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Search Hotels in Downtown South San Francisco, San Francisco

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Check prices for these dates

This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

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Our top choices for Downtown South San Francisco hotels

A La Quinta hotel with a modern facade, a covered entrance, and a parking lot.

1. La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
3.0 star property
Downtown South San Francisco
8.2 out of 10, Very good, (2,140 reviews)
"Nice, clean hotel with a great breakfast very conveniently located near the airport."
United States
Justin
The price is ฿4,536
฿5,297 total
includes taxes & fees
11 Oct - 12 Oct
La Quinta Inn & Suites by Wyndham San Francisco Airport N
An indoor courtyard with a stone floor, a round table with chairs, and potted plants.

2. Airport Inn

Airport Inn
2.0 star property
Downtown South San Francisco
9.0 out of 10, Wonderful, (1,005 reviews)
"One of the best places I’ve stayed in SF area"
United States
Saikiran
The price is ฿3,612
฿4,229 total
includes taxes & fees
29 Oct - 30 Oct
Airport Inn
A hotel room with a bed, a desk, a chair, a TV, and a lamp.

3. Inn By The SFO

Inn By The SFO
2.0 star property
Downtown South San Francisco
7.6 out of 10, Good, (1,006 reviews)
"Clean room, easy access to the 101 and well lit parking at night."
United States
Emmanuel
Inn By The SFO
A neatly made bed with white linens and a folded towel, a wooden headboard, and a window with blinds.

4. Miller Apartments

Miller Apartments
2.0 star property
Downtown South San Francisco
7.2 out of 10, Good, (23 reviews)
"Old house, poorly maintained. I won’t be coming back"
United States
Lou
The price is ฿1,586
฿4,407 total
includes taxes & fees
30 Oct - 31 Oct
Miller Apartments
A multi-level hotel atrium with outdoor seating areas, a pool, and a central lounge.

5. Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
3.5 star property
The East Side, 1.4 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,795 reviews)
"Great place to Stay!"
United States
Carolyn Jeane
The price is ฿4,657
฿5,472 total
includes taxes & fees
16 Oct - 17 Oct
Embassy Suites by Hilton San Francisco Airport Oyster Point
A courtyard with outdoor seating, a glass table, and potted plants.

6. Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North
2.5 star property
The East Side, 1.1 km from Downtown South San Francisco
7.8 out of 10, Good, (1,000 reviews)
"Shuttle and breakfast made this worth it"
United States
Sarah
The price is ฿3,479
฿4,083 total
includes taxes & fees
25 Oct - 26 Oct
Comfort Inn and Suites San Francisco Airport North
A hotel room with a bed, desk, chair, television, and a microwave.

7. Hotel Nova SFO

Hotel Nova SFO
2.5 star property
1.9 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,009 reviews)
"Clean and super convenient to the airport"
United States
Anne
The price is ฿4,833
฿5,629 total
includes taxes & fees
6 Oct - 7 Oct
Hotel Nova SFO
A bar area with a curved wooden counter, bar stools, and a glass display case filled with bottles.

8. Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel
3.0 star property
1.8 km from Downtown South San Francisco
8.4 out of 10, Very good, (1,921 reviews)
"Room was clean and staff was helpful"
United States
Lori
The price is ฿3,678
฿4,332 total
includes taxes & fees
24 Oct - 25 Oct
Best Western Plus Grosvenor Airport Hotel
A hotel lobby with a central reception desk, large columns, and hanging pendant lights.

9. Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North
3.0 star property
The East Side, 1.7 km from Downtown South San Francisco
8.6 out of 10, Excellent, (1,006 reviews)
"Staff were helpful, polite and made sure my stay was comfortable."
United States
kathrina
The price is ฿3,275
฿3,848 total
includes taxes & fees
18 Oct - 19 Oct
Hilton Garden Inn San Francisco Arpt North
Exterior

10. Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
3.0 star property
Oyster Point, 2.2 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2,384 reviews)
"Clean and spacious room, Friendly staff."
United States
Sheila Marie
The price is ฿4,061
฿4,782 total
includes taxes & fees
1 Nov - 2 Nov
Sonesta Select San Francisco Airport Oyster Point Waterfront
A modern lobby with a cityscape mural, a reception desk, seating area, and a door with blinds.

11. Hotel Skye SFO

Hotel Skye SFO
3.0 star property
3.9 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2,034 reviews)
"The room was clean, the breakfast was very handy. Good stay with good value!"
United States
Laurie
The price is ฿3,896
฿4,663 total
includes taxes & fees
25 Oct - 26 Oct
Hotel Skye SFO
A hotel room with a bed, a sofa, a nightstand, and a desk. There are three framed pictures on the wall.

12. The Atrium Hotel

The Atrium Hotel
2.5 star property
3 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,024 reviews)
"Very nice place!"
United States
Ramesh
The price is ฿4,072
฿4,908 total
includes taxes & fees
18 Oct - 19 Oct
The Atrium Hotel
A modern interior with a wooden partition, a stone accent wall, and a bar area.

13. DoubleTree by Hilton San Francisco Airport North Bayfront

DoubleTree by Hilton San Francisco Airport North Bayfront
4.0 star property
3.1 km from Downtown South San Francisco
8.2 out of 10, Very good, (1,778 reviews)
"Great stay!"
United States
Kelcie
The price is ฿3,674
฿4,323 total
includes taxes & fees
11 Oct - 12 Oct
DoubleTree by Hilton San Francisco Airport North Bayfront
A spacious, well-lit atrium with a high ceiling and skylight, featuring a central seating area with a sofa and armchairs, surrounded by a patterned rug.

14. Hotel Aluxor SFO

Hotel Aluxor SFO
2.5 star property
3.7 km from Downtown South San Francisco
8.6 out of 10, Excellent, (2,995 reviews)
"Had a great overnight stay!"
United States
Kenna
The price is ฿3,443
฿4,145 total
includes taxes & fees
25 Oct - 26 Oct
Hotel Aluxor SFO
A reception area with a counter, two patterned chairs, a yellow ottoman, and a large blue potted plant.

15. Hotel Aura SFO

Hotel Aura SFO
3.0 star property
4.4 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2,658 reviews)
"Great airport stay"
United States
Charles
The price is ฿3,594
฿4,292 total
includes taxes & fees
31 Oct - 1 Nov
Hotel Aura SFO
A spacious lobby with a reception desk, seating area, and a high ceiling with chandeliers.

16. La Quinta Inn & Suites by Wyndham San Francisco Airport West

La Quinta Inn & Suites by Wyndham San Francisco Airport West
3.0 star property
5.4 km from Downtown South San Francisco
8.6 out of 10, Excellent, (1,871 reviews)
"Very nice hotel, very reasonable wth a great breakfast! Huge pool, very pretty courtyard and staff is superb!"
United States
Joy
The price is ฿4,688
฿5,389 total
includes taxes & fees
30 Oct - 31 Oct
La Quinta Inn & Suites by Wyndham San Francisco Airport West
An outdoor patio with wooden furniture, a chessboard, and hanging floral decorations.

17. The Millwood - A Boutique Hotel

The Millwood - A Boutique Hotel
3.0 star property
5.4 km from Downtown South San Francisco
9.2 out of 10, Wonderful, (1,041 reviews)
"Very affordable stay near SFO with delightful and helpful staff!"
United States
Jennifer
The price is ฿4,932
฿5,862 total
includes taxes & fees
25 Oct - 26 Oct
The Millwood - A Boutique Hotel
A hotel room with a bed, bedside tables, a desk, a chair, and a large window.

18. Gateway Inn & Suites San Francisco SFO Airport

Gateway Inn & Suites San Francisco SFO Airport
2.0 star property
3.7 km from Downtown South San Francisco
8.6 out of 10, Excellent, (1,114 reviews)
"Nice and close to airport very clean rooms a great little dive"
United States
Julian
The price is ฿2,719
฿3,288 total
includes taxes & fees
18 Oct - 19 Oct
Gateway Inn & Suites San Francisco SFO Airport
A modern hotel lobby with a reception desk, dining area with tables and chairs, and a decorative light fixture.

19. Hotel 1550 - SFO Airport

Hotel 1550 - SFO Airport
3.5 star property
5.1 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,011 reviews)
"Convenient to airport with shuttle service and easy in and accommodations."
United States
Larry
The price is ฿4,151
฿4,872 total
includes taxes & fees
18 Oct - 19 Oct
Hotel 1550 - SFO Airport
A hotel with a modern facade, multiple floors, and a well-lit entrance.

20. The Westin San Francisco Airport

The Westin San Francisco Airport
4.0 star property
6.9 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,792 reviews)
"We were only there the one night as lay-over but from the amenities we saw (pool/hot tub area, exercise facilities, restaurant) and hotel location on the bay it would have been good for an extended stay as well."
United States
Douglas
The price is ฿3,994
฿5,768 total
includes taxes & fees
25 Oct - 26 Oct
The Westin San Francisco Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.
A pier with a large number of sea lions resting on floating platforms.

Fisherman's Wharf

This waterfront neighborhood dates back to the gold rush era and is a hub for tourist activities, sea lions and seafood restaurants.

A cityscape with tall buildings, a central plaza with palm trees, and a flag on one of the buildings.

Union Square

Fashion puts on its finest face in one of the country’s largest shopping plazas.

A trolley on a street with buildings and a clock tower.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and Chase Center are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

A city street with tall buildings, flags, and cars.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

A cityscape with a prominent skyscraper, a bridge, and a mix of modern and historic buildings.

Nob Hill

Examine architecturally significant buildings, visit the Cable Car Museum and enjoy magnificent views of greater San Francisco in this affluent district.

Top Downtown South San Francisco Hotel Reviews

Hyatt Regency San Francisco

Hyatt Regency San Francisco

10/10 Excellent
"It is only missing a real coffee bar."
Jeanette 1-night trip
Posted 3 hours ago
Hyatt Regency San Francisco

Frequently asked questions

What's it like in Downtown South San Francisco?
You'll be sure to have fun exploring South San Francisco's Downtown South San Francisco neighbourhood.
What's a favourite place to stay in Downtown South San Francisco?
Based on our traveller data, La Quinta Inn & Suites by Wyndham San Francisco Airport N is one of the top choices for your stay in Downtown South San Francisco. This hotel offers free breakfast and an outdoor pool.
How many hotels should I expect to find in the Downtown South San Francisco area?
When you want to put your feet up after a day of exploring the sights in South San Francisco, you can choose from 11 Expedia hotels and other accommodation options in Downtown South San Francisco.
If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?
Yes, most hotel bookings are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Downtown South San Francisco.
What can I see and do in this South San Francisco neighbourhood?
South San Francisco Hillside Sign, Sign Hill Park and See's Candies are just a few of the places to visit in and around Downtown South San Francisco. Cinemark Century at Tanforan and K1 Speed San Francisco are also worth a visit when you're out sightseeing in South San Francisco.