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22 Dec - 23 Dec
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23 Dec - 24 Dec
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Our top choices for Buffalo Museum of Science hotels

Interior
InnBuffalo off Elmwood

InnBuffalo off Elmwood

InnBuffalo off Elmwood
2.5 star property
Elmwood Village, 3 km from Buffalo Museum of Science
10.0 out of 10, Exceptional, (190)
"Our favorite inn!! Beautifully and lovingly restored — wonderful staff, rooms, fresh breakfasts…a gem, to be sure."
United States
katherine
The price is ฿4,049
฿4,646 total
includes taxes & fees
5 Jan - 6 Jan 2026
InnBuffalo off Elmwood
Staircase
The Edward Hotel

The Edward Hotel

The Edward Hotel
3.0 star property
Elmwood Village, 2.4 km from Buffalo Museum of Science
9.6 out of 10, Exceptional, (219)
"Great location in Elmwood Village area. Clean room with gas fireplace. Self check- in was easy with staff provided instructions. Many food options within walking distance. "
United States
Jon
The Edward Hotel
Reception
Buffalo Harmony House

Buffalo Harmony House

Buffalo Harmony House
4.5 star property
Allentown, 3.2 km from Buffalo Museum of Science
10.0 out of 10, Exceptional, (47)
"Amazing breakfasts!"
United States
David
Buffalo Harmony House
Lobby
Wyndham Garden Buffalo Downtown

Wyndham Garden Buffalo Downtown

Wyndham Garden Buffalo Downtown
3.0 star property
Downtown Buffalo, 2 km from Buffalo Museum of Science
9.0 out of 10, Wonderful, (1722)
"Great hotel!"
United States
Donovan
The price is ฿3,884
฿4,535 total
includes taxes & fees
29 Dec - 30 Dec
Wyndham Garden Buffalo Downtown
Exterior
The Mansion On Delaware Ave

The Mansion On Delaware Ave

The Mansion On Delaware Ave
4.0 star property
Allentown, 3 km from Buffalo Museum of Science
9.4 out of 10, Exceptional, (1000)
"Fantastic place!"
Canada
Geneviève
The Mansion On Delaware Ave
Exterior
Buffalo Guesthouse

Buffalo Guesthouse

Buffalo Guesthouse
3.0 star property
Allentown, 2.4 km from Buffalo Museum of Science
9.0 out of 10, Wonderful, (119)
"Fantastic stay at the Buffalo Guesthouse. It has a real home feeling. Lovely staff( real friendly atmosphere where you actually engage with other people staying there. Clean, well located and secure. "
Australia
Benjamin
The price is ฿4,410
฿5,060 total
includes taxes & fees
24 Dec - 25 Dec
Buffalo Guesthouse
Suite, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout curtains, iron/ironing board
Best Western on the Avenue

Best Western on the Avenue

Best Western on the Avenue
2.5 star property
Allentown, 2.8 km from Buffalo Museum of Science
8.6 out of 10, Excellent, (1001)
"The rooms were great. The staff was friendly and professional. Breakfast was awesome. Allentown location was ideal. I would stay here for my next visit."
United States
DAVID
The price is ฿4,212
฿4,918 total
includes taxes & fees
29 Dec - 30 Dec
Best Western on the Avenue
1 bedroom, in-room safe, desk, laptop workspace
Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG
2.5 star property
Buffalo Theater District, 3.1 km from Buffalo Museum of Science
8.6 out of 10, Excellent, (1005)
"Staff was pleasant, our suite was clean and well kept. Great breakfast! "
United States
Tricia
The price is ฿3,706
฿4,327 total
includes taxes & fees
29 Dec - 30 Dec
Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG
In-room safe, blackout curtains, free cots/infant beds, free WiFi
Aloft Buffalo Downtown

Aloft Buffalo Downtown

Aloft Buffalo Downtown
3.0 star property
Buffalo Theater District, 3 km from Buffalo Museum of Science
8.2 out of 10, Very good, (347)
"Clean room. Easy access to parking garage. "
United States
Clay
The price is ฿6,376
฿7,444 total
includes taxes & fees
5 Jan - 6 Jan 2026
Aloft Buffalo Downtown
2 bars/lounges
Curtiss Hotel, an Ascend Collection Hotel

Curtiss Hotel, an Ascend Collection Hotel

Curtiss Hotel, an Ascend Collection Hotel
5.0 star property
Buffalo Theater District, 3.4 km from Buffalo Museum of Science
9.4 out of 10, Exceptional, (1002)
"Property and rooms are nice. "
United States
benjamin
The price is ฿6,236
฿7,281 total
includes taxes & fees
25 Dec - 26 Dec
Curtiss Hotel, an Ascend Collection Hotel
Exterior
The Westin Buffalo

The Westin Buffalo

The Westin Buffalo
4.0 star property
Buffalo Theater District, 3.3 km from Buffalo Museum of Science
9.2 out of 10, Wonderful, (400)
"Our go-to in Buffalo ,,"
Canada
Sarah
The price is ฿8,135
฿9,497 total
includes taxes & fees
23 Dec - 24 Dec
The Westin Buffalo
Exterior
Hampton Inn & Suites Buffalo Downtown

Hampton Inn & Suites Buffalo Downtown

Hampton Inn & Suites Buffalo Downtown
2.5 star property
Buffalo Theater District, 3.4 km from Buffalo Museum of Science
8.8 out of 10, Excellent, (1006)
"Hotel was very clean and the staff was friendly. My room was larger than expected. Breakfast was well stocked and had good variety. Great location also!"
United States
Holly
The price is ฿4,095
฿4,781 total
includes taxes & fees
29 Dec - 30 Dec
Hampton Inn & Suites Buffalo Downtown
Exterior
Buffalo Marriott at LECOM HARBORCENTER

Buffalo Marriott at LECOM HARBORCENTER

Buffalo Marriott at LECOM HARBORCENTER
3.5 star property
Downtown Buffalo, 4.4 km from Buffalo Museum of Science
9.4 out of 10, Exceptional, (891)
"Our stay was amazing! The staff at the front desk was very helpful. "
United States
Bobbi Jo
The price is ฿6,564
฿7,664 total
includes taxes & fees
23 Dec - 24 Dec
Buffalo Marriott at LECOM HARBORCENTER
Hallway
The Richardson Hotel

The Richardson Hotel

The Richardson Hotel
3.5 star property
Elmwood Bidwell, 4.1 km from Buffalo Museum of Science
9.0 out of 10, Wonderful, (1006)
"Rhe property is amazing and the staff are too. Jessica made our stay special"
United States
Cindy
The price is ฿3,956
฿4,619 total
includes taxes & fees
8 Jan - 9 Jan 2026
The Richardson Hotel
Exterior detail
Hilton Garden Inn Buffalo Downtown

Hilton Garden Inn Buffalo Downtown

Hilton Garden Inn Buffalo Downtown
3.0 star property
Buffalo Theater District, 3.5 km from Buffalo Museum of Science
8.6 out of 10, Excellent, (1003)
"Everything was great! Thank you for the stay"
Canada
Sydney
The price is ฿3,120
฿3,642 total
includes taxes & fees
19 Jan - 20 Jan 2026
Hilton Garden Inn Buffalo Downtown
Lobby
Hotel at the Lafayette Trademark Collection by Wyndham

Hotel at the Lafayette Trademark Collection by Wyndham

Hotel at the Lafayette Trademark Collection by Wyndham
3.5 star property
Buffalo Theater District, 3.6 km from Buffalo Museum of Science
8.6 out of 10, Excellent, (1004)
"I love the history in the hotel "
United States
Dylan
The price is ฿3,364
฿3,927 total
includes taxes & fees
19 Jan - 20 Jan 2026
Hotel at the Lafayette Trademark Collection by Wyndham
Exterior
Courtyard Buffalo Downtown / Canalside

Courtyard Buffalo Downtown / Canalside

Courtyard Buffalo Downtown / Canalside
3.0 star property
Downtown Buffalo, 4.3 km from Buffalo Museum of Science
9.0 out of 10, Wonderful, (960)
"Nice rooms, great location "
United States
Ellen
The price is ฿5,313
฿6,203 total
includes taxes & fees
20 Jan - 21 Jan 2026
Courtyard Buffalo Downtown / Canalside
Indoor pool
Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center
3.5 star property
Buffalo Theater District, 3.4 km from Buffalo Museum of Science
8.2 out of 10, Very good, (1685)
"Checkin staff very helpful, efficient and pleasant. "
Canada
Carole
The price is ฿3,580
฿4,180 total
includes taxes & fees
12 Jan - 13 Jan 2026
Hyatt Regency Buffalo / Hotel and Conference Center
Exterior
Embassy Suites Buffalo

Embassy Suites Buffalo

Embassy Suites Buffalo
3.5 star property
Buffalo Theater District, 3.4 km from Buffalo Museum of Science
8.2 out of 10, Very good, (1002)
"Excellent breakfast and dinner onsite. Efficient valet parking"
United States
Delos
The price is ฿5,172
฿6,039 total
includes taxes & fees
25 Dec - 26 Dec
Embassy Suites Buffalo
Terrace/patio
Home2 Suites by Hilton Buffalo Airport / Galleria Mall

Home2 Suites by Hilton Buffalo Airport / Galleria Mall

Home2 Suites by Hilton Buffalo Airport / Galleria Mall
3.0 star property
6.3 km from Buffalo Museum of Science
9.0 out of 10, Wonderful, (1001)
"Good size rooms, and comfortable beds too! Good location with restaurants and shopping close by! Would recommend this hotel. "
Canada
Ann
The price is ฿4,095
฿4,658 total
includes taxes & fees
1 Jan - 2 Jan 2026
Home2 Suites by Hilton Buffalo Airport / Galleria Mall
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Buffalo Museum of Science Hotel Reviews

Buffalo Guesthouse

Buffalo Guesthouse

10/10 Excellent
"Staff were very nice and made check in/out super easy. Sure the room was a little small, but that’s what I paid for and expected. Awesome spot for the price! Would love to go again"
Daunte 3-night trip
Posted 8 days ago
Buffalo Guesthouse

Hotels near other Buffalo Museum of Science attractions

Buffalo Central Terminal

You can find out about the history of Buffalo with a stop at Buffalo Central Terminal. Experience the great live music and entertainment choices in this vibrant area.
See properties

War Memorial Stadium

Explore the great outdoors at War Memorial Stadium, a lovely green space in Buffalo. Experience the area's entertainment choices and acclaimed theatre scene.
See properties

Frequently asked questions

What's the area like around Buffalo Museum of Science?
Buffalo Museum of Science is located in a historic area of Buffalo known for its great live music scene. If you're looking for a convenient place to stay, take a look at the 11 hotels and other accommodation options you'll find within a mile.
What's the best place to stay near Buffalo Museum of Science?
Hyatt Regency Buffalo / Hotel and Conference Center is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an indoor pool. It's located 2.1 mi (3.4 km) from Buffalo Museum of Science. Other good choices within 5 miles include Wyndham Garden Buffalo Downtown and Buffalo Guesthouse.
How many hotels will I find close to Buffalo Museum of Science?
Expedia has 11 hotels and other accommodation options within a mile from Buffalo Museum of Science.
If I need to cancel the hotel reservation for my stay near Buffalo Museum of Science, will I receive a refund?
Yes, most hotel room reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to view the best deals near Buffalo Museum of Science.
What can I see and do near Buffalo Museum of Science?
Study the collections at Buffalo AKG Art Museum, Buffalo History Museum or Buffalo and Erie County Naval and Military Park. Some landmarks that you won't want to miss include Buffalo Central Terminal, Statler Tower and Ellicott Square Building. You can watch performances at Shea's Performing Arts Center, Kleinhans Music Hall and Road Less Traveled Theater if you're interested in local theatre.