What's it like in Clayton?

Clayton is a welcoming neighbourhood known for its array of dining options and sporting events. Make sure that you visit Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center as part of your Clayton travel plans.

Where is the best place to stay in Clayton?

Based on our traveller data, Clayton Plaza Hotel & Extended Stay is one of the top choices for your stay in Clayton. This hotel offers free breakfast and an indoor pool. Other good choices for your stay in the neighbourhood include AC Hotel St. Louis Clayton and Le Méridien St. Louis Clayton .

How many hotels will I find in Clayton?

Expedia has 21 hotels and other accommodation options in Clayton to choose from, making this an ideal home base for exploring the greater St. Louis area.

If I need to cancel my hotel reservation in Clayton, will I receive a refund?

Yes, the majority of hotel bookings are refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and be given a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the top deals on offer in Clayton.

What are the top things to see and do in Clayton?

A few attractions you might want to check out while you're in Clayton are Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. When you're sightseeing in St. Louis, St. Louis Zoo and Tao Tennis Center are also worth a stop.

How can I get around Clayton and the greater St. Louis area?

Ready to get out and explore the city? Clayton Station is the closest metro station.

The Best Hotels in Clayton, St. Louis - 2026 Updated Prices

The illuminated Gateway Arch at night with a city skyline in the background.

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Our top choices for Clayton hotels

An outdoor seating area with modern furniture, a bar, and large windows offering views of a cityscape.

1. The Ritz-Carlton, St. Louis

Clayton

Kennedy

฿22,018 total

includes taxes & fees

27 Nov - 28 Nov

A rooftop terrace with a fire feature, outdoor seating, and a city view.

2. Residence Inn By Marriott St. Louis Clayton

Clayton

Carol

฿6,690 total

includes taxes & fees

15 Nov - 16 Nov

A rooftop pool area with multiple lounge chairs and umbrellas, surrounded by a modern building with large windows.

3. Le Méridien St. Louis Clayton

Clayton

Marsha

฿6,044 total

includes taxes & fees

8 Nov - 9 Nov

4. Clayton Plaza Hotel & Extended Stay

Clayton

Sarah

฿4,116 total

includes taxes & fees

8 Nov - 9 Nov

A rooftop terrace with modern outdoor seating, a fire pit, and a view of the cityscape.

5. AC Hotel St. Louis Clayton

Clayton

anthony

฿5,323 total

includes taxes & fees

8 Nov - 9 Nov

A modern lounge area with a stone fireplace, comfortable seating, and a bar in the background.

6. Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Clayton

Kevin

฿4,693 total

includes taxes & fees

1 Nov - 2 Nov

A modern lobby with a fireplace, seating area, and a kitchen counter.

7. Homewood Suites by Hilton St Louis - Galleria

Clayton

Denise

฿4,731 total

includes taxes & fees

15 Nov - 16 Nov

A traditional Tudor-style building with a black awning labeled "28 Sally's Inn."

8. Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Clayton

Jennifer

฿6,193 total

includes taxes & fees

1 Nov - 2 Nov

The exterior of the Charles F. Knight Center with a stone facade, large arched entrance, and a sign above the doors.

9. The Knight Center at Washington University

1.3 km from Clayton

jeffrey

฿4,719 total

includes taxes & fees

28 Nov - 29 Nov

A digital display with three screens showing hotel information.

10. SpringHill Suites St. Louis Brentwood

2.4 km from Clayton

Aaron

฿4,980 total

includes taxes & fees

29 Nov - 30 Nov

An outdoor patio with a fire pit, seating, and a building in the background.

11. Courtyard by Marriott St. Louis Brentwood

1.7 km from Clayton

Anna

฿4,859 total

includes taxes & fees

15 Nov - 16 Nov

An indoor swimming pool with clear glass walls, a tiled floor, and a 'Step Down' sign.

12. Drury Plaza Hotel St. Louis Brentwood

2.5 km from Clayton

Stacey Rochelle

฿5,129 total

includes taxes & fees

22 Nov - 23 Nov

A grand building with a fountain in front.

13. The Cheshire

1.8 km from Clayton

Matthew

฿5,946 total

includes taxes & fees

15 Nov - 16 Nov

A modern lobby with a staircase, seating area, and wall-mounted artwork.

14. Moonrise Hotel

2.6 km from Clayton

Jennifer

฿5,971 total

includes taxes & fees

18 Nov - 19 Nov

An indoor swimming pool with lounge chairs and a pool table, surrounded by large windows.

15. Hampton Inn & Suites St. Louis at Forest Park

Dogtown, 3.9 km from Clayton

Greg

฿5,188 total

includes taxes & fees

15 Nov - 16 Nov

A modern hotel room with a dining area, wooden cabinets, a checkered floor, and a flat-screen TV.

16. Wingate by Wyndham St. Louis Airport

11.5 km from Clayton

Cindy

฿3,675 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with a fire pit, cushioned benches, and a covered patio with string lights.

17. Home2 Suites by Hilton St. Louis/Forest Park

The Grove, 5.6 km from Clayton

Molly

฿6,134 total

includes taxes & fees

15 Nov - 16 Nov

A modern living room with a built-in fireplace, a large flat-screen TV, a unique hexagonal pendant light, and a patterned rug.

18. Hyatt Select St. Louis Airport

10.7 km from Clayton

Thadora

฿4,598 total

includes taxes & fees

10 Nov - 11 Nov

A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.

19. The Royal Sonesta Chase Park Plaza St. Louis

Central West End, 5.1 km from Clayton

Sara

฿6,326 total

includes taxes & fees

22 Nov - 23 Nov

A spacious hotel lobby with multiple seating areas, a reception desk, and large windows offering a view of the cityscape.

20. Renaissance St. Louis Airport Hotel

10.1 km from Clayton

Joy

฿4,389 total

includes taxes & fees

20 Nov - 21 Nov

View all properties

Compare popular hotels in Clayton

Property	Property class	Guest rating
Residence Inn By Marriott St. Louis Clayton	3.0 star property	9.4 Exceptional 249 reviews	View
AC Hotel St. Louis Clayton	2.0 star property	9.2 Wonderful 423 reviews	View
The Ritz-Carlton, St. Louis	5.0 star property	9.2 Wonderful 587 reviews	View
Clayton Plaza Hotel & Extended Stay	3.5 star property	8.8 Excellent 3,503 reviews	View
Le Méridien St. Louis Clayton	4.0 star property	8.8 Excellent 798 reviews	View

Where to stay in Clayton

Find the best Clayton areas for the activities you enjoy most. Learn more about Clayton

The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Old Courthouse to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

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A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

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A historic building with a green dome and adjacent modern high-rise buildings.

Central West End

Enjoy this relaxed area, the ultimate destination for a lazy afternoon. Browse unique stores, admire artworks and sip coffee at sidewalk tables shaded by trees.

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A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

See properties

A large airplane suspended in a net structure in an urban setting with modern buildings in the background.

Downtown West

While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.

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Top Clayton Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent

"Very nice hotel.. love that are arch is right behind it.."

Live by Loews - St.Louis

8/10 Good

"The property is immaculate. The staff is warm and welcoming. The rooms are beautifully designed could be a bit more spacious. The weird thing which maybe I’m just out of touch but there was no microwave in the room and if I understood correctly there is a nightly fee to have one brought to your room. Other than that I enjoyed my stay and now that I’m aware of the amenities I would be prepared in the future"

Moonrise Hotel

10/10 Excellent

"Stayed for a long weekend in October. Front desk staff (shout out Antoine and Duwan!) Were friendly and welcoming. Gave great recs for food and activities. Room was clean and well-stocked. Beds were 8/10 comfy but after a long day exploring I still got 10/10 rest. Location is central to so much STL has to offer and easy for rideshare pickup. Definitely get a drink on the rooftop during your stay!"

Search Hotels in Clayton, St. Louis

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Our top choices for Clayton hotels

1. The Ritz-Carlton, St. Louis

2. Residence Inn By Marriott St. Louis Clayton

3. Le Méridien St. Louis Clayton

4. Clayton Plaza Hotel & Extended Stay

5. AC Hotel St. Louis Clayton

6. Hampton Inn & Suites Clayton/St. Louis-Galleria Area

7. Homewood Suites by Hilton St Louis - Galleria

8. Seven Gables, St. Louis West, a Tribute Portfolio Hotel

9. The Knight Center at Washington University

10. SpringHill Suites St. Louis Brentwood

11. Courtyard by Marriott St. Louis Brentwood

12. Drury Plaza Hotel St. Louis Brentwood

13. The Cheshire

14. Moonrise Hotel

15. Hampton Inn & Suites St. Louis at Forest Park

16. Wingate by Wyndham St. Louis Airport

17. Home2 Suites by Hilton St. Louis/Forest Park

18. Hyatt Select St. Louis Airport

19. The Royal Sonesta Chase Park Plaza St. Louis

20. Renaissance St. Louis Airport Hotel

Compare popular hotels in Clayton

Where to stay in Clayton

Downtown St. Louis

St. Charles Historic District

Central West End

Creve Coeur

Downtown West

Top Clayton Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

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