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Check prices for these dates

Next weekend
23 Oct - 25 Oct
In two weeks
30 Oct - 1 Nov

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Our top choices for Lake Nona Medical City hotels

A swimming pool with sun loungers and palm trees.

1. Courtyard Orlando Lake Nona

Courtyard Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (663 reviews)
"We had an amazing stay! Room was so nice and the perfect location! I dropped off balloons a day early to have in the room as a birthday surprise and the staff was so accommodating and nice! Shout out to Stephen who was great!"
United States
Christine
The price is ฿5,983
฿6,798 total
includes taxes & fees
25 Oct - 26 Oct
Courtyard Orlando Lake Nona
Exterior

2. Aloft by Marriott Orlando Lake Nona

Aloft by Marriott Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (459 reviews)
"nice clean hotel, close to restaurants"
United States
Ali
The price is ฿4,646
฿5,279 total
includes taxes & fees
25 Oct - 26 Oct
Aloft by Marriott Orlando Lake Nona
A swimming pool with sun loungers and palm trees, surrounded by a modern building.

3. Residence Inn Orlando Lake Nona

Residence Inn Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (347 reviews)
"Hotel was very nice."
United States
Christine
The price is ฿6,651
฿7,558 total
includes taxes & fees
1 Nov - 2 Nov
Residence Inn Orlando Lake Nona
A modern restaurant with multiple dining tables and chairs, a bar area, and a television mounted on the wall.

4. Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport
3.0 star property
Airport North, 11.1 km from Lake Nona Medical City
8.8 out of 10, Excellent, (4,279 reviews)
"It was a nice clean place to stay. For another short trip I would definitely stay again."
United States
David Arturo
The price is ฿2,983
฿3,356 total
includes taxes & fees
26 Oct - 27 Oct
Wingate by Wyndham - Orlando International Airport
An outdoor patio area with seating, a bar, and a fire feature.

5. Hyatt House Orlando Airport

Hyatt House Orlando Airport
3.5 star property
Airport North, 10.5 km from Lake Nona Medical City
9.6 out of 10, Exceptional, (2,871 reviews)
"Great staff, good breakfast and excellent location."
United States
Gerardo
The price is ฿4,078
฿4,587 total
includes taxes & fees
2 Nov - 3 Nov
Hyatt House Orlando Airport
An outdoor seating area with green chairs and umbrellas, a fire pit, and a building with large windows in the background.

6. Hampton Inn & Suites Orlando Airport @ Gateway Village

Hampton Inn & Suites Orlando Airport @ Gateway Village
3.0 star property
Airport North, 10.6 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (2,897 reviews)
"Great place"
United States
Wakima
The price is ฿3,385
฿3,808 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn & Suites Orlando Airport @ Gateway Village
A modern lobby with a checkered carpet, seating area, and a reception desk.

7. Holiday Inn Express Orlando International Airport by IHG

Holiday Inn Express Orlando International Airport by IHG
2.5 star property
11.1 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (2,045 reviews)
"Perfect one night stay. The pool was great."
United States
Kara
The price is ฿3,510
฿3,948 total
includes taxes & fees
26 Oct - 27 Oct
Holiday Inn Express Orlando International Airport by IHG
A modern hotel room with a large bed, a nightstand, a drawer, a wall-mounted light, and a window with a view of trees.

8. Ramada by Wyndham Suites Orlando Airport

Ramada by Wyndham Suites Orlando Airport
3.0 star property
Airport North, 10.4 km from Lake Nona Medical City
8.2 out of 10, Very good, (6,173 reviews)
"It was a good stay, place was clean,"
United States
Andreia
The price is ฿2,557
฿2,877 total
includes taxes & fees
20 Oct - 21 Oct
Ramada by Wyndham Suites Orlando Airport
A modern hotel lobby with a large flat-screen TV, a blue sofa, a round wooden table, and a curved reception desk.

9. Cambria Hotel Orlando Airport

Cambria Hotel Orlando Airport
3.0 star property
11.1 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (2,003 reviews)
"Loved our stay, check in was super duper easy and the bed was soo comfy!"
United States
Seth
The price is ฿3,316
฿3,730 total
includes taxes & fees
16 Nov - 17 Nov
Cambria Hotel Orlando Airport
A spacious lobby with a wooden staircase, a reception desk, and a large wall clock.

10. Country Inn & Suites by Radisson, Orlando Airport, FL

Country Inn & Suites by Radisson, Orlando Airport, FL
3.0 star property
Airport North, 11 km from Lake Nona Medical City
8.0 out of 10, Very good, (5,056 reviews)
"I loved the proximity to the airport, the convenience of the surrounding area and the hotel shuttle and breakfast were an added bonus."
United States
RandaShay
The price is ฿2,585
฿2,909 total
includes taxes & fees
26 Oct - 27 Oct
Country Inn & Suites by Radisson, Orlando Airport, FL
A modern dining area with a large table, chairs, and a coffee station.

11. avid hotel Orlando International Airport by IHG

avid hotel Orlando International Airport by IHG
2.5 star property
11.2 km from Lake Nona Medical City
9.2 out of 10, Wonderful, (2,187 reviews)
"Clean and convenient to airport"
United States
Randall
The price is ฿3,242
฿3,648 total
includes taxes & fees
26 Oct - 27 Oct
avid hotel Orlando International Airport by IHG
A modern hotel with a red carpet leading to the entrance, a wooden walkway, and a clear view of the building's facade.

12. EVEN Hotel Orlando International Airport by IHG

EVEN Hotel Orlando International Airport by IHG
3.5 star property
Airport North, 11.1 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (944 reviews)
"Great hotel. Will stay again"
United States
Alex
The price is ฿3,242
฿3,647 total
includes taxes & fees
25 Oct - 26 Oct
EVEN Hotel Orlando International Airport by IHG
A modern gym with treadmills, stationary bikes, and elliptical machines.

13. Wyndham Garden Orlando Airport

Wyndham Garden Orlando Airport
3.0 star property
Belle Isle, 11.9 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (4,218 reviews)
"Beautiful hotel and great amenities."
United States
Tonya
The price is ฿2,941
฿3,309 total
includes taxes & fees
26 Oct - 27 Oct
Wyndham Garden Orlando Airport
A hotel with a prominent tower, palm trees, and a red roof.

14. La Quinta Inn & Suites by Wyndham Orlando Airport

La Quinta Inn & Suites by Wyndham Orlando Airport
3.0 star property
Airport North, 10.9 km from Lake Nona Medical City
7.6 out of 10, Good, (2,852 reviews)
"Room perfect for us breakfast amazing"
United States
Ruthann
The price is ฿2,500
฿2,813 total
includes taxes & fees
18 Nov - 19 Nov
La Quinta Inn & Suites by Wyndham Orlando Airport
A hotel pool area with lounge chairs and umbrellas, surrounded by tall buildings and a sunset sky.

15. Drury Plaza Hotel Orlando - Disney Springs Area

Drury Plaza Hotel Orlando - Disney Springs Area
4.0 star property
22.9 km from Lake Nona Medical City
9.8 out of 10, Exceptional, (6,161 reviews)
"Always love staying here"
United States
Brianne
The price is ฿5,398
฿6,072 total
includes taxes & fees
30 Oct - 31 Oct
Drury Plaza Hotel Orlando - Disney Springs Area
A modern kitchen with wooden cabinets, a central island, and a breakfast bar.

16. Hampton Inn Orlando-International Airport

Hampton Inn Orlando-International Airport
2.5 star property
Airport North, 10.8 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (2,192 reviews)
"Great stay"
United States
Roosevelt
The price is ฿3,239
฿3,644 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn Orlando-International Airport
Room

17. Comfort Suites Orlando International Airport

Comfort Suites Orlando International Airport
2.5 star property
Belle Isle, 12 km from Lake Nona Medical City
8.4 out of 10, Very good, (1,351 reviews)
"Great place to stay"
United States
Sheryl
The price is ฿2,983
฿3,356 total
includes taxes & fees
27 Oct - 28 Oct
Comfort Suites Orlando International Airport
A hotel room with two beds, a flat-screen TV, a desk, and a lamp.

18. Sonesta Essential Orlando Airport

Sonesta Essential Orlando Airport
3.0 star property
12.2 km from Lake Nona Medical City
8.0 out of 10, Very good, (1,296 reviews)
"Great place to stay close to the airport. The breakfast was amazing,"
United States
ian
The price is ฿2,975
฿3,347 total
includes taxes & fees
20 Oct - 21 Oct
Sonesta Essential Orlando Airport
An aerial view of a resort with multiple swimming pools, landscaped gardens, and outdoor seating areas.

19. Rosen Shingle Creek

Rosen Shingle Creek
4.5 star property
16.9 km from Lake Nona Medical City
9.6 out of 10, Exceptional, (4,987 reviews)
"Amazing stay. Super clean, friendly staff, beautiful property"
United States
Kyla
The price is ฿3,984
฿4,482 total
includes taxes & fees
30 Oct - 31 Oct
Rosen Shingle Creek
A hotel pool area with lounge chairs and umbrellas, surrounded by palm trees and modern buildings.

20. Universal's Endless Summer Resort - Surfside Inn and Suites

Universal's Endless Summer Resort - Surfside Inn and Suites
3.0 star property
International Drive District, 21.3 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (2,766 reviews)
"Amazing staff, great location, comfy beds"
Canada
Mia
The price is ฿4,546
฿5,114 total
includes taxes & fees
3 Nov - 4 Nov
Universal's Endless Summer Resort - Surfside Inn and Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Hotels recommended for families in Lake Nona Medical City

Exterior

Aloft by Marriott Orlando Lake Nona

Aloft by Marriott Orlando Lake Nona
3.0 star property
Lake Nona
9.6 out of 10, Exceptional, (459)
The price is ฿4,646
฿5,279 total
includes taxes & fees
25 Oct - 26 Oct
Aloft by Marriott Orlando Lake Nona

Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas for the activities you enjoy most.
The entrance to the Hollywood Studios area with a large sign and distinctive architecture.
Photo by Gary Burke
Open Photo by Gary Burke

Bay Lake

Exciting theme parks plentiful wildlife and top sights from Epcot® to Walt Disney World® Resort – discover Bay Lake, a destination also famous for its entertainment.

A large Ferris wheel with blue lights, surrounded by a cityscape with illuminated buildings and a tall green tower.

International Drive District

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

A roller coaster at Universal Orlando Resort, featuring a tall palm tree and a clear blue sky.
Photo by Peter Sutton
Open Photo by Peter Sutton

Florida Center

If you're spending some time in Florida Center, Universal Orlando Resort and Universal Studios Florida are top sights worth seeing.

A large Ferris wheel with blue lighting, surrounded by a parking lot and buildings.

Champions Gate

Ample dining options and top golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.

A golf course with bunkers, water hazards, and a large lake.

Reunion

The top golf courses and fun-filled water parks are top of the list for many visitors to Reunion. A stop by Reunion Resort Golf Course or Jack Nicklaus Course might round out your trip.

Top Lake Nona Medical City Hotel Reviews

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

10/10 Excellent
"Great stay 5 stars"
Bryan 2-night trip
Posted less than an hour ago
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Frequently asked questions

What's it like in Lake Nona Medical City?
Lake Nona Medical City is a neighbourhood that travellers like for its restaurants.
What's the best accommodation in Lake Nona Medical City?
Based on Expedia customer reviews, Aloft Orlando Lake Nona is the highest ranked property in Lake Nona Medical City. This hotel offers a restaurant and an outdoor pool. Other favourite options in the area include Residence Inn Orlando Lake Nona and Courtyard Orlando Lake Nona.
How many hotels will I find in Lake Nona Medical City?
Expedia has 5 Lake Nona Medical City hotels and other accommodation options, and one might make a good home base for venturing out into the greater Orlando area.
If I need to cancel my hotel reservation in Lake Nona Medical City, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Lake Nona Medical City.
What is there to do around this Orlando neighbourhood?
Eagle Creek Golf Club, USTA National Campus and Austin-Tindall Regional Park are just a few of the places to visit in and around Lake Nona Medical City. When you're sightseeing around the area, Lake Hart and Kissimmee Bay Country Club are a couple of other sights to visit.