Find hotels in San Luis, AZ from ฿1,544

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
27 Dec - 28 Dec
Tomorrow
28 Dec - 29 Dec
Next weekend
2 Jan - 4 Jan
In two weeks
9 Jan - 11 Jan

Filter by

Guest rating
Guest rating
Star rating
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular San Luis attractions

San Luis Lakes State Park

4.0/5 (65 reviews)
You can take time to visit San Luis Lakes State Park during your travels to San Luis. You can enjoy the restaurants while in the area.
See properties

Learn more about San Luis

Border culture thrives at the San Luis I Port of Entry where visitors shop for authentic Mexican goods and crafts. Families enjoy cooling off at Joe Orduño Park with its splash pad and recreation facilities during hot summer days.

See all hotels in San Luis
Prehistoric cliffs in Sierra de las Quijadas National Park, San Luis, Argentina. Arid desert landscape. Red sandstone canyon and valley.

Top San Luis Hotel Reviews

Radisson Hotel Yuma

Radisson Hotel Yuma

10/10 Excellent
"Staff was pleasant. Room was comfy. Will stay again. "
Michelle 3-night trip
Posted 3 days ago
Radisson Hotel Yuma

More cheap stays in San Luis

Motel 6 Yuma, AZ - East

Motel 6 Yuma, AZ - East

1445 E 16th St Yuma AZ
The price is ฿1,398 per night from 4 Jan to 5 Jan
฿1,398
฿1,544 total
4 Jan - 5 Jan 2026
includes taxes & fees
8/10 Very Good! (1,071 reviews)

Frequently asked questions

What's the best place for a stay in San Luis?
Shilo Inn Hotel & Suites - Yuma, located 17.9 mi (28.9 km) from the heart of San Luis, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are La Fuente Inn & Suites and Quality Inn & Suites Yuma. See all available top hotels, or vacation rentals in San Luis.
If I need to cancel my hotel reservation in San Luis, will I receive a refund?
Yes, you'll find most hotel reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in San Luis.
What is staying in San Luis like?
Visitors can enjoy all that San Luis has to offer, including its parks. In San Luis, there are 2 hotels and other accommodation options to choose from. Find out more about San Luis.
What should I do while I'm visiting San Luis?
A couple of favourite places to visit are Colorado River and San Luis Lakes State Park. You'll also find Garita Entrance to Mexico and Marine Corp Air Station Yuma in the area. Take a look at what more there is to see and do in Expedia's San Luis guide.
What's the seasonal weather like in San Luis?
The hottest months are usually July and August, with an average temperature of 34°C, while the coldest months are December and January, with an average of 16°C. Average annual precipitation for San Luis is 90 mm.

Explore a world of travel with Expedia