Find hotels in Seneca, SC from ฿2,203

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15 Dec - 16 Dec
Tomorrow
16 Dec - 17 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for Seneca hotels

Exterior
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (51)
"The place was absolutely magnificent."
United States
David
The price is ฿2,808
฿4,477 total
includes taxes & fees
16 Dec - 17 Dec
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Balcony
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 star property
Seneca
9.4 out of 10, Exceptional, (204)
"Nice hotel by the lake"
United States
Mike
The price is ฿3,628
฿3,991 total
includes taxes & fees
21 Dec - 22 Dec
Fairfield Inn & Suites Seneca Clemson Univ Area
Aerial view
Lakeside Lodge Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1001)
"Great place to stay. "
United States
Gene
The price is ฿3,439
฿4,269 total
includes taxes & fees
19 Dec - 20 Dec
Lakeside Lodge Clemson
Exterior
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (662)
"Great place to stay"
United States
Jose
The price is ฿3,205
฿3,526 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn & Suites Seneca-Clemson Area
Lobby
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (792)
"Michail was the best. He was so welcoming, helpful and professional. Parking was easy and rooms were nice and clean. I will definitely stay again. "
United States
Jakeria
The price is ฿3,003
฿3,304 total
includes taxes & fees
22 Dec - 23 Dec
Tru by Hilton Seneca Clemson
Free daily on-the-go breakfast
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very good, (665)
"Friendly check in, clean room."
United States
connie
The price is ฿2,319
฿2,738 total
includes taxes & fees
27 Dec - 28 Dec
Quality Inn Seneca Clemson Area US-123
Lobby
Best Western Seneca-Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very good, (642)
"The stay was amazing "
United States
Tabatha
The price is ฿2,816
฿3,097 total
includes taxes & fees
21 Dec - 22 Dec
Best Western Seneca-Clemson
Room, 1 King Bed, Non Smoking | Desk, free cots/infant beds, rollaway beds, free WiFi
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
Seneca
6.8 out of 10, (720)
"Room was clean. Quiet place to rest. Lisa at the front desk was very helpful and very nice. "
United States
Teresa
The price is ฿2,226
฿2,448 total
includes taxes & fees
24 Dec - 25 Dec
Days Inn by Wyndham Seneca / Clemson Area
In-room safe, blackout curtains, soundproofing, iron/ironing board
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (743)
"Staff was amazing and our room was clean and comfortable. "
United States
Amanda R
The price is ฿5,332
฿5,918 total
includes taxes & fees
21 Dec - 22 Dec
The Shepherd Hotel Downtown Clemson
Terrace/patio
Hampton Inn & Suites Lavonia

Hampton Inn & Suites Lavonia

Hampton Inn & Suites Lavonia
2.5 star property
Lavonia
9.0 out of 10, Wonderful, (375)
"We felt safe staying in the hotel. It was quiet and the staff were so kind and helpful to us. "
United States
Nancy Barbara
The price is ฿3,458
฿4,134 total
includes taxes & fees
3 Jan - 4 Jan 2026
Hampton Inn & Suites Lavonia
Seasonal outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas
Carolina Camp Cedar

Carolina Camp Cedar

Carolina Camp Cedar
3.5 star property
Pickens
The price is ฿3,032
฿6,276 total
includes taxes & fees
16 Dec - 17 Dec
Carolina Camp Cedar
House (5 Bedrooms) | Interior
6 Mi to Dtwn Anderson: Grand Family Home w/ Yard!

6 Mi to Dtwn Anderson: Grand Family Home w/ Yard!

6 Mi to Dtwn Anderson: Grand Family Home w/ Yard!
3.0 star property
Anderson
The price is ฿10,600
฿29,866 total
includes taxes & fees
16 Dec - 17 Dec
6 Mi to Dtwn Anderson: Grand Family Home w/ Yard!
Reception hall
The Inn at Patrick Square

The Inn at Patrick Square

The Inn at Patrick Square
3.5 star property
Clemson
9.8 out of 10, Exceptional, (783)
"Clean room. Nice front desk concierge. Very cute hotel"
United States
Anisha
The price is ฿4,701
฿5,218 total
includes taxes & fees
25 Dec - 26 Dec
The Inn at Patrick Square
Exterior
Holiday Inn Express Anderson by IHG

Holiday Inn Express Anderson by IHG

Holiday Inn Express Anderson by IHG
2.5 star property
Anderson
8.6 out of 10, Excellent, (384)
"Convenient location to I-85, quiet with nice parking area "
United States
Nancy
The price is ฿3,313
฿3,677 total
includes taxes & fees
19 Dec - 20 Dec
Holiday Inn Express Anderson by IHG
Property amenity
Residence Inn by Marriott Anderson Clemson

Residence Inn by Marriott Anderson Clemson

Residence Inn by Marriott Anderson Clemson
3.0 star property
Anderson
9.8 out of 10, Exceptional, (88)
"Very clean. Breakfast was great. Location was very convenient. Room was very spacious for the price "
United States
linda gaye allen
The price is ฿4,511
฿5,008 total
includes taxes & fees
21 Dec - 22 Dec
Residence Inn by Marriott Anderson Clemson
Exterior
Hampton Inn Hartwell

Hampton Inn Hartwell

Hampton Inn Hartwell
2.5 star property
Hartwell
9.2 out of 10, Wonderful, (337)
"Great stay!"
United States
Daniel
The price is ฿3,078
฿3,698 total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn Hartwell
Terrace/patio
Home2 Suites by Hilton Anderson Downtown

Home2 Suites by Hilton Anderson Downtown

Home2 Suites by Hilton Anderson Downtown
3.0 star property
Anderson
9.4 out of 10, Exceptional, (216)
"great location, super new and clean."
United States
Samuel
The price is ฿4,414
฿4,900 total
includes taxes & fees
21 Dec - 22 Dec
Home2 Suites by Hilton Anderson Downtown
Property entrance
The Bleckley Inn

The Bleckley Inn

The Bleckley Inn
3.5 star property
Anderson
9.8 out of 10, Exceptional, (407)
"Courteous staff, quiet, beautiful accommodations and great location in Downtown Anderson."
United States
Christie
The Bleckley Inn
Meeting facility
The Abernathy of Clemson

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (557)
"location is amazing! "
United States
colleen
The Abernathy of Clemson
Exterior
Hampton Inn Anderson/ Alliance Business Park

Hampton Inn Anderson/ Alliance Business Park

Hampton Inn Anderson/ Alliance Business Park
2.5 star property
Anderson
9.2 out of 10, Wonderful, (806)
"Very comfortable stay convenient to Greenville Spartanburg Airport."
United States
Rick
The price is ฿3,256
฿3,614 total
includes taxes & fees
22 Dec - 23 Dec
Hampton Inn Anderson/ Alliance Business Park
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Seneca

Find the best Seneca areas for the activities you enjoy most.

Downtown

If you're spending some time in Downtown, Seneca Historic District and The Gauntlet are top sights worth seeing.

Serenity Bay

When in Serenity Bay, you can plan a visit to Keowee Key Golf Course and Lake Keowee, some noteworthy sights in the nearby area.

Pine Ridge Point

If you're looking for some top things to see and do in Pine Ridge Point and surrounding area, you can visit Lake Keowee and Keowee Key Golf Course.

Indian Oaks

While Indian Oaks may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Seneca Historic District and Keowee Reservoir.

Keowee Plantation

While Keowee Plantation isn't home to many top sights, Seneca Historic District and Cross Creek Plantation Golf are some notable places to visit nearby.

Stay near popular Seneca attractions

Lovely shot of the Blue Ridge Mountains in the distance, with a rural pasture in the foreground, in late summer when the grass is starting to turn yellow and brown. Upstate South Carolina scene.

Blue Ridge Field

This historic park honours African-American education in Oconee County on the former Blue Ridge High School football grounds. Stroll the paved loop trail and explore community gardens in this peaceful green space.
See properties
High Shoals Falls in South Mountains State Park

High Falls County Park

Nestled along Lake Keowee with the Blue Ridge Mountains as backdrop, High Falls County Park offers pristine swimming and camping spots. Reserve waterfront campsites early to enjoy the park's serene natural setting.
See properties

Learn more about Seneca

Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

See all hotels in Seneca
Lake Keowee South Carolina

Top Seneca Hotel Reviews

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"Everything was clean andwell kept. The supplies for smores and sitting around the fire and wood to burn was great. The picture window in rhe cabin is the best feature of the cabin from the main bed and the bed in the loft. Staff was great."
Stephen 2-night trip
Posted 4 days ago
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

More cheap stays in Seneca

Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

1007 George Smith Mill Rd Anderson SC
The price is ฿1,984 per night from 18 Dec to 19 Dec
฿1,984
฿2,203 total
18 Dec - 19 Dec
includes taxes & fees
7.6/10 Good! (1,002 reviews)

Frequently asked questions

Where is the best place for a stay in Seneca?
Tru by Hilton Seneca Clemson is ranked highly by Expedia customers. This hotel offers free breakfast and free parking. Traveller reviews also recommend Lakeside Lodge Clemson and Hampton Inn & Suites Seneca-Clemson Area as top choices for your visit. See all available top hotels, or vacation rentals in Seneca.
If I need to cancel my hotel reservation in Seneca, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a reservation that's non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Seneca.
What's the best family accommodation in Seneca?
Fairfield Inn & Suites Seneca Clemson Univ Area is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Also, attractions in the area such as Ultimate Action Sports are fun for the whole family. Find more child-friendly accommodations in Seneca.
What is the top LGBTQ-friendly accommodation in Seneca?
Hampton Inn & Suites Seneca-Clemson Area is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi. Tru by Hilton Seneca Clemson is another good choice for your trip. See all available hotels listed as LGBTQ-friendly in Seneca.
What's the best dog-friendly hotel in Seneca?
Quality Inn Seneca Clemson Area US-123 is a top hotel for people travelling with their pets, and offers a seasonal outdoor pool and free WiFi for its human guests. Other good choices for you and your pet's trip include Days Inn by Wyndham Seneca / Clemson Area and Lakeside Lodge Clemson. See more pet-friendly hotel accommodations in Seneca.
What are some hotels with pools in Seneca?
Lakeside Lodge Clemson: Hotel located near Clemson University. Features free self parking, a seasonal outdoor pool and complimentary wireless Internet access. Days Inn by Wyndham Seneca / Clemson Area and Quality Inn Seneca Clemson Area US-123 are two additional hotels that feature an on-site pool. View all hotels with pools in Seneca.
What is staying in Seneca like?
Visitors to Seneca will definitely enjoy the sporting events, lakeside setting and university setting. Welcoming and scenic, this city also attracts tourists with its cafes. In Seneca, there are 286 hotels and other accommodation options to choose from. Find out more about Seneca.
What should I see while I'm in Seneca?
Cultural venues include The Gauntlet and Oconee Community Theatre. Natural beauty is on display at Lake Keowee, Lake Hartwell and Keowee Reservoir. Exploring the waterfront is a great activity, and Keowee Key Golf Course is one place to visit. Take a look at what more there is to see and do in Expedia's Seneca guide.
What's the seasonal weather in Seneca?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 8°C. Average annual precipitation for Seneca is 1565 mm.

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