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Check prices for these dates

Tonight
4 Apr - 5 Apr
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5 Apr - 6 Apr
Next weekend
10 Apr - 12 Apr
In two weeks
17 Apr - 19 Apr

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Our top choices for Main Street Hyannis hotels

Exterior

Hyannis Travel Inn

Hyannis Travel Inn
2.5 star property
0.2 km from Main Street Hyannis
9.6 out of 10, Exceptional, (1,002 reviews)
"Great place "
United States
Shane and Jessica
The price is ฿2,909
฿3,330 total
includes taxes & fees
6 Apr - 7 Apr
Hyannis Travel Inn
Terrace/patio

Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging
3.0 star property
0.6 km from Main Street Hyannis
9.4 out of 10, Exceptional, (1,000 reviews)
"Very clean place"
United States
John
The price is ฿4,368
฿5,935 total
includes taxes & fees
9 Apr - 10 Apr
Anchor In Distinctive Waterfront Lodging
Exterior

Cape Cod Harbor House Inn

Cape Cod Harbor House Inn
2.5 star property
0.4 km from Main Street Hyannis
9.2 out of 10, Wonderful, (309 reviews)
"Great place!"
United States
Sandy
The price is ฿3,105
฿3,554 total
includes taxes & fees
21 Apr - 22 Apr
Cape Cod Harbor House Inn
Luxury King Room | Egyptian cotton sheets, premium bedding, individually decorated

Sea Street Inn

Sea Street Inn
4.0 star property
1.5 km from Main Street Hyannis
9.8 out of 10, Exceptional, (45 reviews)
"Very nicely renovated small property with a fantastic breakfast."
United States
Paul
The price is ฿8,646
฿9,895 total
includes taxes & fees
5 Apr - 6 Apr
Sea Street Inn
Indoor pool, seasonal outdoor pool

Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection
3.0 star property
1.9 km from Main Street Hyannis
9.2 out of 10, Wonderful, (123 reviews)
"Clean room very good place to stay, we will stay again there."
United States
Arezki
The price is ฿3,840
฿4,548 total
includes taxes & fees
16 Apr - 17 Apr
Uncommoner Hotel by Reverie Boutique Collection
Marina

Cape Cod Inn

Cape Cod Inn
2.0 star property
0.2 km from Main Street Hyannis
8.8 out of 10, Excellent, (506 reviews)
"Great location. "
United States
Peter
The price is ฿3,367
฿3,853 total
includes taxes & fees
19 Apr - 20 Apr
Cape Cod Inn
Indoor pool, seasonal outdoor pool, pool umbrellas, pool loungers

Hampton Inn & Suites Cape Cod-West Yarmouth

Hampton Inn & Suites Cape Cod-West Yarmouth
2.5 star property
1.7 km from Main Street Hyannis
8.8 out of 10, Excellent, (1,001 reviews)
"The hotel was very clean and the accommodations exceeded out expectations."
United States
Michael
The price is ฿4,229
฿4,840 total
includes taxes & fees
26 Apr - 27 Apr
Hampton Inn & Suites Cape Cod-West Yarmouth
Indoor pool

Courtyard By Marriott Cape Cod Hyannis

Courtyard By Marriott Cape Cod Hyannis
3.0 star property
1.7 km from Main Street Hyannis
8.8 out of 10, Excellent, (496 reviews)
"Clean spacious rooms, courteous staff, convenient location"
United States
Michelle
The price is ฿4,689
฿5,366 total
includes taxes & fees
19 Apr - 20 Apr
Courtyard By Marriott Cape Cod Hyannis
Indoor pool, seasonal outdoor pool, pool umbrellas, pool loungers

Bayside Resort Hotel

Bayside Resort Hotel
3.0 star property
2.3 km from Main Street Hyannis
8.8 out of 10, Excellent, (1,544 reviews)
"Great family friendly hotel. "
United States
Danielle
The price is ฿3,913
฿4,852 total
includes taxes & fees
12 Apr - 13 Apr
Bayside Resort Hotel
Lobby lounge

Fairfield Inn & Suites by Marriott Cape Cod Hyannis

Fairfield Inn & Suites by Marriott Cape Cod Hyannis
3.0 star property
2.3 km from Main Street Hyannis
8.8 out of 10, Excellent, (687 reviews)
"Clean room, friendly staff and close to a mall."
United States
Geoffrey Eugene
The price is ฿3,862
฿4,420 total
includes taxes & fees
20 Apr - 21 Apr
Fairfield Inn & Suites by Marriott Cape Cod Hyannis
Indoor pool

Courtyard Resort

Courtyard Resort
2.0 star property
0.3 km from Main Street Hyannis
8.4 out of 10, Very good, (70 reviews)
"Everything was good,location was spot on,we'll be back."
United States
susan
The price is ฿3,556
฿4,070 total
includes taxes & fees
12 Apr - 13 Apr
Courtyard Resort
Lobby

Heritage House Inn on Cape Cod, an Ascend Collection Hotel

Heritage House Inn on Cape Cod, an Ascend Collection Hotel
2.5 star property
0.3 km from Main Street Hyannis
8.4 out of 10, Very good, (20 reviews)
"It was ok staff was nice"
United States
Troy
The price is ฿3,723
฿4,261 total
includes taxes & fees
3 May - 4 May
Heritage House Inn on Cape Cod, an Ascend Collection Hotel
Exterior

Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis
4.0 star property
0.9 km from Main Street Hyannis
8.4 out of 10, Very good, (895 reviews)
"Would definitely stay again"
United States
maureen
The price is ฿4,476
฿5,123 total
includes taxes & fees
12 Apr - 13 Apr
Doubletree by Hilton Cape Cod - Hyannis
Free daily continental breakfast

Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod
2.5 star property
0.3 km from Main Street Hyannis
8.0 out of 10, Very good, (1,002 reviews)
"Clean room, friendly staff, felt extremely safe."
United States
Jillian
The price is ฿3,638
฿4,163 total
includes taxes & fees
12 Apr - 13 Apr
Comfort Inn Hyannis - Cape Cod
Exterior

Cape Sands Inn

Cape Sands Inn
2.5 star property
1.9 km from Main Street Hyannis
8.2 out of 10, Very good, (1,031 reviews)
"The place was very clean. Bed was super comfortable. The staff was pleasant and helpful. "
United States
Melissa
The price is ฿2,111
฿2,417 total
includes taxes & fees
7 Apr - 8 Apr
Cape Sands Inn
Front of property

Hyannis Harbor Hotel

Hyannis Harbor Hotel
3.5 star property
0.6 km from Main Street Hyannis
8.0 out of 10, Very good, (1,001 reviews)
"Clean room, helpful front desk."
United States
Mara
The price is ฿4,036
฿5,939 total
includes taxes & fees
3 May - 4 May
Hyannis Harbor Hotel
Exterior

Holiday Inn Hyannis by IHG

Holiday Inn Hyannis by IHG
3.0 star property
2.9 km from Main Street Hyannis
8.2 out of 10, Very good, (1,002 reviews)
"Pool was great!"
United States
Colleen
The price is ฿3,596
฿4,115 total
includes taxes & fees
12 Apr - 13 Apr
Holiday Inn Hyannis by IHG
Room, 1 King Bed | Desk, iron/ironing board, free cots/infant beds, rollaway beds

Hyannis Host Inn

Hyannis Host Inn
2.0 star property
1.6 km from Main Street Hyannis
7.8 out of 10, Good, (457 reviews)
"Was a very nice stay! "
United States
Luis
The price is ฿3,230
฿3,696 total
includes taxes & fees
16 Apr - 17 Apr
Hyannis Host Inn
Exterior

Sea Breeze Inn

Sea Breeze Inn
2.5 star property
1.8 km from Main Street Hyannis
7.8 out of 10, Good, (195 reviews)
"Nice place to stay "
United States
Kevin
The price is ฿2,903
฿3,323 total
includes taxes & fees
11 Apr - 12 Apr
Sea Breeze Inn
Lobby

Hyannis Plaza Hotel

Hyannis Plaza Hotel
2.5 star property
0.9 km from Main Street Hyannis
7.0 out of 10, Good, (1,001 reviews)
"Love this place "
United States
M
The price is ฿3,138
฿3,918 total
includes taxes & fees
15 Apr - 16 Apr
Hyannis Plaza Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Compare popular hotels close to Main Street Hyannis

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Exterior
Hyannis Travel Inn
2.5 star property
9.6
Exceptional
1,002 reviews
View
Terrace/patio
Anchor In Distinctive Waterfront Lodging
3.0 star property
9.4
Exceptional
1,000 reviews
View
Exterior
Cape Cod Harbor House Inn
2.5 star property
9.2
Wonderful
309 reviews
View
Luxury King Room | Egyptian cotton sheets, premium bedding, individually decorated
Sea Street Inn
4.0 star property
9.8
Exceptional
45 reviews
View
Indoor pool, seasonal outdoor pool
Uncommoner Hotel by Reverie Boutique Collection
3.0 star property
9.2
Wonderful
123 reviews
View

Top Main Street Hyannis Hotel Reviews

Hyannis Travel Inn

Hyannis Travel Inn

10/10 Excellent
"Very friendly staff. The property is well kept. I am a multi return customer ."
John 2-night trip
Posted 3 hours ago
Hyannis Travel Inn

Hotels near other Main Street Hyannis attractions

John F. Kennedy Hyannis Museum

4.4/5 (444 reviews)
Learn about the 35th president of the United States at this revealing museum, which is just a short distance from the Kennedy Compound.
See properties

Cape Cod Maritime Museum

4.5/5 (16 reviews)
You can spend an afternoon studying the exhibits at Cape Cod Maritime Museum during your trip to Hyannis. Stroll along the beautiful beaches in this family-friendly area or visit its seafood restaurants.
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Frequently asked questions

What's the area like around Main Street Hyannis?
Main Street Hyannis is located in a walkable area of Hyannis known for its top seafood restaurants and major shopping area. If you're looking for a convenient place to stay, take a look at the 187 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay near Main Street Hyannis?
Adjacent to Main Street Hyannis, Hyannis Travel Inn is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an outdoor pool. Other good options within a short distance include Comfort Inn Hyannis - Cape Cod and Courtyard Resort.
How many hotels can I expect to find near Main Street Hyannis?
Expedia has 187 hotels and other accommodation options within a mile from Main Street Hyannis.
If I need to cancel the hotel reservation for my stay near Main Street Hyannis, will I receive a refund?
Yes! Most hotel reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and get a refund within 24 hours of your booking. Add dates, click "Search", then filter by "fully refundable" to review the top deals on offer near Main Street Hyannis.
What can I see and do near Main Street Hyannis?
John F. Kennedy Hyannis Museum, Whydah Pirate Museum and Cape Cod Maritime Museum feature captivating exhibits. Hyannis Harbor, Edward Gorey House and Sandy Neck Lighthouse are landmarks that you won't want to miss. Local parks like Lewis Bay, Dennis Pond Conservation Area and Veterans Memorial Park are peaceful spots to stop and take in some fresh air.