Santa Cruz Packages (Flight + Hotel)

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ฿27,000 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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    Plan, book, and manage your trip all in one place

Top hotels in Santa Cruz

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is ฿1,941 per night from 30 May to 31 May
฿1,941
฿1,941 total
30 May - 31 May
9.4/10 Exceptional! (116 reviews)
"Good location and value for money."

Reviewed on 23 May 2026

Ibis Santa Cruz DE LA Sierra
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13 Santa Cruz Santa Cruz
The price is ฿3,823 per night from 28 May to 29 May
฿3,823
฿3,823 total
28 May - 29 May
8.2/10 Very Good! (374 reviews)
"The airport shuttle did not meet us after our flight, even though I had contacted the hotel in advance and they confirmed pick up. Very disappointing. The shuttle did take us back to the airport which was convenient. The hotel is terrible at responding to guests in advance if a stay. They eventually ..."

Reviewed on 1 May 2026

Sun Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is ฿4,277 per night from 10 Jun to 11 Jun
฿4,277
฿4,277 total
10 Jun - 11 Jun
9/10 Wonderful! (378 reviews)
"Interesting layout to this hotel with exterior areas incorporated into the footprint of the property. Multiple resturants to chose from. Breakfast buffet was good but variety of fruit offered was a bit lacking. Good locations with great restaurants in area. Items in mini bar were horribly overpriced. ..."

Reviewed on 21 May 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
See all 318 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Cruz holiday package cost?
We make it simple to travel the world, with Santa Cruz holiday packages starting from as little as . You'll have the flexibility to combine your favourite airlines, hotels and car rental. For the ultimate getaway, why not add a couple of tours and activities to your itinerary?
How do I get a cheap travel package to Santa Cruz?
One of the easiest ways to save money (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all covered. Pick a combination that best fits you and watch your savings pile up. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 partner airlines and 1,000,000 properties across the world, which lets you customize your Santa Cruz adventure.
What are the top hotels in Santa Cruz?
For properties in Samaipata with cosy beds and friendly service, look up Sun Hotel and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel. If you're swinging by San Jose de Chiquitos as well, you'll get a great night's sleep at Camino Real Hotel or Marriott Santa Cruz de la Sierra Hotel.
How far in advance should I book my Santa Cruz holiday?
It's hard to pick the best time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to 12 months in advance. If you're booking late, don't stress. Discounted prices occasionally appear within a few weeks of departure dates.
What does an Expedia Santa Cruz travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your favourite combination. After you've made your booking, you can add on the exciting stuff like activities and tours. Our travel packages make it simple to create an exciting Santa Cruz escape.
What should I know before booking a Santa Cruz travel package?
Bundling your bookings into a Santa Cruz holiday package is the most convenient way to organise your trip. Not only that, you'll save just for combining your hotels, flights and car rentals. Once you've booked, why not add on a day tour or an activity?
Can I choose my airline with a Santa Cruz Expedia holiday package?
Yes — that's one of the best things about an Expedia package. You're in control. We have more than 550 airline partners throughout the world, so you have loads of choice when organising your Santa Cruz getaway.
If I'm not able to travel, can I cancel my Santa Cruz holiday package?
Yes you can, and we'll help you every step of the way. You may be able to change or cancel your Santa Cruz holiday package at no cost within 24 hours of booking. However, you may be charged a fee by your hotel, airline or car rental company if you booked more than 24 hours ago. If life throws you a curveball, browse our Customer Service Portal for more information.

What to do in Santa Cruz

Vallegrande City

Vallegrande City Tour

฿939
per adult
Vallegrande City Tour
Common grave, where the body of Che Guevara was found in 1997.

Guided tour of the Che Guevara Museum in Vallegrande

฿615
per adult
Guided tour of the Che Guevara Museum in Vallegrande
Tickets Admission Ernesto Che Guevara Historical Museum in Vallegrande

Guided visit to the Che Guevara Memorial in Vallegrande

฿615
per adult
Guided visit to the Che Guevara Memorial in Vallegrande
See all activities in Santa Cruz
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.