The Best Hotels in South Central Houston, Houston - 2026 Updated Prices

A water feature with multiple tiers and a circular viewing platform at the top.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Compare popular hotels in South Central Houston

Property	Property class	Guest rating
La Maison in Midtown an urban B&B	3.5 star property	9.8 Exceptional 589 reviews	View
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only	3.5 star property	9.6 Exceptional 217 reviews	View
Downtowner Inns - Houston Downtown	2.0 star property	9.2 Wonderful 215 reviews	View
InterContinental Houston by IHG	4.0 star property	9.4 Exceptional 1,000 reviews	View
The Westin Houston Medical Center/Museum District	4.0 star property	9.2 Wonderful 1,173 reviews	View

Where to stay in South Central Houston

Find the best South Central Houston areas for the activities you enjoy most.

A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

See properties

A large, modern shopping mall with a glass ceiling and multiple levels.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

See properties

A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

See properties

A modern cityscape with a tram and tall buildings.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

See properties

An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

See properties

Top South Central Houston Hotel Reviews

Downtowner Inns - Houston Downtown

10/10 Excellent

"A great place and location with a very good price! Would highly recommend this"

Extended Stay America Suites Houston Med Ctr Braeswood Bl

10/10 Excellent

"The staff at this main stay was excellent!! Due to a fall and being a guest on her own, I ended up needing LOTS of help. I don’t ask for help lightly, so for the staff to recognize that I was struggling and insisting on me letting them help without asking, was a God send!!! There were about 5 different staff members who helped me at different times. They included a cleaning staff, maintenance staff, guest check-in person, along with 2 others whom I didn’t recognize their departments. Everyone went out of their way to provide help which prevented me from having to call an ambulance. Thank you all for going ABOVE & BEYOND!!!"

The Westin Houston Medical Center/Museum District

8/10 Good

"Everything was great. Only issue we called for extra sweet and low due to three occupants. I had two friends with me to attend to me after my surgery. I went down stairs after waiting for an hr. The front desk clerk called for them to deliver us the sweet and low. The hostess of the restaurant was at her post and over heard what I needed. She did not offer to get sweet and low from the restaurant even though I purchased coffee at 6am at the restaurant and used sweet and low at that time. Great hotel and staff except for that one issue."

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

10/10 Excellent

"This definitely a different experience than your typical hotel--it's a weird old house with antique furniture and gothic turrets. Everything was clean and well maintained though, and the staff was quite friendly. Breakfast was adequate. Essentially it consisted of complimentary access to a well-stocked kitchen. The pool was not the most meticulously maintained but it was clean enough that we felt comfortable swimming, and the pool area is pleasantly shaded and private. Access in and out of the property is through a gated driveway. The parking is a little tight but ultimately it was easy to get in and out, and the location is very convenient to the museum district."

Frequently asked questions

What's it like in South Central Houston?

Travellers are sure to enjoy a stay in Houston's South Central Houston neighbourhood. Looking for sights you might find in a travel guide about South Central Houston? Consider a visit to Houston Zoo while you're in the neighbourhood.

What's the best accommodation in South Central Houston?

Based on our traveller data, Hilton Houston Plaza/Medical Center is one of the top choices for your stay in South Central Houston. This hotel is a short 2-minute walk from Rice University, and it offers 2 restaurants and 2 bars. Other good options for your stay in the area include Hotel Zaza Houston Museum District and InterContinental Houston by IHG.

How many hotels can I expect to find in the South Central Houston area?

Expedia has 1254 hotels and other accommodation options in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.

If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?

Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals available in South Central Houston.

What is there to do around this Houston neighbourhood?

Spend some time exploring the great outdoors at Hermann Park, Twilight Epiphany Skyspace and Cullen Sculpture Garden. Houston Zoo and TDECU Stadium are some other stops worth a visit in the neighbourhood. Daikin Park and Toyota Center are some popular places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.

How can I get around South Central Houston and the greater Houston area?

For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.

Explore a world of travel with Expedia

More ways to book

Book Hotels in South Central Houston on Expedia.com

Search Hotels in South Central Houston, Houston

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for South Central Houston hotels

1. The Westin Houston Medical Center/Museum District

2. InterContinental Houston by IHG

3. Hilton Houston Plaza/Medical Center

4. Sentral Forme Houston

5. Hotel Zaza Houston Museum District

6. Americas Best Value Inn Medical Center Downtown

7. Houston Marriott Medical Center/Museum District

8. Downtowner Inns - Houston Downtown

9. La Maison in Midtown an urban B&B

10. DoubleTree by Hilton Houston Medical Center Hotel & Suites

11. Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

12. Walkable Eado Condo Near Dtwn: Modern + Chic!

13. Hilton University of Houston

14. Modern 2BR Home With King Beds Near Downtown

15. Southmore Boulevard Motel

16. Scott Inn Suites - Downtown Houston

17. Extended Stay America Suites Houston Med Ctr Braeswood Bl

18. MorningSide Inn

19. Wanderstay Houston Hostel

20. Houston Hideaway Near Downtown Attractions

Compare popular hotels in South Central Houston

Where to stay in South Central Houston

Downtown Houston

The Galleria

Texas Medical Center

Houston Central Business District

Montrose

Top South Central Houston Hotel Reviews

Downtowner Inns - Houston Downtown

Frequently asked questions

Explore a world of travel with Expedia