
Find hotels in Seneca, SC from ฿1,936
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Our top choices for Seneca hotels

Lakeside Lodge Clemson
Lakeside Lodge Clemsoncleanliness Stay within 10 minutes of Clemson University at this lakeside hotel with a pool.

Quality Inn Seneca Clemson Area US-123
Quality Inn Seneca Clemson Area US-123cleanliness Perfect lakeside retreat with a seasonal pool and complimentary amenities.

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoycleanliness Wake up in a scenic waterfront cabin with a patio near Lake Hartwell and Keowee.

Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ Areacleanliness Experience charming South Carolina hospitality near Clemson University and Lake Keowee.

Tru by Hilton Seneca Clemson
Tru by Hilton Seneca Clemsoncleanliness Stay close to Clemson University with free breakfast, WiFi, and parking.

Best Western Seneca-Clemson
Best Western Seneca-Clemsoncleanliness Experience a convenient stay near Clemson University with poolside relaxation.

Hampton Inn & Suites Seneca-Clemson Area
Hampton Inn & Suites Seneca-Clemson Areacleanliness Enjoy proximity to two stunning lakes and Clemson University with outdoor amenities.

Days Inn by Wyndham Seneca / Clemson Area
Days Inn by Wyndham Seneca / Clemson Areacleanliness Stay in Seneca near Lake Hartwell with a seasonal pool and free breakfast.

Hampton Inn Hartwell
Hampton Inn Hartwellcleanliness Find tranquility in Hartwell at this welcoming hotel with pool and fitness options.

Baymont by Wyndham Easley/Greenville
Baymont by Wyndham Easley/Greenville
Days Inn by Wyndham Anderson
Days Inn by Wyndham Andersoncleanliness Quiet retreat in Anderson with seasonal pool and convenient highway access.

Country Inn & Suites by Radisson, Anderson, SC
Country Inn & Suites by Radisson, Anderson, SCcleanliness Experience Lake Hartwell, indoor pool, and generous amenities for business trips.

Rodeway Inn Anderson North - Clemson
Rodeway Inn Anderson North - Clemsoncleanliness Make the trip easier with a cosy motel stay near Anderson's sports hub.

Hilton Garden Inn Anderson
Hilton Garden Inn Andersoncleanliness Serene riverside stay with indoor pool and fitness centre in Anderson.

Quality Inn Clemson near University
Quality Inn Clemson near Universitycleanliness Experience convenient comfort and Southern hospitality in Anderson's entertainment hub.

Microtel Inn & Suites by Wyndham Anderson/Clemson
Microtel Inn & Suites by Wyndham Anderson/Clemsoncleanliness Modern hotel offers pool, free breakfast, and convenient location near Clemson.

Quality Inn & Suites Easley - Greenville
Quality Inn & Suites Easley - Greenvillecleanliness Enjoy a relaxing stay with free breakfast, parking, and WiFi in Easley.

Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference Centercleanliness Enjoy lakeside stays close to Clemson University with 24-hour fitness centre.

Holiday Inn Express Anderson by IHG
Holiday Inn Express Anderson by IHGcleanliness Stay close to Clemson University in a peaceful hotel with a refreshing outdoor pool.

Hampton Inn Anderson/ Alliance Business Park
Hampton Inn Anderson/ Alliance Business Parkcleanliness Modern hotel in Anderson with a 24-hour fitness centre and seasonal pool.
Where to stay in Seneca

Downtown
City centre Seneca captures the essence of small-town Southern charm with its well-preserved railway heritage and historic brick buildings. Tree-lined streets lead to charming shops and local eateries housed in structures dating back to the 1800s. Ram Cat Alley's colourful murals tell stories of local history while the old courthouse square hosts community gatherings. This walkable district offers a peaceful retreat from big city life. Visitors can browse antique stores for railway memorabilia, sample authentic Southern comfort food, or explore the cultural exhibits at the Bertha Lee Strickland Museum. The nearby Lake Keowee provides outdoor recreation just minutes away.
Serenity Bay
Serenity Bay offers a peaceful retreat within Saxony Forest's coastal embrace. The quiet residential streets wind through mature trees, creating a tranquil atmosphere away from tourist crowds. Nature lovers can explore nearby Lake Keowee or enjoy the neighborhood's forest trails. The area perfectly balances woodland serenity with beach proximity. Visitors should plan for self-contained holiday rentals rather than hotels. While dining options are limited within the area, the natural surroundings provide ideal conditions for relaxation and outdoor recreation.

Pine Ridge Point
Lake Keowee's serene waters lap against the shores of Pine Ridge Point, a tranquil residential haven in Seneca. Private docks stretch into crystal-clear waters where boats gently bob. Towering pines create natural privacy between lakefront homes. Visitors enjoy peaceful mornings watching mist rise over the water. This area offers an authentic lakeside living experience without tourist crowds. Holiday rentals range from cosy cabins to luxury estates with private boat slips. Days revolve around swimming, fishing, and water sports on Lake Keowee. Nature trails wind through mature forests for hiking and birdwatching.
Indian Oaks
Indian Oaks offers a tranquil retreat in suburban Seneca where mature oak trees create natural canopies over peaceful residential streets. This family-oriented community provides an authentic glimpse into American suburban living without tourist crowds. Landscaped yards and community green spaces showcase South Carolina's native beauty. Visitors can enjoy quiet morning walks on spacious pavements while listening to birdsong. Lake Keowee lies just beyond the area boundaries for those seeking water activities. With minimal commercial presence, Indian Oaks delivers a genuinely restful experience away from urban bustle.
Stay near popular Seneca attractions
Learn more about Seneca
Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

Top Seneca Hotel Reviews

Quality Inn Seneca Clemson Area US-123
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