A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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Check prices for these dates

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6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

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Our top choices for Defiance hotels

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

1. TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (335 reviews)
"Excellent 1 night stay. Clean and comfortable"
United States
Thomas
The price is ąøæ4,083
ąøæ4,792 total
includes taxes & fees
13 Nov - 14 Nov
TownePlace Suites by Marriott St. Louis Chesterfield
A multi-story hotel with a mix of brick and siding exteriors, multiple windows, and a well-maintained lawn.

2. Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.4 out of 10, Very good, (1,001 reviews)
"This was a clean, safe and convenient place to stay while traveling through St. Louis."
United States
Greg
The price is ąøæ3,394
ąøæ4,003 total
includes taxes & fees
9 Nov - 10 Nov
Holiday Inn Express St. Louis West - O'Fallon by IHG
A hotel room with a bed, a sofa, a coffee table, and wall art.

3. Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,155 reviews)
"Rooms are very clean, the staff is friendly and the location is great. We enjoyed are stay."
United States
Matthew
The price is ąøæ2,742
ąøæ3,234 total
includes taxes & fees
3 Dec - 4 Dec
Sleep Inn & Suites O'Fallon MO - Technology Drive
A hotel entrance with a stone facade, a wooden archway, and a paved walkway.

4. Staybridge Suites O'Fallon Chesterfield by IHG

Staybridge Suites O'Fallon Chesterfield by IHG
3.0 star property
O'Fallon
8.4 out of 10, Very good, (488 reviews)
"Everything was great. Rooms were clean, bedding comfortable, breakfast really good."
United States
Cheri
The price is ąøæ3,827
ąøæ4,514 total
includes taxes & fees
8 Nov - 9 Nov
Staybridge Suites O'Fallon Chesterfield by IHG
A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

5. The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,680 reviews)
"Clean, quiet, great continental breakfast, and close to several places to eat."
United States
Lori
The price is ąøæ2,779
ąøæ3,237 total
includes taxes & fees
1 Dec - 2 Dec
The Wildwood Hotel
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

6. Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites Chesterfield - St. Louis
2.5 star property
Chesterfield
7.8 out of 10, Good, (1,004 reviews)
"Mindy was very nice. Bed not so much, please keep a smoke detector in the room instead of taking it apart."
United States
Charissa
The price is ąøæ2,808
ąøæ3,384 total
includes taxes & fees
29 Nov - 30 Nov
Comfort Inn & Suites Chesterfield - St. Louis
A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

7. Residence Inn by Marriott O'Fallon

Residence Inn by Marriott O'Fallon
3.0 star property
O'Fallon
8.4 out of 10, Very good, (509 reviews)
"Beautiful room, very clean with nice staff"
United States
Rianna
The price is ąøæ4,384
ąøæ5,171 total
includes taxes & fees
22 Nov - 23 Nov
Residence Inn by Marriott O'Fallon
A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

8. Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO
3.0 star property
O'Fallon
8.8 out of 10, Excellent, (765 reviews)
"Everything you could need for an overnight or extended stay. Staff was extremely helpful, and the property is well-maintained."
United States
Duane
The price is ąøæ4,006
ąøæ4,751 total
includes taxes & fees
6 Dec - 7 Dec
Hilton Garden Inn St. Louis/O'Fallon MO
A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

9. Hyatt Place St. Louis/Chesterfield

Hyatt Place St. Louis/Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1,009 reviews)
"Very nice hotel and lovely room"
United States
Karin
The price is ąøæ4,143
ąøæ4,806 total
includes taxes & fees
8 Nov - 9 Nov
Hyatt Place St. Louis/Chesterfield
A modern hotel dining area with a long communal table, multiple chairs, and pendant lighting.

10. Hampton Inn & Suites St. Louis/Chesterfield

Hampton Inn & Suites St. Louis/Chesterfield
3.5 star property
Chesterfield
8.8 out of 10, Excellent, (920 reviews)
"Incredibly clean and modern room and building. Friendly and helpful front desk staff, free shuttle (so helpful), and super close to a bunch of stuff. Would stay again, for longer next time!"
United States
Ellen
The price is ąøæ3,684
ąøæ4,287 total
includes taxes & fees
15 Nov - 16 Nov
Hampton Inn & Suites St. Louis/Chesterfield
An outdoor patio area with wicker furniture and a central fire feature.

11. Courtyard by Marriott St. Louis Chesterfield

Courtyard by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (682 reviews)
"Love the location and most of the staff were very nice! The cafe/Starbucks was a little disappointing."
United States
Kelly
The price is ąøæ3,669
ąøæ4,270 total
includes taxes & fees
20 Nov - 21 Nov
Courtyard by Marriott St. Louis Chesterfield
A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

12. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
2.5 star property
Chesterfield
9.0 out of 10, Wonderful, (1,001 reviews)
"We drove across America and this property stood out by just having the most comfortable beds and a great breakfast , great staff ."
United States
Terry
The price is ąøæ3,696
ąøæ4,301 total
includes taxes & fees
19 Nov - 20 Nov
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
A spacious lobby with a central round table, two sofas, and a chandelier.

13. Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1,313 reviews)
"Great stay. Food was great. Location is great. Will stay again."
United States
Sara
The price is ąøæ4,350
ąøæ5,046 total
includes taxes & fees
22 Nov - 23 Nov
Drury Plaza Hotel St. Louis Chesterfield
A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

14. Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (413 reviews)
"Great hotel and Breakfast is nothing special but it makes sense for the price you pay."
United States
Chantelle
The price is ąøæ2,829
ąøæ3,239 total
includes taxes & fees
24 Nov - 25 Nov
Quality Inn Near Six Flags St. Louis
A spacious lobby with a grand staircase, a fireplace, and comfortable seating areas.

15. Holiday Inn St. Louis West Six Flags by IHG

Holiday Inn St. Louis West Six Flags by IHG
3.0 star property
Eureka
9.0 out of 10, Wonderful, (1,000 reviews)
"Great hotel!"
United States
Rob
The price is ąøæ4,368
ąøæ5,089 total
includes taxes & fees
7 Dec - 8 Dec
Holiday Inn St. Louis West Six Flags by IHG
An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

16. Comfort Inn Near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (1,002 reviews)
"The breakfast was mediocre and there was road noise but other than that, it was a nice stay."
United States
Scott
The price is ąøæ3,045
ąøæ3,486 total
includes taxes & fees
6 Dec - 7 Dec
Comfort Inn Near Six Flags St. Louis
An outdoor patio with a built-in grill, seating area, and stone walls.

17. Residence Inn by Marriott St. Louis Chesterfield

Residence Inn by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (260 reviews)
"Would stay here again!"
United States
Chelsea
The price is ąøæ6,325
ąøæ7,399 total
includes taxes & fees
13 Nov - 14 Nov
Residence Inn by Marriott St. Louis Chesterfield
A modern kitchen with white cabinets, a central island, and a patterned rug.

18. Homewood Suites by Hilton St. Louis-Chesterfield

Homewood Suites by Hilton St. Louis-Chesterfield
3.0 star property
Chesterfield
8.4 out of 10, Very good, (1,002 reviews)
"Over all it was our best stay."
United States
Sekar Reddy
The price is ąøæ3,669
ąøæ4,256 total
includes taxes & fees
13 Nov - 14 Nov
Homewood Suites by Hilton St. Louis-Chesterfield
A spacious hotel lobby with a long reception desk, multiple seating areas, and large windows allowing natural light.

19. Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (742 reviews)
"Great hotel!"
United States
Jill
The price is ąøæ4,807
ąøæ5,454 total
includes taxes & fees
29 Nov - 30 Nov
Hampton Inn St. Louis Wentzville
A hotel reception area with a counter, coffee machines, a refrigerated display, and artwork on the wall.

20. Fairfield Inn & Suites by Marriott St. Louis Chesterfield

Fairfield Inn & Suites by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (1,002 reviews)
"very nice stay. Great room with easy check in ,nice staff, friendly and helpful. Excellent breakfast, with good setup and fresh food."
United States
Charles
The price is ąøæ3,584
ąøæ4,157 total
includes taxes & fees
20 Nov - 21 Nov
Fairfield Inn & Suites by Marriott St. Louis Chesterfield
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

7.8/10 (7 reviews)
This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Top Defiance Hotel Reviews

The Wildwood Hotel

The Wildwood Hotel

10/10 Excellent
"My husband and I stayed here on our wedding night. We parked in the parking garage after checking in and were able to go right into the hallway near the elevators. The jacuzzi tub was amazing! I loved that they had towels specifically for makeup as well as a makeup wipe by the sink in the bathroom because I had forgotten to bring my own. The bed was so comfortable and you couldnā€™t hear other people in the hallway. The continental breakfast served what most hotels serve but everything tasted so much better! We are planning on staying again on our first anniversary!"
Philip 1-night trip
Posted 5 hours ago
The Wildwood Hotel

More cheap stays in Defiance

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

1970 Craig Rd Maryland Heights MO
The price is ąøæ1,999 per night from 9 Nov to 10 Nov
ąøæ1,999
ąøæ2,319 total
9 Nov - 10 Nov
includes taxes & fees

Frequently asked questions

What's the best place to stay in Defiance?
Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Sonesta ES Suites St. Louis - Chesterfield and Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham. See all available top hotels, or vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Sonesta ES Suites St. Louis - Chesterfield: Offers daily, a seasonal outdoor pool and free self parking. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station and St. Louis Zoo. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24Ā°C, while the coldest months are January and February, with an average of 3Ā°C. Average annual precipitation for Defiance is 1228 mm.

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