A calm lake reflecting trees with autumn foliage, a clear sky, and a distant shoreline.

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Check availability on St. Charles Spa Hotels

Next weekend
6 Nov - 8 Nov
In two weeks
13 Nov - 15 Nov

Our top choices for St. Charles hotels with a spa

A modern lobby with orange seating, a flat-screen TV, and a stone accent wall.

1. Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1,003 reviews)
"Wonderful place to stay and great location!"
United States
Robert
The price is ฿4,897
฿5,677 total
includes taxes & fees
15 Nov - 16 Nov
Drury Plaza Hotel St. Louis St. Charles
A brick building with a sign reading "Country Inn & Suites."

2. Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1,106 reviews)
"Very convenient to downtown St Charles. As per previous visits this hotel is excellent for the price range of the rooms."
United States
Stewart
The price is ฿4,304
฿4,946 total
includes taxes & fees
22 Nov - 23 Nov
Country Inn & Suites by Radisson, St. Charles Historic District
A modern hotel lobby with a seating area, a coffee station, and a large window providing natural light.

3. Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area
2.5 star property
St. Charles
9.0 out of 10, Wonderful, (754 reviews)
"Great stay!"
United States
Sara
The price is ฿3,991
฿4,795 total
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn & Suites St. Charles Old Town Area
A multi-level hotel lobby with numerous seating areas, a central water feature, and a variety of plants.

4. Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles
3.5 star property
St. Charles
8.8 out of 10, Excellent, (1,005 reviews)
"Great place to stay"
United States
Elyse
The price is ฿4,404
฿5,061 total
includes taxes & fees
22 Nov - 23 Nov
Embassy Suites by Hilton St. Louis St. Charles
A modern hotel with a prominent Hilton logo, multiple floors, and a well-lit entrance.

5. Tru by Hilton St. Charles St. Louis, MO

Tru by Hilton St. Charles St. Louis, MO
2.5 star property
St. Charles
8.6 out of 10, Excellent, (888 reviews)
"Check-in desk agents were wonderful and very knowledgeable about the area."
United States
Marvin
The price is ฿4,278
฿4,959 total
includes taxes & fees
22 Nov - 23 Nov
Tru by Hilton St. Charles St. Louis, MO
A hotel with a prominent 'Comfort Suites' sign, a covered entrance with columns, and a parking lot.

6. Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1,000 reviews)
"Great stay."
United States
Bryan
The price is ฿3,138
฿3,607 total
includes taxes & fees
29 Nov - 30 Nov
Comfort Suites St Charles - St Louis
A spacious living room with a large sectional sofa, a coffee table, and a fireplace. There is a television mounted on the wall and a chandelier hanging from the ceiling.

7. Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel
3.0 star property
St. Charles
8.2 out of 10, Very good, (1,002 reviews)
"Hotel was clean and staff were super friendly. Breakfast was good and coffee bar was excellent!"
United States
Steven
The price is ฿2,943
฿3,411 total
includes taxes & fees
1 Nov - 2 Nov
Best Western Plus The Charles Hotel
A hotel room with a bed, a desk with two chairs, a TV, and a mirror.

8. Candlewood Suites St Louis St Charles by IHG

Candlewood Suites St Louis St Charles by IHG
2.5 star property
St. Charles
7.6 out of 10, Good, (830 reviews)
"Only stayed for 6 hours after returning from a trip but the staff who checked me in was awesome and v3ry helpful!!!"
United States
Jeffrey
The price is ฿2,837
฿3,261 total
includes taxes & fees
29 Nov - 30 Nov
Candlewood Suites St Louis St Charles by IHG
A spacious lobby with a reception desk, seating area, and a fireplace.

9. Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn
2.5 star property
St. Charles
5.6 out of 10, (1,002 reviews)
"Clean and quiet with very friendly and professional staff."
United States
Gonzalo
The price is ฿3,374
฿3,911 total
includes taxes & fees
13 Nov - 14 Nov
Americas Best Value Inn & Suites St. Louis, St. Charles Inn
A living room with a brown leather sectional sofa, a glass coffee table, a wooden side table with drawers, a mirror, and a framed picture on the wall.

10. Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.2 out of 10, Very good, (1,000 reviews)
"Clean room, staff was polite and helpful!"
United States
Tammie
The price is ฿2,699
฿3,102 total
includes taxes & fees
8 Nov - 9 Nov
Super 8 by Wyndham St Charles
A Holiday Inn Express & Suites hotel with a covered entrance and a brick facade.

11. Holiday Inn Express Hotel and Suites St. Charles by IHG

Holiday Inn Express Hotel and Suites St. Charles by IHG
3.0 star property
St. Charles
8.2 out of 10, Very good, (771 reviews)
"As always with a Holiday Inn property, our room was clean and very comfortable. The staff was very friendly. Breakfast was good and served hot."
United States
sharon
The price is ฿3,513
฿4,037 total
includes taxes & fees
28 Nov - 29 Nov
Holiday Inn Express Hotel and Suites St. Charles by IHG
A reception desk with a wooden counter, a computer, a telephone, and a small plant. There are three pendant lights above the desk.

12. Country Inn & Suites by Radisson, St. Peters, MO

Country Inn & Suites by Radisson, St. Peters, MO
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,004 reviews)
"Great location. Friendly staff decent breakfast."
United States
Heather
The price is ฿2,842
฿3,267 total
includes taxes & fees
29 Nov - 30 Nov
Country Inn & Suites by Radisson, St. Peters, MO
A swimming pool area with red and white lounge chairs, a glass table, and a blue and yellow ceiling.

13. Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,003 reviews)
"Fantastic place to stay! The staff was amazing!"
United States
Catherine
The price is ฿3,698
฿4,250 total
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn St. Charles St. Peters
A reception area with a counter, a clock, a coffee station, and a seating area with chairs and a table.

14. Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
St. Charles
6.8 out of 10, (1,002 reviews)
"It was nice"
United States
Christoph
The price is ฿2,126
฿2,443 total
includes taxes & fees
12 Nov - 13 Nov
Relax Inn Saint Charles
A spacious lobby with a staircase, a reception desk, and a green wall with white floral patterns.

15. Sleep Inn Saint Charles North

Sleep Inn Saint Charles North
2.5 star property
St. Charles
5.8 out of 10, (564 reviews)
"Great stay!"
United States
Christine
The price is ฿2,459
฿2,826 total
includes taxes & fees
27 Nov - 28 Nov
Sleep Inn Saint Charles North
A multi-story hotel with a parking lot in front.

16. WoodSpring Suites St Louis St Charles

WoodSpring Suites St Louis St Charles
2.5 star property
St. Charles
5.6 out of 10, (308 reviews)
"Clean and staff was nice."
United States
Erica
The price is ฿2,871
฿3,299 total
includes taxes & fees
5 Nov - 6 Nov
WoodSpring Suites St Louis St Charles
A hotel room with a large bed, a desk, and a television.

17. Home2 Suites by Hilton St. Charles St.Louis

Home2 Suites by Hilton St. Charles St.Louis
3.0 star property
St. Charles
The price is ฿3,850
฿4,272 total
includes taxes & fees
1 Dec - 2 Dec
Home2 Suites by Hilton St. Charles St.Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in St. Charles

Pool
Hot tub

Top St. Charles Hotel Reviews

Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent
"Awesome location! We were able to walk to Union Station attractions as well as The Enterprise Center. The dinner and breakfast buffets are top notch!"
Tammy 1-night trip
Posted 2 hours ago
Drury Plaza Hotel St. Louis Union Station

Frequently asked questions

Looking for a spa hotel in St. Charles?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travellers highly recommend the restaurants in St. Charles. Enjoy the historical sites and riverfront during your holiday. Hotels with spas are a great way to break away from your daily routine and add a layer of luxury to your stay.
What is the best spa hotel in St. Charles?
Ameristar Casino Resort and Spa is a top luxury spa hotel featuring 6 restaurants, a casino, a 24-hour fitness centre and an outdoor pool. Treat yourself to a facial, body scrub or hydrotherapy at Ara.
How many spa hotels will I find in St. Charles?
Among Expedia's 178 accommodation options in St. Charles, there is 1 spa hotel.
What's there to see and do in St. Charles?
Experience all that St. Charles has to offer when you visit Historic Main Street, Katy Trail and Lewis & Clark Boathouse and Nature Center. If you have some spare time during your trip, you might want to check out St Charles Convention Center and Ameristar Casino St. Charles.
What is a St. Charles spa hotel?
Spa hotels in St. Charles provide lodging and have a full on-site spa which offers services such as couples massages as well as body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on holiday.