A grand church interior with high vaulted ceilings, large columns, and a central altar.

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Check availability on Santo Spirito Spa Hotels

Next weekend
9 Oct - 11 Oct
In two weeks
16 Oct - 18 Oct

Our top choices for Santo Spirito hotels with a spa

A room with a bed, a tray with teapots, a window with curtains, and a potted plant.

1. SPIRIT OF FLORENCE Boutique Rooms

SPIRIT OF FLORENCE Boutique Rooms
Historic Centre of Florence
10.0 out of 10, Exceptional, (27 reviews)
  • cleanliness
    Rejuvenate with deep-tissue or Swedish massages at this elegant B&B near Piazza Santo Spirito.
The price is ฿4,916
฿5,861 total
includes taxes & fees
2 Nov - 3 Nov
SPIRIT OF FLORENCE Boutique Rooms
A modern spa room with a couple in white robes, a massage table, and a wooden cabinet with a mirror.

2. Palazzo Montebello

Palazzo Montebello
4.0 star property
Historic Centre of Florence
9.2 out of 10, Wonderful, (1,001 reviews)
  • cleanliness
    Relax at this boutique Florentine hotel with on-site spa services, garden sanctuary, and individually decorated rooms with premium bedding.
The price is ฿5,706
฿6,806 total
includes taxes & fees
1 Nov - 2 Nov
Palazzo Montebello
A hotel entrance with a glass facade, a red carpet, and a ceiling with circular patterns.

3. Grand Hotel Adriatico

Grand Hotel Adriatico
4.0 star property
Historic Centre of Florence
8.8 out of 10, Excellent, (1,001 reviews)
  • cleanliness
    Riverside hotel spa offers couples treatments, massage rooms, and garden views, ideal for a serene wellness retreat in Florence.
The price is ฿6,318
฿7,479 total
includes taxes & fees
3 Nov - 4 Nov
Grand Hotel Adriatico
A heated floor bath with a blue light, surrounded by dark stone flooring and a textured wall.

4. The Moon Boutique Hotel & Spa

The Moon Boutique Hotel & Spa
4.0 star property
Historic Centre of Florence
9.6 out of 10, Exceptional, (607 reviews)
  • cleanliness
    Modern spa sanctuary in Florence with private treatment rooms and Turkish bath offers a rejuvenating escape in a Tuscan-style hotel.
The price is ฿5,137
฿6,179 total
includes taxes & fees
2 Nov - 3 Nov
The Moon Boutique Hotel & Spa
A sauna with wooden walls and benches.

5. Hotel Spadai

Hotel Spadai
4.0 star property
Historic Centre of Florence
9.8 out of 10, Exceptional, (1,002 reviews)
  • cleanliness
    Serene spa retreat in central Florence offers rejuvenating treatments in luxurious surroundings.
The price is ฿11,640
฿13,333 total
includes taxes & fees
3 Nov - 4 Nov
Hotel Spadai
A bathtub with white flowers floating on the water.

6. The St. Regis Florence

The St. Regis Florence
5.0 star property
Historic Centre of Florence
9.6 out of 10, Exceptional, (280 reviews)
  • cleanliness
    Riverside spa retreat offers deep-tissue massages and aromatherapy in Florence's art-filled heart.
The price is ฿43,264
฿48,195 total
includes taxes & fees
1 Nov - 2 Nov
The St. Regis Florence
A hotel lobby with a checkered floor, green walls, and a reception desk with a green cabinet and a statue.

7. Hotel La Gemma

Hotel La Gemma
5.0 star property
Historic Centre of Florence
9.6 out of 10, Exceptional, (255 reviews)
  • cleanliness
    Unwind in Florence at this luxury hotel's Allure Spa offering couples treatments, steam room, and sauna escapes.
The price is ฿25,796
฿28,982 total
includes taxes & fees
30 Oct - 31 Oct
Hotel La Gemma
A room with a patterned tiled floor, two leopard print chairs, a wooden table with a candle, and a wooden cabinet.

8. Hotel Adler Cavalieri

Hotel Adler Cavalieri
4.0 star property
Historic Centre of Florence
8.6 out of 10, Excellent, (612 reviews)
The price is ฿5,532
฿6,614 total
includes taxes & fees
2 Nov - 3 Nov
Hotel Adler Cavalieri
A modern bathroom with a large glass window overlooking the ocean.

9. Helvetia & Bristol Firenze – Starhotels Collezione

Helvetia & Bristol Firenze – Starhotels Collezione
5.0 star property
Historic Centre of Florence
9.2 out of 10, Wonderful, (577 reviews)
  • cleanliness
    Rejuvenate in this luxury Florentine boutique hotel with 4 treatment rooms and a traditional Turkish bath, steps from Ponte Vecchio.
The price is ฿18,198
฿20,623 total
includes taxes & fees
2 Nov - 3 Nov
Helvetia & Bristol Firenze – Starhotels Collezione
A hotel room with a bed, a bedside table, a wall-mounted light fixture, and a door leading to another room.

10. Tivoli Palazzo Gaddi Firenze Hotel

Tivoli Palazzo Gaddi Firenze Hotel
5.0 star property
Historic Centre of Florence
9.6 out of 10, Exceptional, (315 reviews)
The price is ฿12,258
฿14,088 total
includes taxes & fees
1 Nov - 2 Nov
Tivoli Palazzo Gaddi Firenze Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Santo Spirito

Pool
Breakfast included

Top Santo Spirito Hotel Reviews

Frequently asked questions

Looking to holiday at a spa hotel in Santo Spirito?
Treat yourself to some time in a luxurious spa hotel and you won't regret it. Travellers like the riverfront in Santo Spirito. Take in the culture at the art galleries and monuments during your stay. Spa hotels are a great way to break away from your daily routine and add a layer of luxury to your stay.
What is the best spa hotel in Santo Spirito?
Della Calza Spa & Foresteria is a top spa hotel featuring a bar, an indoor pool and a restaurant. Spend an afternoon at the spa where you'll find facials, body treatments and couples treatments.
How many spa hotels are there in Santo Spirito?
Among Expedia's 474 accommodation options in Santo Spirito, there is 1 spa hotel.
What's there to see and do in Santo Spirito?
Experience all that Santo Spirito has to offer when you visit Piazza Santo Spirito, Santo Spirito Basilica and Arno River. If you have extra time while you're in the area, you might want to see Torrigiani Garden and Piazza del Carmine.
What is a Santo Spirito spa hotel?
Spa hotels in Santo Spirito have full on-site spas and offer services including facials and a selection of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation and relaxation.