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Our top choices for Upstate South Carolina hotels

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

1. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Rubin

฿2,821 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor patio with a modern design, featuring a seating area with sofas and a fire pit, surrounded by plants and under a pergola with hanging lights.

2. SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Deborah

฿5,410 total

includes taxes & fees

22 Nov - 23 Nov

A multi-level hotel lobby with a central atrium, multiple dining areas, and a reception desk.

3. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Shirleen

฿3,730 total

includes taxes & fees

23 Nov - 24 Nov

A modern kitchen with hanging light fixtures and bar seating.

4. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jamie

฿4,251 total

includes taxes & fees

24 Nov - 25 Nov

An indoor swimming pool with a tiled floor, a covered area, and a seating area with chairs.

5. Drury Inn & Suites Greenville

Greenville

Jamie

฿4,265 total

includes taxes & fees

12 Nov - 13 Nov

A spacious lobby with a modern design, featuring a reception desk, seating area with sofas and armchairs, and a large chandelier.

6. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Taleigha

฿3,326 total

includes taxes & fees

29 Nov - 30 Nov

A multi-story hotel with a stone facade, large windows, and outdoor seating areas.

7. Hampton Inn & Suites Greenville-Downtown-RiverPlace

Greenville Downtown

Cindy

฿5,611 total

includes taxes & fees

22 Nov - 23 Nov

A modern hotel room with a large bed, a desk, and a kitchenette.

8. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Maclin

฿2,648 total

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with modern furniture, a chandelier, and potted plants.

9. Hilton Greenville

Greenville

William

฿4,044 total

includes taxes & fees

22 Nov - 23 Nov

An outdoor patio with a brick fireplace, outdoor kitchen, and seating area.

10. Residence Inn by Marriott Greenville

Greenville

gina

฿4,782 total

includes taxes & fees

22 Nov - 23 Nov

A modern outdoor seating area with a glass-top coffee table, blue sofas, and orange patterned cushions.

11. Tru by Hilton Greenville Woodruff Road

Greenville

Amy

฿4,054 total

includes taxes & fees

23 Nov - 24 Nov

12. Hyatt Place Greenville Downtown

Greenville Downtown

Tamara

฿4,855 total

includes taxes & fees

29 Nov - 30 Nov

A spacious lobby with a large beige sofa, a fireplace, and a modern chandelier.

13. Hilton Garden Inn Greenville

Greenville

Valerie

฿3,417 total

includes taxes & fees

22 Nov - 23 Nov

A covered outdoor area with a grill and seating, surrounded by brick walls and windows.

14. Homewood Suites by Hilton Greenville Downtown

Greenville Downtown

Cyrus

฿5,141 total

includes taxes & fees

24 Nov - 25 Nov

A modern hotel lobby with a bar area, seating, and a reception desk.

15. Holiday Inn Greenville - Woodruff Road by IHG

Greenville

Rick

฿3,754 total

includes taxes & fees

1 Nov - 2 Nov

A buffet with various food items, including omelets and other dishes, displayed in metal trays.

16. Holiday Inn Express & Suites Greenville - Downtown by IHG

Greenville Downtown

James

฿4,417 total

includes taxes & fees

29 Nov - 30 Nov

A modern hotel room with a large bed, a desk, and a seating area with chairs and a table.

17. Hampton Inn Greenville I-385 - Woodruff Rd.

Greenville

Joseph

฿3,885 total

includes taxes & fees

12 Nov - 13 Nov

A circular outdoor seating area with a fire pit, surrounded by sofas and chairs, in front of a multi-story building.

18. Courtyard by Marriott Greenville Haywood Mall

Greenville

alejandro

฿4,185 total

includes taxes & fees

23 Nov - 24 Nov

A Comfort Inn hotel with a stone facade, a clear sign indicating a 12'6" clearance, and a well-lit entrance.

19. Comfort Inn Greenville - Haywood Mall

Greenville

Paul

฿3,382 total

includes taxes & fees

8 Nov - 9 Nov

A modern lobby with a reception desk, seating area, and a kitchen in the background.

20. Courtyard by Marriott Greenville Downtown

Greenville Downtown

Ray

฿5,470 total

includes taxes & fees

8 Nov - 9 Nov

View all properties

Compare top hotels in Upstate South Carolina

Best Western Plus Greenville I-385 Inn & Suites 2.5 star property Greenville View	SpringHill Suites by Marriott Greenville Downtown 2.5 star property Greenville Downtown View	Embassy Suites Greenville Golf Resort & Conference Center 3.5 star property Greenville View	DoubleTree by Hilton Greenville Woodruff Road 3.0 star property Greenville View	Drury Inn & Suites Greenville 3.0 star property Greenville View
9.2 Wonderful 1,596 reviews	9.6 Exceptional 1,000 reviews	9.0 Wonderful 1,441 reviews	9.2 Wonderful 1,000 reviews	9.4 Exceptional 1,094 reviews
The price is ฿2,564 ฿2,821 total includes taxes & fees 1 Nov - 2 Nov	The price is ฿4,775 ฿5,410 total includes taxes & fees 22 Nov - 23 Nov	The price is ฿3,292 ฿3,730 total includes taxes & fees 23 Nov - 24 Nov	The price is ฿3,752 ฿4,251 total includes taxes & fees 24 Nov - 25 Nov	The price is ฿3,877 ฿4,265 total includes taxes & fees 12 Nov - 13 Nov
Yes, Breakfast included Yes, Pool No Spa No Pet-friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa No Pet-friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking	No Breakfast included Yes, Pool No Spa No Pet-friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking

Holiday Rentals in Upstate South Carolina

Aparthotel

stayAPT Suites Greenville-Haywood Mall

Greenville

"The kitchen was nice and came with basic utensils which was helpful"

Apartment

A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great location, convenient!"

Cottage

A living room with a blue sofa, a round coffee table with a vase of flowers, a patterned rug, and a chair. There are paintings on the walls and a window with curtains.

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"My wife and I enjoyed our stay here. 10/10 experience."

Mobile Home

A wooden dining table with green placemats, surrounded by chairs, in a cabin with large windows and wooden walls.

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

A living room with a sofa, a dining table, chairs, a kitchen area, and a view through large windows.

Greer Guest House < 1 Mi to Park & Downtown Area!

Greer

"Nice place en Greenville area "

Cottage

A modern living room with a ceiling fan, a sofa, a chair, and a coffee table. There is a kitchen in the background with cabinets and a countertop.

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Apartment

A large house with a spacious driveway and a pond in the background.

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

A room with two wooden beds, each with a nightstand, a lamp, and a window with curtains.

Cleveland Home w/ South Saluda Fishing Access

Cleveland

"This was a fishing trip that myself and a couple of my friends went on. The cabin was exactly as described in the listing and then some. Very clean and had every amenity you could think of. The host lives next door and went above and beyond making sure we had everything we needed and were comfortable. He even lent us his state pass to get into the parks and supplied his vast knowledge of where and what to use for fishing in the creeks. Will definitely be going back sometime in the near future."

Cottage

A wooden deck with a bench and a welcome mat, overlooking a well-maintained lawn and trees.

Serene Cabin w/ Pond & Creek on South Saluda River

Cleveland

"I chose this cabin due to its close proximity to the pretty place chapel. The property was BEAUTIFUL and tucked away. The silence and change of scenery was well needed and felt like we were at home. I honestly don’t have enough good things to say about the host Mr. Steve and his generosity and professionalism!"

Cottage

A cozy cabin interior with a dining area, kitchen, and living space.

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Seneca

"Beautiful and quaint cabin! Highly recommend, great view of the lake."

Cottage

A spacious living room with a large sofa, a kitchen area with a bar, and a view of the outdoors through the windows.

Waterfront Cabin w/ Private Dock on Lake Hartwell!

Townville

"We booked last minute for Clemson parents weekend. It worked out fine, it is really in the middle of no where. There are no outlets in the bathroom you have to use the kitchen mirror and outlets to get ready. There was a coffee machine but no coffee. It was very clean. The deck needs some work."

Apartment

A sandy beach with a calm lake surrounded by trees.

Lake Keowee Condo: Resort Pools & Lake Access!

Salem

"Wow!! Absolutely beautiful property. Recent remodel with beautiful and very tasteful design. Amazingly clean, organized and tidy. We are from Denver and did not have exposure to Lake Keowee. The lake was beautiful with great walking trails on the property. Special and spectacular spot! We will definitely go back. This is a gated community. Super comfortable king beds and nice linens."

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Take a campus tour or just explore the area of Clemson University during your travels in Clemson. Experience the area's theatre scene or attend a football match.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina