The Best Hotels Closest to Sioux Empire Medical Museum in Sioux Falls - 2026 Updated Prices

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Our top choices for Sioux Empire Medical Museum hotels

A spacious bar area with a large TV screen, a fireplace, and a wine rack.

A spacious lobby with modern seating, large windows, and a city view.

A hotel room with a large bed, wooden wardrobe, a TV, and a kitchenette area.

A modern bar area with a black marble column, bar stools, and a view of the city through large windows.

1. Highpoint Hotel

University Heights, 0.2 km from Sioux Empire Medical Museum

Randell J

฿4,077

฿4,540 total

includes taxes & fees

18 Oct - 19 Oct

A large, two-story building with a stone facade and multiple windows, illuminated by warm lighting.

A stone pillar with a fire pit in the center, surrounded by blue chairs.

An indoor swimming pool with a water slide, a large umbrella structure, and a frog-shaped water feature.

A spacious lobby with multiple seating areas, a fireplace, and large windows.

2. Clubhouse Hotel Suites Sioux Falls

Mall District, 2.8 km from Sioux Empire Medical Museum

Jordyn

฿4,484

฿5,379 total

includes taxes & fees

25 Oct - 26 Oct

A lobby with a large safe, a checkered floor, and a sofa with cushions.

A modern hotel room with a desk, chair, and bed. It features a large window with a city view, a flat-screen TV, and a wooden wardrobe.

A lobby with a grand chandelier, blue curtains, and a round glass table with a vase of flowers.

A bar area with high stools and tables, a bar counter with bottles, and a seating area with cushioned chairs.

3. Hotel On Phillips

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Judy

฿5,260

฿5,838 total

includes taxes & fees

11 Oct - 12 Oct

A patio with wicker chairs and a round table with a fire pit.

A breakfast area with a long table, orange chairs, and various breakfast items displayed on shelves.

A modern hotel room with a bed, a sofa, a small table, a TV, and a bathroom visible through an open door.

An indoor swimming pool with two lanes, safety railings, and lounge chairs.

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

University Heights, 0.2 km from Sioux Empire Medical Museum

Ross

฿4,104

฿4,569 total

includes taxes & fees

18 Oct - 19 Oct

A Hampton Inn hotel with a modern design, featuring a prominent red sign, a covered entrance, and stone pillars.

A swimming pool with clear water, surrounded by a tiled deck and seating areas.

A hotel room with a desk, two beds, a TV, and a window with a striped blind.

A snack and beverage display area with various snacks and drinks.

5. Hampton Inn Sioux Falls

Mall District, 3.1 km from Sioux Empire Medical Museum

Mary

฿3,605

฿4,022 total

includes taxes & fees

1 Nov - 2 Nov

A modern lobby with a glass fireplace, seating areas, and indoor plants.

A modern building with a sign reading "THE STEEL DISTRICT" and a covered walkway.

A modern dining area with a large marble table, comfortable chairs, a built-in fireplace, and a large TV mounted on a dark wall.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

6. Canopy By Hilton Sioux Falls Downtown

Downtown Sioux Falls, 2.5 km from Sioux Empire Medical Museum

Marnie

฿5,106

฿5,870 total

includes taxes & fees

1 Nov - 2 Nov

A buffet with labeled containers of omelets and other dishes.

A reception area with a glass door entrance, a reception desk, and a computer station.

A Holiday Inn Express & Suites building with a brick facade, illuminated signage, and a covered entrance area.

A hotel room with a large bed, a small desk, a chair, a kitchenette, and a nightstand with a lamp.

7. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

Mall District, 3.1 km from Sioux Empire Medical Museum

Hagel

฿3,524

฿3,933 total

includes taxes & fees

18 Oct - 19 Oct

A long communal dining table with chairs, a bar area with shelves of bottles, and a brick wall with a mirror.

A multi-story hotel with a modern design, featuring balconies on each floor and a visible restaurant named "CRAVE" at the ground level.

A multi-story hotel with a modern design, featuring a central courtyard and a river in front.

A modern lobby with seating areas, a large pillar, and a wall mural.

8. Hilton Garden Inn Sioux Falls Downtown

Downtown Sioux Falls, 2.1 km from Sioux Empire Medical Museum

Samuel

฿4,135

฿4,804 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with multiple seating areas, a bar, and a staircase leading to an upper level.

A modern hotel lobby with a bar area, seating arrangements, and a view of the lobby.

A large conference room with a central stage, round tables with white chairs, and a patterned carpet.

A hotel room with a bed, a sofa, a chair, a desk, and a large window with a city view.

9. Holiday Inn Sioux Falls-City Centre by IHG

Downtown Sioux Falls, 1.9 km from Sioux Empire Medical Museum

Stacey

฿3,691

฿4,620 total

includes taxes & fees

11 Oct - 12 Oct

A multi-story hotel with a flat roof, a landscaped area with a water feature, and a bridge connecting to another building.

A swimming pool with lounge chairs and umbrellas, a view of the outside, and a sign indicating the hotel name.

A restaurant with a long wooden table, multiple chairs, a bar area, and a stone wall.

A hotel room with a wooden table, a laptop, a telephone, a glass of orange juice, a lamp, and a chair.

10. Country Inn & Suites by Radisson, Sioux Falls

Downtown Sioux Falls, 2 km from Sioux Empire Medical Museum

Hayley

฿3,061

฿3,425 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with two beds, a desk with a computer, a television, and a couch.

A hotel reception area with a Christmas tree, a clock, and a sign indicating a non-smoking policy.

A sign for Center Inn with a parking lot and buildings in the background.

A restaurant interior with wooden tables and chairs, a 'Welcome' sign, decorative wall art, a TV, and a window view.

11. The Center Inn

All Saints, 2.4 km from Sioux Empire Medical Museum

Marissa

฿3,199

฿3,577 total

includes taxes & fees

9 Oct - 10 Oct

A hotel room with a bed, two bedside lamps, a nightstand, a mirror, and a small desk with a telephone.

A small cafe with a 'Good Morning' sign, a coffee machine, a microwave, and a refrigerator.

A small, cozy room with a sofa, two armchairs, a coffee table, and a desk with a lamp. There are two framed pictures on the wall.

12. Valley Inn

University Heights, 0.2 km from Sioux Empire Medical Museum

Robert

฿2,743

฿3,077 total

includes taxes & fees

6 Oct - 7 Oct

An indoor pool area with a slide, seating, and tropical decor.

A modern restaurant with a central bar, red cushioned chairs, and a 'TEAM ROOM' sign.

A lobby with a stone fire feature, seating area, and a reception desk.

A restaurant with booths and tables, a TV screen, and a view of the outdoors.

13. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Northwest Sioux Falls, 2.9 km from Sioux Empire Medical Museum

Sami

฿2,082

฿2,351 total

includes taxes & fees

11 Oct - 12 Oct

A living room with a fireplace, a television, a chandelier, a sofa, and a coffee table.

A wooden door with a glass panel, leading to a brick-paved entrance.

A dining room with a wooden table, six chairs, and a chandelier.

A cozy living room with a sectional sofa, a wooden coffee table, and a chandelier.

14. Historic Twin Tudors Inn

1.4 km from Sioux Empire Medical Museum

Anonymous traveller

฿8,529

฿9,690 total

includes taxes & fees

12 Oct - 13 Oct

15. Sioux Falls Inn

Northwest Sioux Falls, 3.1 km from Sioux Empire Medical Museum

Stephanie

฿1,839

฿2,084 total

includes taxes & fees

6 Oct - 7 Oct

A multi-story hotel with a modern design, featuring a central entrance and multiple balconies.

A hotel room with a bed, a window with blinds, a heater, a nightstand, and a painting on the wall.

A hallway with a wooden floor, a small black desk with a mirror, and a door with a glass panel.

A laundry room with multiple white washers and dryers, wooden flooring, and a door on the left.

16. WoodSpring Suites Sioux Falls

2.8 km from Sioux Empire Medical Museum

Catherine

฿2,651

฿2,975 total

includes taxes & fees

6 Oct - 7 Oct

A reception area with a counter, a food mart sign, and a security camera.

A breakfast bar with seating, a microwave, toaster, and a coffee maker.

A hotel room with two beds, a desk, a chair, and a TV.

A swimming pool with a tiled floor, a poolside table, and chairs.

17. Ramada by Wyndham Sioux Falls

2.6 km from Sioux Empire Medical Museum

Tiffany

฿1,826

฿2,070 total

includes taxes & fees

18 Oct - 19 Oct

A modern hotel room with a kitchenette, a bed, a desk, and a chair.

A modern hotel room with a kitchenette, a bed, a sofa, a dining area, and a view of the outdoors.

A compact hotel room with a kitchenette, a bed, a TV, and a seating area.

A modern living room with a flat-screen TV, a sofa, a coffee table, and a dining area with a table and chairs.

18. Staybridge Suites Sioux Falls Southwest by IHG

South Sioux Falls, 5.2 km from Sioux Empire Medical Museum

Bailey

฿4,061

฿4,522 total

includes taxes & fees

1 Nov - 2 Nov

A swimming pool with clear blue water, surrounded by a tiled deck and a seating area with chairs and tables.

A modern hotel room with a kitchenette, a sofa, a dining table, a small round table, a bed, and a view of the outdoors.

An outdoor patio area with tables and chairs, string lights, and a view of the city skyline.

A Comfort Inn & Suites hotel with a modern design, featuring a covered entrance and a clear view of the building's facade.

19. Comfort Inn & Suites at Sanford Sports Complex

Northwest Sioux Falls, 6 km from Sioux Empire Medical Museum

jason

฿3,434

฿3,835 total

includes taxes & fees

18 Oct - 19 Oct

A deck with outdoor furniture, a fire pit, and a view of a body of water.

A modern hotel lobby with a dining area, seating arrangements, and a kitchen in the background.

A modern bar area with seating, a counter with a beverage display, and a large window providing a view.

A reception area with a herringbone-patterned wall, a reception desk, and seating area with chairs and a table.

20. Hyatt Place Sioux Falls South

Mall District, 3.8 km from Sioux Empire Medical Museum

Catherine

฿3,926

฿4,374 total

includes taxes & fees

11 Oct - 12 Oct

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Compare popular hotels close to Sioux Empire Medical Museum

Property	Property class	Guest rating
Highpoint Hotel	9.8 Exceptional 355 reviews	View
Clubhouse Hotel Suites Sioux Falls	9.6 Exceptional 1,233 reviews	View
Hotel On Phillips	9.6 Exceptional 1,609 reviews	View
Home2 Suites By Hilton Sioux Falls/Sanford Medical Center	9.4 Exceptional 676 reviews	View
Hampton Inn Sioux Falls	9.4 Exceptional 1,007 reviews	View

Top Sioux Empire Medical Museum Hotel Reviews

Hotel On Phillips

10/10 Excellent

"Exceptional hotel just wish they had breakfast."

Clubhouse Hotel Suites Sioux Falls

10/10 Excellent

"The employees were friendly. The pool was nice for the young ones. The breakfast was good"

Highpoint Hotel

10/10 Excellent

"Very convenient if you are an outpatient from surgery or visiting someone who is in the Sanford hospital! Nice to not have to drive and can walk to patients room just down the hallway. Rooms are spacious snd new, comfortable beds, big tv, comes with microwave and and refrigerator, would highly recommend!"

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

10/10 Excellent

"Todo super"

Valley Inn

10/10 Excellent

"This is a nice quiet place to stay. A little off the beaten path, but great for what we needed. Will stay again."

Country Inn & Suites by Radisson, Sioux Falls

10/10 Excellent

"Convenient location; very close to the airport!"

Holiday Inn Sioux Falls-City Centre by IHG

10/10 Excellent

"We had a good one night stay for a concert at the Denny Sanford. Easy to find, easy to park."

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

8.0/10 (242 reviews)

Explore the campus of University of Sioux Falls during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Augustana College

8.2/10 (310 reviews)

Take a campus tour or just explore the area of Augustana College during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Center for Western Studies

You can spend time exploring the galleries in Center for Western Studies during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Delbridge Museum of Natural History

6.0/10 (1 review)

You can spend time browsing the exhibits at Delbridge Museum of Natural History during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Washington Pavilion

Washington Pavilion is just one of the places to see in Sioux Falls, so why not enjoy the other things to explore during your travels?

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Washington Pavilion of Arts and Science

9.0/10 (132 reviews)

You can make plans for a show at Washington Pavilion of Arts and Science during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Pettigrew Home and Museum

You can spend time studying the exhibits at Pettigrew Home and Museum during your trip to Sioux Falls. Attend a sporting event or discover the area's beautiful waterfalls.

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Club David

After visiting Club David, make a plan to see the other sights and activities in Sioux Falls.

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Frequently asked questions

What's the area like around Sioux Empire Medical Museum?

Sioux Empire Medical Museum is located in a welcoming area of Sioux Falls known for its beautiful waterfalls and sporting events. If you're looking for a convenient place to stay, take a look at the 136 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Sioux Empire Medical Museum?

Adjacent to Sioux Empire Medical Museum, Highpoint Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and free parking. Other good choices close by include Valley Inn and Home2 Suites By Hilton Sioux Falls/Sanford Medical Center.

How many hotels are there close to Sioux Empire Medical Museum?

Expedia has 136 hotels and other accommodation options within a mile from Sioux Empire Medical Museum.

If I need to cancel the hotel reservation for my stay near Sioux Empire Medical Museum, will I receive a refund?

Yes, the majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then use the "fully refundable" filter to view the best options available near Sioux Empire Medical Museum.

What can I see and do near Sioux Empire Medical Museum?

Washington Pavilion of Arts and Science, Old Courthouse Museum and Center for Western Studies feature a variety of fascinating exhibits to see while you're in town. Learn about local history at St. Joseph Cathedral and Pettigrew Home and Museum. You can enjoy live performances at Edith Mortenson Theatre Center and Orpheum Theatre Center.

Search Hotels Near Sioux Empire Medical Museum, Sioux Falls

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Sioux Empire Medical Museum hotels

1. Highpoint Hotel

2. Clubhouse Hotel Suites Sioux Falls

3. Hotel On Phillips

4. Home2 Suites By Hilton Sioux Falls/Sanford Medical Center

5. Hampton Inn Sioux Falls

6. Canopy By Hilton Sioux Falls Downtown

7. Holiday Inn Express & Suites Sioux Falls At Empire Mall by IHG

8. Hilton Garden Inn Sioux Falls Downtown

9. Holiday Inn Sioux Falls-City Centre by IHG

10. Country Inn & Suites by Radisson, Sioux Falls

11. The Center Inn

12. Valley Inn

13. Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

14. Historic Twin Tudors Inn

15. Sioux Falls Inn

16. WoodSpring Suites Sioux Falls

17. Ramada by Wyndham Sioux Falls

18. Staybridge Suites Sioux Falls Southwest by IHG

19. Comfort Inn & Suites at Sanford Sports Complex

20. Hyatt Place Sioux Falls South

Compare popular hotels close to Sioux Empire Medical Museum

Top Sioux Empire Medical Museum Hotel Reviews

Hotel On Phillips

Clubhouse Hotel Suites Sioux Falls

Highpoint Hotel

Ramada by Wyndham Sioux Falls Airport-Waterpark & Event Ctr

Valley Inn

Country Inn & Suites by Radisson, Sioux Falls

Holiday Inn Sioux Falls-City Centre by IHG

Other attractions near Sioux Empire Medical Museum

University of Sioux Falls

Augustana College

Center for Western Studies

Delbridge Museum of Natural History

Washington Pavilion

Washington Pavilion of Arts and Science

Pettigrew Home and Museum

Club David

Frequently asked questions