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Find hotels in Upstate South Carolina, SC from ฿2,157

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15 Dec - 16 Dec
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16 Dec - 17 Dec
This weekend
19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for Upstate South Carolina hotels

Meeting facility
The Abernathy of Clemson

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (557)
"location is amazing! "
United States
colleen
The Abernathy of Clemson
Fireplace
Courtyard Marriott Clemson

Courtyard Marriott Clemson

Courtyard Marriott Clemson
3.0 star property
Clemson
9.0 out of 10, Wonderful, (523)
"Great property "
United States
Shaun
The price is ฿3,379
฿3,750 total
includes taxes & fees
21 Dec - 22 Dec
Courtyard Marriott Clemson
Two queen beds nonsmoking | In-room safe, desk, blackout curtains, iron/ironing board
Hampton Inn Easley

Hampton Inn Easley

Hampton Inn Easley
2.5 star property
Easley
9.4 out of 10, Exceptional, (681)
"Friendly staff, very comfortable room, excellent hot breakfast."
United States
Thomas
The price is ฿4,346
฿4,824 total
includes taxes & fees
1 Jan - 2 Jan 2026
Hampton Inn Easley
Reception hall
The Inn at Patrick Square

The Inn at Patrick Square

The Inn at Patrick Square
3.5 star property
Clemson
9.8 out of 10, Exceptional, (783)
"Clean room. Nice front desk concierge. Very cute hotel"
United States
Anisha
The price is ฿4,701
฿5,218 total
includes taxes & fees
16 Dec - 17 Dec
The Inn at Patrick Square
Deluxe Single Room | Desk, laptop workspace
SUN AND SAND MOTEL

SUN AND SAND MOTEL

SUN AND SAND MOTEL
Spartanburg
6.8 out of 10, (11)
"Wonderful"
United States
Heather
The price is ฿2,046
฿2,271 total
includes taxes & fees
17 Dec - 18 Dec
SUN AND SAND MOTEL
View from property
Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
3.0 star property
Clemson
9.6 out of 10, Exceptional, (960)
"Great place to stay!"
United States
Mindi
The price is ฿4,701
฿5,218 total
includes taxes & fees
16 Dec - 17 Dec
Clemson University's James F. Martin Inn
Lobby
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (792)
"Michail was the best. He was so welcoming, helpful and professional. Parking was easy and rooms were nice and clean. I will definitely stay again. "
United States
Jakeria
The price is ฿3,003
฿3,304 total
includes taxes & fees
21 Dec - 22 Dec
Tru by Hilton Seneca Clemson
Lobby
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
2.5 star property
Clemson
8.2 out of 10, Very good, (1001)
"Great stay "
United States
Linda
The price is ฿2,923
฿3,244 total
includes taxes & fees
22 Dec - 23 Dec
Comfort Inn & Suites Clemson - University Area
Exterior
Urban Boutique Hotel, BW Signature Collection

Urban Boutique Hotel, BW Signature Collection

Urban Boutique Hotel, BW Signature Collection
2.5 star property
Greenville
8.0 out of 10, Very good, (927)
"The staff was very accommodating of my special needs. I d stayed here before and love this place. "
United States
Dorothea
The price is ฿1,961
฿2,157 total
includes taxes & fees
28 Dec - 29 Dec
Urban Boutique Hotel, BW Signature Collection
Terrace/patio
Home2 Suites by Hilton Greenville Downtown

Home2 Suites by Hilton Greenville Downtown

Home2 Suites by Hilton Greenville Downtown
3.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1004)
"Super clean! Friendly staff and breakfast was great!"
United States
April
The price is ฿3,382
฿3,720 total
includes taxes & fees
21 Dec - 22 Dec
Home2 Suites by Hilton Greenville Downtown
Aerial view
Lakeside Lodge Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1001)
"Great place to stay. "
United States
Gene
The price is ฿3,439
฿4,269 total
includes taxes & fees
19 Dec - 20 Dec
Lakeside Lodge Clemson
Exterior
Woodspring Suites Greenville Airport

Woodspring Suites Greenville Airport

Woodspring Suites Greenville Airport
2.5 star property
Greenville
8.2 out of 10, Very good, (302)
"Clean room, friendly staff, I would definitely stay here again!"
United States
Melissa
The price is ฿2,492
฿2,742 total
includes taxes & fees
16 Dec - 17 Dec
Woodspring Suites Greenville Airport
Exterior
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (662)
"Great place to stay"
United States
Jose
The price is ฿3,205
฿3,526 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn & Suites Seneca-Clemson Area
In-room safe, blackout curtains, soundproofing, iron/ironing board
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (743)
"Staff was amazing and our room was clean and comfortable. "
United States
Amanda R
The price is ฿5,332
฿5,918 total
includes taxes & fees
21 Dec - 22 Dec
The Shepherd Hotel Downtown Clemson
Exterior
Aloft Greenville Downtown

Aloft Greenville Downtown

Aloft Greenville Downtown
3.0 star property
Greenville Downtown
9.0 out of 10, Wonderful, (1005)
"Clean room and great staff! "
United States
Katherine
The price is ฿3,952
฿4,348 total
includes taxes & fees
21 Dec - 22 Dec
Aloft Greenville Downtown
Lobby
Best Western Seneca-Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very good, (642)
"The stay was amazing "
United States
Tabatha
The price is ฿2,816
฿3,097 total
includes taxes & fees
21 Dec - 22 Dec
Best Western Seneca-Clemson
Lobby
Tru by Hilton Greenville Woodruff Road

Tru by Hilton Greenville Woodruff Road

Tru by Hilton Greenville Woodruff Road
2.5 star property
Greenville
9.2 out of 10, Wonderful, (286)
"Very clean property felt welcoming staff was great"
United States
Christopher
The price is ฿2,751
฿3,324 total
includes taxes & fees
21 Dec - 22 Dec
Tru by Hilton Greenville Woodruff Road
Free daily buffet breakfast
Homewood Suites by Hilton Greenville

Homewood Suites by Hilton Greenville

Homewood Suites by Hilton Greenville
3.0 star property
Greenville
9.0 out of 10, Wonderful, (393)
"Very cleaned and great breakfast selection "
United States
Pedro
The price is ฿3,508
฿3,975 total
includes taxes & fees
11 Jan - 12 Jan 2026
Homewood Suites by Hilton Greenville
Exterior
Holiday Inn Greenville - Woodruff Road by IHG

Holiday Inn Greenville - Woodruff Road by IHG

Holiday Inn Greenville - Woodruff Road by IHG
3.0 star property
Greenville
8.6 out of 10, Excellent, (669)
"Friendly staff"
United States
Candice
The price is ฿3,723
฿4,095 total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Greenville - Woodruff Road by IHG
Exterior
Home2 Suites by Hilton Duncan

Home2 Suites by Hilton Duncan

Home2 Suites by Hilton Duncan
3.0 star property
Duncan
9.4 out of 10, Exceptional, (283)
"The lady that greeted us was excellent and exceptional "
United States
Manuel
The price is ฿3,483
฿3,866 total
includes taxes & fees
25 Dec - 26 Dec
Home2 Suites by Hilton Duncan
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Holiday Rentals in Upstate South Carolina

Cottage
Signature Cottage, 2 Bedrooms | Living room | 43-inch Smart TV with cable channels, TV, Netflix
Clemson Memorabilia House

Clemson Memorabilia House

Clemson Memorabilia House
3.0 star property
Clemson
9.8 out of 10, Exceptional, (9)
"We enjoyed our stay, it was the perfect size for our family of four. "
Clemson Memorabilia House
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Stay near popular Southeastern United States attractions

"Clemson University is an American public, coeducational, land-grant and sea-grant research university located in Clemson, South Carolina, United States.More clemson images:"

Clemson University

4.7/5 (738 reviews)
Take a campus tour or just explore the area of Clemson University during your travels in Clemson. Experience the area's theatre scene or attend a football match.
See properties
Exploring Falls Park on the Reedy in Downtown Greenville, South Carolina during a peaceful afternoon stroll with scenic views

Falls Park on the Reedy

4.7/5 (1,399 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theatre scene or attend a sporting event in this family-friendly area.
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
The view from Caesars Head after a storm
Photo by Michelle Hendrix
Open Photo by Michelle Hendrix

Top Upstate South Carolina Hotel Reviews

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

10/10 Excellent
"Great staff, professional and helpful. Very clean rooms."
Jerry 3-night trip
Posted 3 days ago
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
ECHO Suites Extended Stay by Wyndham Spartanburg

ECHO Suites Extended Stay by Wyndham Spartanburg

10/10 Excellent
"I was impressed upon entrance to the lobby! Everything was clean in neat and the receptionist was AWESOME!"
Angela 2-night trip
Posted 6 days ago
ECHO Suites Extended Stay by Wyndham Spartanburg

More cheap stays in Upstate South Carolina

Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

1007 George Smith Mill Rd Anderson SC
The price is ฿1,984 per night from 23 Dec to 24 Dec
฿1,984
฿2,203 total
23 Dec - 24 Dec
includes taxes & fees
7.6/10 Good! (1,002 reviews)

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