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Our top choices for Mayo Clinic hotels

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

1. Sonesta Select Scottsdale at Mayo Clinic Campus

Sonesta Select Scottsdale at Mayo Clinic Campus
3.0 star property
Mayo Clinic
8.4 out of 10, Very good, (1,082 reviews)
"all good happy place to stay"
United States
louis
The price is ฿3,146
฿3,585 total
includes taxes & fees
22 Nov - 23 Nov
Sonesta Select Scottsdale at Mayo Clinic Campus
A modern dining area with multiple tables and chairs, a fireplace, and a television mounted on the wall.

2. Comfort Suites Scottsdale Talking Stick Entertainment District

Comfort Suites Scottsdale Talking Stick Entertainment District
2.5 star property
9.7 km from Mayo Clinic
9.2 out of 10, Wonderful, (2,071 reviews)
"would definitely stay here again"
United States
LAURA
The price is ฿3,434
฿3,915 total
includes taxes & fees
29 Nov - 30 Nov
Comfort Suites Scottsdale Talking Stick Entertainment District
A modern infinity pool with a view of mountains and a sunset.

3. Talking Stick Resort

Talking Stick Resort
4.0 star property
9 km from Mayo Clinic
9.4 out of 10, Exceptional, (5,188 reviews)
"I loved staying here!"
United States
Jessica
The price is ฿4,268
฿5,821 total
includes taxes & fees
22 Nov - 23 Nov
Talking Stick Resort
A hotel lobby with a reception desk, seating area, and a large wall mural.

4. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale
3.0 star property
Central Scottsdale, 9 km from Mayo Clinic
8.8 out of 10, Excellent, (1,900 reviews)
"The hotel was very clean and our room was pretty quiet. We will stay there again."
United States
Kristle
The price is ฿3,146
฿3,585 total
includes taxes & fees
1 Dec - 2 Dec
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale
An outdoor seating area with sofas, tables, and umbrellas, featuring a fire feature in the center.

5. Hyatt Place Scottsdale - North

Hyatt Place Scottsdale - North
3.0 star property
14.2 km from Mayo Clinic
9.4 out of 10, Exceptional, (1,295 reviews)
"Clean rooms, friendly staff, good breakfast spread."
United States
Ted
The price is ฿4,367
฿4,977 total
includes taxes & fees
22 Nov - 23 Nov
Hyatt Place Scottsdale - North
A spacious lobby with a large seating area, a reception desk, and artwork on the walls.

6. Best Western Plus Scottsdale Thunderbird Suites

Best Western Plus Scottsdale Thunderbird Suites
3.0 star property
Thunderbird Industrial Airpark, 12.3 km from Mayo Clinic
8.8 out of 10, Excellent, (1,002 reviews)
"All around a great place to stay for the price, thanks again."
United States
Irene
The price is ฿3,576
฿4,076 total
includes taxes & fees
29 Nov - 30 Nov
Best Western Plus Scottsdale Thunderbird Suites
A courtyard with outdoor seating and a fire pit, surrounded by a building with multiple windows and doors.

7. Aiden by Best Western Scottsdale North

Aiden by Best Western Scottsdale North
3.0 star property
8.8 km from Mayo Clinic
9.0 out of 10, Wonderful, (1,214 reviews)
"Great breakfast and served until 10:00 a.m. all days; could sleep in."
United States
Marie
The price is ฿3,291
฿3,751 total
includes taxes & fees
22 Nov - 23 Nov
Aiden by Best Western Scottsdale North
A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.

8. Inn at Eagle Mountain

Inn at Eagle Mountain
3.5 star property
3 km from Mayo Clinic
9.0 out of 10, Wonderful, (1,035 reviews)
"Great place to stay, very roomy"
United States
Jose Jr
The price is ฿5,208
฿5,945 total
includes taxes & fees
18 Nov - 19 Nov
Inn at Eagle Mountain
A pathway lined with tall cacti and palm trees, leading to a building with arched balconies and a stucco exterior.

9. Holiday Inn Club Vacations Scottsdale Resort by IHG

Holiday Inn Club Vacations Scottsdale Resort by IHG
4.0 star property
13.3 km from Mayo Clinic
9.2 out of 10, Wonderful, (1,065 reviews)
"Amazing 10n out of 10 Cant wait to go back."
United States
Christine
The price is ฿6,492
฿8,734 total
includes taxes & fees
30 Nov - 1 Dec
Holiday Inn Club Vacations Scottsdale Resort by IHG
A spacious, modern lounge area with multiple seating arrangements, including tables and chairs, and a large window providing a view of the outdoors.

10. Holiday Inn Express & Suites Phoenix - Airport North by IHG

Holiday Inn Express & Suites Phoenix - Airport North by IHG
2.5 star property
23.2 km from Mayo Clinic
9.4 out of 10, Exceptional, (2,432 reviews)
"We enjoyed the stay"
Canada
XIN
The price is ฿3,280
฿3,708 total
includes taxes & fees
24 Nov - 25 Nov
Holiday Inn Express & Suites Phoenix - Airport North by IHG
A modern outdoor lounge area with sofas, chairs, and a glass-top coffee table with a fire feature.

11. Hyatt House North Scottsdale

Hyatt House North Scottsdale
3.5 star property
14.2 km from Mayo Clinic
9.6 out of 10, Exceptional, (1,013 reviews)
"Awesome staff and great area"
United States
Chantella
The price is ฿4,518
฿5,149 total
includes taxes & fees
15 Nov - 16 Nov
Hyatt House North Scottsdale
A hotel with a modern design, featuring a prominent entrance and multiple floors.

12. Springhill Suites By Marriott Phoenix Downtown

Springhill Suites By Marriott Phoenix Downtown
3.0 star property
29.2 km from Mayo Clinic
9.2 out of 10, Wonderful, (1,086 reviews)
"Great stay."
United States
Beverly
The price is ฿3,101
฿3,506 total
includes taxes & fees
26 Nov - 27 Nov
Springhill Suites By Marriott Phoenix Downtown
A spacious living area with a kitchen, modern furniture, and a fireplace.

13. Fountain Park Hotel, BW Signature Collection

Fountain Park Hotel, BW Signature Collection
3.0 star property
7.2 km from Mayo Clinic
9.0 out of 10, Wonderful, (1,002 reviews)
"The location to family was perfect. We used the work out facilities and enjoyed many near by restaurants. We've stayed at this property several times throughout the past 15 years. The price point is perfect for our needs."
United States
Laura
The price is ฿3,982
฿4,547 total
includes taxes & fees
29 Nov - 30 Nov
Fountain Park Hotel, BW Signature Collection
An outdoor dining area with wicker furniture and candles, overlooking a well-maintained garden and buildings.

14. Sonesta Suites Scottsdale Gainey Ranch

Sonesta Suites Scottsdale Gainey Ranch
3.5 star property
12.4 km from Mayo Clinic
9.0 out of 10, Wonderful, (1,095 reviews)
"Great location and hotel."
United States
Hilda
The price is ฿5,154
฿7,018 total
includes taxes & fees
25 Nov - 26 Nov
Sonesta Suites Scottsdale Gainey Ranch
A modern hotel room with a grey sofa, a round table, a bed with white linens, a large abstract painting, a floor lamp, and a window with curtains.

15. Hyatt Place Tempe Phoenix Airport

Hyatt Place Tempe Phoenix Airport
3.0 star property
23.5 km from Mayo Clinic
9.0 out of 10, Wonderful, (1,219 reviews)
"Great location..very good accommodations"
United States
dularie
The price is ฿3,380
฿3,856 total
includes taxes & fees
22 Nov - 23 Nov
Hyatt Place Tempe Phoenix Airport
A spacious lobby with a fireplace, seating areas, and large windows.

16. Hilton Garden Inn Phoenix Airport North

Hilton Garden Inn Phoenix Airport North
3.0 star property
24.2 km from Mayo Clinic
8.6 out of 10, Excellent, (2,801 reviews)
"Great hotel!"
United States
Aaliyah
The price is ฿3,101
฿3,506 total
includes taxes & fees
22 Nov - 23 Nov
Hilton Garden Inn Phoenix Airport North
A lobby with a stone fireplace, wooden beams, and a chandelier.

17. Great Wolf Lodge Arizona

Great Wolf Lodge Arizona
4.0 star property
10.3 km from Mayo Clinic
8.8 out of 10, Excellent, (1,001 reviews)
"Loved everything about our stay!"
United States
Dejanira
The price is ฿5,319
฿6,225 total
includes taxes & fees
7 Dec - 8 Dec
Great Wolf Lodge Arizona
A modern hotel with a brick facade, large windows, and a covered entrance area.

18. Springhill Suites Phoenix Scottsdale Marriott

Springhill Suites Phoenix Scottsdale Marriott
2.0 star property
18.3 km from Mayo Clinic
9.4 out of 10, Exceptional, (467 reviews)
"Centrally located. Nice stay for family."
United States
Lucinda
The price is ฿3,385
฿3,858 total
includes taxes & fees
22 Nov - 23 Nov
Springhill Suites Phoenix Scottsdale Marriott
A spacious lobby with a reception desk, seating area, and a staircase.

19. Hilton Phoenix Airport

Hilton Phoenix Airport
4.0 star property
25 km from Mayo Clinic
8.8 out of 10, Excellent, (1,074 reviews)
"Overall a great stay."
United States
Ilene
The price is ฿3,385
฿3,827 total
includes taxes & fees
22 Nov - 23 Nov
Hilton Phoenix Airport
An outdoor seating area with sofas, chairs, and a fire pit.

20. Home2 Suites by Hilton Phoenix Airport North, AZ

Home2 Suites by Hilton Phoenix Airport North, AZ
3.0 star property
23.1 km from Mayo Clinic
9.4 out of 10, Exceptional, (1,000 reviews)
"Everything was good with this hotel, and it was perfectly located for us as an airport hotel."
United States
Mark
The price is ฿3,243
฿3,667 total
includes taxes & fees
22 Nov - 23 Nov
Home2 Suites by Hilton Phoenix Airport North, AZ
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Mayo Clinic

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.
Sonesta Select Scottsdale at Mayo Clinic Campus
3.0 star property
8.4
Very good
1,082 reviews
View
A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.
Inn at Eagle Mountain
3.5 star property
9.0
Wonderful
1,035 reviews
View
A modern infinity pool with a view of mountains and a sunset.
Talking Stick Resort
4.0 star property
9.4
Exceptional
5,188 reviews
View
A modern dining area with multiple tables and chairs, a fireplace, and a television mounted on the wall.
Comfort Suites Scottsdale Talking Stick Entertainment District
2.5 star property
9.2
Wonderful
2,071 reviews
View
A hotel lobby with a reception desk, seating area, and a large wall mural.
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale
3.0 star property
8.8
Excellent
1,900 reviews
View

Where to stay in Mayo Clinic

Find the best Mayo Clinic areas for the activities you enjoy most.
A cityscape with prominent buildings including a Chase bank and The Arizona Republic building.

Downtown Phoenix

Cheer on the Phoenix Suns at an NBA game or walk around the city’s historic precinct as you explore the state capital.

A fountain with three horses, surrounded by red flowers and storefronts.

Old Town

Gourmet restaurants interesting history and top sights from Scottsdale Waterfront to Western Spirit: Scottsdale's Museum of the West – discover Old Town, a destination also famous for its shopping.

A hiker on a rocky trail with mountains in the background.

Rio Verde Foothills

If you're looking for some top things to see and do in Rio Verde Foothills and surrounding area, you can visit Golf Club Scottsdale and Tom's Thumb Trail.

A rocky hill with palm trees and a body of water.

Camelback East

You might take some time to check out the abundant dining options in Camelback East. Spend some time visiting top spots like Biltmore Fashion Park, and catch the metro at 44th Street - Washington Station or 50th Street Station to see more of the area.

A mountainous landscape with a city in the valley below.

North Phoenix

While you're in North Phoenix, take in top sights like Reach 11 Sports Complex and jump on the metro at 19th Avenue/ Dunlap Station to see more of the city.

Top Mayo Clinic Hotel Reviews

A lobby with stone flooring, wooden furniture, a fireplace, and modern lighting fixtures.
Inn at Eagle Mountain

Inn at Eagle Mountain

Inn at Eagle Mountain
Eagle Mountain

10/10 Excellent

Amazing place couldn’t fault it at all. Bed so comfortable views amazing and great golf course next door.
United Kingdom
Rene
Reviewed August 10, 2026
Inn at Eagle Mountain

Frequently Asked Questions

What is Mayo Clinic like?

Travellers will be sure to find plenty to entertain them in Scottsdale's Mayo Clinic neighbourhood.

Where is the best place to stay in Mayo Clinic?

Based on Expedia customer reviews, Sonesta Select Scottsdale at Mayo Clinic Campus is the highest ranked property in Mayo Clinic. This hotel offers a restaurant and an outdoor pool.

How many hotels should I expect to find in the Mayo Clinic area?

With 14 Expedia hotels and other accommodation options in Mayo Clinic to choose from, this is a good starting point for exploring the greater Scottsdale area.

If I need to cancel my hotel reservation in Mayo Clinic, will I receive a refund?

Yes! Most hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you may still be able to cancel and be given a refund within a 24-hour period of booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best options available in Mayo Clinic.

What is there to do around this Scottsdale neighbourhood?

A few places to visit in the area around Mayo Clinic include Eagle Mountain Golf Course, Golf Club at Eagle Mountain and SunRidge Canyon Golf Club. Make a stop at Talking Stick Resort Casino and OdySea Aquarium while you're sightseeing around the area.