A water feature with multiple tiers and a circular viewing platform at the top.

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2 Oct - 4 Oct
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9 Oct - 11 Oct

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Our top choices for South Central Houston hotels

A spacious living area with a dining table, chairs, and a chandelier.

1. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,003 reviews)
"Great place!"
United States
Madiha
The price is ฿8,793
฿11,866 total
includes taxes & fees
4 Oct - 5 Oct
Hotel Zaza Houston Museum District
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

2. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very good, (2,172 reviews)
"Beautiful Hotel and excellent Service"
United States
olga
The price is ฿3,250
฿3,841 total
includes taxes & fees
11 Oct - 12 Oct
Hilton Houston Plaza/Medical Center
A spacious lobby with modern furniture, large windows, and indoor plants.

3. InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.4 out of 10, Exceptional, (1,004 reviews)
"Great stay!"
United States
Luke
The price is ฿5,676
฿7,312 total
includes taxes & fees
25 Oct - 26 Oct
InterContinental Houston by IHG
A rooftop pool area with lounge chairs and a view of a tall building at night.

4. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,220 reviews)
"great location and the hotel is quite comfortable"
United States
Juan
The price is ฿5,713
฿7,111 total
includes taxes & fees
11 Oct - 12 Oct
The Westin Houston Medical Center/Museum District
A modern restaurant with a bar area, featuring a patterned floor, multiple dining tables, and contemporary lighting fixtures.

5. Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,001 reviews)
"They are very accommodating. Easy access to Houston Methodist Hoptial."
United States
Melanie
The price is ฿6,015
฿8,129 total
includes taxes & fees
18 Oct - 19 Oct
Houston Marriott Medical Center/Museum District
A modern hotel room with a large bed, a black leather sofa, a wooden coffee table, and a desk with a mirror.

6. Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
9.2 out of 10, Wonderful, (248 reviews)
"Second time stay here. Lovely place"
United States
Jaelon
The price is ฿3,224
฿3,772 total
includes taxes & fees
5 Oct - 6 Oct
Downtowner Inns - Houston Downtown
A high-rise hotel with a rooftop pool, multiple floors, and a cityscape view.

7. Sentral Forme Houston

Sentral Forme Houston
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (89 reviews)
"Great place to stay!"
United States
Keeshaun
The price is ฿5,395
฿7,295 total
includes taxes & fees
5 Oct - 6 Oct
Sentral Forme Houston
A multi-story hotel with a brick facade, balconies, and a well-lit entrance.

8. La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (601 reviews)
"Lovely welcoming staff, beautiful building with wonderful communal areas. We enjoyed the outside verandah. It's in a fairly noisy location but this didn't bother us. Walking distance to local bars/restaurants, 10 minutes drive to Downtown. Oh and let's not forget the lovely breakfast!"
United Kingdom
Joanna
The price is ฿6,012
฿7,034 total
includes taxes & fees
5 Oct - 6 Oct
La Maison in Midtown an urban B&B
A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

9. DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (685 reviews)
"Great hotel"
United States
Brandon
The price is ฿4,379
฿5,123 total
includes taxes & fees
25 Oct - 26 Oct
DoubleTree by Hilton Houston Medical Center Hotel & Suites
A modern kitchen with dark wood cabinets, a granite countertop, and a built-in island with a glass enclosure.

10. Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1,000 reviews)
"Clean room, comfortable stay"
United States
Susanne
The price is ฿2,484
฿2,906 total
includes taxes & fees
2 Oct - 3 Oct
Americas Best Value Inn Medical Center Downtown
A large, multi-story house with a swimming pool, outdoor seating, and a red umbrella.

11. Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (221 reviews)
"The room was very clean, the staff was just great and the breakfast was very good! The Parking was a little difficult, but it was very safe!"
United States
Walter
The price is ฿5,909
฿7,418 total
includes taxes & fees
5 Oct - 6 Oct
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
A spacious lobby with a large sectional sofa, a coffee table, and a reception desk.

12. Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (983 reviews)
"Pretty amazing stay"
United States
DELISA
The price is ฿5,205
฿6,090 total
includes taxes & fees
13 Oct - 14 Oct
Hilton University of Houston
A spacious lobby with a high ceiling, a central seating area with sofas and armchairs, a staircase leading to an upper level, and a flat-screen TV mounted on the wall.

13. Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
6.2 out of 10, (1,000 reviews)
"The perfect place to stay!"
Mexico
Maria Fernanda
The price is ฿2,601
฿3,052 total
includes taxes & fees
8 Oct - 9 Oct
Extended Stay America Suites Houston Med Ctr Braeswood Bl
A modern kitchen with a large island, bar stools, and a stainless steel refrigerator.

14. Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
3.0 star property
South Central Houston
9.8 out of 10, Exceptional, (80 reviews)
"Solo trip and it was a perfect location staff was nice and it was nice and clean!! Would stay there again. "
United States
Sharon
The price is ฿4,658
฿5,449 total
includes taxes & fees
5 Oct - 6 Oct
Wanderstay Boutique Hotel
A modern reception area with a blackboard, a blue sofa, a yellow armchair, and a colorful rug.

15. Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.2 out of 10, Very good, (214 reviews)
"Excellent stay experience"
United States
Binkeung
The price is ฿1,738
฿2,034 total
includes taxes & fees
2 Oct - 3 Oct
Wanderstay Houston Hostel
A hotel room with a bed, a desk, a chair, a mirror, a television, and a heater.

16. Scott Inn Suites - Downtown Houston

Scott Inn Suites - Downtown Houston
2.0 star property
South Central Houston
8.4 out of 10, Very good, (47 reviews)
"Nice staff, good clean room and close to public transportation"
United States
Sergio
The price is ฿2,050
฿2,566 total
includes taxes & fees
8 Oct - 9 Oct
Scott Inn Suites - Downtown Houston
A hotel room with a bed, bedside table, desk, and a mirror.

17. Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (245 reviews)
"Very sweet lady I will be back"
United States
LaKeara
The price is ฿1,965
฿2,299 total
includes taxes & fees
13 Oct - 14 Oct
Southmore Boulevard Motel
A bedroom with a bed, a nightstand, a window with curtains, and a view of greenery outside.

18. Modern 3BR Near UH Downtown Toyota Center NRG

Modern 3BR Near UH Downtown Toyota Center NRG
2.0 star property
South Central Houston
The price is ฿3,936
฿29,509 total
includes taxes & fees
14 Oct - 15 Oct
Modern 3BR Near UH Downtown Toyota Center NRG
A modern kitchen with stainless steel appliances, a granite countertop, and a dining area with a glass table and metal chairs.

19. Walkable Eado Condo Near Dtwn: Modern + Chic!

Walkable Eado Condo Near Dtwn: Modern + Chic!
3.0 star property
South Central Houston
The price is ฿4,167
฿13,774 total
includes taxes & fees
4 Oct - 5 Oct
Walkable Eado Condo Near Dtwn: Modern + Chic!
A reception desk with a computer, a keyboard, a mouse, and a telephone. There are certificates and keys on the wall.

20. Golden Motel Near Houston Medical Center

Golden Motel Near Houston Medical Center
2.5 star property
South Central Houston
2.0 out of 10, (4 reviews)
"Room smelt like cigarettes burnt wholes in the wall and bed sheet all 6 walls had stains toilet seat look like someone stood on it "
United States
Jacari
The price is ฿2,183
฿2,685 total
includes taxes & fees
14 Oct - 15 Oct
Golden Motel Near Houston Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in South Central Houston

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern kitchen with a large island, bar stools, and a stainless steel refrigerator.
Wanderstay Boutique Hotel
3.0 star property
9.8
Exceptional
80 reviews
View
A multi-story hotel with a brick facade, balconies, and a well-lit entrance.
La Maison in Midtown an urban B&B
3.5 star property
9.8
Exceptional
601 reviews
View
A modern hotel room with a large bed, a black leather sofa, a wooden coffee table, and a desk with a mirror.
Downtowner Inns - Houston Downtown
2.0 star property
9.2
Wonderful
248 reviews
View
A large, multi-story house with a swimming pool, outdoor seating, and a red umbrella.
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
9.6
Exceptional
221 reviews
View
A spacious lobby with modern furniture, large windows, and indoor plants.
InterContinental Houston by IHG
4.0 star property
9.4
Exceptional
1,004 reviews
View

Where to stay in South Central Houston

Find the best South Central Houston areas for the activities you enjoy most.
A sculpture garden with abstract art pieces in a city park.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

A modern building with a covered outdoor area and a circular garden feature.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Central Houston Hotel Reviews

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown

8/10 Good
"I did not realize this motel is located so close to a noisy highway until I arrived there. Most of the rooms are facing the highway, except for a handful rooms at the rear. The lady receptionist, Mary was extremely helpful. Mary let me have a room on level 2 at the rear, away from the noisy highway. As there is no elevator in the building, Mary carried my large suitcase up to level 2, and into my room. The room is clean and spacious. The other 2 staff, Peter and Daniel were very friendly too. I needed to check out 2 nights earlier, and received no refund; this is ok. I am not sure if I would stay here again, as there is no guarantee that I would be able to get a room away from the noisy highway again."
Simone 4-night trip
Posted 13 hours ago
Downtowner Inns - Houston Downtown

Frequently asked questions

What's it like in South Central Houston?
Travellers are sure to enjoy a stay in Houston's South Central Houston neighbourhood. Make sure that you visit TDECU Stadium and Children's Museum of Houston as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on our traveller data, Hotel Zaza Houston Museum District is one of the top choices for your stay in South Central Houston. This hotel is a short 6-minute walk from Rice University, and it offers a full-service spa and a restaurant. Other good options for your stay in the area include Hilton Houston Plaza/Medical Center and The Westin Houston Medical Center/Museum District.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1272 hotels and other accommodation options in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals available in South Central Houston.
What is there to do around this Houston neighbourhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden and Twilight Epiphany Skyspace. TDECU Stadium and Children's Museum of Houston are some other stops worth a visit in the neighbourhood. Daikin Park and Toyota Center are some popular places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.