Search Hotels in South Main, Houston

Start date: Check-in selected.
To Date
End date: Check-out

    Change your mind

    Book hotels with free cancellation

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
25 Oct - 26 Oct
Tomorrow
26 Oct - 27 Oct
Next weekend
31 Oct - 2 Nov
In two weeks
7 Nov - 9 Nov

Filter by

Guest rating
Guest rating
Star rating

Top Trending Hotels Near South Main, Houston

Lobby
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.2 out of 10, Good, (1172)
"Everyone was very pleasant, I will be returning."
United States
Amy
The price is ฿3,238
฿3,788 total
includes taxes & fees
27 Oct - 28 Oct
Wyndham Houston near NRG Park/Medical Center
1 bedroom, hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6 out of 10, (1002)
"Everything was great"
United States
Yeimi
The price is ฿1,928
฿2,256 total
includes taxes & fees
24 Nov - 25 Nov
Quality Inn & Suites NRG Park - Medical Center
Gazebo
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6 out of 10, (948)
"Great place to stay, Breakfast not so fulfilling but good service and clean rooms."
United States
ALBERTO
The price is ฿2,584
฿3,023 total
includes taxes & fees
27 Oct - 28 Oct
Wingate Houston near NRG Park/Medical Center
Lobby
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.6 out of 10, Excellent, (1000)
"Loved staying at the Comfort Suites ."
United States
Linda
The price is ฿2,796
฿3,272 total
includes taxes & fees
14 Nov - 15 Nov
Comfort Suites Houston near Medical Center- NRG Stadium
Exterior
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4 out of 10, Good, (804)
"The staff is great. The area is questionable due to homeless population."
United States
Bryana
The price is ฿2,420
฿2,832 total
includes taxes & fees
29 Oct - 30 Oct
Candlewood Suites Houston Medical Center by IHG
Exterior
The Lancaster Hotel
The Lancaster Hotel
4.0 star property
9.8 out of 10, Exceptional, (1004)
"Great place... lots of nice people and nice rooms."
United States
Kenneth
The price is ฿7,918
฿9,264 total
includes taxes & fees
26 Oct - 27 Oct
The Lancaster Hotel
Lobby
Hyatt Place Houston Medical Center
Hyatt Place Houston Medical Center
3.0 star property
9.2 out of 10, Wonderful, (2059)
"Great place to stay!"
United States
Jason
The price is ฿3,864
฿4,545 total
includes taxes & fees
23 Nov - 24 Nov
Hyatt Place Houston Medical Center
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, pool loungers
Hyatt Regency Houston/Galleria
Hyatt Regency Houston/Galleria
4.0 star property
9.0 out of 10, Wonderful, (1109)
"Wonderful property!!! Very much enjoyed our stay! "
United States
Matthew
The price is ฿4,710
฿5,548 total
includes taxes & fees
23 Nov - 24 Nov
Hyatt Regency Houston/Galleria
Exterior detail
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
8.2 out of 10, Very good, (2744)
"Great location and rooms"
United States
Miriam
The price is ฿3,806
฿4,484 total
includes taxes & fees
23 Nov - 24 Nov
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Lobby
Hyatt House Houston Medical Center
Hyatt House Houston Medical Center
3.0 star property
9.2 out of 10, Wonderful, (1141)
"Great stay"
United States
Kurt
The price is ฿3,864
฿4,545 total
includes taxes & fees
23 Nov - 24 Nov
Hyatt House Houston Medical Center
Front of property
Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
9.0 out of 10, Wonderful, (3579)
"The staff and hotel were wonderful. Close to my meeting location and the rooms were exquisite. "
United States
Candy
The price is ฿4,081
฿4,774 total
includes taxes & fees
24 Nov - 25 Nov
Blossom Hotel Houston, Curio Collection by Hilton
City view from property
The Whitehall Houston
The Whitehall Houston
4.0 star property
8.6 out of 10, Excellent, (1827)
"Great staff nice rooms"
United States
Matthew
The price is ฿3,869
฿4,527 total
includes taxes & fees
22 Nov - 23 Nov
The Whitehall Houston
Breakfast, lunch, brunch served; American cuisine, garden views
Hyatt Regency Houston West
Hyatt Regency Houston West
3.5 star property
8.6 out of 10, Excellent, (1210)
"It’s a beautiful hotel, price is good. "
United States
Yan
The price is ฿4,088
฿4,783 total
includes taxes & fees
9 Nov - 10 Nov
Hyatt Regency Houston West
Interior
Omni Houston Hotel
Omni Houston Hotel
4.0 star property
9.0 out of 10, Wonderful, (1000)
"Really enjoyed my stay. "
United States
kenneth
The price is ฿5,730
฿6,805 total
includes taxes & fees
23 Nov - 24 Nov
Omni Houston Hotel
Exterior
La Quinta Inn & Suites by Wyndham Houston Southwest
La Quinta Inn & Suites by Wyndham Houston Southwest
3.0 star property
7.0 out of 10, Good, (1034)
"Great stay. "
United States
Larissa
The price is ฿1,987
฿2,325 total
includes taxes & fees
25 Nov - 26 Nov
La Quinta Inn & Suites by Wyndham Houston Southwest
Exterior
The Royal Sonesta Houston Galleria
The Royal Sonesta Houston Galleria
4.0 star property
8.4 out of 10, Very good, (1316)
"Great place, staff was nice, "
United States
Jamyal
The price is ฿3,892
฿4,554 total
includes taxes & fees
16 Nov - 17 Nov
The Royal Sonesta Houston Galleria
Exterior
Holiday Inn Express & Suites Houston – Downtown North by IHG
Holiday Inn Express & Suites Houston – Downtown North by IHG
2.5 star property
9.2 out of 10, Wonderful, (598)
"Nice staff and very clean "
United States
Luis
The price is ฿3,369
฿3,941 total
includes taxes & fees
23 Nov - 24 Nov
Holiday Inn Express & Suites Houston – Downtown North by IHG
Lobby
Club Quarters Hotel Downtown, Houston
Club Quarters Hotel Downtown, Houston
4.0 star property
8.4 out of 10, Very good, (3824)
"Stay was great, check in was very easy and it was in a great location "
United States
Kristianna
The price is ฿3,797
฿4,443 total
includes taxes & fees
26 Oct - 27 Oct
Club Quarters Hotel Downtown, Houston
Premium bedding, desk, iron/ironing board, free WiFi
Haven Inn & Suites Downtown Houston
Haven Inn & Suites Downtown Houston
2.5 star property
9.4 out of 10, Exceptional, (1003)
"Very clean and safe, would stay again"
United States
Krimson
Haven Inn & Suites Downtown Houston
Lobby
Sonesta ES Suites Houston Galleria
Sonesta ES Suites Houston Galleria
3.0 star property
8.2 out of 10, Very good, (1108)
"Nice stay"
United States
Steven
The price is ฿4,219
฿4,936 total
includes taxes & fees
2 Nov - 3 Nov
Sonesta ES Suites Houston Galleria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Hotels in South Main with free breakfast

Exterior
La Quinta Inn & Suites by Wyndham Deer Park
La Quinta Inn & Suites by Wyndham Deer Park
3.0 star property
  • Breakfast included
8.4 out of 10, Very good, (406)
The price is ฿2,878
฿3,367 total
includes taxes & fees
22 Nov - 23 Nov
La Quinta Inn & Suites by Wyndham Deer Park
See more properties

Hotels in South Main with a pool

Gazebo
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center
3.0 star property
  • Pool
6.6 out of 10, (948)
The price is ฿2,584
฿3,023 total
includes taxes & fees
27 Oct - 28 Oct
Wingate Houston near NRG Park/Medical Center
See more properties

Top guest rated hotels in South Main

Lobby
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center
3.5 star property
    7.2 out of 10, Good, (1172)
    The price is ฿3,238
    ฿3,788 total
    includes taxes & fees
    27 Oct - 28 Oct
    Wyndham Houston near NRG Park/Medical Center
    See more properties

    Where to stay in South Main

    Find the best South Main areas for the activities you enjoy most.
    Discovery Green showing city views, modern architecture and a high-rise building

    Downtown Houston

    Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

    The Galleria

    Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.

    Texas Medical Center

    Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

    Menil Collection featuring interior views and art

    Montrose

    Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

    Northside

    While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more of the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

    Top South Main Hotel Reviews

    Hilton Houston Plaza/Medical Center

    Hilton Houston Plaza/Medical Center

    10/10 Excellent
    "I didn’t have any breakfast "
    Kamela 1-night trip
    Posted 1 day ago
    Hilton Houston Plaza/Medical Center

    Explore a world of travel with Expedia

    Frequently asked questions

    What is South Main like?
    You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
    Where is the best hotel for a stay in South Main?
    Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
    How many hotels should I expect to find in South Main?
    If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodation options to choose from.
    If I need to cancel my hotel reservation in South Main, will I receive a refund?
    Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
    What can I see and do in this Houston neighbourhood?
    NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
    How can I get around South Main and the greater Houston area?
    Ready to get out and explore the city? Fannin South Station is the closest metro station.