Default HTG hotel image

Search Hotels in Lake Nona Medical City, Orlando

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Lake Nona Medical City hotels

A swimming pool with sun loungers and palm trees.

1. Courtyard Orlando Lake Nona

Courtyard Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (663 reviews)
"We had an amazing stay! Room was so nice and the perfect location! I dropped off balloons a day early to have in the room as a birthday surprise and the staff was so accommodating and nice! Shout out to Stephen who was great!"
United States
Christine
The price is ฿6,021
฿6,841 total
includes taxes & fees
1 Nov - 2 Nov
Courtyard Orlando Lake Nona
Exterior

2. Aloft by Marriott Orlando Lake Nona

Aloft by Marriott Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (458 reviews)
"nice clean hotel, close to restaurants"
United States
Ali
The price is ฿4,659
฿5,293 total
includes taxes & fees
25 Oct - 26 Oct
Aloft by Marriott Orlando Lake Nona
A swimming pool with sun loungers and palm trees, surrounded by a modern building.

3. Residence Inn Orlando Lake Nona

Residence Inn Orlando Lake Nona
3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (347 reviews)
"Hotel was very nice."
United States
Christine
The price is ฿10,393
฿11,810 total
includes taxes & fees
10 Nov - 11 Nov
Residence Inn Orlando Lake Nona
An outdoor patio area with seating, a bar, and a fire feature.

4. Hyatt House Orlando Airport

Hyatt House Orlando Airport
3.5 star property
Airport North, 10.5 km from Lake Nona Medical City
9.6 out of 10, Exceptional, (2,890 reviews)
"Great staff, good breakfast and excellent location."
United States
Gerardo
The price is ฿4,003
฿4,503 total
includes taxes & fees
3 Nov - 4 Nov
Hyatt House Orlando Airport
A modern restaurant with multiple dining tables and chairs, a bar area, and a television mounted on the wall.

5. Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport
3.0 star property
Airport North, 11.1 km from Lake Nona Medical City
8.8 out of 10, Excellent, (4,276 reviews)
"It was a nice clean place to stay. For another short trip I would definitely stay again."
United States
David Arturo
The price is ฿2,986
฿3,360 total
includes taxes & fees
21 Oct - 22 Oct
Wingate by Wyndham - Orlando International Airport
A modern hotel lobby with a large flat-screen TV, a blue sofa, a round wooden table, and a curved reception desk.

6. Cambria Hotel Orlando Airport

Cambria Hotel Orlando Airport
3.0 star property
11.1 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (1,992 reviews)
"Love the staff location and rooms, very convenient and comfortable!"
United States
Quintin
The price is ฿3,325
฿3,740 total
includes taxes & fees
16 Nov - 17 Nov
Cambria Hotel Orlando Airport
An outdoor seating area with green chairs and umbrellas, a fire pit, and a building with large windows in the background.

7. Hampton Inn & Suites Orlando Airport @ Gateway Village

Hampton Inn & Suites Orlando Airport @ Gateway Village
3.0 star property
Airport North, 10.6 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (2,890 reviews)
"Great place"
United States
Wakima
The price is ฿3,404
฿3,829 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn & Suites Orlando Airport @ Gateway Village
A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract artwork on the wall.

8. Hyatt Place Orlando Airport

Hyatt Place Orlando Airport
3.0 star property
Airport North, 11 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (1,941 reviews)
"This property was very clean, very friendly staff, reasonably priced.!!!! I would recommend for short or long stay!"
United States
Rosalyn
The price is ฿3,385
฿3,808 total
includes taxes & fees
16 Nov - 17 Nov
Hyatt Place Orlando Airport
A modern lobby with a checkered carpet, seating area, and a reception desk.

9. Holiday Inn Express Orlando International Airport by IHG

Holiday Inn Express Orlando International Airport by IHG
2.5 star property
11.1 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (2,043 reviews)
"Wonderful stay! The staff were very accommodating and made us feel so comfortable. The breakfast was absolutely delicious and offered a great variety."
United States
Lorellie
The price is ฿3,519
฿3,959 total
includes taxes & fees
2 Nov - 3 Nov
Holiday Inn Express Orlando International Airport by IHG
A spacious lobby with a wooden staircase, a reception desk, and a large wall clock.

10. Country Inn & Suites by Radisson, Orlando Airport, FL

Country Inn & Suites by Radisson, Orlando Airport, FL
3.0 star property
Airport North, 11 km from Lake Nona Medical City
8.0 out of 10, Very good, (5,049 reviews)
"I loved the proximity to the airport, the convenience of the surrounding area and the hotel shuttle and breakfast were an added bonus."
United States
RandaShay
The price is ฿2,592
฿2,916 total
includes taxes & fees
4 Nov - 5 Nov
Country Inn & Suites by Radisson, Orlando Airport, FL
A modern hotel room with a large bed, a nightstand, a drawer, a wall-mounted light, and a window with a view of trees.

11. Ramada by Wyndham Suites Orlando Airport

Ramada by Wyndham Suites Orlando Airport
3.0 star property
Airport North, 10.4 km from Lake Nona Medical City
8.2 out of 10, Very good, (6,162 reviews)
"Staff and breakfast excellent"
United States
Beatriz
The price is ฿2,573
฿2,895 total
includes taxes & fees
20 Oct - 21 Oct
Ramada by Wyndham Suites Orlando Airport
A modern dining area with a large table, chairs, and a coffee station.

12. avid hotel Orlando International Airport by IHG

avid hotel Orlando International Airport by IHG
2.5 star property
11.2 km from Lake Nona Medical City
9.2 out of 10, Wonderful, (2,185 reviews)
"Hotel was nice and clean I like the stay at avid"
United States
Shant
The price is ฿3,284
฿3,695 total
includes taxes & fees
16 Nov - 17 Nov
avid hotel Orlando International Airport by IHG
A modern hotel with a red carpet leading to the entrance, a wooden walkway, and a clear view of the building's facade.

13. EVEN Hotel Orlando International Airport by IHG

EVEN Hotel Orlando International Airport by IHG
3.5 star property
Airport North, 11.1 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (934 reviews)
"Great hotel. Will stay again"
United States
Alex
The price is ฿3,385
฿3,808 total
includes taxes & fees
20 Oct - 21 Oct
EVEN Hotel Orlando International Airport by IHG
A hotel with a prominent tower, palm trees, and a red roof.

14. La Quinta Inn & Suites by Wyndham Orlando Airport

La Quinta Inn & Suites by Wyndham Orlando Airport
3.0 star property
Airport North, 10.9 km from Lake Nona Medical City
7.6 out of 10, Good, (2,835 reviews)
"Clean rooms, nice breakfast, and airport shuttle."
United States
Angella
The price is ฿2,544
฿2,863 total
includes taxes & fees
19 Oct - 20 Oct
La Quinta Inn & Suites by Wyndham Orlando Airport
A modern gym with treadmills, stationary bikes, and elliptical machines.

15. Wyndham Garden Orlando Airport

Wyndham Garden Orlando Airport
3.0 star property
Belle Isle, 11.9 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (4,202 reviews)
The price is ฿2,949
฿3,318 total
includes taxes & fees
20 Oct - 21 Oct
Wyndham Garden Orlando Airport
A hotel pool area with lounge chairs and umbrellas, surrounded by tall buildings and a sunset sky.

16. Drury Plaza Hotel Orlando - Disney Springs Area

Drury Plaza Hotel Orlando - Disney Springs Area
4.0 star property
22.9 km from Lake Nona Medical City
9.8 out of 10, Exceptional, (6,151 reviews)
"Always love staying here"
United States
Brianne
The price is ฿6,146
฿6,915 total
includes taxes & fees
25 Oct - 26 Oct
Drury Plaza Hotel Orlando - Disney Springs Area
A modern kitchen with wooden cabinets, a central island, and a breakfast bar.

17. Hampton Inn Orlando-International Airport

Hampton Inn Orlando-International Airport
2.5 star property
Airport North, 10.8 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (2,187 reviews)
"Great stay"
United States
Roosevelt
The price is ฿3,259
฿3,667 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn Orlando-International Airport
Room

18. Comfort Suites Orlando International Airport

Comfort Suites Orlando International Airport
2.5 star property
Belle Isle, 12 km from Lake Nona Medical City
8.4 out of 10, Very good, (1,348 reviews)
"Great place to stay"
United States
Sheryl
The price is ฿3,002
฿3,377 total
includes taxes & fees
27 Oct - 28 Oct
Comfort Suites Orlando International Airport
A hotel room with two beds, a flat-screen TV, a desk, and a lamp.

19. Sonesta Essential Orlando Airport

Sonesta Essential Orlando Airport
3.0 star property
12.2 km from Lake Nona Medical City
8.0 out of 10, Very good, (1,290 reviews)
"Clean room, friendly staffs"
United States
Tien
The price is ฿2,983
฿3,356 total
includes taxes & fees
18 Oct - 19 Oct
Sonesta Essential Orlando Airport
A pool area with people swimming and relaxing.

20. Universal's Endless Summer Resort - Dockside Inn and Suites

Universal's Endless Summer Resort - Dockside Inn and Suites
3.0 star property
Florida Center, 21 km from Lake Nona Medical City
9.2 out of 10, Wonderful, (5,779 reviews)
"Great stay!"
United States
Stephanie
The price is ฿4,843
฿5,449 total
includes taxes & fees
2 Nov - 3 Nov
Universal's Endless Summer Resort - Dockside Inn and Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Hotels recommended for families in Lake Nona Medical City

Exterior

Aloft by Marriott Orlando Lake Nona

Aloft by Marriott Orlando Lake Nona
3.0 star property
Lake Nona
9.6 out of 10, Exceptional, (458)
The price is ฿4,659
฿5,293 total
includes taxes & fees
25 Oct - 26 Oct
Aloft by Marriott Orlando Lake Nona

Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas for the activities you enjoy most.
The entrance to the Hollywood Studios area with a large sign and distinctive architecture.
Photo by Gary Burke
Open Photo by Gary Burke

Bay Lake

Exciting theme parks plentiful wildlife and top sights from Epcot® to Walt Disney World® Resort – discover Bay Lake, a destination also famous for its entertainment.

A large Ferris wheel with blue lights, surrounded by a cityscape with illuminated buildings and a tall green tower.

International Drive District

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

A roller coaster at Universal Orlando Resort, featuring a tall palm tree and a clear blue sky.
Photo by Peter Sutton
Open Photo by Peter Sutton

Florida Center

If you're spending some time in Florida Center, Universal Orlando Resort and Universal Studios Florida are top sights worth seeing.

A large Ferris wheel with blue lighting, surrounded by a parking lot and buildings.

Champions Gate

Ample dining options and top golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.

A golf course with bunkers, water hazards, and a large lake.

Reunion

The top golf courses and fun-filled water parks are top of the list for many visitors to Reunion. A stop by Reunion Resort Golf Course or Jack Nicklaus Course might round out your trip.

Top Lake Nona Medical City Hotel Reviews

Westgate Lakes Resort & Spa Universal Studios Area

Westgate Lakes Resort & Spa Universal Studios Area

10/10 Excellent
"We had a wonderful stay at Westgate! The resort was nice, comfortable, and conveniently located near everything we wanted to visit. The attractions, restaurants, and shopping areas were all within easy reach, which made our trip even more enjoyable. We had a great experience and would definitely recommend Westgate to anyone visiting Orlando. We would love to stay here again!"
Zaida 3-night trip
Posted less than an hour ago
Westgate Lakes Resort & Spa Universal Studios Area

Frequently asked questions

What's it like in Lake Nona Medical City?
Lake Nona Medical City is a neighbourhood that travellers like for its restaurants.
What's the best accommodation in Lake Nona Medical City?
Based on Expedia customer reviews, Aloft Orlando Lake Nona is the highest ranked property in Lake Nona Medical City. This hotel offers a restaurant and an outdoor pool. Other favourite options in the area include Residence Inn Orlando Lake Nona and Courtyard Orlando Lake Nona.
How many hotels will I find in Lake Nona Medical City?
Expedia has 5 Lake Nona Medical City hotels and other accommodation options, and one might make a good home base for venturing out into the greater Orlando area.
If I need to cancel my hotel reservation in Lake Nona Medical City, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Lake Nona Medical City.
What is there to do around this Orlando neighbourhood?
Eagle Creek Golf Club, USTA National Campus and Austin-Tindall Regional Park are just a few of the places to visit in and around Lake Nona Medical City. When you're sightseeing around the area, Lake Hart and Kissimmee Bay Country Club are a couple of other sights to visit.