Santana Packages (Flight + Hotel)

Book a Hotel + Flight or Car together to unlock savings

Photo by Norberto Moctezuma Gomez
  • Plan, book, travel with confidence

  • Better together

    Save up to ฿4,531 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Top hotels in Santana

Aquarius Vacation Club at Boqueron Beach Resort

Aquarius Vacation Club at Boqueron Beach Resort

3.5 out of 5
Carretera 101 Km 18.1 Cabo Rojo
9.2/10 Wonderful! (2,202 reviews)
Good service

Reviewed on 27 Dec 2025

Aquarius Vacation Club at Boqueron Beach Resort
Costa Bahia Hotel & Convention Center

Costa Bahia Hotel & Convention Center

3.5 out of 5
Exit 205 Road 127 Km 8.6 Guayanilla
8.8/10 Excellent! (1,887 reviews)
Awesome breakfast

Reviewed on 30 Dec 2025

Costa Bahia Hotel & Convention Center
Holiday Inn Mayaguez and Tropical Casino by IHG

Holiday Inn Mayaguez and Tropical Casino by IHG

3.5 out of 5
2701 Highway #2 Hostos Avenue Mayagüez
Fully refundable
The price is ฿4,656 per night from 20 Jan to 21 Jan
฿4,656
฿5,168 total
20 Jan - 21 Jan 2026
includes taxes & fees
9.4/10 Exceptional! (1,170 reviews)
Excellent

Reviewed on 28 Dec 2025

Holiday Inn Mayaguez and Tropical Casino by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.