Cheap Flights from Panama from ฿5,050

View ฿5,050 flight on Fri, 14 Nov 2025Opens in a new window

Popular airlines from Panama

  • Avianca

    Avianca

  • United

    United

  • Copa

    Copa

  • Delta

    Delta

  • American Airlines

    American Airlines

  • Aeromexico

    Aeromexico

  • Turkish Airlines

    Turkish Airlines

    notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
    deals illustration

    Book smarter

    Save up to 40% on select hotels after you book a flight*
    trophy illustration

    Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheapest flights from Panama

These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Fri, 14 Nov - Fri, 21 Nov
PTY
Panama City
MDE
Medellin
฿9,505 Return, found 5 days ago
฿9,505
Return
found 5 days ago
Select Copa flight, departing Fri, 14 Nov from Panama City to Medellin, returning Fri, 21 Nov, priced at ฿9,505 found 5 days ago
avianca
Fri, 14 Nov - Fri, 21 Nov
PTY
Panama City
MDE
Medellin
฿9,620 Return, found 5 days ago
฿9,620
Return
found 5 days ago
Select avianca flight, departing Fri, 14 Nov from Panama City to Medellin, returning Fri, 21 Nov, priced at ฿9,620 found 5 days ago
Copa
Fri, 14 Nov - Fri, 21 Nov
PTY
Panama City
MDE
Medellin
฿9,855 Return, found 5 days ago
฿9,855
Return
found 5 days ago
Select Copa flight, departing Fri, 14 Nov from Panama City to Medellin, returning Fri, 21 Nov, priced at ฿9,855 found 5 days ago
avianca
Fri, 14 Nov - Fri, 21 Nov
PTY
Panama City
MDE
Medellin
฿10,115 Return, found 5 days ago
฿10,115
Return
found 5 days ago
Select avianca flight, departing Fri, 14 Nov from Panama City to Medellin, returning Fri, 21 Nov, priced at ฿10,115 found 5 days ago
Copa
Fri, 14 Nov - Fri, 21 Nov
PTY
Panama City
MDE
Medellin
฿10,850 Return, found 5 days ago
฿10,850
Return
found 5 days ago
Select Copa flight, departing Fri, 14 Nov from Panama City to Medellin, returning Fri, 21 Nov, priced at ฿10,850 found 5 days ago
avianca
Fri, 14 Nov - Fri, 21 Nov
PTY
Panama City
MDE
Medellin
฿10,860 Return, found 5 days ago
฿10,860
Return
found 5 days ago
Select avianca flight, departing Fri, 14 Nov from Panama City to Medellin, returning Fri, 21 Nov, priced at ฿10,860 found 5 days ago
Copa
Fri, 14 Nov - Fri, 21 Nov
PTY
Panama City
MDE
Medellin
฿11,085 Return, found 5 days ago
฿11,085
Return
found 5 days ago
Select Copa flight, departing Fri, 14 Nov from Panama City to Medellin, returning Fri, 21 Nov, priced at ฿11,085 found 5 days ago
Aeromexico
Wed, 3 Dec - Wed, 10 Dec
PTY
Panama City
CUN
Cancun
฿12,380 Return, found 2 hours ago
฿12,380
Return
found 2 hours ago
Select Aeromexico flight, departing Wed, 3 Dec from Panama City to Cancun, returning Wed, 10 Dec, priced at ฿12,380 found 2 hours ago
United
Tue, 2 Dec - Wed, 10 Dec
PTY
Panama City
MIA
Miami
฿17,735 Return, found 2 hours ago
฿17,735
Return
found 2 hours ago
Select United flight, departing Tue, 2 Dec from Panama City to Miami, returning Wed, 10 Dec, priced at ฿17,735 found 2 hours ago
American Airlines
Tue, 2 Dec - Wed, 10 Dec
PTY
Panama City
MIA
Miami
฿19,580 Return, found 2 hours ago
฿19,580
Return
found 2 hours ago
Select American Airlines flight, departing Tue, 2 Dec from Panama City to Miami, returning Wed, 10 Dec, priced at ฿19,580 found 2 hours ago
*Available to Expedia members.