A large white building with a dome and a statue in front, surrounded by fountains and trees.

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Check availability on St. Louis Spa Hotels

This weekend
30 Oct - 1 Nov
Next weekend
6 Nov - 8 Nov

Our top choices for St. Louis hotels with a spa

A modern hotel lobby with a glass facade, seating area, and a staircase.

1. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1,002 reviews)
  • cleanliness
    Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
The price is ฿12,666
฿14,811 total
includes taxes & fees
8 Nov - 9 Nov
Four Seasons Hotel St Louis
A reception area with a wooden counter, a staircase with a colorful mural, and a sign reading 'Locust Street Athletic and Swim Club.'

2. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
4.5 star property
Downtown West
9.0 out of 10, Wonderful, (2,148 reviews)
  • cleanliness
    Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
The price is ฿4,852
฿5,842 total
includes taxes & fees
22 Nov - 23 Nov
21C Museum Hotel St Louis
A well-lit lobby with a chandelier, potted plants, and a seating area.

3. Truitt Hotel

Truitt Hotel
2.0 star property
Lafayette Square
10.0 out of 10, Exceptional, (21 reviews)
The price is ฿5,675
฿6,888 total
includes taxes & fees
12 Nov - 13 Nov
Truitt Hotel
A reception desk with a modern design, a large abstract wall, and a seating area with a chair.

4. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.6 out of 10, Excellent, (1,080 reviews)
  • cleanliness
    Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
The price is ฿5,377
฿6,845 total
includes taxes & fees
17 Nov - 18 Nov
Ameristar Casino Resort and Spa
A hotel room with two beds, a framed picture on the wall, and a window with curtains.

5. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (586 reviews)
  • cleanliness
    Revel in a rejuvenating spa retreat with aromatherapy treatments and hot stone massages at this luxury St. Louis hotel.
The price is ฿19,557
฿22,830 total
includes taxes & fees
1 Nov - 2 Nov
The Ritz-Carlton, St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in St. Louis

Pool
Hot tub

Top St. Louis Hotel Reviews

The Westin St. Louis

The Westin St. Louis

10/10 Excellent
"Room was clean, staff helpful. Super close to stadium"
Kassidy 1-night trip
Posted 1 hour ago
The Westin St. Louis

Frequently asked questions

Looking to holiday at a spa hotel in St. Louis?
Soothe the senses with some time in one of our wonderful spa hotels. Travellers love the fascinating museums and live music scene in St. Louis so get ready for a cultural tour. Hotels with spas are the perfect way to break away from your daily routine and add a layer of luxury to your holiday.
What is the best spa hotel in St. Louis?
Ameristar Casino Resort and Spa is a top luxury spa hotel featuring 6 restaurants, a casino, a 24-hour fitness centre and an outdoor pool. Treat yourself to a facial, body scrub or hydrotherapy at Ara. Another popular spa hotel in St. Louis is Four Seasons Hotel St Louis.
How many spa hotels will I find in St. Louis?
Among Expedia's 1964 accommodation options in St. Louis, there are 2 spa hotels.
What's there to see and do in St. Louis?
Experience St. Louis and visit St. Louis Union Station, St. Louis Zoo and St. Louis Aquarium at Union Station. If you have spare time during your trip, you might want to make a stop at The St. Louis Wheel and Energizer Park.
What is a St. Louis spa hotel?
Spa hotels in St. Louis provide lodging and have an on-site spa offering services such as therapies and beauty treatments. Some also offer in-room treatments. Spa hotels are ideal if you are looking for some R&R during your holiday.