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Our top choices for Upstate South Carolina hotels

A modern kitchen with a central island, bar stools, and pendant lighting.

1. Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

Spartanburg

Melinda

฿3,947 total

includes taxes & fees

27 Nov - 28 Nov

A modern hotel lobby with a long reception desk, bar area with stools, seating with patterned cushions, and a large window offering a view of greenery.

2. Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG

Spartanburg

Deborah

฿3,857 total

includes taxes & fees

28 Nov - 29 Nov

A multi-level hotel lobby with a central atrium, multiple dining areas, and a reception desk.

3. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Shirleen

฿3,730 total

includes taxes & fees

23 Nov - 24 Nov

A spacious lobby with a reception desk, green seating area, and multiple tables and chairs.

4. Home2 Suites by Hilton Duncan

Duncan

Marina

฿4,584 total

includes taxes & fees

29 Nov - 30 Nov

A modern hotel lobby with a fireplace, comfortable seating, and a large window.

5. Hampton Inn & Suites Greenville Airport, SC

Greenville

Freda

฿3,730 total

includes taxes & fees

29 Nov - 30 Nov

An outdoor seating area with sofas, a fire pit, and string lights.

6. Tru by Hilton Spartanburg

Spartanburg

Volodymyr

฿3,964 total

includes taxes & fees

29 Nov - 30 Nov

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

7. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Rubin

฿2,821 total

includes taxes & fees

1 Nov - 2 Nov

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

8. Hilton Garden Inn Spartanburg

Spartanburg

Patrick

฿3,788 total

includes taxes & fees

29 Nov - 30 Nov

A modern kitchen with a central island, equipped with a microwave, toaster, and coffee machine.

9. Comfort Suites At WestGate Mall

Spartanburg

Willie

฿3,279 total

includes taxes & fees

29 Nov - 30 Nov

A modern lobby with a reception desk, seating area, and a television screen.

10. Best Western Spartanburg I-26

Spartanburg

Santhosh

฿3,468 total

includes taxes & fees

8 Nov - 9 Nov

A modern interior with a fireplace, seating, and a wooden accent wall.

11. Hampton Inn & Suites Greenville/Spartanburg I-85, SC

Duncan

Nilda

฿3,725 total

includes taxes & fees

30 Nov - 1 Dec

A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.

12. Hotel Hartness

Greenville

Nicole

฿7,396 total

includes taxes & fees

22 Nov - 23 Nov

A rooftop bar with seating, a bar area, and a view of the cityscape at dusk.

13. AC Hotel by Marriott Spartanburg

Spartanburg

Willow

฿5,580 total

includes taxes & fees

28 Nov - 29 Nov

A modern living room with a fireplace, seating area, and a kitchen in the background.

14. Comfort Suites Greenville Airport

Greenville

Azalia

฿3,395 total

includes taxes & fees

29 Nov - 30 Nov

A modern kitchen with hanging light fixtures and bar seating.

15. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jamie

฿4,251 total

includes taxes & fees

24 Nov - 25 Nov

A multi-level hotel lobby with seating areas, a fireplace, and a staircase.

16. Four Points by Sheraton Spartanburg

Spartanburg

Derrick

฿4,854 total

includes taxes & fees

8 Nov - 9 Nov

A hotel lobby with a curved outdoor seating area, a fire pit, and a pool.

17. Spartanburg Marriott

Spartanburg

Tamela

฿4,417 total

includes taxes & fees

8 Nov - 9 Nov

An indoor swimming pool with multiple lanes, lounge chairs, and a clear view of the sky through large windows.

18. Holiday Inn Express & Suites Greenville-Spartanburg (Duncan) by IHG

Duncan

Dawn

฿3,416 total

includes taxes & fees

29 Nov - 30 Nov

19. Clarion Inn

Greenville

Johnny

฿2,693 total

includes taxes & fees

29 Nov - 30 Nov

A modern living room with a fireplace, two sofas, and a coffee table.

20. Best Western Spartanburg Northwest

Spartanburg

Herbert

฿3,700 total

includes taxes & fees

8 Nov - 9 Nov

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Holiday Rentals in Upstate South Carolina

Aparthotel

stayAPT Suites Greenville-Haywood Mall

Greenville

"The kitchen was nice and came with basic utensils which was helpful"

Apartment

A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great location, convenient!"

Cottage

A living room with a sofa, a dining table, chairs, a kitchen area, and a view through large windows.

Greer Guest House < 1 Mi to Park & Downtown Area!

Greer

"Nice place en Greenville area "

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"My wife and I enjoyed our stay here. 10/10 experience."

Mobile Home

A wooden dining table with green placemats, surrounded by chairs, in a cabin with large windows and wooden walls.

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

A living room with a blue sofa, a round coffee table with a vase of flowers, a patterned rug, and a chair. There are paintings on the walls and a window with curtains.

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Apartment

A large house with a spacious driveway and a pond in the background.

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

A modern living room with a ceiling fan, a sofa, a chair, and a coffee table. There is a kitchen in the background with cabinets and a countertop.

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cottage

A patio area with a red umbrella, metal chairs, a table, and a fire pit.

Cleveland Home w/ South Saluda Fishing Access

Cleveland

"This was a fishing trip that myself and a couple of my friends went on. The cabin was exactly as described in the listing and then some. Very clean and had every amenity you could think of. The host lives next door and went above and beyond making sure we had everything we needed and were comfortable. He even lent us his state pass to get into the parks and supplied his vast knowledge of where and what to use for fishing in the creeks. Will definitely be going back sometime in the near future."

Cottage

A wooden deck with a bench and a welcome mat, overlooking a well-maintained lawn and trees.

Serene Cabin w/ Pond & Creek on South Saluda River

Cleveland

"I chose this cabin due to its close proximity to the pretty place chapel. The property was BEAUTIFUL and tucked away. The silence and change of scenery was well needed and felt like we were at home. I honestly don’t have enough good things to say about the host Mr. Steve and his generosity and professionalism!"

Apartment

A bedroom with two beds, a ceiling fan, and a window with blinds.

Steps to Lake Greenwood: Waterfront Gem w/ Patio

Greenwood

"Me and my family really enjoyed the property the view. Everything was nice. We really enjoyed it. Hopefully, we’ll be coming back soon."

Cottage

A modern kitchen with blue cabinets, a central island, and a spiral staircase leading to an upper level.

Greenwood Getaway w/ Furnished Patio & Lake View

Greenwood

"wonderful hosts, pet friendly, very clean"

Apartment

A sandy beach with a calm lake surrounded by trees.

Lake Keowee Condo: Resort Pools & Lake Access!

Salem

"Wow!! Absolutely beautiful property. Recent remodel with beautiful and very tasteful design. Amazingly clean, organized and tidy. We are from Denver and did not have exposure to Lake Keowee. The lake was beautiful with great walking trails on the property. Special and spectacular spot! We will definitely go back. This is a gated community. Super comfortable king beds and nice linens."

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Take a campus tour or just explore the area of Clemson University during your travels in Clemson. Experience the area's theatre scene or attend a football match.

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Learn more about Upstate South Carolina

Check out the local area in Upstate South Carolina—home to attractions like Discovery Island Water Park and Heritage Park.

See all hotels in Upstate South Carolina

A multi-tiered waterfall cascading over rocks in a forested area.

Top Upstate South Carolina Hotel Reviews

Best Western Plus Clemson Hotel & Conference Center

10/10 Excellent

"Excellent"

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent

"Very nice place to stay. Friendly staff, nice evening reception (free drink and some very simple finger food). The breakfast choices were great- definitely go with an omelet as the scrambled eggs were cold. Only surprise was having to pay for parking per night!"