What is South Main like?

You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to Reliant Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on our traveller data, Wyndham Houston at Reliant Park & Medical Center is one of the top choices for your stay in South Main. This hotel is a short 3-minute walk from Reliant Park, and it offers a restaurant and an outdoor pool.

How many hotels should I expect to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.

What can I see and do in this Houston neighbourhood?

Reliant Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as Reliant Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.

The Best Hotels in South Main, Houston - 2026 Updated Prices

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Our top choices for South Main hotels

1. Wyndham Houston at Reliant Park & Medical Center

South Main

Miguel

฿3,654 total

includes taxes & fees

24 Sept - 25 Sept

Desk, laptop workspace, iron/ironing board (on request), rollaway beds

2. Comfort Suites Houston near Medical Center- NRG Stadium

South Main

chris

฿3,674 total

includes taxes & fees

21 Sept - 22 Sept

3. Wingate Houston at Reliant Park & Medical Center

South Main

Terry

฿3,558 total

includes taxes & fees

27 Sept - 28 Sept

Hypo-allergenic bedding, in-room safe, desk, blackout curtains

4. Quality Inn & Suites NRG Park - Medical Center

South Main

Oscar

฿2,696 total

includes taxes & fees

5 Oct - 6 Oct

Coffee/tea maker, full-sized fridge, microwave, stovetop

5. Candlewood Suites Houston Medical Center by IHG

South Main

Michelle

฿3,225 total

includes taxes & fees

18 Sept - 19 Sept

6. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

1.4 km from South Main

Kevin

฿4,590 total

includes taxes & fees

24 Sept - 25 Sept

7. Hyatt Place Houston Medical Center

Texas Medical Center, 3.1 km from South Main

Lamarr

฿4,961 total

includes taxes & fees

5 Oct - 6 Oct

8. InterContinental Houston by IHG

Texas Medical Center, 4.1 km from South Main

Eric

฿7,114 total

includes taxes & fees

19 Sept - 20 Sept

9. Blossom Hotel Houston, Curio Collection by Hilton

Texas Medical Center, 3.5 km from South Main

Kamauri

฿6,067 total

includes taxes & fees

20 Sept - 21 Sept

10. Hyatt House Houston Medical Center

Texas Medical Center, 3.1 km from South Main

Kelly

฿4,642 total

includes taxes & fees

21 Sept - 22 Sept

11. Courtyard By Marriott Houston Medical Center Reliant Park

2.7 km from South Main

Jorge

฿4,360 total

includes taxes & fees

20 Sept - 21 Sept

12. Hilton Garden Inn Houston Medical Center, TX

Texas Medical Center, 4.7 km from South Main

Tameka

฿4,407 total

includes taxes & fees

26 Sept - 27 Sept

Outdoor pool, free pool cabanas, pool umbrellas

13. The Westin Houston Medical Center/Museum District

Texas Medical Center, 4.4 km from South Main

Juan

฿5,661 total

includes taxes & fees

27 Sept - 28 Sept

14. Home2 Suites by Hilton Houston Medical Center, TX

Texas Medical Center, 4.7 km from South Main

Charles

฿5,042 total

includes taxes & fees

26 Sept - 27 Sept

15. Hotel Ylem

2.3 km from South Main

GUSTAVO

฿2,991 total

includes taxes & fees

22 Sept - 23 Sept

16. Hilton Houston Plaza/Medical Center

Texas Medical Center, 4.4 km from South Main

Cindy

฿4,149 total

includes taxes & fees

11 Oct - 12 Oct

Suite, 1 Bedroom | Desk, blackout curtains, iron/ironing board, free WiFi

17. Hyatt Place Houston/Galleria

8.7 km from South Main

Adaobi

฿4,237 total

includes taxes & fees

21 Sept - 22 Sept

Premium bedding, pillow-top beds, minibar, in-room safe

18. Hotel Zaza Houston Museum District

6.3 km from South Main

Tina

฿11,430 total

includes taxes & fees

19 Sept - 20 Sept

19. Holiday Inn Express Houston - Galleria Area by IHG

The Galleria, 8.6 km from South Main

Kaylyn

฿4,911 total

includes taxes & fees

20 Sept - 21 Sept

20. Drury Inn & Suites Houston Near the Galleria

The Galleria, 9.4 km from South Main

Andrei

฿3,634 total

includes taxes & fees

20 Sept - 21 Sept

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Compare popular hotels in South Main

Property	Property class	Guest rating
Comfort Suites Houston near Medical Center- NRG Stadium	2.5 star property	8.8 Excellent 1,000 reviews	View
Candlewood Suites Houston Medical Center by IHG	2.5 star property	7.4 Good 897 reviews	View
Wyndham Houston at Reliant Park & Medical Center	3.5 star property	7.2 Good 1,406 reviews	View
Quality Inn & Suites NRG Park - Medical Center	2.5 star property	6.6 1,004 reviews	View
Wingate Houston at Reliant Park & Medical Center	3.0 star property	6.6 1,002 reviews	View

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

A cityscape with modern skyscrapers and a park with trees and people.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

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A person walking in front of a building with a brick facade and three arched windows.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.

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A cityscape with tall buildings, including a prominent one with 'Texas Children's Hospital' on it, under a partly cloudy sky.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

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An art gallery with a minimalist design, featuring a central bench and large abstract paintings on the walls.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.

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A large rectangular reflecting pool with a tall building in the background.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

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Top South Main Hotel Reviews

Blossom Hotel Houston, Curio Collection by Hilton

10/10 Excellent

"Amazing stay!! Near the stadium, we were there for a game....beautiful building with an inside drop off area. Hotel staff (Petrece at the front desk) were so accommodating and kind. We flew in for the 12:00 game and they let us check in early. Amazing breakfast buffet, worth the money for the convenience and quality of the food. The room had such great little details, the nighlight and shower cap and scented shampoo and soaps and the rooftop pool was great after all our walking. But above all...the bed! So so comfortable. If you are in Houston for a game, this is your place for sure! Thank you everyone at Blossom for such a great stay."