Search Hotels in South Main, Houston
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Our top choices for South Main hotels
1. Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,376 reviews)
"Room was clean and the staff was very nice."
Juan
The price is ฿3,064
฿3,585 total
includes taxes & fees
2 Aug - 3 Aug
2. Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.8 out of 10, Excellent, (1,006 reviews)
"Friendly staff. Nice comfortable room at a very reasonable rate. Lobby area was very clean. The pool area however left much to be desired; it was small and not clean at all."
ken
The price is ฿3,455
฿4,042 total
includes taxes & fees
24 Aug - 25 Aug
3. Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Good parking"
joseph
The price is ฿2,809
฿3,286 total
includes taxes & fees
3 Aug - 4 Aug
4. Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,003 reviews)
"convenient to medical center"
Mike
The price is ฿1,983
฿2,320 total
includes taxes & fees
29 Aug - 30 Aug
5. Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (889 reviews)
"This place had"
Marvin
The price is ฿2,470
฿2,890 total
includes taxes & fees
27 Aug - 28 Aug
6. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG1.4 km from South Main
9.4 out of 10, Exceptional, (1,005 reviews)
"My stay was great"
Cheryl
The price is ฿3,958
฿4,658 total
includes taxes & fees
9 Aug - 10 Aug
7. Hyatt Place Houston Medical Center
Hyatt Place Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,644 reviews)
"Great place to visit"
Jasmine
The price is ฿4,239
฿4,986 total
includes taxes & fees
13 Aug - 14 Aug
8. Hyatt House Houston Medical Center
Hyatt House Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,274 reviews)
"Very reliable hotel"
Leland
The price is ฿4,217
฿4,960 total
includes taxes & fees
15 Aug - 16 Aug
9. Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by HiltonTexas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,842 reviews)
"Excellent staff, service and amenities. Everything was great, highly recommend staying here!"
Feroze
The price is ฿4,933
฿5,772 total
includes taxes & fees
30 Aug - 31 Aug
10. Hilton Garden Inn Houston Medical Center, TX
Hilton Garden Inn Houston Medical Center, TXTexas Medical Center, 4.7 km from South Main
9.2 out of 10, Wonderful, (1,000 reviews)
"The staff was very accommodating and the place was very clean."
Donald
The price is ฿3,804
฿4,451 total
includes taxes & fees
20 Aug - 21 Aug
11. The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictTexas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,160 reviews)
"The bar was great vibes and the morning bartender was the best definitely will visit again soon!"
Brandon
The price is ฿5,078
฿6,321 total
includes taxes & fees
9 Aug - 10 Aug
12. Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.4 out of 10, Very good, (2,065 reviews)
"Great place to stay at super clean and nice area and everything was nearby"
Marvin
The price is ฿3,605
฿4,256 total
includes taxes & fees
30 Aug - 31 Aug
13. Hotel Ylem
Hotel Ylem2.3 km from South Main
8.4 out of 10, Very good, (1,538 reviews)
"Great staff, good breakfast and room in good condition"
Bruno
The price is ฿2,501
฿3,093 total
includes taxes & fees
7 Aug - 8 Aug
14. Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (375 reviews)
"Clean quiet rooms nice breakfast great staff"
Keitha
The price is ฿2,974
฿3,480 total
includes taxes & fees
3 Aug - 4 Aug
15. Home2 Suites by Hilton at the Galleria
Home2 Suites by Hilton at the GalleriaGreater Uptown, 8 km from South Main
9.0 out of 10, Wonderful, (1,004 reviews)
"Great place to stay"
Tyson
The price is ฿3,531
฿4,131 total
includes taxes & fees
7 Aug - 8 Aug
16. DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway Plaza6.6 km from South Main
8.4 out of 10, Very good, (1,772 reviews)
"Excellent place to stay with family"
Fahad
The price is ฿3,040
฿3,557 total
includes taxes & fees
7 Aug - 8 Aug
17. Hotel Zaza Houston Museum District
Hotel Zaza Houston Museum District6.3 km from South Main
9.2 out of 10, Wonderful, (1,002 reviews)
"Everything was excellent! We enjoyed our stay"
Pablo
The price is ฿7,731
฿10,364 total
includes taxes & fees
1 Aug - 2 Aug
18. Best Western Plus Downtown Inn & Suites
Best Western Plus Downtown Inn & Suites10.2 km from South Main
9.2 out of 10, Wonderful, (1,110 reviews)
"Great place to stay, book here all the time when it town."
MARCOS
The price is ฿3,942
฿4,612 total
includes taxes & fees
12 Aug - 13 Aug
19. Hyatt Place Houston/Galleria
Hyatt Place Houston/Galleria8.7 km from South Main
8.8 out of 10, Excellent, (1,558 reviews)
"Excellent stay!!!"
Loukisha
The price is ฿3,595
฿4,229 total
includes taxes & fees
4 Aug - 5 Aug
20. Holiday Inn Express Houston - Galleria Area by IHG
Holiday Inn Express Houston - Galleria Area by IHGThe Galleria, 8.6 km from South Main
9.4 out of 10, Exceptional, (1,000 reviews)
"Great stay"
JonTaria
The price is ฿3,939
฿4,608 total
includes taxes & fees
8 Aug - 9 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.8 Excellent 1,006 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,376 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 889 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,003 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,001 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Top South Main Hotel Reviews
Blossom Hotel Houston, Curio Collection by Hilton
8/10 Good
