood. Daikin Park and Toyota Center are some popular places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.