Search Hotels in South Central Houston, Houston

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Our top choices for South Central Houston hotels

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very good, (1,948 reviews)
"Great stay and clean room"
United States
Ethel
The price is ฿4,385
฿5,168 total
includes taxes & fees
5 Jul - 6 Jul
Hilton Houston Plaza/Medical Center

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,157 reviews)
"Clean room,restaurant exceptional,excellent staff."
United States
Craig
The price is ฿4,927
฿6,133 total
includes taxes & fees
5 Jul - 6 Jul
The Westin Houston Medical Center/Museum District

InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,006 reviews)
"Great stay, nice staff"
United States
Allen David
The price is ฿5,205
฿6,745 total
includes taxes & fees
7 Jun - 8 Jun
InterContinental Houston by IHG

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
9.2 out of 10, Wonderful, (158 reviews)
"Great place. The staff is very friendly and the place is clean."
United States
Fernando
The price is ฿3,141
฿3,675 total
includes taxes & fees
7 Jun - 8 Jun
Downtowner Inns - Houston Downtown

Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,001 reviews)
"Nice and helpful staff, clean rooms, nice amenities "
United States
Andrea
The price is ฿6,184
฿8,306 total
includes taxes & fees
6 Jun - 7 Jun
Houston Marriott Medical Center/Museum District

Sentral Forme Houston

Sentral Forme Houston
4.5 star property
South Central Houston
8.8 out of 10, Excellent, (48 reviews)
"Very chic, very interesting room. Love this place"
United States
Chase
The price is ฿6,184
฿8,193 total
includes taxes & fees
8 Jun - 9 Jun
Sentral Forme Houston

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,012 reviews)
"Overall great hotel. Definitely will be staying here again. Shout out to the staff crew."
United States
Vincent
The price is ฿7,249
฿9,984 total
includes taxes & fees
5 Jun - 6 Jun
Hotel Zaza Houston Museum District

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (597 reviews)
"was ok"
United States
Guillermo
The price is ฿4,876
฿5,704 total
includes taxes & fees
7 Jun - 8 Jun
DoubleTree by Hilton Houston Medical Center Hotel & Suites

Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1,007 reviews)
"Convenient location and comfortable room."
United States
Rogelio
The price is ฿2,716
฿3,178 total
includes taxes & fees
7 Jun - 8 Jun
Americas Best Value Inn Medical Center Downtown

Golden Motel Near Houston Medical Center

Golden Motel Near Houston Medical Center
2.5 star property
South Central Houston
2.0 out of 10, (2 reviews)
"Room smelt like cigarettes burnt wholes in the wall and bed sheet all 6 walls had stains toilet seat look like someone stood on it "
United States
Jacari
The price is ฿2,127
฿2,701 total
includes taxes & fees
7 Jun - 8 Jun
Golden Motel Near Houston Medical Center

Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (950 reviews)
"The hotel was clean, staff were friendly and the location was perfect for our event. I will definitely stay there again. "
United States
Ricardo
The price is ฿5,416
฿6,337 total
includes taxes & fees
30 Jun - 1 Jul
Hilton University of Houston

La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (575 reviews)
"We felt welcome from the moment we walked in. The owners are so hospitable and the place such a delight. Loved the generous breakfast and ambiance- great parking as well!"
United States
Carolina
The price is ฿7,166
฿8,384 total
includes taxes & fees
7 Jun - 8 Jun
La Maison in Midtown an urban B&B

Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
5.8 out of 10, (1,015 reviews)
"Perfect place for my family and I to stay when one of us has an appointment at MD Anderson. Super affordable and extremely close to the appointment locations. Stayed there 4 times with out any issues."
United States
Catherine
The price is ฿2,768
฿3,248 total
includes taxes & fees
5 Jun - 6 Jun
Extended Stay America Suites Houston Med Ctr Braeswood Bl

Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
3.0 star property
South Central Houston
9.8 out of 10, Exceptional, (76 reviews)
"Solo trip and it was a perfect location staff was nice and it was nice and clean!! Would stay there again. "
United States
Sharon
The price is ฿6,950
฿8,132 total
includes taxes & fees
7 Jun - 8 Jun
Wanderstay Boutique Hotel

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (213 reviews)
"Neat place. They had snacks available and also helped with our bags."
United States
David
The price is ฿6,773
฿8,416 total
includes taxes & fees
8 Jun - 9 Jun
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Hideaway Near Downtown Attractions

Houston Hideaway Near Downtown Attractions
2.0 star property
South Central Houston
The price is ฿1,910
฿16,270 total
includes taxes & fees
8 Jun - 9 Jun
Houston Hideaway Near Downtown Attractions

Cozy 2BR Near NRG & Downtown FIFA World Cup

Cozy 2BR Near NRG & Downtown FIFA World Cup
3.0 star property
South Central Houston
The price is ฿3,514
฿9,592 total
includes taxes & fees
8 Jun - 9 Jun
Cozy 2BR Near NRG & Downtown FIFA World Cup

Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (238 reviews)
"I enjoyed my stay at this hotel."
United States
Tamela
The price is ฿3,367
฿3,939 total
includes taxes & fees
8 Jun - 9 Jun
Southmore Boulevard Motel

Luxury Med Center Fully Equipped King Sized Bed Condos

Luxury Med Center Fully Equipped King Sized Bed Condos
4.0 star property
South Central Houston
8.4 out of 10, Very good, (92 reviews)
"Facility was nice. DRIFTRS, the management company, is really bad. We were there for 4 days. Upon arrival we noticed no toilet paper and half the light bulbs burned out. The place was so dark I needed a flashlight to use the kitchen. We reported these issues immediately. They told us to use kitchen paper towels as toilet paper and did not respond to all the burned out light bulbs. We woke up every morning with the apartment hot and stuffy. The NEST thermostat is programmed to continually...
United States
Gordon
The price is ฿4,570
฿8,455 total
includes taxes & fees
30 Jun - 1 Jul
Luxury Med Center Fully Equipped King Sized Bed Condos

MorningSide Inn

MorningSide Inn
2.0 star property
South Central Houston
6.0 out of 10, (514 reviews)
"There is no coffeemaker anywhere no schuttel. This place should be razed ."
United States
Barbara
The price is ฿4,287
฿5,015 total
includes taxes & fees
6 Jun - 7 Jun
MorningSide Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Central Houston

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Exterior
La Maison in Midtown an urban B&B
3.5 star property
9.8
Exceptional
575 reviews
View
Laptop workspace, blackout curtains, soundproofing, iron/ironing board
Downtowner Inns - Houston Downtown
2.0 star property
9.2
Wonderful
158 reviews
View
Premium bedding, pillow-top beds, minibar, in-room safe
Hotel Zaza Houston Museum District
4.5 star property
9.2
Wonderful
1,012 reviews
View
Outdoor pool, free pool cabanas, pool umbrellas
The Westin Houston Medical Center/Museum District
4.0 star property
9.2
Wonderful
1,157 reviews
View
Exterior
InterContinental Houston by IHG
4.0 star property
9.2
Wonderful
1,006 reviews
View

Where to stay in South Central Houston

Find the best South Central Houston areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Central Houston Hotel Reviews

Frequently asked questions

What's it like in South Central Houston?
Travellers are sure to enjoy a stay in Houston's South Central Houston neighbourhood. Looking for sights you might find in a travel guide about South Central Houston? Consider a visit to Houston Zoo while you're in the neighbourhood.
What's the best accommodation in South Central Houston?
Based on our traveller data, Hotel Zaza Houston Museum District is one of the top choices for your stay in South Central Houston. This hotel offers a full-service spa and a restaurant. Other good options for your stay in the area include Hilton Houston Plaza/Medical Center and Sentral Forme Houston.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1197 hotels and other accommodation options in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals available in South Central Houston.
What is there to do around this Houston neighbourhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden and Bagby Dog Park. Houston Zoo and Fertitta Center are some other stops worth a visit in the neighbourhood. Toyota Center and Daikin Park are some popular places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.