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Our top choices for Colon hotels with a spa

Radisson Colon 2,000 Hotel & Casino

Radisson Colon 2,000 Hotel & Casino
4.0 star property
Barrio Sur
8.2 out of 10, Very good, (828)
"Check in was very speedy and welcoming . Javier at the front desk was easy to understand and friendly . Room was nice and bed was comfortable ."
United States
SEAN
The price is ฿2,808
฿3,089 total
includes taxes & fees
28 Dec - 29 Dec
Radisson Colon 2,000 Hotel & Casino

SAND DIAMOND HOTEL

SAND DIAMOND HOTEL
3.0 star property
Colon
8.6 out of 10, Excellent, (214)
"Great hotel"
United States
DIANA
The price is ฿3,698
฿4,067 total
includes taxes & fees
28 Dec - 29 Dec
SAND DIAMOND HOTEL

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (644)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is ฿6,968
฿7,665 total
includes taxes & fees
25 Jan - 26 Jan 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (996)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is ฿4,167
฿4,584 total
includes taxes & fees
9 Jan - 10 Jan 2026
Sheraton Grand Panama

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
Veracruz
8.0 out of 10, Very good, (1000)
"Great place and location, excellent food choices! "
United States
Francisco
The price is ฿7,082
฿7,790 total
includes taxes & fees
8 Jan - 9 Jan 2026
The Westin Playa Bonita Panama

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
San Francisco
9.4 out of 10, Exceptional, (2138)
"Great location of the hotel with a lovely breakfast and friendly staff"
United States
fouad
The price is ฿3,354
฿3,690 total
includes taxes & fees
16 Jan - 17 Jan 2026
Plaza Paitilla Inn Hotel

Hyatt Regency Panama City

Hyatt Regency Panama City
4.5 star property
Bella Vista
10.0 out of 10, Exceptional, (135)
"Great hotel fair price"
United States
Santiago
The price is ฿4,871
฿5,358 total
includes taxes & fees
3 Jan - 4 Jan 2026
Hyatt Regency Panama City

Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
4.5 star property
Casco Viejo
9.8 out of 10, Exceptional, (258)
"Great location!"
United States
Erik
The price is ฿10,697
฿11,767 total
includes taxes & fees
10 Jan - 11 Jan 2026
Hotel La Compañía Casco Antiguo

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (565)
"Amazing hotel , location , staff and amenities . Clean, elegant , great service. "
United States
Nicole
The price is ฿11,357
฿12,493 total
includes taxes & fees
13 Jan - 14 Jan 2026
Sofitel Legend Casco Viejo, Panama City

Hotel San Felipe

Hotel San Felipe
4.0 star property
Casco Viejo
9.4 out of 10, Exceptional, (254)
"Nice hotel, perfect area in the old quarter. Clean, comfortable, great staff. Highly recommend!"
Canada
Neil
The price is ฿3,625
฿3,987 total
includes taxes & fees
7 Jan - 8 Jan 2026
Hotel San Felipe
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Colon Hotel Reviews

Frequently asked questions

Looking to holiday at a spa hotel in Colon?
Book one of our fantastic spa hotels and treat yourself from the moment you arrive. Discover the lakeside setting in Colon—worth a picture or two! Make sure you enjoy the shops during your stay. Spa hotels are the perfect way to take a break from your routine and add a layer of luxury to your stay.
What is the best spa hotel in Colon?
Radisson Colon 2,000 Hotel & Casino is a top spa hotel featuring a casino, a shopping centre, a pool and a fitness centre. Spend an afternoon at the spa where you'll find hot stone massages, sports massages and reflexology.
How many spa hotels are there in Colon?
Among Expedia's 17 accommodation options in Colon, there is 1 spa hotel.
What's there to see and do in Colon?
Enjoy Colon and visit Colon 2000, Colon Free Zone and Gamboa Rainforest Resort. If you have a bit of extra time while you're in the area, you might want to check out Limon Bay and Canal Expansion Observation Center.
What is a Colon spa hotel?
Spa hotels in Colon provide lodging and have a full on-site spa offering services such as facials and beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation and relaxation.