Find hotels in Seneca, SC from ฿1,936

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Seneca hotels

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,001 reviews)
  • cleanliness
    Stay within 10 minutes of Clemson University at this lakeside hotel with a pool.
"Great place to stay. "
United States
Gene
The price is ฿3,395
฿4,215 total
includes taxes & fees
31 Jan - 1 Feb
Lakeside Lodge Clemson

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very good, (673 reviews)
  • cleanliness
    Perfect lakeside retreat with a seasonal pool and complimentary amenities.
"Our stay was very nice. Clean room. The outside was clean. "
United States
Gayle
The price is ฿2,425
฿2,858 total
includes taxes & fees
5 Feb - 6 Feb
Quality Inn Seneca Clemson Area US-123

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (57 reviews)
  • cleanliness
    Wake up in a scenic waterfront cabin with a patio near Lake Hartwell and Keowee.
"Excellent stay."
United States
Beonca
The price is ฿2,356
฿3,962 total
includes taxes & fees
3 Feb - 4 Feb
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 star property
Seneca
9.4 out of 10, Exceptional, (206 reviews)
  • cleanliness
    Experience charming South Carolina hospitality near Clemson University and Lake Keowee.
"Spotless, friendly staff, great location. "
United States
Cari
The price is ฿3,893
฿4,283 total
includes taxes & fees
3 Feb - 4 Feb
Fairfield Inn & Suites Seneca Clemson Univ Area

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (805 reviews)
  • cleanliness
    Stay close to Clemson University with free breakfast, WiFi, and parking.
"Perfect stay for a weekend. Lots of shopping and restaurants nearby. Clean safe area annd the staff was wonderful!"
United States
Cindy
The price is ฿3,039
฿3,343 total
includes taxes & fees
4 Feb - 5 Feb
Tru by Hilton Seneca Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very good, (646 reviews)
  • cleanliness
    Experience a convenient stay near Clemson University with poolside relaxation.
"The stay was amazing "
United States
Tabatha
The price is ฿3,045
฿3,349 total
includes taxes & fees
8 Feb - 9 Feb
Best Western Seneca-Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (675 reviews)
  • cleanliness
    Enjoy proximity to two stunning lakes and Clemson University with outdoor amenities.
"Everything was excellent "
United States
Debby
The price is ฿3,840
฿4,224 total
includes taxes & fees
8 Feb - 9 Feb
Hampton Inn & Suites Seneca-Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
Seneca
6.8 out of 10, (724 reviews)
  • cleanliness
    Stay in Seneca near Lake Hartwell with a seasonal pool and free breakfast.
"Room was clean. Quiet place to rest. Lisa at the front desk was very helpful and very nice. "
United States
Teresa
The price is ฿2,171
฿2,388 total
includes taxes & fees
4 Feb - 5 Feb
Days Inn by Wyndham Seneca / Clemson Area

Hampton Inn Hartwell

Hampton Inn Hartwell
2.5 star property
Hartwell
9.0 out of 10, Wonderful, (350 reviews)
  • cleanliness
    Find tranquility in Hartwell at this welcoming hotel with pool and fitness options.
"Great stay!"
United States
Daniel
The price is ฿3,039
฿3,651 total
includes taxes & fees
5 Feb - 6 Feb
Hampton Inn Hartwell

Baymont by Wyndham Easley/Greenville

Baymont by Wyndham Easley/Greenville
2.5 star property
Easley
7.4 out of 10, Good, (770 reviews)
"Good breakfast friendly staff "
United States
brian
The price is ฿1,913
฿2,123 total
includes taxes & fees
1 Mar - 2 Mar
Baymont by Wyndham Easley/Greenville

Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson
2.0 star property
Anderson
7.8 out of 10, Good, (1,001 reviews)
  • cleanliness
    Quiet retreat in Anderson with seasonal pool and convenient highway access.
"The room was spotless, the property well kept, the staff was kind and helpful and the location was great! "
United States
Kayla
The price is ฿1,959
฿2,175 total
includes taxes & fees
1 Feb - 2 Feb
Days Inn by Wyndham Anderson

Country Inn & Suites by Radisson, Anderson, SC

Country Inn & Suites by Radisson, Anderson, SC
2.5 star property
Anderson
8.4 out of 10, Very good, (1,000 reviews)
  • cleanliness
    Experience Lake Hartwell, indoor pool, and generous amenities for business trips.
"Everything was clean and breakfast was a nice spread. "
United States
Sheri
The price is ฿3,395
฿3,768 total
includes taxes & fees
2 Feb - 3 Feb
Country Inn & Suites by Radisson, Anderson, SC

Rodeway Inn Anderson North - Clemson

Rodeway Inn Anderson North - Clemson
2.0 star property
Anderson
7.8 out of 10, Good, (322 reviews)
  • cleanliness
    Make the trip easier with a cosy motel stay near Anderson's sports hub.
"Room was spotless an the stay was great."
United States
Benito
The price is ฿2,025
฿2,247 total
includes taxes & fees
1 Feb - 2 Feb
Rodeway Inn Anderson North - Clemson

Hilton Garden Inn Anderson

Hilton Garden Inn Anderson
3.0 star property
Anderson
9.0 out of 10, Wonderful, (697 reviews)
  • cleanliness
    Serene riverside stay with indoor pool and fitness centre in Anderson.
"Rooms were clean, staff were friendly, and we had 2 good night’s sleep."
United States
Sadie
The price is ฿3,295
฿3,657 total
includes taxes & fees
5 Feb - 6 Feb
Hilton Garden Inn Anderson

Quality Inn Clemson near University

Quality Inn Clemson near University
2.5 star property
Anderson
7.0 out of 10, Good, (895 reviews)
  • cleanliness
    Experience convenient comfort and Southern hospitality in Anderson's entertainment hub.
"Bueno was "
Mexico
Alejandro
The price is ฿1,615
฿1,793 total
includes taxes & fees
17 Feb - 18 Feb
Quality Inn Clemson near University

Microtel Inn & Suites by Wyndham Anderson/Clemson

Microtel Inn & Suites by Wyndham Anderson/Clemson
2.0 star property
Anderson
8.2 out of 10, Very good, (1,000 reviews)
  • cleanliness
    Modern hotel offers pool, free breakfast, and convenient location near Clemson.
"Room was clean, front desk people were very nice. "
United States
Caressa
The price is ฿2,489
฿2,763 total
includes taxes & fees
1 Feb - 2 Feb
Microtel Inn & Suites by Wyndham Anderson/Clemson

Quality Inn & Suites Easley - Greenville

Quality Inn & Suites Easley - Greenville
2.5 star property
Easley
7.0 out of 10, Good, (398 reviews)
  • cleanliness
    Enjoy a relaxing stay with free breakfast, parking, and WiFi in Easley.
"Very clean, friendly staff"
United States
Song
The price is ฿1,744
฿1,936 total
includes taxes & fees
6 Feb - 7 Feb
Quality Inn & Suites Easley - Greenville

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
2.5 star property
Clemson
8.2 out of 10, Very good, (1,001 reviews)
  • cleanliness
    Enjoy lakeside stays close to Clemson University with 24-hour fitness centre.
"Rooms are clean. Staff was very pleasant. "
United States
Regina
The price is ฿2,965
฿3,291 total
includes taxes & fees
2 Feb - 3 Feb
Best Western Plus Clemson Hotel & Conference Center

Holiday Inn Express Anderson by IHG

Holiday Inn Express Anderson by IHG
2.5 star property
Anderson
8.6 out of 10, Excellent, (386 reviews)
  • cleanliness
    Stay close to Clemson University in a peaceful hotel with a refreshing outdoor pool.
"Convenient location to I-85, quiet with nice parking area "
United States
Nancy
The price is ฿3,270
฿3,630 total
includes taxes & fees
1 Feb - 2 Feb
Holiday Inn Express Anderson by IHG

Hampton Inn Anderson/ Alliance Business Park

Hampton Inn Anderson/ Alliance Business Park
2.5 star property
Anderson
9.2 out of 10, Wonderful, (820 reviews)
  • cleanliness
    Modern hotel in Anderson with a 24-hour fitness centre and seasonal pool.
"Staff, Just a Nice Hotel"
United States
Christopher
The price is ฿3,536
฿3,925 total
includes taxes & fees
7 Feb - 8 Feb
Hampton Inn Anderson/ Alliance Business Park
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Where to stay in Seneca

Find the best Seneca areas for the activities you enjoy most.

Downtown

City centre Seneca captures the essence of small-town Southern charm with its well-preserved railway heritage and historic brick buildings. Tree-lined streets lead to charming shops and local eateries housed in structures dating back to the 1800s. Ram Cat Alley's colourful murals tell stories of local history while the old courthouse square hosts community gatherings. This walkable district offers a peaceful retreat from big city life. Visitors can browse antique stores for railway memorabilia, sample authentic Southern comfort food, or explore the cultural exhibits at the Bertha Lee Strickland Museum. The nearby Lake Keowee provides outdoor recreation just minutes away.

Serenity Bay

Serenity Bay offers a peaceful retreat within Saxony Forest's coastal embrace. The quiet residential streets wind through mature trees, creating a tranquil atmosphere away from tourist crowds. Nature lovers can explore nearby Lake Keowee or enjoy the neighborhood's forest trails. The area perfectly balances woodland serenity with beach proximity. Visitors should plan for self-contained holiday rentals rather than hotels. While dining options are limited within the area, the natural surroundings provide ideal conditions for relaxation and outdoor recreation.

Pine Ridge Point

Lake Keowee's serene waters lap against the shores of Pine Ridge Point, a tranquil residential haven in Seneca. Private docks stretch into crystal-clear waters where boats gently bob. Towering pines create natural privacy between lakefront homes. Visitors enjoy peaceful mornings watching mist rise over the water. This area offers an authentic lakeside living experience without tourist crowds. Holiday rentals range from cosy cabins to luxury estates with private boat slips. Days revolve around swimming, fishing, and water sports on Lake Keowee. Nature trails wind through mature forests for hiking and birdwatching.

Indian Oaks

Indian Oaks offers a tranquil retreat in suburban Seneca where mature oak trees create natural canopies over peaceful residential streets. This family-oriented community provides an authentic glimpse into American suburban living without tourist crowds. Landscaped yards and community green spaces showcase South Carolina's native beauty. Visitors can enjoy quiet morning walks on spacious pavements while listening to birdsong. Lake Keowee lies just beyond the area boundaries for those seeking water activities. With minimal commercial presence, Indian Oaks delivers a genuinely restful experience away from urban bustle.

Stay near popular Seneca attractions

Learn more about Seneca

Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

Lake Keowee South Carolina

Top Seneca Hotel Reviews

More cheap stays in Seneca

Frequently asked questions

Where is the best place for a stay in Seneca?
Tru by Hilton Seneca Clemson is ranked highly by Expedia customers. This hotel offers free breakfast and free parking. Traveller reviews also recommend Hampton Inn & Suites Seneca-Clemson Area and Best Western Seneca-Clemson as top choices for your visit. See all available top hotels, or vacation rentals in Seneca.
If I need to cancel my hotel reservation in Seneca, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a reservation that's non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Seneca.
What's the best family accommodation in Seneca?
Fairfield Inn & Suites Seneca Clemson Univ Area is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Also, attractions in the area such as Ultimate Action Sports are fun for the whole family. Find more child-friendly accommodations in Seneca.
What is the top LGBTQ-friendly accommodation in Seneca?
Hampton Inn & Suites Seneca-Clemson Area is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi. Tru by Hilton Seneca Clemson is another good choice for your trip. See all available hotels listed as LGBTQ-friendly in Seneca.
What's the best dog-friendly hotel in Seneca?
Lakeside Lodge Clemson is a top hotel for people travelling with their pets, and offers a restaurant and a seasonal outdoor pool for its human guests. Other good choices for you and your pet's trip include Days Inn by Wyndham Seneca / Clemson Area and Tru by Hilton Seneca Clemson. See more pet-friendly hotel accommodations in Seneca.
What are some hotels with pools in Seneca?
Lakeside Lodge Clemson: Hotel located near Clemson University. Features free self parking, a seasonal outdoor pool and complimentary wireless Internet access. Hampton Inn & Suites Seneca-Clemson Area and Quality Inn Seneca Clemson Area US-123 are two additional hotels that feature an on-site pool. View all hotels with pools in Seneca.
What is staying in Seneca like?
Visitors to Seneca will definitely enjoy the sporting events, lakeside setting and university setting. Welcoming and scenic, this city also attracts tourists with its cafes. In Seneca, there are 289 hotels and other accommodation options to choose from. Find out more about Seneca.
What should I see while I'm in Seneca?
Cultural venues include The Gauntlet and Oconee Community Theatre. Natural beauty is on display at Keowee Reservoir, Lake Keowee and Lake Hartwell. Exploring the waterfront is a great activity, and Keowee Key Golf Course is one place to visit. Take a look at what more there is to see and do in Expedia's Seneca guide.
What's the seasonal weather in Seneca?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 8°C. Average annual precipitation for Seneca is 1565 mm.

Explore a world of travel with Expedia