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Our top choices for Odessa Regional Medical Center hotels

Outdoor pool, open 10:00 AM to 10:00 PM, pool cabanas (surcharge)
Odessa Marriott Hotel & Conference Center

Odessa Marriott Hotel & Conference Center

Odessa Marriott Hotel & Conference Center
4.0 star property
0.2 km from Odessa Regional Medical Center
9.2 out of 10, Wonderful, (467)
"Rooms and hotel were great"
United States
John
The price is ฿5,589
฿6,427 total
includes taxes & fees
9 Jan - 10 Jan 2026
Odessa Marriott Hotel & Conference Center
Free breakfast
Holiday Inn Express & Suites Odessa I-20 by IHG

Holiday Inn Express & Suites Odessa I-20 by IHG

Holiday Inn Express & Suites Odessa I-20 by IHG
2.5 star property
3.1 km from Odessa Regional Medical Center
8.8 out of 10, Excellent, (470)
"Room was nicely cleaned & staff was very polite. "
United States
Mariano
The price is ฿3,114
฿3,618 total
includes taxes & fees
18 Jan - 19 Jan 2026
Holiday Inn Express & Suites Odessa I-20 by IHG
Desk, laptop workspace, blackout curtains, iron/ironing board
MainStay Suites Odessa I-20

MainStay Suites Odessa I-20

MainStay Suites Odessa I-20
2.5 star property
3 km from Odessa Regional Medical Center
8.2 out of 10, Very good, (300)
"Very clean very spacious rooms friendly staff loved it"
United States
Jamayea
The price is ฿2,237
฿2,572 total
includes taxes & fees
16 Jan - 17 Jan 2026
MainStay Suites Odessa I-20
Lobby
Motel 6 Odessa, TX - 2nd Street

Motel 6 Odessa, TX - 2nd Street

Motel 6 Odessa, TX - 2nd Street
2.0 star property
1.9 km from Odessa Regional Medical Center
7.8 out of 10, Good, (502)
"Te staff was rude at check in and seem to have an issue with two men checking in."
United States
Michael
The price is ฿1,887
฿2,170 total
includes taxes & fees
1 Jan - 2 Jan 2026
Motel 6 Odessa, TX - 2nd Street
Suite, 1 King Bed, Jetted Tub, Pool View (with Sofabed) | View from room
SureStay Plus Hotel by Best Western Odessa

SureStay Plus Hotel by Best Western Odessa

SureStay Plus Hotel by Best Western Odessa
3.0 star property
2.7 km from Odessa Regional Medical Center
7.4 out of 10, Good, (78)
"Very nice place to stay "
United States
Jerry
The price is ฿2,642
฿3,039 total
includes taxes & fees
1 Jan - 2 Jan 2026
SureStay Plus Hotel by Best Western Odessa
Room, Non Smoking | Rollaway beds, free WiFi
Villa West Inn

Villa West Inn

Villa West Inn
2.0 star property
2.6 km from Odessa Regional Medical Center
7.4 out of 10, Good, (178)
"Clean room, clean toilet and good staffs."
United States
Francis
The price is ฿1,887
฿2,171 total
includes taxes & fees
1 Jan - 2 Jan 2026
Villa West Inn
Blackout curtains, free WiFi, bed sheets
Motel 6 Odessa, TX

Motel 6 Odessa, TX

Motel 6 Odessa, TX
2.0 star property
2.8 km from Odessa Regional Medical Center
6.8 out of 10, (553)
"The room was very clean. And management was very helpful."
United States
Bonnie
The price is ฿2,013
฿2,315 total
includes taxes & fees
1 Jan - 2 Jan 2026
Motel 6 Odessa, TX
Living area
DELUX INN

DELUX INN

DELUX INN
2.5 star property
2.5 km from Odessa Regional Medical Center
6.8 out of 10, (24)
"Best hotel "
United States
Poncho
The price is ฿2,045
฿2,351 total
includes taxes & fees
1 Jan - 2 Jan 2026
DELUX INN
View from room
MCM Elegante Hotel and Conference Center Odessa

MCM Elegante Hotel and Conference Center Odessa

MCM Elegante Hotel and Conference Center Odessa
3.5 star property
6 km from Odessa Regional Medical Center
9.0 out of 10, Wonderful, (1006)
"incredible stay at a 5 star hotel in Odessa Texas. Room was clean; Staff was excellent; Food was delicious. was pleasantly surprised. will stay out there again while visiting family & friends!"
United States
Patricia
The price is ฿3,148
฿3,620 total
includes taxes & fees
1 Jan - 2 Jan 2026
MCM Elegante Hotel and Conference Center Odessa
Children’s area
Staybridge Suites Odessa - Interstate HWY 20 by IHG

Staybridge Suites Odessa - Interstate HWY 20 by IHG

Staybridge Suites Odessa - Interstate HWY 20 by IHG
3.0 star property
4.6 km from Odessa Regional Medical Center
8.8 out of 10, Excellent, (145)
"Excellent "
United States
Jeannette
The price is ฿2,485
฿2,858 total
includes taxes & fees
3 Jan - 4 Jan 2026
Staybridge Suites Odessa - Interstate HWY 20 by IHG
Exterior
Courtyard Odessa

Courtyard Odessa

Courtyard Odessa
3.0 star property
8.6 km from Odessa Regional Medical Center
9.2 out of 10, Wonderful, (657)
"Nice place for the money"
United States
Wesley
The price is ฿2,485
฿2,908 total
includes taxes & fees
3 Jan - 4 Jan 2026
Courtyard Odessa
Outdoor pool
Homewood Suites by Hilton Odessa

Homewood Suites by Hilton Odessa

Homewood Suites by Hilton Odessa
3.0 star property
8.6 km from Odessa Regional Medical Center
9.2 out of 10, Wonderful, (497)
"Clean and nice place to stay. Highly recommended."
United States
Jenny
The price is ฿3,070
฿3,557 total
includes taxes & fees
17 Jan - 18 Jan 2026
Homewood Suites by Hilton Odessa
Exterior
Fairfield Inn & Suites Odessa

Fairfield Inn & Suites Odessa

Fairfield Inn & Suites Odessa
2.5 star property
5.3 km from Odessa Regional Medical Center
8.8 out of 10, Excellent, (412)
"The rooms were clean and spacious. And the free breakfast was the best! I would totally stay here again. "
United States
Tina
The price is ฿2,926
฿3,437 total
includes taxes & fees
16 Jan - 17 Jan 2026
Fairfield Inn & Suites Odessa
View from property
Residence Inn Odessa

Residence Inn Odessa

Residence Inn Odessa
3.0 star property
9.5 km from Odessa Regional Medical Center
9.2 out of 10, Wonderful, (739)
"Good location "
United States
Benito Torres
The price is ฿2,737
฿3,203 total
includes taxes & fees
3 Jan - 4 Jan 2026
Residence Inn Odessa
Front of property – evening/night
Holiday Inn Odessa by IHG

Holiday Inn Odessa by IHG

Holiday Inn Odessa by IHG
3.0 star property
6.4 km from Odessa Regional Medical Center
8.8 out of 10, Excellent, (469)
"Great staff. Nice place to rest."
United States
LISET L ORTIZ
The price is ฿2,454
฿2,859 total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Odessa by IHG
Seasonal outdoor pool, open 7:00 AM to 10:00 PM, pool loungers
Hawthorn Extended Stay by Wyndham Odessa

Hawthorn Extended Stay by Wyndham Odessa

Hawthorn Extended Stay by Wyndham Odessa
3.5 star property
4.7 km from Odessa Regional Medical Center
8.6 out of 10, Excellent, (269)
"Clean room, reasonable price and restaurant on site which was perfect after a long day of driving"
United States
Kimberly
The price is ฿2,803
฿3,223 total
includes taxes & fees
9 Jan - 10 Jan 2026
Hawthorn Extended Stay by Wyndham Odessa
Property amenity
Candlewood Suites Odessa by IHG

Candlewood Suites Odessa by IHG

Candlewood Suites Odessa by IHG
2.5 star property
4.6 km from Odessa Regional Medical Center
8.6 out of 10, Excellent, (190)
"It was a smaller place than i have stayed before, it does not have a pool, but still great place to stay."
United States
Alice
The price is ฿2,380
฿2,737 total
includes taxes & fees
3 Jan - 4 Jan 2026
Candlewood Suites Odessa by IHG
Breakfast meal
Holiday Inn Express Hotel & Suites Odessa by IHG

Holiday Inn Express Hotel & Suites Odessa by IHG

Holiday Inn Express Hotel & Suites Odessa by IHG
2.5 star property
6.6 km from Odessa Regional Medical Center
8.8 out of 10, Excellent, (405)
"Great staff, clean room"
United States
Jeffery
The price is ฿2,781
฿3,198 total
includes taxes & fees
1 Jan - 2 Jan 2026
Holiday Inn Express Hotel & Suites Odessa by IHG
Lobby
Best Western Plus North Odessa Inn & Suites

Best Western Plus North Odessa Inn & Suites

Best Western Plus North Odessa Inn & Suites
2.5 star property
8.6 km from Odessa Regional Medical Center
9.0 out of 10, Wonderful, (590)
"Clean, friendly staff, great coffee. comfy beds. wish they had streaming services on the TV's though. "
United States
David
The price is ฿2,741
฿3,152 total
includes taxes & fees
9 Jan - 10 Jan 2026
Best Western Plus North Odessa Inn & Suites
Desk, laptop workspace, blackout curtains, iron/ironing board
Sleep Inn & Suites Odessa near University

Sleep Inn & Suites Odessa near University

Sleep Inn & Suites Odessa near University
2.5 star property
5.2 km from Odessa Regional Medical Center
8.6 out of 10, Excellent, (466)
"Very good"
United States
Sharmin
The price is ฿2,005
฿2,306 total
includes taxes & fees
23 Jan - 24 Jan 2026
Sleep Inn & Suites Odessa near University
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Odessa Regional Medical Center Hotel Reviews

MCM Grande Hotel FunDome Odessa

MCM Grande Hotel FunDome Odessa

10/10 Excellent
"Everything stood out, thanks to God of course!! "
Edward 1-night trip
Posted 7 days ago
MCM Grande Hotel FunDome Odessa
Extended Stay America Select Suites - Odessa

Extended Stay America Select Suites - Odessa

10/10 Excellent
"The room was perfect and the staff was great . "
Patrick 1-night trip
Posted 2 months ago
Extended Stay America Select Suites - Odessa

Hotels near other Odessa Regional Medical Center attractions

Odessa Jackrabbit Statue

You can learn about the history of Odessa when you stop by Odessa Jackrabbit Statue. While in this family-friendly area, you can savour the top-notch restaurants.
See properties

White-Pool House

4.3/5 (20 reviews)
You can find out about the history of Odessa when you stop by White-Pool House. Experience the area's entertainment venues or attend a sporting event.
See properties

Frequently asked questions

What's the area like around Odessa Regional Medical Center?
Odessa Regional Medical Center is located in Odessa. This family-friendly area is known for its array of dining options. If you're looking for a convenient place to stay, take a look at the 15 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Odessa Regional Medical Center?
Adjacent to Odessa Regional Medical Center, Odessa Marriott Hotel & Conference Center is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices within a few miles include MCM Grande Hotel FunDome Odessa and MCM Elegante Hotel and Conference Center Odessa.
How many hotels can I expect to find near Odessa Regional Medical Center?
Expedia has 15 hotels and other accommodation options within a mile from Odessa Regional Medical Center.
If I need to cancel the hotel reservation for my stay near Odessa Regional Medical Center, will I receive a refund?
Yes! The majority of hotel bookings are fully refundable if you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then use the "fully refundable" filter to review the best deals near Odessa Regional Medical Center.
What can I see and do near Odessa Regional Medical Center?
Study the collections at White-Pool House, Ellen Noel Art Museum or Parker House Museum. Create some family memories at Altitude Trampoline Park and Fun City. Attractions like Globe of the Great Southwest and Presidential Museum and Leadership Library highlight the local culture.