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Check prices for these dates

Tonight
22 Aug - 23 Aug
Tomorrow
23 Aug - 24 Aug
Next weekend
28 Aug - 30 Aug
In two weeks
4 Sep - 6 Sep

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Our top choices for Mississippi River hotels

1. The Eagles Nest Inn

The Eagles Nest Inn
14.2 km from Mississippi River
United States
Gary
฿3,675
฿4,173 total
includes taxes & fees
23 Aug - 24 Aug
The Eagles Nest Inn

2. River's Edge Motel

River's Edge Motel
13.6 km from Mississippi River
United States
Payton
฿2,614
฿2,967 total
includes taxes & fees
23 Aug - 24 Aug
River's Edge Motel

3. Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
30.3 km from Mississippi River
United States
Steve
฿3,860
฿4,491 total
includes taxes & fees
13 Sept - 14 Sept
Sleep Inn & Suites Hannibal West

4. Best Western On The River

Best Western On The River
25.3 km from Mississippi River
United States
Carolyn
฿3,920
฿4,522 total
includes taxes & fees
29 Aug - 30 Aug
Best Western On The River

5. Heritage Hotel Quincy

Heritage Hotel Quincy
47.8 km from Mississippi River
United States
Dustine
฿2,290
฿2,610 total
includes taxes & fees
23 Aug - 24 Aug
Heritage Hotel Quincy

6. Oak Hill Inn & Suites

Oak Hill Inn & Suites
71.8 km from Mississippi River
United States
Candace
฿3,308
฿3,770 total
includes taxes & fees
23 Aug - 24 Aug
Oak Hill Inn & Suites

7. Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
30 km from Mississippi River
United States
Patricia
฿2,258
฿2,627 total
includes taxes & fees
30 Aug - 31 Aug
Quality Inn & Suites Hannibal West

8. Lighthouse Inn & Suites

Lighthouse Inn & Suites
25.8 km from Mississippi River
United States
Kari
฿5,864
฿6,764 total
includes taxes & fees
23 Aug - 24 Aug
Lighthouse Inn & Suites

9. Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
93.3 km from Mississippi River
United States
Serah
฿3,646
฿4,392 total
includes taxes & fees
20 Sept - 21 Sept
Holiday Inn Express & Suites St Peters by IHG

10. Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
95.3 km from Mississippi River
United States
Melanie
฿3,593
฿4,131 total
includes taxes & fees
30 Aug - 31 Aug
Drury Inn & Suites St. Louis St. Peters

11. Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown
47.8 km from Mississippi River
United States
leon
฿3,935
฿4,485 total
includes taxes & fees
22 Sept - 23 Sept
Quality Inn & Suites Quincy - Downtown

12. Stoney Creek Inn Quincy

Stoney Creek Inn Quincy
46.5 km from Mississippi River
United States
Axel
฿3,823
฿4,357 total
includes taxes & fees
13 Sept - 14 Sept
Stoney Creek Inn Quincy

13. The Green Tree Inn

The Green Tree Inn
95 km from Mississippi River
United States
Vernon
฿7,008
฿7,781 total
includes taxes & fees
28 Aug - 29 Aug
The Green Tree Inn

14. Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
26.2 km from Mississippi River
United States
Tracey
฿2,617
฿3,116 total
includes taxes & fees
23 Aug - 24 Aug
Comfort Inn & Suites - Hannibal

15. Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG
46.1 km from Mississippi River
United States
Debra
฿3,790
฿4,320 total
includes taxes & fees
20 Sept - 21 Sept
Holiday Inn Quincy East by IHG

16. Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
26.3 km from Mississippi River
United States
Barbara
฿1,944
฿2,242 total
includes taxes & fees
23 Aug - 24 Aug
Super 8 by Wyndham Hannibal

17. Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
26.1 km from Mississippi River
United States
Erik
฿1,895
฿2,185 total
includes taxes & fees
24 Aug - 25 Aug
Motel 6 Hannibal, MO

18. Courtyard by Marriott St. Louis St. Peters

Courtyard by Marriott St. Louis St. Peters
97.2 km from Mississippi River
United States
Krischel
฿3,940
฿4,732 total
includes taxes & fees
1 Sept - 2 Sept
Courtyard by Marriott St. Louis St. Peters

19. Holiday Inn Express and Suites Alton St Louis Area by IHG

Holiday Inn Express and Suites Alton St Louis Area by IHG
110.6 km from Mississippi River
United States
Thomas
฿3,876
฿4,418 total
includes taxes & fees
20 Sept - 21 Sept
Holiday Inn Express and Suites Alton St Louis Area by IHG

20. TownePlace Suites by Marriott Wentzville

TownePlace Suites by Marriott Wentzville
86.6 km from Mississippi River
United States
Adrian
฿4,998
฿5,891 total
includes taxes & fees
30 Aug - 31 Aug
TownePlace Suites by Marriott Wentzville
View all properties

Compare popular hotels close to Mississippi River

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Restaurant
The Eagles Nest Inn
9.4
Exceptional
26 reviews
View
Property grounds
River's Edge Motel
9.0
Wonderful
384 reviews
View
Exterior
Sleep Inn & Suites Hannibal West
9.6
Exceptional
1,002 reviews
View
Room
Best Western On The River
8.6
Excellent
1,006 reviews
View
Breakfast area
Heritage Hotel Quincy
8.8
Excellent
438 reviews
View

Top Mississippi River Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent
"Property was excellent. Kickback was amazing"
Mike 1-night trip
Posted less than an hour ago
Drury Plaza Hotel St. Louis at the Arch
Moonrise Hotel

Moonrise Hotel

8/10 Good
"The desk staff was very friendly. The room was clean and comfortable. Just don't get a room by the elevator. You'll hear it going up and down constantly. It is a great place if you're seeing a show at the Pageant. A head's up if want to eat after a show. Most places close or stop serving food at 10:00. I thought that was odd for a Friday night. Even the hotel bar stopped serving food at 10. My husband finally find a little place around the corner for a sandwich."
Jacqueline 1-night trip
Posted 1 hour ago
Moonrise Hotel
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

8/10 Good
"Really enjoyed my stay. Everything was clean and the staff were very professional."
Allen 1-night trip
Posted 1 hour ago
Renaissance St. Louis Airport Hotel
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

10/10 Excellent
"Great location!"
Megan 1-night trip
Posted 1 hour ago
Hyatt Regency St. Louis at The Arch
Drury Inn & Suites St. Louis Airport

Drury Inn & Suites St. Louis Airport

10/10 Excellent
"Amazing staff&stay. Great location near UMSL- what a way to give a parent ease for freshman drop off!!! Thank you"
Candace 2-night trip
Posted 1 hour ago
Drury Inn & Suites St. Louis Airport
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

10/10 Excellent
"We were traveling with 2 kids. The pool was awesome-salt, I believe. They even had pool noodles! The breakfast was like a restaurant; buffet and made to order, all included. Parking in the ramp was literally in the back of the building with a hallway into the hotel, super easy. Do eat or bring food back bc delivery and availability in the area was limited. 3 cheeseburger baskets was $76 with fees. Otherwise, easy to get to the zoo and other attractions."
carrie 2-night trip
Posted 3 hours ago
Clayton Plaza Hotel & Extended Stay
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

10/10 Excellent
"Very hospitable"
Renee 1-night trip
Posted 3 hours ago
Hollywood Casino & Hotel St. Louis
Live by Loews - St.Louis

Live by Loews - St.Louis

10/10 Excellent
"Perfect location, great room, fabulous property overall. Highly recommend."
Amber 1-night trip
Posted 4 hours ago
Live by Loews - St.Louis
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

10/10 Excellent
"Good place"
Anurag 3-night trip
Posted 13 hours ago
Pear Tree Inn St. Louis Near Union Station

Other attractions near Mississippi River

Mark Twain Cave

8.8/10 (89 reviews)
You can find out about the history of Hannibal with a visit to Mark Twain Cave. While in this family-friendly area, you can savour the top-notch restaurants.
See properties

Sawyer's Creek Fun Park

7.8/10 (16 reviews)
Explore the great outdoors at Sawyer's Creek Fun Park, a lovely green space in Hannibal. While in this walkable area, you can savour the top-notch restaurants.
See properties

Lovers Leap

8.8/10 (171 reviews)
Find out about the history of Hannibal when you spend time at Lovers Leap. While in this walkable area, you can savour the top-notch restaurants.
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Sodalis Nature Preserve

Explore the great outdoors at Sodalis Nature Preserve, a lovely green space in Hannibal. While in this family-friendly area, you can savour the top-notch restaurants.
See properties

Bluff City Theater

7.6/10 (5 reviews)
Get tickets for a show at Bluff City Theater, a theatre with a story to tell in Hannibal. While in this walkable area, you can savour the top-notch restaurants.
See properties

Planters Barn Theater

8.8/10 (22 reviews)
Get tickets for a show at Planters Barn Theater, a popular theatre in Hannibal. While in this walkable area, you can savour the top-notch restaurants.
See properties

Big River Train Town

8.0/10 (25 reviews)
You can browse the exhibits at Big River Train Town, a museum with a story of its own, during your travels to Hannibal. While in this family-friendly area, you can savour the top-notch restaurants.
See properties

Mark Twain Boyhood Home and Museum

9.0/10 (278 reviews)
Find out about the history of Hannibal with a stop at Mark Twain Boyhood Home and Museum. While in this walkable area, you can savour the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best hotel to stay close to Mississippi River?
Hollywood Casino & Hotel St. Louis is one of the top choices for your stay based on our traveller data, and this hotel offers a casino and 7 restaurants. You'll find it 65.7 mi (105.7 km) from Mississippi River. Other good options around the area include Hyatt Regency St. Louis at The Arch and Clayton Plaza Hotel & Extended Stay.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.