A large white building with a dome and a statue in front, surrounded by fountains and trees.

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Our top choices for St. Louis hotels with a spa

Restaurant

21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (1,968 reviews)
  • cleanliness
    Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
The price is ฿4,810
฿5,792 total
includes taxes & fees
6 Aug - 7 Aug
21C Museum Hotel St Louis
Hot tub, body treatments, hydrotherapy, aromatherapy, body scrubs

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.6 out of 10, Excellent, (1,009 reviews)
  • cleanliness
    Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
The price is ฿4,941
฿6,330 total
includes taxes & fees
3 Aug - 4 Aug
Ameristar Casino Resort and Spa
Couples treatment room(s), hot tub, body treatments, aromatherapy

Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1,000 reviews)
  • cleanliness
    Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
The price is ฿12,557
฿14,683 total
includes taxes & fees
22 Jul - 23 Jul
Four Seasons Hotel St Louis
Reception

The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (575 reviews)
  • cleanliness
    Revel in a rejuvenating spa retreat with aromatherapy treatments and hot stone massages at this luxury St. Louis hotel.
The price is ฿16,709
฿19,506 total
includes taxes & fees
19 Jul - 20 Jul
The Ritz-Carlton, St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in St. Louis

Pool
Hot tub

Top St. Louis Hotel Reviews

Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent
"Loved how close everything was and the kick back is great and the food is good"
Bryan 3-night trip
Posted less than an hour ago
Drury Plaza Hotel St. Louis Union Station

Frequently asked questions

Looking to holiday at a spa hotel in St. Louis?
Soothe the senses with some time in one of our wonderful spa hotels. Travellers love the fascinating museums and live music scene in St. Louis so get ready for a cultural tour. Hotels with spas are the perfect way to break away from your daily routine and add a layer of luxury to your holiday.
What is the best spa hotel in St. Louis?
Ameristar Casino Resort and Spa is a top luxury spa hotel featuring 6 restaurants, a casino, a 24-hour fitness centre and an outdoor pool. Treat yourself to a facial, body scrub or hydrotherapy at Ara. Another popular spa hotel in St. Louis is Four Seasons Hotel St Louis.
How many spa hotels will I find in St. Louis?
Among Expedia's 1968 accommodation options in St. Louis, there are 2 spa hotels.
What's there to see and do in St. Louis?
Experience St. Louis and visit St. Louis Union Station, Busch Stadium and Gateway Arch. If you have spare time during your trip, you might want to make a stop at St. Louis Zoo and St. Louis Aquarium at Union Station.
What is a St. Louis spa hotel?
Spa hotels in St. Louis provide lodging and have an on-site spa offering services such as therapies and beauty treatments. Some also offer in-room treatments. Spa hotels are ideal if you are looking for some R&R during your holiday.