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21 Aug - 23 Aug
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28 Aug - 30 Aug

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Our top choices for Lake Nona Medical City hotels

A swimming pool with sun loungers and palm trees.

1. Courtyard Orlando Lake Nona

Courtyard Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (652 reviews)
"Convenience and great staff"
United States
William
The price is ฿4,832
฿5,490 total
includes taxes & fees
6 Sept - 7 Sept
Courtyard Orlando Lake Nona
A swimming pool with sun loungers and palm trees, surrounded by a modern building.

2. Residence Inn Orlando Lake Nona

Residence Inn Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (342 reviews)
"Outstanding service from customer service attention to room service. Impeccable team."
United States
Edwin
The price is ฿5,753
฿6,536 total
includes taxes & fees
6 Sept - 7 Sept
Residence Inn Orlando Lake Nona

3. Aloft by Marriott Orlando Lake Nona

Aloft by Marriott Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (436 reviews)
"Great stay"
United States
Melissa
The price is ฿4,569
฿5,192 total
includes taxes & fees
30 Aug - 31 Aug
Aloft by Marriott Orlando Lake Nona
A hotel atrium with a central fountain, palm trees, and a circular seating area.

4. Hyatt Regency Orlando International Airport

Hyatt Regency Orlando International Airport
4.0 star property
7.7 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (4,412 reviews)
"Very nice rooms and extremely convenient stay. "
United States
Gregory
The price is ฿5,884
฿6,620 total
includes taxes & fees
7 Sept - 8 Sept
Hyatt Regency Orlando International Airport
An outdoor patio area with seating, a bar, and a fire feature.

5. Hyatt House Orlando Airport

Hyatt House Orlando Airport
3.5 star property
Airport North, 10.5 km from Lake Nona Medical City
9.6 out of 10, Exceptional, (2,951 reviews)
"Staff was so kind and helpful; breakfast was great; airport shuttle awesome!"
United States
Suzanne
The price is ฿3,616
฿4,068 total
includes taxes & fees
30 Aug - 31 Aug
Hyatt House Orlando Airport
A Holiday Inn Express hotel with a covered entrance, palm trees, and a clear blue sky.

6. Holiday Inn Express Orlando International Airport by IHG

Holiday Inn Express Orlando International Airport by IHG
2.5 star property
11.1 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (2,049 reviews)
"Great place to stay, the staff is great sh"
Mexico
Isabella
The price is ฿2,890
฿3,252 total
includes taxes & fees
24 Aug - 25 Aug
Holiday Inn Express Orlando International Airport by IHG
An outdoor seating area with green chairs and umbrellas, a fire pit, and a building with large windows in the background.

7. Hampton Inn & Suites Orlando Airport @ Gateway Village

Hampton Inn & Suites Orlando Airport @ Gateway Village
3.0 star property
Airport North, 10.6 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (2,815 reviews)
"Very clean, great breakfast and amazing pool!!"
United States
andrea
The price is ฿2,938
฿3,305 total
includes taxes & fees
27 Aug - 28 Aug
Hampton Inn & Suites Orlando Airport @ Gateway Village
A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract artwork on the wall.

8. Hyatt Place Orlando Airport

Hyatt Place Orlando Airport
3.0 star property
Airport North, 11 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (1,860 reviews)
"Very friendly staff and clean rooms."
United States
Tyler
The price is ฿3,322
฿3,738 total
includes taxes & fees
26 Aug - 27 Aug
Hyatt Place Orlando Airport
A modern dining area with a large table, chairs, and a coffee station.

9. avid hotel Orlando International Airport by IHG

avid hotel Orlando International Airport by IHG
2.5 star property
11.2 km from Lake Nona Medical City
9.2 out of 10, Wonderful, (2,227 reviews)
"Nice staff and nice stay"
United States
Breana
The price is ฿2,792
฿3,141 total
includes taxes & fees
21 Sept - 22 Sept
avid hotel Orlando International Airport by IHG
A modern restaurant with multiple dining tables and chairs, a bar area, and a television mounted on the wall.

10. Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport
3.0 star property
Airport North, 11.1 km from Lake Nona Medical City
8.8 out of 10, Excellent, (4,180 reviews)
"The location was great for our purposes, close to the airport with restaurants and shopping within walking distance."
United States
Deisha
The price is ฿2,457
฿2,764 total
includes taxes & fees
6 Sept - 7 Sept
Wingate by Wyndham - Orlando International Airport
A modern hotel room with a large bed, a nightstand, a drawer, a wall-mounted light, and a window with a view of trees.

11. Ramada by Wyndham Suites Orlando Airport

Ramada by Wyndham Suites Orlando Airport
3.0 star property
Airport North, 10.4 km from Lake Nona Medical City
8.4 out of 10, Very good, (6,066 reviews)
"we loved the proximity to the airport, nice restaurants. staff were very friendly and breakfast was nice"
United States
Dwayne
The price is ฿2,596
฿2,921 total
includes taxes & fees
20 Sept - 21 Sept
Ramada by Wyndham Suites Orlando Airport
A modern bar area with marble countertops, a variety of liquor bottles, and a large screen displaying financial information.

12. Holiday Inn Orlando International Airport by IHG

Holiday Inn Orlando International Airport by IHG
3.5 star property
Airport North, 10.8 km from Lake Nona Medical City
8.4 out of 10, Very good, (1,527 reviews)
"The hotel was beautiful and staff was very friendly. Definitely would stay again. Location great."
United States
Latonia
The price is ฿2,956
฿3,326 total
includes taxes & fees
21 Sept - 22 Sept
Holiday Inn Orlando International Airport by IHG
A modern hotel lobby with a large flat-screen TV, a blue sofa, a round wooden table, and a curved reception desk.

13. Cambria Hotel Orlando Airport

Cambria Hotel Orlando Airport
3.0 star property
11.1 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (1,984 reviews)
"Very nice hotel"
United States
Juan
The price is ฿3,046
฿3,426 total
includes taxes & fees
10 Sept - 11 Sept
Cambria Hotel Orlando Airport
A modern hotel with a glass facade, palm trees, and a sign reading "DoubleTree by Hilton."

14. DoubleTree by Hilton Orlando Airport

DoubleTree by Hilton Orlando Airport
4.0 star property
Airport North, 11.2 km from Lake Nona Medical City
8.6 out of 10, Excellent, (2,632 reviews)
"Hotel smells amazing, the staff are so friendly and helpful, hotel location was everything!"
United States
LaShawn
The price is ฿3,216
฿3,618 total
includes taxes & fees
13 Sept - 14 Sept
DoubleTree by Hilton Orlando Airport
A modern gym with treadmills, stationary bikes, and elliptical machines.

15. Wyndham Garden Orlando Airport

Wyndham Garden Orlando Airport
3.0 star property
Belle Isle, 11.9 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (4,150 reviews)
"Great place to stay"
United States
Gabriel
The price is ฿2,759
฿3,104 total
includes taxes & fees
20 Sept - 21 Sept
Wyndham Garden Orlando Airport
A modern hotel with a red carpet leading to the entrance, a wooden walkway, and a clear view of the building's facade.

16. EVEN Hotel Orlando International Airport by IHG

EVEN Hotel Orlando International Airport by IHG
3.5 star property
Airport North, 11.1 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (767 reviews)
"Good Hotel near the airport"
United States
Marlon
The price is ฿2,923
฿3,289 total
includes taxes & fees
20 Sept - 21 Sept
EVEN Hotel Orlando International Airport by IHG
A modern kitchen with wooden cabinets, a central island, and a breakfast bar.

17. Hampton Inn Orlando-International Airport

Hampton Inn Orlando-International Airport
2.5 star property
Airport North, 10.8 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (2,126 reviews)
"Nice stay."
United States
Tammy
The price is ฿2,803
฿3,154 total
includes taxes & fees
31 Aug - 1 Sept
Hampton Inn Orlando-International Airport
A spacious lobby with a wooden staircase, a reception desk, and a large wall clock.

18. Country Inn & Suites by Radisson, Orlando Airport, FL

Country Inn & Suites by Radisson, Orlando Airport, FL
3.0 star property
Airport North, 11 km from Lake Nona Medical City
7.8 out of 10, Good, (4,902 reviews)
"Fantastic stay."
United States
Adley
The price is ฿2,541
฿2,858 total
includes taxes & fees
6 Sept - 7 Sept
Country Inn & Suites by Radisson, Orlando Airport, FL
A modern living room with a stone fireplace, a sofa, a coffee table, and a lamp.

19. Fairfield Inn By Marriott Orlando Airport

Fairfield Inn By Marriott Orlando Airport
3.5 star property
Airport North, 10.8 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (2,609 reviews)
"Excelente Hotel!"
United States
Gary
The price is ฿2,764
฿3,109 total
includes taxes & fees
6 Sept - 7 Sept
Fairfield Inn By Marriott Orlando Airport
A hotel with a prominent tower, palm trees, and a red roof.

20. La Quinta Inn & Suites by Wyndham Orlando Airport

La Quinta Inn & Suites by Wyndham Orlando Airport
3.0 star property
Airport North, 10.9 km from Lake Nona Medical City
7.4 out of 10, Good, (2,580 reviews)
"Wonderful stay"
United States
Maria
The price is ฿2,339
฿2,631 total
includes taxes & fees
21 Sept - 22 Sept
La Quinta Inn & Suites by Wyndham Orlando Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas for the activities you enjoy most.
The entrance to the Hollywood Studios area with a large sign and distinctive architecture.
Photo by Gary Burke
Open Photo by Gary Burke

Bay Lake

Exciting theme parks plentiful wildlife and top sights from Epcot® to Walt Disney World® Resort – discover Bay Lake, a destination also famous for its entertainment.

The entrance to Aquatica with colorful signage and a water slide.

International Drive District

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

A golf course with bunkers, water hazards, and a large lake.

Reunion

The top golf courses and fun-filled water parks are top of the list for many visitors to Reunion. A stop by Reunion Resort Golf Course or Jack Nicklaus Course might round out your trip.

A roller coaster at Universal Orlando Resort, featuring a tall palm tree and a clear blue sky.
Photo by Peter Sutton
Open Photo by Peter Sutton

Florida Center

If you're spending some time in Florida Center, Universal Orlando Resort and Universal Studios Florida are top sights worth seeing.

A large Ferris wheel with blue lighting, surrounded by a parking lot and buildings.

Champions Gate

Ample dining options and top golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.

Top Lake Nona Medical City Hotel Reviews

Lake Buena Vista Resort Village & Spa

Lake Buena Vista Resort Village & Spa

10/10 Excellent
"Staff was amazing"
Yanique 2-night trip
Posted 1 hour ago
Lake Buena Vista Resort Village & Spa

Frequently asked questions

What's it like in Lake Nona Medical City?
Lake Nona Medical City is a neighbourhood that travellers like for its restaurants.
What's the best accommodation in Lake Nona Medical City?
Based on Expedia customer reviews, Aloft Orlando Lake Nona is the highest ranked property in Lake Nona Medical City. This hotel offers a restaurant and an outdoor pool. Other favourite options in the area include Residence Inn Orlando Lake Nona and Courtyard Orlando Lake Nona.
How many hotels will I find in Lake Nona Medical City?
Expedia has 5 Lake Nona Medical City hotels and other accommodation options, and one might make a good home base for venturing out into the greater Orlando area.
If I need to cancel my hotel reservation in Lake Nona Medical City, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Lake Nona Medical City.
What is there to do around this Orlando neighbourhood?
Eagle Creek Golf Club, USTA National Campus and Austin-Tindall Regional Park are just a few of the places to visit in and around Lake Nona Medical City. When you're sightseeing around the area, Lake Hart and Kissimmee Bay Country Club are a couple of other sights to visit.