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1 Oct - 2 Oct
Tomorrow
2 Oct - 3 Oct
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

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Our top choices for San Francisco hotels

A pool area with lounge chairs and a covered seating area, surrounded by modern buildings.
A modern hotel with a prominent entrance, outdoor seating area, and a handicap-accessible parking space.
A spacious lobby with modern seating, a central coffee table, and decorative hanging lights.
A spacious lobby with a central water feature, multiple seating areas, and a curved ceiling with hanging lights.

1. Hotel Mykonos Panama

Hotel Mykonos Panama
Nuevo Santiago
United States
Ismael
฿3,023
฿3,325 total
includes taxes & fees
2 Oct - 3 Oct
Hotel Mykonos Panama
A pool surrounded by palm trees and a tiled roof structure.
A building with a curved facade, a balcony with metal railings, and a door with a sign.
A hallway with a glass partition leading to a dining area, a stone wall, and a metal gate with decorative patterns.
A spacious room with a high ceiling, a large window, and a wooden door leading to another area. There are several potted plants and a small table with a vase.

2. Hotel Gran David

Hotel Gran David
Santiago
United States
Roxani
฿2,569
฿2,826 total
includes taxes & fees
23 Oct - 24 Oct
Hotel Gran David
A swimming pool with a water slide, surrounded by palm trees and lounge chairs.
A hammock suspended between two white walls in a room with a balcony.
A multi-story hotel with balconies, a pool, and a reflection in the water.
A modern bedroom with a large bed, a small table, and a chair. There is a window with curtains and a lamp on the wall.

3. HOTEL VISTA LAGO

HOTEL VISTA LAGO
La Pena
United States
Hedwig
฿2,571
฿2,828 total
includes taxes & fees
2 Oct - 3 Oct
HOTEL VISTA LAGO
A modern lobby with a sofa, armchairs, a desk, and a large window offering a view of the cityscape.
A lobby with a reception desk, two armchairs, a sofa, and a table with a lamp.
A bathroom with a tiled shower wall, a sink, and a towel rack.
A hotel room with two single beds, a desk with a chair, a television, and a door.

4. Hotel Plaza Los Tucanes

Hotel Plaza Los Tucanes
Nuevo Santiago
United States
James
฿1,741
฿1,915 total
includes taxes & fees
6 Oct - 7 Oct
Hotel Plaza Los Tucanes
Restaurant
Hotel Anachoreo with a corrugated metal roof, surrounded by tropical vegetation.
A blue building with a tiled porch, surrounded by lush greenery and a garden.
A room with two beds, a refrigerator, and a coat rack.

5. Hotel Anachoreo

Hotel Anachoreo
Santa Fe
United States
John
฿2,841
฿3,126 total
includes taxes & fees
2 Oct - 3 Oct
Hotel Anachoreo
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Top San Francisco Hotel Reviews

HOTEL VISTA LAGO

HOTEL VISTA LAGO

10/10 Excellent
"Todo perfecto"
Michele 2-night trip
Posted 12 days ago
HOTEL VISTA LAGO
La Qhia Eco Retreat

La Qhia Eco Retreat

10/10 Excellent
"This is a beautiful property but remember it is somewhat rustic. The neighborhood roosters make sure to wake you. The rooms are comfortable and with the mountain air and ceiling fan you don’t miss AC. Free breakfast was tasty. Dinner was good but lunch is not available. The best part is the well maintained landscaping. We were fortunate to have a peaceful rainy day that was heaven on the covered patio with hammocks. The staff is friendly & helpful."
Patricia 3-night trip
Posted 3 weeks ago
La Qhia Eco Retreat
Hotel Anachoreo

Hotel Anachoreo

8/10 Good
"Light"
luis 1-night trip
Posted 1 month ago
Hotel Anachoreo
Hotel Plaza Los Tucanes

Hotel Plaza Los Tucanes

10/10 Excellent
"Excelente"
Olopilel 1-night trip
Posted 1 month ago
Hotel Plaza Los Tucanes
Hotel Galería

Hotel Galería

10/10 Excellent
"Hay un restaurante en el hotel con desayuno y comida económica y muy sabrosa. La ubicación del hotel es muy céntrica. Es seguro. Tiene centro comercial al lado. Parqueo de carro seguro. Es perfecto para una visita a Santiago."
Lionel 1-night trip
Posted 6 months ago
Hotel Galería

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Frequently asked questions

What's the best place for a stay in San Francisco?
Hotel Mykonos Panama, located 10.4 mi (16.8 km) from the heart of San Francisco, is a top choice for your stay, based on our traveller data. Other good options for your stay in the area are Hotel Gran David and HOTEL VISTA LAGO. See all available top hotels, or vacation rentals in San Francisco.
If I need to cancel my hotel reservation in San Francisco, will I receive a refund?
Yes! You'll find that most room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in San Francisco.
What is staying in San Francisco like?
Visitors to San Francisco will definitely find plenty to explore and enjoy. There are 18 hotels and other accommodation options in the surrounding area. Find out more about San Francisco.
What should I see while I'm in San Francisco?
Places to visit in the wider area include Laguna de La Yeguada, Parque Acuatico Italia Guadalupe Panama and Catedral of Santiago Apostol. You'll also find Los Pozos Termales and Omar Torrijos Herrera Stadium in the area. Take a look at what more there is to see and do in Expedia's San Francisco guide.
What's the seasonal weather like in San Francisco?
The hottest months are usually March and April, with an average temperature of 27°C, while the coldest months are January and December, with an average of 25°C. The rainiest months in San Francisco are October, August, June and November, with each month seeing an average of 447 mm of rainfall.