A vibrant mural on a building, depicting a large figure with a heart-shaped halo, surrounded by various characters in colorful attire.

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Check availability on Mission District Luxury Hotels

This weekend
28 Aug - 30 Aug
Next weekend
4 Sep - 6 Sep

Our top choices for Mission District luxury hotels

A spacious lobby with large windows, a seating area with a sofa and chairs, and a counter with a coffee station.

1. LUMA Hotel San Francisco

LUMA Hotel San Francisco
4.0 star property
Downtown San Francisco
9.6 out of 10, Exceptional, (2,586 reviews)
The price is ฿6,953
฿8,183 total
includes taxes & fees
18 Sept - 19 Sept
LUMA Hotel San Francisco
A modern building facade with vertical wooden slats, a glass entrance, and a sign reading "La Société Bar & Cafe".

2. Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA
4.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (1,264 reviews)
The price is ฿5,293
฿7,541 total
includes taxes & fees
18 Sept - 19 Sept
Hyatt Regency San Francisco Downtown SOMA
A modern interior with a fireplace, sofas, a coffee table, and a bookshelf.

3. Grand Hyatt San Francisco

Grand Hyatt San Francisco
4.0 star property
Union Square
9.0 out of 10, Wonderful, (1,005 reviews)
The price is ฿4,967
฿7,404 total
includes taxes & fees
18 Sept - 19 Sept
Grand Hyatt San Francisco
A modern bar area with a curved ceiling and large windows offering a city view.

4. San Francisco Marriott Marquis

San Francisco Marriott Marquis
4.0 star property
Downtown San Francisco
8.8 out of 10, Excellent, (1,232 reviews)
The price is ฿5,281
฿7,704 total
includes taxes & fees
4 Sept - 5 Sept
San Francisco Marriott Marquis
A luxurious interior with a round dining table, green upholstered seating, and a central fountain.

5. The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square
4.5 star property
Union Square
8.8 out of 10, Excellent, (2,238 reviews)
  • cleanliness
    Historic luxury in Union Square with fitness centre, fine dining, and concierge services.
The price is ฿7,612
฿10,437 total
includes taxes & fees
11 Sept - 12 Sept
The Westin St. Francis San Francisco on Union Square
A rooftop terrace with tables and potted plants, overlooking a cityscape with a prominent tower and a bridge.

6. Four Seasons Hotel San Francisco at Embarcadero

Four Seasons Hotel San Francisco at Embarcadero
5.0 star property
Downtown San Francisco
9.6 out of 10, Exceptional, (1,001 reviews)
  • cleanliness
    Spectacular luxury in San Francisco with breathtaking city views, pillowtop beds, and personalised turndown service.
The price is ฿14,776
฿17,390 total
includes taxes & fees
18 Sept - 19 Sept
Four Seasons Hotel San Francisco at Embarcadero
A modern hotel with a sleek exterior and a parked sports car in front.

7. Hotel VIA

Hotel VIA
4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (1,575 reviews)
The price is ฿7,071
฿8,322 total
includes taxes & fees
3 Sept - 4 Sept
Hotel VIA
A spacious lobby with modern seating, a large abstract sculpture, and a high ceiling with linear lighting.

8. Hyatt Regency San Francisco

Hyatt Regency San Francisco
4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (2,440 reviews)
The price is ฿6,542
฿9,210 total
includes taxes & fees
30 Aug - 31 Aug
Hyatt Regency San Francisco
A hotel room with a large window, a sofa, two armchairs, a coffee table, a lamp, and a TV.

9. InterContinental San Francisco by IHG

InterContinental San Francisco by IHG
4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (1,094 reviews)
  • cleanliness
    Unwind in city centre SF sophistication with Michelin-star dining, health club, and indoor pool sanctuary.
The price is ฿5,851
฿8,744 total
includes taxes & fees
3 Sept - 4 Sept
InterContinental San Francisco by IHG
A high-rise room with a city view, a sofa, two chairs, a small table, and a patterned rug.

10. Hilton San Francisco Union Square

Hilton San Francisco Union Square
4.0 star property
Union Square
8.6 out of 10, Excellent, (1,628 reviews)
The price is ฿5,634
฿6,631 total
includes taxes & fees
11 Sept - 12 Sept
Hilton San Francisco Union Square
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mission District Hotel Reviews

Club Quarters Hotel Embarcadero, San Francisco

Club Quarters Hotel Embarcadero, San Francisco

10/10 Excellent
"Very clean rooms"
Luke 5-night trip
Posted 3 hours ago
Club Quarters Hotel Embarcadero, San Francisco

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Mission District?
Use Expedia to arrange your flight to San Francisco International Airport (SFO) airport or Oakland, CA (OAK-Oakland Intl.) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are an important consideration when you plan a holiday, so we make it easy to find what you'd like to make your stay relaxing and comfortable. If you want a posh hotel that has a spa, an indoor pool or luxury bedding, Expedia can help you find the best luxury hotel experience that Mission District offers. During your visit, you might want to enjoy the bars which Mission District is known for.
What's there to see and do in Mission District?
Take in the sights and attractions that Mission District offers with a visit to SOMA Pilipinas, Southern Exposure and San Francisco Public Library. If you have spare time during your trip, you might want to make a stop at SF Armory and Mission San Francisco de Asís.
How can I get around Mission District?
It's easier to get around town comfortably when you know your options. Walk to nearby metro stations such as 16th Street Mission Station, 24th Street Mission Station and Right Of Way/20th St Stop.