A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

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Check availability on Mytilene Spa Hotels

Tonight
12 Oct - 13 Oct
Tomorrow
13 Oct - 14 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Our top choices for Mytilene hotels with a spa

A modern bathroom with a glass-enclosed shower, a bench, and a bed with towels.
A hotel room with a large bed, a desk, a chair, a small refrigerator, a staircase, and a nightstand with a lamp.
A multi-story hotel with a central courtyard, balconies, and a rooftop terrace.
A buffet with various food items including fruits, vegetables, and desserts.

1. Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel
Lesvos
  • Escape to a boutique spa retreat with hot springs and massage therapy in the heart of Mytilene.
฿4,120
฿4,626 total
includes taxes & fees
9 Nov - 10 Nov
Theofilos Paradise Boutique Hotel
A person standing on a balcony overlooking a pool and a modern building with a clear view of the sea.
A person standing by a glass railing, holding a cup, with a view of the sea and mountains in the background.
A sauna with a glass enclosure, wooden benches, and a control panel.
A modern hotel with a swimming pool, outdoor seating, and a view of the sea.

2. Elysion Hotel

Elysion Hotel
Lesvos
  • Immerse in a rejuvenating Greek island escape with tennis courts, seasonal pools, and serene balconied rooms overlooking Lesvos.
฿3,266
฿4,141 total
includes taxes & fees
13 Oct - 14 Oct
Elysion Hotel
Two wicker chairs with cushions, a decorative plant, and a small round table with candles and a tray.
An outdoor seating area with stone walls, two large woven vases, and several bean bags.
A resort with a pool, outdoor seating, and a view of the sea at dusk.
A modern hotel room with a large bed, a dining area with a view of the sea, and a balcony with a table and chairs.

3. Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat
Lesvos
  • Relax in a coastal spa haven with hydrotherapy, hot springs, and three indoor pools for ultimate rejuvenation.
฿2,943
฿3,788 total
includes taxes & fees
31 Oct - 1 Nov
Mythical Coast Wellness Retreat
A woman sitting by a pool with a drink, overlooking a modern outdoor bar and lounge area with outdoor seating.
A residential area with a swimming pool, outdoor seating, and a view of the sea.
A woman sitting on a lounge chair under a large umbrella, with other lounge chairs and umbrellas in the background.
A modern house with a stone facade, a covered patio, and a swimming pool.

4. Elies Residences

Elies Residences
Lesvos
  • Relax in premium villas with spa treatments and outdoor pool in this serene getaway.
฿3,703
฿4,131 total
includes taxes & fees
13 Oct - 14 Oct
Elies Residences
A balcony with a view of the sea, a seating area, and a bed with pillows.
A modern bathroom with a large, round vessel sink, a mirror, and a potted plant.
A modern outdoor seating area with a view of the sea, featuring a sofa, a wooden table, and a potted plant.
A person standing by a hot tub on a balcony overlooking the sea.

5. Olive Green Studios and Apartments

Olive Green Studios and Apartments
Lesvos
  • Rejuvenating seaside retreat offers in-room massages and a tranquil garden sanctuary, perfect for a wellness escape by the beach.
฿2,729
฿3,065 total
includes taxes & fees
13 Oct - 14 Oct
Olive Green Studios and Apartments
View all properties

Choose what matters most at spa hotels in Mytilene

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Mytilene Hotel Reviews

Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel

8/10 Good
"Staff was nice. Large breakfast spread. Location is great."
Caroline 1-night trip
Posted 2 months ago
Theofilos Paradise Boutique Hotel

Frequently asked questions

Looking to holiday at a spa hotel in Mytilene?
Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Discover the museums and churches in Mytilene—your cultural tour starts here. Enjoy the architecture and sea views during your holiday. Spa hotels are a great way to break out of your routine and add a layer of luxury to your holiday.
What is the best spa hotel in Mytilene?
Mythical Coast Wellness Retreat is a top beach spa hotel featuring 5 restaurants, 5 bars, 3 indoor pools and 5 cafes. Treat yourself to a facial, body scrub or Swedish massage at Mythical Coast Spa. Another popular spa hotel in Mytilene is Theofilos Paradise Boutique Hotel.
How many spa hotels are there in Mytilene?
Among Expedia's 88 accommodation options in Mytilene, there are 2 spa hotels.
What's there to see and do in Mytilene?
When you're in Mytilene, enjoy exploring the sights and attractions here including Port of Mytilene, Mytilini Castle and Roman Aqueduct at Moria. If you have a bit of extra time while you're in the area, you might want to check out Thermes Gera Hot Springs and St Hermogenes Charamida Lesvos.
What is a Mytilene spa hotel?
Spa hotels in Mytilene feature full on-site spas offering services including couples massages and a range of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are ideal if you are looking for some R&R during your holiday.