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Check prices for these dates

This weekend
11 Sep - 13 Sep
Next weekend
18 Sep - 20 Sep

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Our top choices for Downtown South San Francisco hotels

A La Quinta hotel with a modern facade, a covered entrance, and a parking lot.

1. La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
3.0 star property
Downtown South San Francisco
8.2 out of 10, Very good, (2,141 reviews)
"Everything good I like this hotel a lot"
United States
Juana
The price is ฿3,889
฿4,553 total
includes taxes & fees
20 Sept - 21 Sept
La Quinta Inn & Suites by Wyndham San Francisco Airport N
An indoor courtyard with a stone floor, a round table with chairs, and potted plants.

2. Airport Inn

Airport Inn
2.0 star property
Downtown South San Francisco
9.0 out of 10, Wonderful, (1,004 reviews)
"One of the best places I’ve stayed in SF area"
United States
Saikiran
The price is ฿3,614
฿4,230 total
includes taxes & fees
9 Sept - 10 Sept
Airport Inn
A hotel room with a bed, a desk, a chair, a TV, and a lamp.

3. Inn By The SFO

Inn By The SFO
2.0 star property
Downtown South San Francisco
7.6 out of 10, Good, (1,002 reviews)
"Very cozy spot in South San Francisco. Very accessible to the city."
United States
Ben
The price is ฿2,442
฿2,885 total
includes taxes & fees
9 Sept - 10 Sept
Inn By The SFO
A neatly made bed with white linens and a folded towel, a wooden headboard, and a window with blinds.

4. Miller Apartments

Miller Apartments
2.0 star property
Downtown South San Francisco
7.4 out of 10, Good, (20 reviews)
"I liked the room"
United States
Lina
The price is ฿1,357
฿4,092 total
includes taxes & fees
9 Sept - 10 Sept
Miller Apartments
An outdoor patio with modern seating, a fire feature, and string lights.

5. Home2 Suites by Hilton San Francisco Airport North

Home2 Suites by Hilton San Francisco Airport North
3.0 star property
The East Side, 1.5 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (1,261 reviews)
"Clean, convenient, staff was awesome… would definitely book again."
United States
Evelyn
The price is ฿4,288
฿5,012 total
includes taxes & fees
18 Sept - 19 Sept
Home2 Suites by Hilton San Francisco Airport North
A multi-level hotel atrium with outdoor seating areas, a pool, and a central lounge.

6. Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
3.5 star property
The East Side, 1.4 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,744 reviews)
"Our stay was great!"
United States
jenny
The price is ฿4,883
฿5,732 total
includes taxes & fees
2 Oct - 3 Oct
Embassy Suites by Hilton San Francisco Airport Oyster Point
A bar area with a curved wooden counter, bar stools, and a glass display case filled with bottles.

7. Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel
3.0 star property
1.8 km from Downtown South San Francisco
8.4 out of 10, Very good, (1,913 reviews)
"Location is perfect"
United States
Kenneth
The price is ฿3,577
฿4,213 total
includes taxes & fees
2 Oct - 3 Oct
Best Western Plus Grosvenor Airport Hotel
A hotel room with a bed, desk, chair, television, and a microwave.

8. Hotel Nova SFO

Hotel Nova SFO
2.5 star property
1.9 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,026 reviews)
"I had a great stay!"
United States
Brenden
The price is ฿3,552
฿4,159 total
includes taxes & fees
9 Sept - 10 Sept
Hotel Nova SFO
A reception area with a counter, two patterned chairs, a yellow ottoman, and a large blue potted plant.

9. Hotel Aura SFO

Hotel Aura SFO
3.0 star property
4.4 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2,672 reviews)
"Great airport stay"
United States
Charles
The price is ฿3,700
฿4,411 total
includes taxes & fees
4 Oct - 5 Oct
Hotel Aura SFO
A modern hotel entrance with a covered waiting area, glass doors, and a clear sky.

10. Aloft by Marriott San Francisco Airport

Aloft by Marriott San Francisco Airport
3.0 star property
6.9 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2,263 reviews)
"A fine option if you need ri stay near the airport ."
United States
Celeste
The price is ฿4,444
฿5,108 total
includes taxes & fees
4 Oct - 5 Oct
Aloft by Marriott San Francisco Airport

11. Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
3.0 star property
Oyster Point, 2.2 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2,364 reviews)
"The beat stay staff all shifts was very helpful ..very informative for seeing the town ai will be back"
United States
Ebony
The price is ฿3,983
฿4,691 total
includes taxes & fees
20 Sept - 21 Sept
Sonesta Select San Francisco Airport Oyster Point Waterfront
A modern lobby with a cityscape mural, a reception desk, seating area, and a door with blinds.

12. Hotel Skye SFO

Hotel Skye SFO
3.0 star property
3.9 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (1,989 reviews)
"Good Place to Stay"
United States
ABHISHEK
The price is ฿4,115
฿4,910 total
includes taxes & fees
11 Sept - 12 Sept
Hotel Skye SFO
A spacious lobby with a reception desk, seating area, and a high ceiling with chandeliers.

13. La Quinta Inn & Suites by Wyndham San Francisco Airport West

La Quinta Inn & Suites by Wyndham San Francisco Airport West
3.0 star property
5.4 km from Downtown South San Francisco
8.6 out of 10, Excellent, (1,835 reviews)
"Clean rooms, breakfast and were very friendly."
United States
Victor
The price is ฿4,333
฿4,980 total
includes taxes & fees
20 Sept - 21 Sept
La Quinta Inn & Suites by Wyndham San Francisco Airport West
A courtyard with outdoor seating, a glass table, and potted plants.

14. Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North
2.5 star property
The East Side, 1.1 km from Downtown South San Francisco
7.8 out of 10, Good, (1,002 reviews)
"Shuttle and breakfast made this worth it"
United States
Sarah
The price is ฿3,381
฿3,969 total
includes taxes & fees
4 Oct - 5 Oct
Comfort Inn and Suites San Francisco Airport North
A hotel with a modern facade, multiple floors, and a well-lit entrance.

15. The Westin San Francisco Airport

The Westin San Francisco Airport
4.0 star property
6.9 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,815 reviews)
"Great location and very close to the airport"
United States
Karl
The price is ฿4,177
฿5,958 total
includes taxes & fees
27 Sept - 28 Sept
The Westin San Francisco Airport
A hotel room with a bed, a sofa, a nightstand, and a desk. There are three framed pictures on the wall.

16. The Atrium Hotel

The Atrium Hotel
2.5 star property
3 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,014 reviews)
"Staff are friendly and professional. Like the clean room, free breakfast and free parking. We will definitely come stay again."
United States
BIENVENIDO
The price is ฿3,868
฿4,669 total
includes taxes & fees
4 Oct - 5 Oct
The Atrium Hotel
A modern interior with a wooden partition, a stone accent wall, and a bar area.

17. DoubleTree by Hilton San Francisco Airport North Bayfront

DoubleTree by Hilton San Francisco Airport North Bayfront
4.0 star property
3.1 km from Downtown South San Francisco
8.2 out of 10, Very good, (1,741 reviews)
"Great location and very friendly staff!"
United States
Jamie
The price is ฿3,212
฿3,790 total
includes taxes & fees
18 Sept - 19 Sept
DoubleTree by Hilton San Francisco Airport North Bayfront
A multi-level hotel atrium with a central open space, multiple seating areas, and a glass ceiling.

18. Hyatt Regency San Francisco Airport

Hyatt Regency San Francisco Airport
4.0 star property
8.3 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (1,568 reviews)
"Nice place to stay"
United States
Roberto
The price is ฿4,510
฿6,063 total
includes taxes & fees
25 Sept - 26 Sept
Hyatt Regency San Francisco Airport
An outdoor patio with wooden furniture, a chessboard, and hanging floral decorations.

19. The Millwood - A Boutique Hotel

The Millwood - A Boutique Hotel
3.0 star property
5.4 km from Downtown South San Francisco
9.2 out of 10, Wonderful, (1,030 reviews)
"It is a cute property with nice, clean rooms. Breakfast was included and was good. The parking lot is small and tight but otherwise a great stay."
United States
Nick
The price is ฿5,288
฿6,268 total
includes taxes & fees
20 Sept - 21 Sept
The Millwood - A Boutique Hotel
An outdoor patio with round tables and chairs, a view of the sea, and parked cars in the background.

20. Bay Landing San Francisco Airport Hotel

Bay Landing San Francisco Airport Hotel
3.0 star property
7.9 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (4,978 reviews)
"Perfect location, excellent breakfast and very nice staff"
United States
Prakhar
The price is ฿4,664
฿5,258 total
includes taxes & fees
4 Oct - 5 Oct
Bay Landing San Francisco Airport Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.
A street with shops, including a crystal shop and a crepes cafe.

Fisherman's Wharf

This waterfront neighborhood dates back to the gold rush era and is a hub for tourist activities, sea lions and seafood restaurants.

A cityscape with tall buildings, a central plaza with palm trees, and a flag on one of the buildings.

Union Square

Fashion puts on its finest face in one of the country’s largest shopping plazas.

A trolley on a street with buildings and a clock tower.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and San Francisco Bay are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

A cityscape with modern skyscrapers, a central park with pathways, and a few people walking.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

A street lined with historic buildings, parked cars, and a clear blue sky.

Nob Hill

Examine architecturally significant buildings, visit the Cable Car Museum and enjoy magnificent views of greater San Francisco in this affluent district.

Top Downtown South San Francisco Hotel Reviews

Parc 55 San Francisco - A Hilton Hotel

Parc 55 San Francisco - A Hilton Hotel

10/10 Excellent
"The room was clean and when we left the do not enter sign on the door they respected that but let a card letting us know they didn’t go in that day. We have stayed at other hotels where w leave the sign out and they still enter and it’s very frustrating so it was very nice to have our privacy respected that day."
Logan 4-night trip
Posted 1 hour ago
Parc 55 San Francisco - A Hilton Hotel

Frequently asked questions

What's it like in Downtown South San Francisco?
You'll be sure to have fun exploring South San Francisco's Downtown South San Francisco neighbourhood.
What's a favourite place to stay in Downtown South San Francisco?
Based on our traveller data, La Quinta Inn & Suites by Wyndham San Francisco Airport N is one of the top choices for your stay in Downtown South San Francisco. This hotel offers free breakfast and an outdoor pool.
How many hotels should I expect to find in the Downtown South San Francisco area?
When you want to put your feet up after a day of exploring the sights in South San Francisco, you can choose from 10 Expedia hotels and other accommodation options in Downtown South San Francisco.
If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?
Yes, most hotel bookings are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Downtown South San Francisco.
What can I see and do in this South San Francisco neighbourhood?
South San Francisco Hillside Sign, Sign Hill Park and See's Candies are just a few of the places to visit in and around Downtown South San Francisco. Cinemark Century at Tanforan and K1 Speed San Francisco are also worth a visit when you're out sightseeing in South San Francisco.