Santo Antonio Packages (Flight + Hotel)
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ฿27,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Where to stay in Santo Antonio
Find the best Santo Antonio areas and neighborhoods for the activities you enjoy most. Learn more about Santo Antonio
Manaus Centro
2 out of top 10 points of interest in this area
Manaus Centro is noteworthy for its theatres, and you can make a stop at top attractions like Teatro Amazonas and Palacio Rio Negro.
Ponta Negra
1 out of top 10 points of interest in this area
Visitors to Ponta Negra enjoy its river views, and if you want to do some exploring, Ponta Negra Beach is worth a stop.
Adrianopolis
1 out of top 10 points of interest in this area
Visitors to Adrianopolis enjoy its shopping, and if you want to do some exploring, Manauara Shopping is worth a stop.
Cidade Nova Manaus
While Cidade Nova Manaus isn't home to many top sights, Amazon Arena and Archipelago of Anavilhanas are some notable places to visit nearby.
Industrial District
1 out of top 10 points of interest in this area
Industrial District is noteworthy for its restaurants, and you can make a stop at top attractions like Studio 5 Festival Mall Manaus and Convention Center and Povos da Amazonia Cultural Center.
Top hotels in Santo Antonio
Da Vinci Hotel & Conventions by Easy Hotéis
Rua Belo Horizonte, 240A - Adrianopolis Manaus AM
Fully refundableReserve now, pay when you stay
฿1,937
฿1,976 total
25 Oct - 26 Oct
includes taxes & fees
Hotel Intercity Manaus
Rua Professor Marciano Armond, 544 Manaus AM
฿2,451
฿2,500 total
15 Nov - 16 Nov
includes taxes & fees
Hotel Express Vieiralves
Rua Rio Branco, s/n Manaus AM
Fully refundableReserve now, pay when you stay
฿1,549
฿1,580 total
18 Oct - 19 Oct
includes taxes & fees
8.4/10 Very good! (1,001 reviews)
"Nice breakfast and restaurant"
Reviewed on 24 Sept 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Santo Antonio holiday package cost?
Browse and book everything in one place with our Santo Antonio holiday packages, which start from a low . Choose the hotels and flights that match your travel plans. Then, add on one or two experiences or tours for a memorable escape.
How do I get a cheap travel package to Santo Antonio?
If you love amazing deals, bundle your bookings into a Santo Antonio holiday package. Whether you're searching for hotels, flights, tours or rental cars, you can book everything in one place. You'll have ample choice at your fingertips as well. Expedia has more than 550 airlines and 1,000,000 hotels worldwide to choose from. Fly with who you prefer, stay anywhere you like and save a pretty penny — now that's the perfect escape!
Where should I stay in Santo Antonio?
Most visitors who travel to Santo Antonio put both Teatro Amazonas and Amazon Arena on their to-do lists. Why not reserve a hotel close to one of these fantastic attractions?
How far in advance should I book my Santo Antonio holiday?
Your best bet is to book early. Airlines usually release flights nearly 12 months in advance, and this is an ideal opportunity to score some of the lowest prices. Boss just told you to take all your holiday days next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at an affordable price.
What does an Expedia Santo Antonio travel package include?
Hotels, rental cars and flights — we've got them all. With Expedia, you can shape your Santo Antonio package just how you like it. All you have to do is decide exactly what you need. Once you've made your booking, you can add extras like tours and activities. The more you bundle, the greater the savings!
What should I know before booking a Santo Antonio travel package?
So many places to venture to, so many things to see. With a package, you can cross more of them off your list. Combine your flights, hotels and rental cars and get ready to save.
Can I choose my airline with a Santo Antonio Expedia holiday package?
With a holiday package, you're the boss. Whether you're eager to fly to Santo Antonio in economy or first class, simply pick from the available airline options. Expedia has access to more than 550 partner airlines around the world.
If I'm not able to travel, can I cancel my Santo Antonio holiday package?
If your travel plans in Santo Antonio have been upended, it's a relief to know that it is possible to cancel or amend your booking. If your booking was made in the last 24 hours, you may be able to get a refund. If your booking was made more than 24 hours ago, your hotel, airline or car rental company may impose fees. For more information, check our Customer Service Portal.
Things to do
Manaus: MUSA and INPA Museums with Observation Tower Tour
฿2,170
per adult
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.