Santa Ana Travel Guide

Panama City

A gazebo with columns, a large tree with hanging roots, and a building in the background.
A waterfront cityscape with numerous boats docked along the shore and a clear sky.

Stay near popular Santa Ana attractions

El Machetazo Santa Ana

You can browse for the perfect souvenirs at El Machetazo Santa Ana during your visit to Panama City. Amble around the area's parks or visit its shops.
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Things to do

Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

฿1,721
per adult
98% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
Panama City: POIN Swing Experience

Panama City: POIN Swing Experience

฿1,062
per adult
100% of travellers recommend
Panama City: POIN Swing Experience
Panama City: Poin Glass Observation Deck Ticket with VR Tour

Panama City: Poin Glass Observation Deck Ticket with VR Tour

฿1,062
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
Panama City: Self-Guided Bike Rental with Digital Map

Panama City: Self-Guided Bike Rental with Digital Map

฿497
per adult
Panama City: Self-Guided Bike Rental with Digital Map
MiraLift

Transfer to Panama Canal (Miraflores Locks)

฿463
per adult
100% of travellers recommend
Transfer to Panama Canal (Miraflores Locks)
Swing on the Panama City Skyline

Swing on the Panama City Skyline

฿1,062
per adult
100% of travellers recommend
Swing on the Panama City Skyline
See all activities in Panama City

Top hotels in Santa Ana

Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste Panama City Provincia de Panamá
The price is ฿2,117 per night from 25 Aug to 26 Aug
฿2,117
฿3,309 total
25 Aug - 26 Aug
includes taxes & fees
Stay at this business-friendly condo in Panama City. Enjoy free Wi-Fi, breakfast (surcharge) and a 24-hour front desk. Popular attractions Albrook Shopping Mall ...
Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
The price is ฿4,497 per night from 15 Sept to 16 Sept
฿4,497
฿4,946 total
15 Sept - 16 Sept
includes taxes & fees
Stay at this luxury hotel in Panama City. Enjoy free breakfast, free Wi-Fi and 3 restaurants. Our guests praise the breakfast and the pool in their reviews. ...
Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
The price is ฿4,116 per night from 21 Sept to 22 Sept
฿4,116
฿4,744 total
21 Sept - 22 Sept
includes taxes & fees
Stay at this family-friendly hotel in Tocumen. Enjoy free Wi-Fi, breakfast (surcharge) and a free airport shuttle. Our guests praise the breakfast and the pool ...
8.6/10 Excellent! (2,710 reviews)
"Toute"

Reviewed on 23 Aug 2026

Crowne Plaza Panama Airport by IHG
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Plaza de la Independencia Casco Viejo Panama City Panama
The price is ฿5,992 per night from 22 Sept to 23 Sept
฿5,992
฿6,591 total
22 Sept - 23 Sept
includes taxes & fees
Stay at this spa hotel in Panama City. Enjoy free Wi-Fi, a full-service spa and 3 restaurants. Our guests praise the helpful staff and the clean rooms in their ...
Central Hotel Panama Casco Viejo
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz Veracruz Panama
The price is ฿8,894 per night from 25 Aug to 26 Aug
฿8,894
฿8,894 total
25 Aug - 26 Aug
includes taxes & fees
Stay at this beach resort in Veracruz. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the pool and the helpful staff in their reviews. ...
7.6/10 Good! (1,079 reviews)
"Room service took too long and usually arrived cold. More lunch time options would be nice. A more diversified seafood menu would also have been appreciated."

Reviewed on 23 Aug 2026

Dreams Playa Bonita Panama - All Inclusive
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
The price is ฿6,406 per night from 5 Sept to 6 Sept
฿6,406
฿7,046 total
5 Sept - 6 Sept
includes taxes & fees
Stay at this luxury hotel in Panama City. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their reviews. ...
8.4/10 Very good! (1,691 reviews)
"Service was great !!"

Reviewed on 24 Aug 2026

Megapolis Hotel Panamá
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Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.
A coastal cityscape with buildings, a hill with a church, and a clear blue sky.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A spiraling skyscraper against a clear blue sky.
Photo by My World
Open Photo by My World

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

A bridge over a body of water with several boats.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

A coastal cityscape with high-rise buildings, a calm sea, and a rocky shoreline.

Calidonia

Calidonia is a destination travellers like for its shopping, and you might hop aboard the metro at Lotería Station or Santo Tomás Station to explore sights like Via Espana.

Santa Ana Travel Guide