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Our top choices for Mercy Hospital Jefferson hotels

Free buffet breakfast
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
2.5 star property
2.1 km from Mercy Hospital Jefferson
9.4 out of 10, Exceptional, (703)
"Nice, clean hotel. Would stay again."
United States
Lori
The price is ฿4,020
฿4,596 total
includes taxes & fees
1 Jan - 2 Jan 2026
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Lobby
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
2.1 km from Mercy Hospital Jefferson
8.0 out of 10, Very good, (897)
"Breakfast was great! Location right off interstate was perfect. The property is a little old."
United States
Mindy
The price is ฿2,928
฿3,348 total
includes taxes & fees
18 Jan - 19 Jan 2026
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Lobby sitting area
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South
2.5 star property
2.3 km from Mercy Hospital Jefferson
7.8 out of 10, Good, (914)
"Clean room. Easy check in"
United States
Henrick
The price is ฿2,394
฿2,798 total
includes taxes & fees
1 Jan - 2 Jan 2026
Comfort Inn Festus - St Louis South
Meeting facility
Baymont by Wyndham Festus

Baymont by Wyndham Festus

Baymont by Wyndham Festus
3.0 star property
1.8 km from Mercy Hospital Jefferson
6.8 out of 10, (926)
"Room was good and staff was helpful and friendly"
United States
Michael
The price is ฿2,514
฿2,875 total
includes taxes & fees
1 Jan - 2 Jan 2026
Baymont by Wyndham Festus
Gift shop
Corner George Inn Bed & Breakfast

Corner George Inn Bed & Breakfast

Corner George Inn Bed & Breakfast
2.5 star property
14.3 km from Mercy Hospital Jefferson
9.0 out of 10, Wonderful, (154)
"Hosts were excellent, very quiet and the breakfast was wonderful"
United States
Mark
The price is ฿4,071
฿4,518 total
includes taxes & fees
1 Jan - 2 Jan 2026
Corner George Inn Bed & Breakfast
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mercy Hospital Jefferson Hotel Reviews

River City Casino & Hotel

River City Casino & Hotel

10/10 Excellent
"Very clean rooms and building. Was very impressed. We're only there for a night while driving through but was a great place to stay the night and the price was unbeatable. "
Daniel 1-night trip
Posted 2 days ago
River City Casino & Hotel

Hotels near other Mercy Hospital Jefferson attractions

Tranquil autumn landscape along the Osage River and Lake Ozarks in Missouri, United States

Sunset Park

After visiting Sunset Park, make a plan to see the other sights and activities in Festus. While in this family-friendly area, you can enjoy the restaurants.
See properties
Flowering Red Bud tree, with purple buds, sidewalk, and historic black iron fence at Lafayette Park in St. Louis, Missouri.

West City Park

After visiting West City Park, make a plan to see the other sights and activities in Festus. While in this family-friendly area, you can enjoy the restaurants.
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Frequently asked questions

What's the area like around Mercy Hospital Jefferson?
Mercy Hospital Jefferson is located in Crystal City. You'll find 11 hotels and other accommodations within a few miles for a convenient home base.
What's the best hotel to stay near Mercy Hospital Jefferson?
La Quinta Inn & Suites by Wyndham Festus - St. Louis South is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and free parking. It's located 1.3 mi (2.1 km) from Mercy Hospital Jefferson. Other good choices within 5 miles include Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG and Comfort Inn Festus - St Louis South.
How many hotels are there close to Mercy Hospital Jefferson?
Expedia has 11 hotels and other accommodation options a few miles from Mercy Hospital Jefferson.
If I need to cancel the hotel reservation for my stay near Mercy Hospital Jefferson, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and get a refund within 24 hours of booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the top deals on offer near Mercy Hospital Jefferson.