The Best Hotels in Sant' Ambrogio, Florence - 2026 Updated Prices

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Compare popular hotels in Sant' Ambrogio

Property	Property class	Guest rating
The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World	5.0 star property	10.0 Exceptional 23 reviews	View
Hotel Regency	5.0 star property	9.4 Exceptional 458 reviews	View
Hotel Villa Liana	3.0 star property	8.8 Excellent 360 reviews	View
Hotel Bodoni	2.0 star property	8.2 Very good 853 reviews	View
Hotel Bavaria	1.0 star property	8.2 Very good 450 reviews	View

Where to stay in Sant' Ambrogio

Find the best Sant' Ambrogio areas for the activities you enjoy most.

A river with buildings on the right bank.

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

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A historic building with intricate architectural details, including a dome and ornate facades.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Cathedral of Santa Maria del Fiore or Piazza del Duomo while you're exploring the neighbourhood.

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A historic bridge with arches over a river, surrounded by yellow buildings and a crowd of people.

San Giovanni

If you're spending some time in San Giovanni, Cathedral of Santa Maria del Fiore and Piazza della Signoria are top sights worth seeing.

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A historic church with intricate architecture and a large open plaza with people.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

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An ornate building with intricate architectural details and a clear blue sky in the background.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

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Top Sant' Ambrogio Hotel Reviews

Hotel Bavaria

10/10 Excellent

"⭐⭐⭐⭐⭐ We had a wonderful stay at this hotel! The room was clean, comfortable, and full of character, with beautiful traditional décor that made the experience feel unique and authentic. The bed was comfortable, and the room had everything we needed for a relaxing stay. The location was excellent—perfect for exploring the city while still being peaceful and quiet at night. The staff were friendly, welcoming, and always happy to help with any questions. We truly enjoyed our time here and would happily stay again. Thank you for making our visit so enjoyable!"

I Quattro Poeti

8/10 Good

"Glad we got free breakfast. Do NOT book here if lugging baggage up 90 steps (yes, I counted) would be a challenge for you as there is no elevator. Read all emailed instructions VERY carefully as there are several doors, key boxes, etc you'll need codes for. All the info is there but it can feel like a scavenger hunt. Our room was a bit disappointing as it had no view. The only window was about 4 meters high so it only provided light. Overall very cramped. Another positive was the AC - during a very hot day, the AC did a great job of cooling down the room."

Palazzo Pazzi Vitali By Geco Vacation Rentals

10/10 Excellent

"This property is under-rated and we are thankful we stumbled upon this. We had a nearly 3000 sf apartment to ourselves and the photos don't do it justice. We stay at luxury lodging everywhere we go and this was no different. There was so much room to relax and spread out. Great for multi family, or large family. Our unit on the second floor was ideal because the bedrooms were in the ack and very quiet. While the main living areas overlook this beautiful street with opera singers and live music in the afternoon. It radiates throughout the room. This place is gorgeous and worth every penny. Very clean and had everything you could need to stay for a lengthy period of time. Very centrally located too! "

Frequently asked questions

What's it like in Sant' Ambrogio?

Guests are sure to enjoy their time checking out all that Florence's Sant' Ambrogio neighbourhood has to offer. Make sure that you visit Jewish Museum and Piazza Massimo D'Azeglio as part of your Sant' Ambrogio travel plans.

What's a favourite hotel to stay in Sant' Ambrogio?

Based on our traveller data, Hotel Regency is one of the top choices for your stay in Sant' Ambrogio. This hotel is a short 15-minute walk from Piazza del Duomo, and it offers free breakfast and a restaurant. Other good options for your stay in the neighbourhood include Hotel Bavaria and Hotel Cardinal Of Florence.

How many hotels can I expect to find in Sant' Ambrogio?

If you're searching for places to stay in Florence, Expedia has something to meet your needs with 532 Sant' Ambrogio hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in Sant' Ambrogio, will I receive a refund?

Yes, you'll find most hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best options available in Sant' Ambrogio.

What is there to do around this Florence neighbourhood?

Landmarks in Sant' Ambrogio that you won't want to miss include Great Synagogue of Florence and Church of Santa Maria Maddalena dei Pazzi. Jewish Museum and Piazza Massimo D'Azeglio are also a couple of places to visit in the neighbourhood. Don't miss favourite places to visit in the surrounding area, such as Cathedral of Santa Maria del Fiore, Piazza del Duomo and Piazza della Signoria. When you're sightseeing in Florence, Piazza di Santa Maria Novella and FiesoleBike Day Tours are also worth a stop.

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Our top choices for Sant' Ambrogio hotels

1. Hotel Regency

2. Hotel Bodoni

3. Hotel Cardinal Of Florence

4. Alfieri9

5. Hotel Villa Liana

6. Villa Tortorelli

7. The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

8. Palazzo dei Ciompi Suites

9. Locanda Orchidea - B&B

10. Casa Rovai Guest House

11. Dimora del Cardinale - Residenza d'epoca

12. Tosca

13. Boheme

14. B&B di Piazza del Duomo

15. Residenza D'Epoca Sant'Egidio

16. Hotel Bavaria

17. PALAZZO TESTA - LOCAZIONE TURISTICA

18. Residenza d'Epoca Borgo Albizi

19. Mamo Florence - Dante & Virgilio Apartments

20. Firenze Suite

Compare popular hotels in Sant' Ambrogio

Where to stay in Sant' Ambrogio

Historic Centre of Florence

Duomo

San Giovanni

Santa Maria Novella

Santa Croce

Top Sant' Ambrogio Hotel Reviews

Hotel Bavaria

Frequently asked questions

Explore a world of travel with Expedia