Search Hotels in Serra Mesa, San Diego

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Our top choices for Serra Mesa hotels

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.8 km from Serra Mesa
9.2 out of 10, Wonderful, (1,805 reviews)
"Awesome place "
United States
Jonathan
The price is ฿2,386
฿3,017 total
includes taxes & fees
5 Apr - 6 Apr
Sycuan Casino Resort

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
2.5 star property
14 km from Serra Mesa
8.4 out of 10, Very good, (1,000 reviews)
"Great accommodations, friendly staff, they met all our needs."
United States
Scott
The price is ฿4,689
฿5,158 total
includes taxes & fees
24 Apr - 25 Apr
Best Western Plus La Mesa San Diego

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
10.1 km from Serra Mesa
8.4 out of 10, Very good, (3,406 reviews)
"Nice hotel with great location "
United States
DIANA
The price is ฿5,513
฿7,773 total
includes taxes & fees
5 Apr - 6 Apr
Sheraton San Diego Resort

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
28.1 km from Serra Mesa
9.0 out of 10, Wonderful, (1,247 reviews)
"Great place and service. Will definitely stay there again. "
United States
Maria
The price is ฿3,991
฿4,539 total
includes taxes & fees
14 Apr - 15 Apr
Best Western Americana Inn

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
26 km from Serra Mesa
9.8 out of 10, Exceptional, (1,105 reviews)
"Best hotel breakfast ever Rooms very spacious Nice big bathtub and nice shower I will definitely use this hotel again"
United States
Kenneth
The price is ฿6,405
฿7,058 total
includes taxes & fees
26 Apr - 27 Apr
Ayres Hotel San Diego South - Chula Vista

Courtyard by Marriott San Diego Central

Courtyard by Marriott San Diego Central
3.0 star property
2.6 km from Serra Mesa
8.6 out of 10, Excellent, (1,007 reviews)
"Nice gym! Clean room and nice staff! "
United States
Martin
The price is ฿4,223
฿4,854 total
includes taxes & fees
5 Apr - 6 Apr
Courtyard by Marriott San Diego Central

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
10.6 km from Serra Mesa
9.2 out of 10, Wonderful, (1,719 reviews)
"Great location for the airport stay"
United States
Christopher
The price is ฿5,676
฿6,524 total
includes taxes & fees
5 Apr - 6 Apr
Hampton Inn & Suites San Diego Airport Liberty Station

Embassy Suites by Hilton San Diego La Jolla

Embassy Suites by Hilton San Diego La Jolla
4.0 star property
University City, 10.3 km from Serra Mesa
8.8 out of 10, Excellent, (1,903 reviews)
"Quick stay for one night and everything went very smoothly"
United States
Christopher
The price is ฿6,350
฿8,229 total
includes taxes & fees
16 Apr - 17 Apr
Embassy Suites by Hilton San Diego La Jolla

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
18.7 km from Serra Mesa
8.6 out of 10, Excellent, (1,572 reviews)
"Really enjoyed our stay. "
United States
Maricruz
The price is ฿3,300
฿3,630 total
includes taxes & fees
3 May - 4 May
La Quinta Inn by Wyndham San Diego Chula Vista

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
7.9 km from Serra Mesa
9.2 out of 10, Wonderful, (1,069 reviews)
"Clean room, friendly staff, and only a 15 minute walk to Old Town. Also conveniently located close to the airport just a short shuttle drive away. "
United States
Olivia
The price is ฿4,015
฿4,615 total
includes taxes & fees
4 Apr - 5 Apr
Holiday Inn Express San Diego Airport - Old Town by IHG

Country Inn & Suites by Radisson, San Diego North, CA

Country Inn & Suites by Radisson, San Diego North, CA
3.0 star property
11.7 km from Serra Mesa
9.0 out of 10, Wonderful, (1,449 reviews)
"Paid parking, good breakfast, quiet area"
United States
Anna
The price is ฿4,931
฿5,668 total
includes taxes & fees
5 Apr - 6 Apr
Country Inn & Suites by Radisson, San Diego North, CA

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.1 km from Serra Mesa
9.2 out of 10, Wonderful, (3,754 reviews)
"Great hotel"
United States
Deante
The price is ฿5,190
฿5,720 total
includes taxes & fees
5 Apr - 6 Apr
Best Western Plus Marina Gateway Hotel

Pleasant Inn

Pleasant Inn
2.5 star property
4.8 km from Serra Mesa
8.6 out of 10, Excellent, (1,354 reviews)
"Another wonderful stay! "
United States
Gene
The price is ฿3,050
฿3,500 total
includes taxes & fees
12 Apr - 13 Apr
Pleasant Inn

Hampton Inn San Diego-Kearny Mesa

Hampton Inn San Diego-Kearny Mesa
2.5 star property
3.5 km from Serra Mesa
9.0 out of 10, Wonderful, (1,006 reviews)
"The rooms was a nice size and clean. The staff was nice and their breakfast was better than expected. "
United States
elisa
The price is ฿4,622
฿5,304 total
includes taxes & fees
12 Apr - 13 Apr
Hampton Inn San Diego-Kearny Mesa

Lamplighter Inn & Suites at SDSU

Lamplighter Inn & Suites at SDSU
2.5 star property
8.4 km from Serra Mesa
9.0 out of 10, Wonderful, (1,389 reviews)
"Nice pool area."
Canada
Natalia
Lamplighter Inn & Suites at SDSU

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4,207 reviews)
"great place"
Canada
souheil
The price is ฿3,494
฿4,016 total
includes taxes & fees
5 Apr - 6 Apr
Wyndham Garden San Diego Near SeaWorld

DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar
4.0 star property
Carmel Valley, 17.4 km from Serra Mesa
8.6 out of 10, Excellent, (2,261 reviews)
"Great place to stay ! "
United States
Yuko
The price is ฿5,373
฿6,122 total
includes taxes & fees
12 Apr - 13 Apr
DoubleTree by Hilton San Diego - Del Mar

Best Western San Diego/Miramar Hotel

Best Western San Diego/Miramar Hotel
2.5 star property
10.1 km from Serra Mesa
7.8 out of 10, Good, (1,252 reviews)
"Great stay."
United States
Suma
The price is ฿3,703
฿4,257 total
includes taxes & fees
9 Apr - 10 Apr
Best Western San Diego/Miramar Hotel

HYATT house San Diego/Sorrento Mesa

HYATT house San Diego/Sorrento Mesa
3.0 star property
11.8 km from Serra Mesa
9.0 out of 10, Wonderful, (1,001 reviews)
"Enjoyed our stay very much "
United States
Peggy Sue
The price is ฿4,864
฿5,591 total
includes taxes & fees
3 Apr - 4 Apr
HYATT house San Diego/Sorrento Mesa

The Sands of La Jolla

The Sands of La Jolla
2.5 star property
12 km from Serra Mesa
9.0 out of 10, Wonderful, (776 reviews)
"Quick easy, nice stay."
United States
Ella
The price is ฿4,209
฿4,745 total
includes taxes & fees
12 Apr - 13 Apr
The Sands of La Jolla
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Sunset Cliffs Natural Park.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 39 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.