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Check prices for these dates

This weekend
6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

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Our top choices for Substance hotels

A rooftop lounge with a fire pit, large windows, and a city view.

1. Circa Resort & Casino – Adults Only

Circa Resort & Casino – Adults Only
4.5 star property
Downtown Las Vegas, 0.5 km from Substance
9.4 out of 10, Exceptional, (5,774 reviews)
"Great place to stay"
United States
Cesar
The price is ฿4,012
฿6,439 total
includes taxes & fees
8 Nov - 9 Nov
Circa Resort & Casino – Adults Only
A grand hotel lobby with a long wooden corridor, ornate chandeliers, and a central decorative fireplace.

2. Main Street Station Hotel, Casino and Brewery

Main Street Station Hotel, Casino and Brewery
2.5 star property
Downtown Las Vegas, 0.6 km from Substance
9.0 out of 10, Wonderful, (3,935 reviews)
"Great place to stay!!!"
United States
Michelle
The price is ฿920
฿2,297 total
includes taxes & fees
17 Nov - 18 Nov
Main Street Station Hotel, Casino and Brewery
A storefront with a glass door, a black awning, and a floral archway.

3. The ENGLISH Hotel, Las Vegas, a Tribute Portfolio Hotel, 21 and over

The ENGLISH Hotel, Las Vegas, a Tribute Portfolio Hotel, 21 and over
4.0 star property
Arts District, 1.4 km from Substance
9.2 out of 10, Wonderful, (159 reviews)
"Great stay"
United States
Enrico
The price is ฿5,428
฿6,134 total
includes taxes & fees
22 Nov - 23 Nov
The ENGLISH Hotel, Las Vegas, a Tribute Portfolio Hotel, 21 and over
A bar area with a leather couch, red chairs, and a bar counter.

4. Downtown Grand Las Vegas

Downtown Grand Las Vegas
3.5 star property
Downtown Las Vegas, 0.2 km from Substance
8.6 out of 10, Excellent, (9,895 reviews)
"Friendly staff, great location, easy parking."
United States
Amy
The price is ฿1,404
฿3,073 total
includes taxes & fees
17 Nov - 18 Nov
Downtown Grand Las Vegas
A hotel room with a large bed, a desk, a chair, a lamp, and a window with curtains.

5. Four Queens Hotel and Casino

Four Queens Hotel and Casino
3.5 star property
Downtown Las Vegas, 0.3 km from Substance
8.6 out of 10, Excellent, (7,473 reviews)
"Always a nice place to stay"
United States
jose
The price is ฿2,326
฿2,629 total
includes taxes & fees
8 Nov - 9 Nov
Four Queens Hotel and Casino
An outdoor seating area with a wooden bench, a table with food, potted plants, and a view of the building's interior through a glass door.

6. AC Hotel by Marriott Las Vegas Symphony Park

AC Hotel by Marriott Las Vegas Symphony Park
2.0 star property
1.2 km from Substance
8.8 out of 10, Excellent, (295 reviews)
"Great stay. Only thing that wasnt great was bar and restaurant service. Bar staff was very rude and made us feel like we were a hindrance."
United States
Alison
The price is ฿4,181
฿5,567 total
includes taxes & fees
8 Nov - 9 Nov
AC Hotel by Marriott Las Vegas Symphony Park
A hotel with a prominent 'D' logo, a swimming pool, and palm trees.

7. the D Las Vegas

the D Las Vegas
3.5 star property
Downtown Las Vegas, 0.2 km from Substance
8.6 out of 10, Excellent, (7,741 reviews)
"Nice place to stay."
United States
Dave
The price is ฿978
฿2,627 total
includes taxes & fees
9 Nov - 10 Nov
the D Las Vegas
A hotel with a modern facade, large signage for Marriott and Element brands, and a prominent entrance with a palm tree in the foreground.

8. Element by Marriott Las Vegas Symphony Park

Element by Marriott Las Vegas Symphony Park
3.0 star property
1.2 km from Substance
8.8 out of 10, Excellent, (160 reviews)
"Spotless, brand-new feel in a quiet location ​Fantastic hotel! It was clean, quiet, and still smelled brand new. Staying in Symphony Park provided a relaxing break from the busy Strip while keeping us close to our festival venue. Modern, great facilities, and a wonderful overall stay."
United States
Suzanne
The price is ฿4,518
฿5,948 total
includes taxes & fees
23 Nov - 24 Nov
Element by Marriott Las Vegas Symphony Park
A spacious lobby with a stone floor, wooden beams, and a large chandelier.

9. El Cortez Hotel and Casino - 21 and Over

El Cortez Hotel and Casino - 21 and Over
3.0 star property
Downtown Las Vegas, 0.2 km from Substance
8.4 out of 10, Very good, (7,070 reviews)
"I loved our stay. The rooms were cute and conveniently across the casino!"
United States
Evelia
The price is ฿1,333
฿2,651 total
includes taxes & fees
25 Nov - 26 Nov
El Cortez Hotel and Casino - 21 and Over
A brightly lit hotel with a prominent sign for 'Plaza' and 'Pinkbox' on the left, a carousel in the center, and a 'Casino' sign on the right.

10. Plaza Hotel & Casino

Plaza Hotel & Casino
4.0 star property
Downtown Las Vegas, 0.6 km from Substance
8.4 out of 10, Very good, (5,736 reviews)
"The location is great free parking and breakfast options"
United States
saul
The price is ฿1,274
฿2,926 total
includes taxes & fees
9 Nov - 10 Nov
Plaza Hotel & Casino
A rooftop pool with lounge chairs and a view of the city skyline.

11. Hotel Apache

Hotel Apache
3.5 star property
Downtown Las Vegas, 0.4 km from Substance
8.4 out of 10, Very good, (1,169 reviews)
"Always a nice place to stay"
United States
jose
The price is ฿1,652
฿1,867 total
includes taxes & fees
1 Dec - 2 Dec
Hotel Apache
A hotel with a prominent sign reading "California Hotel & Casino."

12. California Hotel and Casino

California Hotel and Casino
3.5 star property
Downtown Las Vegas, 0.5 km from Substance
8.8 out of 10, Excellent, (1,476 reviews)
"Friendly staff and clean rooms"
United States
Zoe
The price is ฿1,074
฿2,470 total
includes taxes & fees
17 Nov - 18 Nov
California Hotel and Casino
A bedroom with a bed, a small table, and a chair. There is a bathroom with a sink, mirror, and shower.

13. Desert Moon Motel

Desert Moon Motel
2.5 star property
Downtown Las Vegas, 1.5 km from Substance
8.4 out of 10, Very good, (523 reviews)
"A great value for an extremely nice and clean hotel room. Great staff and location too !"
United States
Grant
The price is ฿1,880
฿2,124 total
includes taxes & fees
15 Nov - 16 Nov
Desert Moon Motel
A hotel with a large indoor pool, palm trees, and a modern building in the background.

14. Golden Nugget Las Vegas Hotel & Casino

Golden Nugget Las Vegas Hotel & Casino
4.0 star property
Downtown Las Vegas, 0.4 km from Substance
8.2 out of 10, Very good, (14,865 reviews)
"Wonderful stay, clean rooms, comfy beds, large bathrooms, and lovely restaurants!"
United States
Andrea
The price is ฿1,194
฿3,101 total
includes taxes & fees
9 Nov - 10 Nov
Golden Nugget Las Vegas Hotel & Casino
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and tall buildings.

15. Oasis at Gold Spike

Oasis at Gold Spike
3.5 star property
Downtown Las Vegas, < 0.1 km from Substance
8.2 out of 10, Very good, (2,344 reviews)
"Great hotel"
United States
Zachary
The price is ฿1,693
฿2,866 total
includes taxes & fees
8 Nov - 9 Nov
Oasis at Gold Spike
A hotel room with two beds, a desk, a chair, a large mirror, and a decorative wall with geometric patterns.

16. Downtowner Boutique Hotel

Downtowner Boutique Hotel
3.0 star property
Downtown Las Vegas, 0.4 km from Substance
8.0 out of 10, Very good, (186 reviews)
"Cute clean hotel, located just off the hustle and bustle of Fremont street."
United States
Nicholas
The price is ฿1,183
฿2,099 total
includes taxes & fees
8 Nov - 9 Nov
Downtowner Boutique Hotel
A nighttime view of a pool area with a city skyline in the background, including a prominent tower.

17. Bposhtels Las Vegas

Bposhtels Las Vegas
2.5 star property
1.8 km from Substance
7.8 out of 10, Good, (353 reviews)
"The manager was very kind The house keeping was great and polite I. Would love to stay again but now have a local id Thanks Nichole"
United States
Nichole
The price is ฿775
฿1,257 total
includes taxes & fees
5 Nov - 6 Nov
Bposhtels Las Vegas
A hotel with a prominent tower and the name "STRAT" illuminated on the facade.

18. The STRAT Hotel, Casino & Tower

The STRAT Hotel, Casino & Tower
4.0 star property
Las Vegas Strip, 2.9 km from Substance
7.6 out of 10, Good, (25,995 reviews)
"I love staying here when I visit!"
United States
Steve
The price is ฿456
฿2,428 total
includes taxes & fees
12 Nov - 13 Nov
The STRAT Hotel, Casino & Tower
The exterior of the Golden Gate Hotel with a prominent sign, a modern architectural design, and a parking lot with visible cars.

19. Golden Gate Hotel and Casino

Golden Gate Hotel and Casino
2.5 star property
Downtown Las Vegas, 0.5 km from Substance
7.6 out of 10, Good, (1,171 reviews)
"Great place to stay"
United States
Christian
The price is ฿809
฿2,436 total
includes taxes & fees
9 Nov - 10 Nov
Golden Gate Hotel and Casino
A hotel room with a large bed, a bedside table, a chair, a desk, and a mirror.

20. Crown Motel

Crown Motel
2.5 star property
Sunrise Manor, 3.1 km from Substance
7.4 out of 10, Good, (80 reviews)
"Decent hotel"
United States
Jeff
The price is ฿4,521
฿5,446 total
includes taxes & fees
5 Nov - 6 Nov
Crown Motel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare top hotels near Substance

A rooftop lounge with a fire pit, large windows, and a city view.

Circa Resort & Casino – Adults Only

4.5 star property
Downtown Las Vegas, 0.5 km from Substance
View
A grand hotel lobby with a long wooden corridor, ornate chandeliers, and a central decorative fireplace.

Main Street Station Hotel, Casino and Brewery

2.5 star property
Downtown Las Vegas, 0.6 km from Substance
View
A storefront with a glass door, a black awning, and a floral archway.

The ENGLISH Hotel, Las Vegas, a Tribute Portfolio Hotel, 21 and over

4.0 star property
Arts District, 1.4 km from Substance
View
A bar area with a leather couch, red chairs, and a bar counter.

Downtown Grand Las Vegas

3.5 star property
Downtown Las Vegas, 0.2 km from Substance
View
A hotel room with a large bed, a desk, a chair, a lamp, and a window with curtains.

Four Queens Hotel and Casino

3.5 star property
Downtown Las Vegas, 0.3 km from Substance
View
9.4
Exceptional
5,774 reviews
9.0
Wonderful
3,935 reviews
9.2
Wonderful
159 reviews
8.6
Excellent
9,895 reviews
8.6
Excellent
7,473 reviews
The price is ฿4,012
฿6,439 total
includes taxes & fees
8 Nov - 9 Nov
The price is ฿920
฿2,297 total
includes taxes & fees
17 Nov - 18 Nov
The price is ฿5,428
฿6,134 total
includes taxes & fees
22 Nov - 23 Nov
The price is ฿1,404
฿3,073 total
includes taxes & fees
17 Nov - 18 Nov
The price is ฿2,326
฿2,629 total
includes taxes & fees
8 Nov - 9 Nov
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • No Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • No Pet-friendly
  • No WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • No Pet-friendly
  • Yes, WiFi included
  • Yes, Parking

Top Substance Hotel Reviews

SAHARA Las Vegas

SAHARA Las Vegas

10/10 Excellent
"It’s a very nice hotel, quiet and clean, I would recommend this hotel. It is worth the stay…at a good price."
Lisa 3-night trip
Posted 1 hour ago
SAHARA Las Vegas

Other attractions near Substance

The exterior of the Neonopolis building with the Telemundo Las Vegas sign above.

Neonopolis

You can spend time exploring the galleries in Neonopolis in Las Vegas. Discover the entertainment choices and casinos in this family-friendly area.
See properties

Frequently asked questions

What's the area like around Substance?
Substance is located in Las Vegas. This welcoming area is known for its array of dining options and bar scene. If you're looking for a convenient place to stay, take a look at the 156 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay near Substance?
Adjacent to Substance, Golden Nugget Las Vegas Hotel & Casino is one of the top choices for your stay based on our traveller data, and this resort offers 2 outdoor pools and a full-service spa. Other good options within a short distance include Plaza Hotel & Casino and Downtown Grand Las Vegas.
How many hotels will I be able to find close to Substance?
Expedia has 156 hotels and other accommodation options within a mile from Substance.
If I need to cancel the hotel reservation for my stay near Substance, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within 24 hours of booking. Enter your dates, click on "Search", then you can filter by "fully refundable" to view the top deals on offer near Substance.
What can I see and do near Substance?
You might want to spend some time browsing the exhibits at Mob Museum, The Neon Museum or Zak Bagans Haunted Museum. Old Las Vegas Mormon Fort State Historic Park, Harrison House and First AME Church are monuments to see when you're exploring the area around Substance. You can watch performances at Colosseum at Caesars Palace, Sphere and Dolby Live if you're interested in local theatre.